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Title: The structural fate of lipid nanoparticles in the extracellular matrix

Abstract

Hydrogels cause unilamellar liposomes to transform into aggregates of multilamellar structures through an osmotic effect.

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [3]; ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [1]
  1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, USA
  2. School of Chemistry, School of Materials Science and Engineering, Australian Centre for Nanomedicine, University of New South Wales, Sydney NSW 2052, Australia
  3. Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea
Publication Date:
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1556792
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Materials Horizons
Additional Journal Information:
Journal Name: Materials Horizons Journal Volume: 7 Journal Issue: 1; Journal ID: ISSN 2051-6347
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Bandara, Sarith R., Molley, Thomas G., Kim, Hojun, Bharath, Priyalini A., Kilian, Kristopher A., and Leal, Cecilia. The structural fate of lipid nanoparticles in the extracellular matrix. United Kingdom: N. p., 2020. Web. doi:10.1039/C9MH00835G.
Bandara, Sarith R., Molley, Thomas G., Kim, Hojun, Bharath, Priyalini A., Kilian, Kristopher A., & Leal, Cecilia. The structural fate of lipid nanoparticles in the extracellular matrix. United Kingdom. doi:10.1039/C9MH00835G.
Bandara, Sarith R., Molley, Thomas G., Kim, Hojun, Bharath, Priyalini A., Kilian, Kristopher A., and Leal, Cecilia. Thu . "The structural fate of lipid nanoparticles in the extracellular matrix". United Kingdom. doi:10.1039/C9MH00835G.
@article{osti_1556792,
title = {The structural fate of lipid nanoparticles in the extracellular matrix},
author = {Bandara, Sarith R. and Molley, Thomas G. and Kim, Hojun and Bharath, Priyalini A. and Kilian, Kristopher A. and Leal, Cecilia},
abstractNote = {Hydrogels cause unilamellar liposomes to transform into aggregates of multilamellar structures through an osmotic effect.},
doi = {10.1039/C9MH00835G},
journal = {Materials Horizons},
number = 1,
volume = 7,
place = {United Kingdom},
year = {2020},
month = {1}
}

Journal Article:
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Works referenced in this record:

Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis
journal, January 2015

  • Abdeen, Amr A.; Lee, Junmin; Mo, Samuel H.
  • Journal of Materials Chemistry B, Vol. 3, Issue 40
  • DOI: 10.1039/C5TB01294E

The Configuration of the Polyoxyethylene Chain
journal, April 1965

  • Mark, J. E.; Flory, P. J.
  • Journal of the American Chemical Society, Vol. 87, Issue 7
  • DOI: 10.1021/ja01085a001

Role of lipid polymorphism in acoustically sensitive liposomes
journal, January 2014

  • Kang, Minjee; Huang, Grace; Leal, Cecilia
  • Soft Matter, Vol. 10, Issue 44
  • DOI: 10.1039/C4SM01431F

PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine
journal, December 2008


The osmotic pressure of chondroitin sulphate solutions: Experimental measurements and theoretical analysis
journal, November 1998


Super-swelled lyotropic single crystals
journal, September 2017

  • Kim, Hojun; Song, Ziyuan; Leal, Cecilia
  • Proceedings of the National Academy of Sciences, Vol. 114, Issue 41
  • DOI: 10.1073/pnas.1710774114

Interaction of Gold Nanoparticles with Common Human Blood Proteins
journal, December 2009

  • Lacerda, Silvia H. De Paoli; Park, Jung Jin; Meuse, Curt
  • ACS Nano, Vol. 4, Issue 1
  • DOI: 10.1021/nn9011187

Neurofilaments Function as Shock Absorbers: Compression Response Arising from Disordered Proteins
journal, September 2016


Host Matrix Modulation by Tumor Exosomes Promotes Motility and Invasiveness
journal, August 2013

  • Mu, Wei; Rana, Sanyukta; Zöller, Margot
  • Neoplasia, Vol. 15, Issue 8
  • DOI: 10.1593/neo.13786

Inhibition of Liposome-Induced Complement Activation by Incorporated Poly(Ethylene Glycol)-Lipids
journal, September 1998

  • Bradley, Amanda J.; Devine, Dana V.; Ansell, Steven M.
  • Archives of Biochemistry and Biophysics, Vol. 357, Issue 2
  • DOI: 10.1006/abbi.1998.0798

Liposomes as nanomedical devices
journal, February 2015

  • Bozzuto, Giuseppina; Molinari, Agnese
  • International Journal of Nanomedicine
  • DOI: 10.2147/IJN.S68861

The Scherrer Formula for X-Ray Particle Size Determination
journal, November 1939


Renal clearance of quantum dots
journal, September 2007

  • Soo Choi, Hak; Liu, Wenhao; Misra, Preeti
  • Nature Biotechnology, Vol. 25, Issue 10
  • DOI: 10.1038/nbt1340

Structure of Lung-Mimetic Multilamellar Bodies with Lipid Compositions Relevant in Pneumonia
journal, May 2018


Emerging Droplet Microfluidics
journal, May 2017


Polymeric Substrates with Tunable Elasticity and Nanoscopically Controlled Biomolecule Presentation
journal, October 2010

  • Aydin, Daniel; Louban, Ilia; Perschmann, Nadine
  • Langmuir, Vol. 26, Issue 19
  • DOI: 10.1021/la103065x

Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
journal, January 2007

  • Cedervall, T.; Lynch, I.; Lindman, S.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 7
  • DOI: 10.1073/pnas.0608582104

Swelling pressures of proteoglycans at the concentrations found in cartilaginous tissues
journal, December 1979


Matrigel: A complex protein mixture required for optimal growth of cell culture
journal, February 2010

  • Hughes, Chris S.; Postovit, Lynne M.; Lajoie, Gilles A.
  • PROTEOMICS, Vol. 10, Issue 9
  • DOI: 10.1002/pmic.200900758

The extracellular matrix at a glance
journal, December 2010

  • Frantz, C.; Stewart, K. M.; Weaver, V. M.
  • Journal of Cell Science, Vol. 123, Issue 24
  • DOI: 10.1242/jcs.023820

Passive Tumor Targeting of Renal-Clearable Luminescent Gold Nanoparticles: Long Tumor Retention and Fast Normal Tissue Clearance
journal, March 2013

  • Liu, Jinbin; Yu, Mengxiao; Zhou, Chen
  • Journal of the American Chemical Society, Vol. 135, Issue 13
  • DOI: 10.1021/ja401612x

Crossover regime for the diffusion of nanoparticles in polyethylene glycol solutions: influence of the depletion layer
journal, January 2011

  • Ziębacz, Natalia; Wieczorek, Stefan A.; Kalwarczyk, Tomasz
  • Soft Matter, Vol. 7, Issue 16
  • DOI: 10.1039/c0sm01357a

Liposome—complement interactions in rat serum: implications for liposome survival studies
journal, April 1994

  • Devine, Dana V.; Wong, Kenneth; Serrano, Katherine
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1191, Issue 1
  • DOI: 10.1016/0005-2736(94)90231-3

Porosity Inherent to Chemically Crosslinked Polymers. Poly( N -vinylimidazole) Hydrogels
journal, March 2008

  • Calvino-Casilda, V.; López-Peinado, A. J.; Vaganova, E.
  • The Journal of Physical Chemistry B, Vol. 112, Issue 10
  • DOI: 10.1021/jp7106473

Clearance Pathways and Tumor Targeting of Imaging Nanoparticles
journal, June 2015


Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects
journal, May 2010

  • Maeda, Hiroshi
  • Bioconjugate Chemistry, Vol. 21, Issue 5, p. 797-802
  • DOI: 10.1021/bc100070g

Biodegradable liposome-encapsulated hydrogels for biomedical applications: a marriage of convenience
journal, January 2016

  • Grijalvo, Santiago; Mayr, Judith; Eritja, Ramon
  • Biomaterials Science, Vol. 4, Issue 4
  • DOI: 10.1039/C5BM00481K

The emergence of nanomedicine: a field in the making
journal, June 2006


Liposomal Formulations in Clinical Use: An Updated Review
journal, March 2017


Secreted Biomolecules Alter the Biological Identity and Cellular Interactions of Nanoparticles
journal, May 2014

  • Albanese, Alexandre; Walkey, Carl D.; Olsen, Jonathan B.
  • ACS Nano, Vol. 8, Issue 6
  • DOI: 10.1021/nn4061012

Ion binding on polyuronates - alginate and pectin
journal, January 1975


Macromolecular crowding: Macromolecules friend or foe
journal, September 2015

  • Mittal, Shruti; Chowhan, Rimpy Kaur; Singh, Laishram Rajendrakumar
  • Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1850, Issue 9
  • DOI: 10.1016/j.bbagen.2015.05.002

Protein diffusion in photopolymerized poly(ethylene glycol) hydrogel networks
journal, August 2011


State-of-the-art in design rules for drug delivery platforms: Lessons learned from FDA-approved nanomedicines
journal, August 2014


Capturing extracellular matrix properties in vitro: Microengineering materials to decipher cell and tissue level processes
journal, April 2016

  • Abdeen, Amr A.; Lee, Junmin; Kilian, Kristopher A.
  • Experimental Biology and Medicine, Vol. 241, Issue 9
  • DOI: 10.1177/1535370216644532

Effects of the poly(ethylene glycol) hydrogel crosslinking mechanism on protein release
journal, January 2016

  • Lee, Soah; Tong, Xinming; Yang, Fan
  • Biomaterials Science, Vol. 4, Issue 3
  • DOI: 10.1039/C5BM00256G

New-concept chemotherapy by nanoparticles of biodegradable polymers: where are we now?
journal, October 2006


Morphology of Photopolymerized End-Linked Poly(ethylene glycol) Hydrogels by Small-Angle X-ray Scattering
journal, August 2010

  • Waters, Dale J.; Engberg, Kristin; Parke-Houben, Rachel
  • Macromolecules, Vol. 43, Issue 16
  • DOI: 10.1021/ma101070s

Swelling of dextran gel and osmotic pressure of soluble dextran in the presence of salts
journal, January 2001

  • Livney, Yoav D.; Ramon, Ory; Kesselman, Ellina
  • Journal of Polymer Science Part B: Polymer Physics, Vol. 39, Issue 22
  • DOI: 10.1002/polb.10038

Measuring the Force Ejecting DNA from Phage
journal, May 2004

  • Evilevitch, Alex; Castelnovo, Martin; Knobler, Charles M.
  • The Journal of Physical Chemistry B, Vol. 108, Issue 21
  • DOI: 10.1021/jp0376525

Matrigel: Basement membrane matrix with biological activity
journal, October 2005


Preparation of Hydrogel Substrates with Tunable Mechanical Properties
journal, June 2010


Gelation of aqueous gelatin solutions. I. Structural investigation
journal, January 1988


The stabilization of primitive bicontinuous cubic phases with tunable swelling over a wide composition range
journal, January 2019

  • Leung, Sherry S. W.; Leal, Cecilia
  • Soft Matter, Vol. 15, Issue 6
  • DOI: 10.1039/C8SM02059K

Liposomal drug delivery systems: From concept to clinical applications
journal, January 2013


Review and analysis of FDA approved drugs using lipid-based formulations
journal, July 2017


Circulating Extracellular Vesicles in Human Disease
journal, September 2018

  • Shah, Ravi; Patel, Tushar; Freedman, Jane E.
  • New England Journal of Medicine, Vol. 379, Issue 10
  • DOI: 10.1056/NEJMra1704286

Dynamic and structural aspects of PEGylated liposomes monitored by NMR
journal, September 2008

  • Leal, Cecília; Rögnvaldsson, Sibylla; Fossheim, Sigrid
  • Journal of Colloid and Interface Science, Vol. 325, Issue 2
  • DOI: 10.1016/j.jcis.2008.05.051