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Title: Noncontact tip-enhanced Raman spectroscopy for nanomaterials and biomedical applications

Abstract

Tip-enhanced Raman spectroscopy (TERS) has been established as one the most efficient analytical techniques for probing vibrational states with nanoscale resolution. While TERS may be a source of unique information about chemical structure and interactions, it has a limited use for materials with rough or sticky surfaces. Development of the TERS approach utilizing a non-contact scanning probe microscopy mode can significantly extend the number of applications. Here we demonstrate a proof of the concept and feasibility of a non-contact TERS approach and test it on various materials. Our experiments show that non-contact TERS can provide 10 nm spatial resolution and a Raman signal enhancement factor of 105, making it very promising for chemical imaging of materials with high aspect ratio surface patterns and biomaterials.

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [3]; ORCiD logo [4];  [4];  [5]; ORCiD logo [6];  [2]; ORCiD logo [7]; ORCiD logo [8];  [7]; ORCiD logo [3]; ORCiD logo [2]
  1. Department of Mechanical Engineering, Tufts University, Medford, USA, Chemical Sciences Division
  2. Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, USA
  3. Center for Nanophase Materials Sciences, Computational Sciences and Engineering Division, Oak Ridge National Laboratory, Oak Ridge, USA
  4. Energy & Transportation Science Division, Oak Ridge National Laboratory, Oak Ridge, USA
  5. Institute of Problems of Chemical Physics RAS, Moscow region, Russia
  6. National University of Science and Technology MISIS, Moscow, Russia
  7. Department of Medicine, University of Tennessee Health Science Center, Memphis, USA
  8. Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, USA
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1558813
Alternate Identifier(s):
OSTI ID: 1559580; OSTI ID: 1606971
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Published Article
Journal Name:
Nanoscale Advances
Additional Journal Information:
Journal Name: Nanoscale Advances Journal Volume: 1 Journal Issue: 9; Journal ID: ISSN 2516-0230
Publisher:
Royal Society of Chemistry
Country of Publication:
United Kingdom
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 47 OTHER INSTRUMENTATION

Citation Formats

Voylov, Dmitry N., Bocharova, Vera, Lavrik, Nickolay V., Vlassiouk, Ivan, Polizos, Georgios, Volodin, Alexei, Shulga, Yury M., Kisliuk, Alexander, Thiyagarajan, Thirumagal, Miller, Duane D., Narayanan, Ramesh, Sumpter, Bobby G., and Sokolov, Alexei P. Noncontact tip-enhanced Raman spectroscopy for nanomaterials and biomedical applications. United Kingdom: N. p., 2019. Web. https://doi.org/10.1039/C9NA00322C.
Voylov, Dmitry N., Bocharova, Vera, Lavrik, Nickolay V., Vlassiouk, Ivan, Polizos, Georgios, Volodin, Alexei, Shulga, Yury M., Kisliuk, Alexander, Thiyagarajan, Thirumagal, Miller, Duane D., Narayanan, Ramesh, Sumpter, Bobby G., & Sokolov, Alexei P. Noncontact tip-enhanced Raman spectroscopy for nanomaterials and biomedical applications. United Kingdom. https://doi.org/10.1039/C9NA00322C
Voylov, Dmitry N., Bocharova, Vera, Lavrik, Nickolay V., Vlassiouk, Ivan, Polizos, Georgios, Volodin, Alexei, Shulga, Yury M., Kisliuk, Alexander, Thiyagarajan, Thirumagal, Miller, Duane D., Narayanan, Ramesh, Sumpter, Bobby G., and Sokolov, Alexei P. Wed . "Noncontact tip-enhanced Raman spectroscopy for nanomaterials and biomedical applications". United Kingdom. https://doi.org/10.1039/C9NA00322C.
@article{osti_1558813,
title = {Noncontact tip-enhanced Raman spectroscopy for nanomaterials and biomedical applications},
author = {Voylov, Dmitry N. and Bocharova, Vera and Lavrik, Nickolay V. and Vlassiouk, Ivan and Polizos, Georgios and Volodin, Alexei and Shulga, Yury M. and Kisliuk, Alexander and Thiyagarajan, Thirumagal and Miller, Duane D. and Narayanan, Ramesh and Sumpter, Bobby G. and Sokolov, Alexei P.},
abstractNote = {Tip-enhanced Raman spectroscopy (TERS) has been established as one the most efficient analytical techniques for probing vibrational states with nanoscale resolution. While TERS may be a source of unique information about chemical structure and interactions, it has a limited use for materials with rough or sticky surfaces. Development of the TERS approach utilizing a non-contact scanning probe microscopy mode can significantly extend the number of applications. Here we demonstrate a proof of the concept and feasibility of a non-contact TERS approach and test it on various materials. Our experiments show that non-contact TERS can provide 10 nm spatial resolution and a Raman signal enhancement factor of 105, making it very promising for chemical imaging of materials with high aspect ratio surface patterns and biomaterials.},
doi = {10.1039/C9NA00322C},
journal = {Nanoscale Advances},
number = 9,
volume = 1,
place = {United Kingdom},
year = {2019},
month = {9}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1039/C9NA00322C

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