Emerging platforms for co-utilization of one-carbon substrates by photosynthetic organisms
Abstract
One-carbon substrates have generated increasing attention as long-term sustainable feedstocks for biobased production of fuels and chemicals. However, their physicochemical properties present significant biological and operational challenges for commercial bioprocesses including kinetically slower substrate activation, high energetic cost of assimilation, low mass transfer, substrate toxicity, and low productivity titers. Several different routes including optimization of native pathways, synthetic pathways, and hybrid methods are being explored to overcome these challenges. Integration of emerging biological solutions with process improvements is enabling faster bioprocess development for cost-effective conversion of one-carbon substrates into fuels and chemicals.
- Authors:
-
[1];
[2];
[3]
- MOgene Green Chemicals, St. Louis, MO (United States)
- Spruce Capital Partners, San Francisco, CA (United States)
- Washington Univ., St. Louis, MO (United States)
- Publication Date:
- Research Org.:
- MOgene Green Chemicals, St. Louis, MO (United States)
- Sponsoring Org.:
- USDOE Advanced Research Projects Agency - Energy (ARPA-E); USDOE Office of Science (SC), Engineering & Technology. Office of Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs; USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1613601
- Alternate Identifier(s):
- OSTI ID: 1548663
- Grant/Contract Number:
- AR0000457; SC0015814
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Current Opinion in Biotechnology
- Additional Journal Information:
- Journal Volume: 53; Journal ID: ISSN 0958-1669
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Singh, Abhay K., Kishore, Ganesh M., and Pakrasi, Himadri B. Emerging platforms for co-utilization of one-carbon substrates by photosynthetic organisms. United States: N. p., 2018.
Web. doi:10.1016/j.copbio.2018.02.002.
Singh, Abhay K., Kishore, Ganesh M., & Pakrasi, Himadri B. Emerging platforms for co-utilization of one-carbon substrates by photosynthetic organisms. United States. https://doi.org/10.1016/j.copbio.2018.02.002
Singh, Abhay K., Kishore, Ganesh M., and Pakrasi, Himadri B. Sat .
"Emerging platforms for co-utilization of one-carbon substrates by photosynthetic organisms". United States. https://doi.org/10.1016/j.copbio.2018.02.002. https://www.osti.gov/servlets/purl/1613601.
@article{osti_1613601,
title = {Emerging platforms for co-utilization of one-carbon substrates by photosynthetic organisms},
author = {Singh, Abhay K. and Kishore, Ganesh M. and Pakrasi, Himadri B.},
abstractNote = {One-carbon substrates have generated increasing attention as long-term sustainable feedstocks for biobased production of fuels and chemicals. However, their physicochemical properties present significant biological and operational challenges for commercial bioprocesses including kinetically slower substrate activation, high energetic cost of assimilation, low mass transfer, substrate toxicity, and low productivity titers. Several different routes including optimization of native pathways, synthetic pathways, and hybrid methods are being explored to overcome these challenges. Integration of emerging biological solutions with process improvements is enabling faster bioprocess development for cost-effective conversion of one-carbon substrates into fuels and chemicals.},
doi = {10.1016/j.copbio.2018.02.002},
journal = {Current Opinion in Biotechnology},
number = ,
volume = 53,
place = {United States},
year = {Sat Mar 03 00:00:00 EST 2018},
month = {Sat Mar 03 00:00:00 EST 2018}
}
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