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Title: Lignin biosynthesis and its integration into metabolism

Abstract

Lignin is a principal structural component of cell walls in higher terrestrial plants. It reinforces the cell walls, facilitates water transport, and acts as a physical barrier to pathogens. Lignin is typically described as being composed of p-hydroxyphenyl (H), guaiacyl (G), and syringyl (S) units that derive from the polymerization of the hydroxycinnamyl alcohols, p-coumaryl, coniferyl, and sinapyl alcohol, respectively. Yet, lignin also derives from various other aromatic monomers. In this work, we review the biosynthetic pathway to the lignin monomers, and how flux through the pathway is regulated. Upon perturbation of the phenylpropanoid pathway, pathway intermediates may successfully incorporate into the lignin polymer, thereby affecting its physicochemical properties, or may remain soluble as such or as derivatized molecules that might interfere with physiological processes.

Authors:
 [1];  [1]; ORCiD logo [2];  [1]
  1. Ghent Univ. (Belgium); VIB Center for Plant Systems Biology, Ghent (Belgium)
  2. Univ. of Wisconsin, Madison, WI (United States)
Publication Date:
Research Org.:
USDOE Great Lakes Bioenergy Research Center, Madison, WI (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23); Research Foundation Flanders (FWO)
OSTI Identifier:
1556084
Grant/Contract Number:  
SC0018409
Resource Type:
Accepted Manuscript
Journal Name:
Current Opinion in Biotechnology
Additional Journal Information:
Journal Volume: 56; Journal Issue: C; Journal ID: ISSN 0958-1669
Publisher:
Elsevier
Country of Publication:
United States
Language:
English

Citation Formats

Vanholme, Ruben, De Meester, Barbara, Ralph, John, and Boerjan, Wout. Lignin biosynthesis and its integration into metabolism. United States: N. p., 2019. Web. doi:10.1016/j.copbio.2019.02.018.
Vanholme, Ruben, De Meester, Barbara, Ralph, John, & Boerjan, Wout. Lignin biosynthesis and its integration into metabolism. United States. doi:10.1016/j.copbio.2019.02.018.
Vanholme, Ruben, De Meester, Barbara, Ralph, John, and Boerjan, Wout. Sat . "Lignin biosynthesis and its integration into metabolism". United States. doi:10.1016/j.copbio.2019.02.018.
@article{osti_1556084,
title = {Lignin biosynthesis and its integration into metabolism},
author = {Vanholme, Ruben and De Meester, Barbara and Ralph, John and Boerjan, Wout},
abstractNote = {Lignin is a principal structural component of cell walls in higher terrestrial plants. It reinforces the cell walls, facilitates water transport, and acts as a physical barrier to pathogens. Lignin is typically described as being composed of p-hydroxyphenyl (H), guaiacyl (G), and syringyl (S) units that derive from the polymerization of the hydroxycinnamyl alcohols, p-coumaryl, coniferyl, and sinapyl alcohol, respectively. Yet, lignin also derives from various other aromatic monomers. In this work, we review the biosynthetic pathway to the lignin monomers, and how flux through the pathway is regulated. Upon perturbation of the phenylpropanoid pathway, pathway intermediates may successfully incorporate into the lignin polymer, thereby affecting its physicochemical properties, or may remain soluble as such or as derivatized molecules that might interfere with physiological processes.},
doi = {10.1016/j.copbio.2019.02.018},
journal = {Current Opinion in Biotechnology},
number = C,
volume = 56,
place = {United States},
year = {2019},
month = {3}
}

Journal Article:
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This content will become publicly available on March 23, 2020
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