Oral immunization of mice with Lactococcus lactis expressing Shiga toxin truncate confers enhanced protection against Shiga toxins of Escherichia coli O157:H7 and Shigella dysenteriae

doi:10.1111/apm.12983

This content will become publicly available on August 27, 2020

Title: Oral immunization of mice with Lactococcus lactis expressing Shiga toxin truncate confers enhanced protection against Shiga toxins of Escherichia coli O157:H7 and Shigella dysenteriae

Authors:

Sreerohini, Sagi ^[1]; Balakrishna, Konduru ^[1]; Parida, Manmohan ^[1]

Division of Food Microbiology Defence Food Research Laboratory Mysore India

Publication Date:: 2019-08-28

Sponsoring Org.:: USDOE Office of Electricity Delivery and Energy Reliability (OE), Power Systems Engineering Research and Development (R&D) (OE-10)

OSTI Identifier:: 1559100

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: APMIS

Additional Journal Information:: Journal Name: APMIS Journal Volume: 127 Journal Issue: 10; Journal ID: ISSN 0903-4641

Publisher:: Wiley-Blackwell

Country of Publication:: Country unknown/Code not available

Language:: English

Citation Formats


                    Sreerohini, Sagi, Balakrishna, Konduru, and Parida, Manmohan. Oral immunization of mice with Lactococcus lactis expressing Shiga toxin truncate confers enhanced protection against Shiga toxins of Escherichia coli O157:H7 and Shigella dysenteriae.  Country unknown/Code not available: N. p., 2019. 
        Web.  doi:10.1111/apm.12983.

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                    Sreerohini, Sagi, Balakrishna, Konduru, & Parida, Manmohan. Oral immunization of mice with Lactococcus lactis expressing Shiga toxin truncate confers enhanced protection against Shiga toxins of Escherichia coli O157:H7 and Shigella dysenteriae.  Country unknown/Code not available.  doi:10.1111/apm.12983.

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                    Sreerohini, Sagi, Balakrishna, Konduru, and Parida, Manmohan. Wed .  
        "Oral immunization of mice with Lactococcus lactis expressing Shiga toxin truncate confers enhanced protection against Shiga toxins of Escherichia coli O157:H7 and Shigella dysenteriae".  Country unknown/Code not available.  doi:10.1111/apm.12983.

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@article{osti_1559100,

  title        = {Oral immunization of mice with Lactococcus lactis expressing Shiga toxin truncate confers enhanced protection against Shiga toxins of Escherichia coli O157:H7 and Shigella dysenteriae},

  author       = {Sreerohini, Sagi and Balakrishna, Konduru and Parida, Manmohan},

  abstractNote = {},

  doi          = {10.1111/apm.12983},

  journal      = {APMIS},

  number       = 10,

  volume       = 127,

  place        = {Country unknown/Code not available},

  year         = {2019},

  month        = {8}

}

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DOI: 10.1111/apm.12983

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Similar Records

This content will become publicly available on August 27, 2020

Title: Oral immunization of mice with Lactococcus lactis expressing Shiga toxin truncate confers enhanced protection against Shiga toxins of Escherichia coli O157:H7 and Shigella dysenteriae

Citation Formats

A simple method for expression and purification of Shiga toxin 1 (Stx1) with biological activities by using a single-promoter vector and native signal peptide: Expression and Purification of Shiga Toxin 1 journal, July 2015

Protection against human papillomavirus type 16-induced tumors in C57BL/6 mice by mucosal vaccination with Lactococcus lactis NZ9000 expressing E6 oncoprotein journal, January 2019

Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins journal, April 2009

Evaluation of recombinant SEA-TSST fusion toxoid for protection against superantigen induced toxicity in mouse model journal, September 2015

Cloning a Truncated Fragment (stx2a1) of the Shiga-Like Toxin 2A1 Subunit of EHEC O157:H7: Candidate Immunogen for a Subunit Vaccine journal, May 2009

Development of a hybrid Shiga holotoxoid vaccine to elicit heterologous protection against Shiga toxins types 1 and 2☆ journal, May 2006

Enhanced immunogenicity of a novel Stx2Am-Stx1B fusion protein in a mice model of enterohemorrhagic Escherichia coli O157:H7 infection journal, January 2011

Treatment options for HUS secondary to Escherichia coli O157:H7 journal, February 2009

Verotoxins induce apoptosis in human renal tubular epithelium derived cells journal, June 1998

Shiga Toxin (Stx) Classification, Structure, and Function journal, August 2014

Oral immunization with recombinant Lactococcus lactis confers protection against respiratory pneumococcal infection journal, October 2008

A rapid method for the discrimination of genes encoding classical Shiga toxin (Stx) 1 and its variants, Stx1c and Stx1d, inEscherichia coli journal, December 2004

Enterohaemorrhagic Escherichia coli and Shigella dysenteriae type 1-induced haemolytic uraemic syndrome journal, May 2008

Release of Shiga Toxin by Membrane Vesicles in Shigella dysenteriae Serotype 1 Strains and In Vitro Effects of Antimicrobials on Toxin Production and Release journal, December 2004

Development of Recombinant Lactococcus lactis Displaying Albumin-Binding Domain Variants against Shiga Toxin 1 B Subunit journal, September 2016

Genetic toxoids of Shiga toxin types 1 and 2 protect mice against homologous but not heterologous toxin challenge journal, February 2006

Pathogenesis and Diagnosis of Shiga Toxin-Producing Escherichia coli Infections journal, July 1998

Renal histopathology in fatal cases of diarrhoea-associated haemolytic uraemic syndrome journal, September 1997

Identification, Characterization, and Distribution of a Shiga Toxin 1 Gene Variant (stx1c) in Escherichia coli Strains Isolated from Humans journal, April 2002

Oral immunization with Lactococcus lactis-expressing EspB induces protective immune responses against Escherichia coli O157:H7 in a murine model of colonization journal, June 2014

Haemolytic uraemic syndrome during shigellosis journal, July 2012

Recent Progress of Shiga Toxin Neutralizer for Treatment of Infections by Shiga Toxin-Producing Escherichia coli journal, June 2011

Mucosal Immunity and Protection Against HIV/SIV Infection: Strategies and Challenges for Vaccine Design journal, January 2009

Shiga Toxin Associated Hemolytic Uremic Syndrome journal, June 2015

Approaches to treatment of emerging Shiga toxin-producing Escherichia coli infections highlighting the O104:H4 serotype journal, March 2015

Expression of Helicobacter pylori urease subunit B gene in Lactococcus lactis MG1363 and its use as a vaccine delivery system against H. pylori infection in mice journal, July 2001

The Hemolytic Uremic Syndrome journal, December 1995

Antibody Therapy in the Management of Shiga Toxin-Induced Hemolytic Uremic Syndrome journal, October 2004

Globotriaosyl ceramide receptor function - Where membrane structure and pathology intersect journal, December 2009

New insights in mucosal vaccine development journal, January 2012

Fusion expression and immunogenicity of EHEC EspA-Stx2Al protein: Implications for the vaccine development journal, August 2009

Purification and characterization of verocytotoxin 2 journal, June 1988

The recombinant Lactococcus lactis oral vaccine induces protection against C. difficile spore challenge in a mouse model journal, March 2015

Childhood Hemolytic Uremic Syndrome, United Kingdom and Ireland journal, April 2005

Modulation of Gut-Associated Lymphoid Tissue Functions with Genetically Modified Lactococcus lactis journal, November 2009

Shigella sonnei and hemolytic uremic syndrome: A case report and literature review journal, January 2017

10 years of the nisin-controlled gene expression system (NICE) in Lactococcus lactis journal, August 2005

Sex differences in vaccine-induced humoral immunity journal, December 2018

Effects of Antibiotics on Shiga Toxin 2 Production and Bacteriophage Induction by Epidemic Escherichia coli O104:H4 Strain journal, March 2012

Oral immunization with Lactococcus lactis secreting attenuated recombinant staphylococcal enterotoxin B induces a protective immune response in a murine model journal, January 2013

Mucosal priming of the murine immune system against enterohemorrhagic Escherichia coli O157:H7 using Lactococcus lactis expressing the type III secretion system protein EspB journal, March 2013

Oral immunization of mice with recombinant Lactococcus lactis expressing Cu,Zn superoxide dismutase of Brucella abortus triggers protective immunity journal, February 2012

A simple method for expression and purification of Shiga toxin 1 (Stx1) with biological activities by using a single-promoter vector and native signal peptide: Expression and Purification of Shiga Toxin 1
journal, July 2015

Protection against human papillomavirus type 16-induced tumors in C57BL/6 mice by mucosal vaccination with Lactococcus lactis NZ9000 expressing E6 oncoprotein
journal, January 2019

Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins
journal, April 2009

Evaluation of recombinant SEA-TSST fusion toxoid for protection against superantigen induced toxicity in mouse model
journal, September 2015

Cloning a Truncated Fragment (stx2a1) of the Shiga-Like Toxin 2A1 Subunit of EHEC O157:H7: Candidate Immunogen for a Subunit Vaccine
journal, May 2009

Development of a hybrid Shiga holotoxoid vaccine to elicit heterologous protection against Shiga toxins types 1 and 2☆
journal, May 2006

Enhanced immunogenicity of a novel Stx2Am-Stx1B fusion protein in a mice model of enterohemorrhagic Escherichia coli O157:H7 infection
journal, January 2011

Treatment options for HUS secondary to Escherichia coli O157:H7
journal, February 2009

Verotoxins induce apoptosis in human renal tubular epithelium derived cells
journal, June 1998

Shiga Toxin (Stx) Classification, Structure, and Function
journal, August 2014

Oral immunization with recombinant Lactococcus lactis confers protection against respiratory pneumococcal infection
journal, October 2008

A rapid method for the discrimination of genes encoding classical Shiga toxin (Stx) 1 and its variants, Stx1c and Stx1d, inEscherichia coli
journal, December 2004

Enterohaemorrhagic Escherichia coli and Shigella dysenteriae type 1-induced haemolytic uraemic syndrome
journal, May 2008

Release of Shiga Toxin by Membrane Vesicles in Shigella dysenteriae Serotype 1 Strains and In Vitro Effects of Antimicrobials on Toxin Production and Release
journal, December 2004

Development of Recombinant Lactococcus lactis Displaying Albumin-Binding Domain Variants against Shiga Toxin 1 B Subunit
journal, September 2016

Genetic toxoids of Shiga toxin types 1 and 2 protect mice against homologous but not heterologous toxin challenge
journal, February 2006

Pathogenesis and Diagnosis of Shiga Toxin-Producing Escherichia coli Infections
journal, July 1998

Renal histopathology in fatal cases of diarrhoea-associated haemolytic uraemic syndrome
journal, September 1997

Identification, Characterization, and Distribution of a Shiga Toxin 1 Gene Variant (stx1c) in Escherichia coli Strains Isolated from Humans
journal, April 2002

Oral immunization with Lactococcus lactis-expressing EspB induces protective immune responses against Escherichia coli O157:H7 in a murine model of colonization
journal, June 2014

Haemolytic uraemic syndrome during shigellosis
journal, July 2012

Recent Progress of Shiga Toxin Neutralizer for Treatment of Infections by Shiga Toxin-Producing Escherichia coli
journal, June 2011

Mucosal Immunity and Protection Against HIV/SIV Infection: Strategies and Challenges for Vaccine Design
journal, January 2009

Shiga Toxin Associated Hemolytic Uremic Syndrome
journal, June 2015

Approaches to treatment of emerging Shiga toxin-producing Escherichia coli infections highlighting the O104:H4 serotype
journal, March 2015

Expression of Helicobacter pylori urease subunit B gene in Lactococcus lactis MG1363 and its use as a vaccine delivery system against H. pylori infection in mice
journal, July 2001

The Hemolytic Uremic Syndrome
journal, December 1995

Antibody Therapy in the Management of Shiga Toxin-Induced Hemolytic Uremic Syndrome
journal, October 2004

Globotriaosyl ceramide receptor function - Where membrane structure and pathology intersect
journal, December 2009

New insights in mucosal vaccine development
journal, January 2012

Fusion expression and immunogenicity of EHEC EspA-Stx2Al protein: Implications for the vaccine development
journal, August 2009

Purification and characterization of verocytotoxin 2
journal, June 1988

The recombinant Lactococcus lactis oral vaccine induces protection against C. difficile spore challenge in a mouse model
journal, March 2015

Childhood Hemolytic Uremic Syndrome, United Kingdom and Ireland
journal, April 2005

Modulation of Gut-Associated Lymphoid Tissue Functions with Genetically Modified Lactococcus lactis
journal, November 2009

Shigella sonnei and hemolytic uremic syndrome: A case report and literature review
journal, January 2017

10 years of the nisin-controlled gene expression system (NICE) in Lactococcus lactis
journal, August 2005

Sex differences in vaccine-induced humoral immunity
journal, December 2018

Effects of Antibiotics on Shiga Toxin 2 Production and Bacteriophage Induction by Epidemic Escherichia coli O104:H4 Strain
journal, March 2012

Oral immunization with Lactococcus lactis secreting attenuated recombinant staphylococcal enterotoxin B induces a protective immune response in a murine model
journal, January 2013

Mucosal priming of the murine immune system against enterohemorrhagic Escherichia coli O157:H7 using Lactococcus lactis expressing the type III secretion system protein EspB
journal, March 2013

Oral immunization of mice with recombinant Lactococcus lactis expressing Cu,Zn superoxide dismutase of Brucella abortus triggers protective immunity
journal, February 2012