Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species

Stachel, Shawn J.; Egbertson, Melissa S.; Wai, Jenny; Machacek, Michelle; Toolan, Dawn M.; Swestock, John; Eddins, Donnie M.; Puri, Vanita; McGaughey, Georgia; Su, Hua-Poo; Perlow, Debbie; Wang, Deping; Ma, Lei; Parthasarathy, Gopal; Reid, John C.; Abeywickrema, Pravien D.; Smith, Sean M.; Uslaner, Jason M.

doi:10.1016/j.bmcl.2018.01.039

Title: Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species

Journal Article · 01 April 2018 · Bioorganic and Medicinal Chemistry Letters

DOI: https://doi.org/10.1016/j.bmcl.2018.01.039 · OSTI ID:1548752

; Egbertson, Melissa S.; Wai, Jenny;

; Toolan, Dawn M.; Swestock, John; Eddins, Donnie M.; Puri, Vanita; McGaughey, Georgia; Su, Hua-Poo; Perlow, Debbie; Wang, Deping; Ma, Lei; Parthasarathy, Gopal; Reid, John C.; Abeywickrema, Pravien D.; Smith, Sean M.; Uslaner, Jason M.

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Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: W-31109-ENG-38

OSTI ID:: 1548752

Journal Information:: Bioorganic and Medicinal Chemistry Letters, Journal Name: Bioorganic and Medicinal Chemistry Letters Journal Issue: 6 Vol. 28; ISSN 0960-894X

Publisher:: ElsevierCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (10)

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The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque Uslaner, Jason M.; Eddins, Donnie; Puri, Vanita Psychopharmacology, Vol. 225, Issue 1 https://doi.org/10.1007/s00213-012-2788-8	journal	July 2012
The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey Eddins, Donnie; Hamill, Terence G.; Puri, Vanita Psychopharmacology, Vol. 231, Issue 3 https://doi.org/10.1007/s00213-013-3260-0	journal	September 2013
Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold Beaulieu, Christian; Guay, Daniel; Wang, Zhaoyin Bioorganic & Medicinal Chemistry Letters, Vol. 18, Issue 8 https://doi.org/10.1016/j.bmcl.2008.03.015	journal	April 2008
Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore Li, Lianhai; Beaulieu, Christian; Carriere, Marie-Claude Bioorganic & Medicinal Chemistry Letters, Vol. 20, Issue 24 https://doi.org/10.1016/j.bmcl.2010.10.018	journal	December 2010
Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance Boess, Frank G.; Hendrix, Martin; van der Staay, Franz-Josef Neuropharmacology, Vol. 47, Issue 7 https://doi.org/10.1016/j.neuropharm.2004.07.040	journal	December 2004
Predicting the severity of everyday functional disability in people with schizophrenia: cognitive deficits, functional capacity, symptoms, and health status Harvey, Philip D.; Strassnig, Martin World Psychiatry, Vol. 11, Issue 2 https://doi.org/10.1016/j.wpsyc.2012.05.004	journal	June 2012
X-ray Crystal Structure of Phosphodiesterase 2 in Complex with a Highly Selective, Nanomolar Inhibitor Reveals a Binding-Induced Pocket Important for Selectivity Zhu, Jian; Yang, Qiqi; Dai, Dandan Journal of the American Chemical Society, Vol. 135, Issue 32 https://doi.org/10.1021/ja404449g	journal	July 2013
Discovery of a Potent and Selective Prostaglandin D ₂ Receptor Antagonist, [(3 R )-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[ b ]indol-3-yl]-acetic Acid (MK-0524) ^† Sturino, Claudio F.; O'Neill, Gary; Lachance, Nicolas Journal of Medicinal Chemistry, Vol. 50, Issue 4 https://doi.org/10.1021/jm0603668	journal	February 2007
The Inverted “U-Shaped” Dose-Effect Relationships in Learning and Memory: Modulation of Arousal and Consolidation Baldi, Elisabetta; Bucherelli, Corrado Nonlinearity in Biology, Toxicology, Medicine, Vol. 3, Issue 1 https://doi.org/10.2201/nonlin.003.01.002	journal	January 2005

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