Chronological Switch from Translesion Synthesis to Homology-Dependent Gap Repair In Vivo

Fujii, Shingo; Isogawa, Asako; Fuchs, Robert P.

doi:10.5487/TR.2018.34.4.297

Title: Chronological Switch from Translesion Synthesis to Homology-Dependent Gap Repair In Vivo

Journal Article · 15 October 2018 · Toxicological research

DOI: https://doi.org/10.5487/TR.2018.34.4.297 · OSTI ID:1559160

Fujii, Shingo ^[1]; Isogawa, Asako ^[1]; Fuchs, Robert P. ^[1]

DNA Damage Tolerance CNRS, Marseille (France); Institut Paoli-Calmettes, Marseille (France); Aix-Marseille Univ., Marseille (France); Inserm, Marseille (France)

Cells are constantly exposed to endogenous and exogenous chemical and physical agents that damage their genome by forming DNA lesions. These lesions interfere with the normal functions of DNA such as transcription and replication, and need to be either repaired or tolerated. DNA lesions are accurately removed via various repair pathways. In contrast, tolerance mechanisms do not remove lesions but only allow replication to proceed despite the presence of unrepaired lesions. Cells possess two major tolerance strategies, namely translesion synthesis (TLS), which is an error-prone strategy and an accurate strategy based on homologous recombination (homology-dependent gap repair [HDGR]). Thus, the mutation frequency reflects the relative extent to which the two tolerance pathways operate in vivo. In the present paper, we review the present understanding of the mechanisms of TLS and HDGR and propose a novel and comprehensive view of the way both strategies interact and are regulated in vivo.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1559160

Journal Information:: Toxicological research, Journal Name: Toxicological research Journal Issue: 4 Vol. 34; ISSN 1976-8257

Publisher:: Korean Society of ToxicologyCopyright Statement

Country of Publication:: United States

Language:: English

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