Pathogenic budding yeasts isolated outside of clinical settings
Abstract
Budding yeasts are distributed across a wide range of habitats, including as human commensals. However, under some conditions, these commensals can cause superficial, invasive, and even lethal infections. Despite their importance to human health, little is known about the ecology of these opportunistic pathogens, aside from their associations with mammals and clinical environments. During a survey of approximately 1000 non-clinical samples across the United States of America, we isolated 54 strains of budding yeast species considered opportunistic pathogens, including Candida albicans and Candida (Nakaseomyces) glabrata. We report that, as a group, pathogenic yeasts were positively associated with fruits and soil environments, whereas the species Pichia kudriavzevii (syn. Candida krusei syn. Issatchenkia orientalis) had a significant association with plants. Of the four species that cause 95% of candidiasis, we found a positive association with soil. These results indicate that pathogenic yeast ecology is more complex and diverse than is currently appreciated and raises the possibility that these additional environments could be a point of contact for human infections.
- Authors:
-
[3]
- Univ. of Wisconsin-Madison, Madison, WI (United States); USDOE Great Lakes Bioenergy Research Center, Madison, WI (United States)
- Univ. of Wisconsin-Madison, Madison, WI (United States)
- Univ. of Wisconsin-Madison, Madison, WI (United States); USDOE Great Lakes Bioenergy Research Center, Madison, WI (United States)
- Publication Date:
- Research Org.:
- Great Lakes Bioenergy Research Center (GLBRC), Madison, WI (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER); National Institutes of Health (NIH); National Science Foundation (NSF)
- OSTI Identifier:
- 1548305
- Grant/Contract Number:
- SC0018409
- Resource Type:
- Accepted Manuscript
- Journal Name:
- FEMS Yeast Research
- Additional Journal Information:
- Journal Volume: 19; Journal Issue: 3; Journal ID: ISSN 1567-1364
- Publisher:
- Federation of European Microbiological Societies - Oxford University Press
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; pathogen; Candida albicans; Candida glabrata; ecology; Candida tropicalis; wild yeasts
Citation Formats
Opulente, Dana A., Langdon, Quinn K., Buh, Kelly V., Haase, Max A. B., Sylvester, Kayla, Moriarty, Ryan V., Jarzyna, Martin, Considine, Samantha L., Schneider, Rachel M., and Hittinger, Chris Todd. Pathogenic budding yeasts isolated outside of clinical settings. United States: N. p., 2019.
Web. doi:10.1093/femsyr/foz032.
Opulente, Dana A., Langdon, Quinn K., Buh, Kelly V., Haase, Max A. B., Sylvester, Kayla, Moriarty, Ryan V., Jarzyna, Martin, Considine, Samantha L., Schneider, Rachel M., & Hittinger, Chris Todd. Pathogenic budding yeasts isolated outside of clinical settings. United States. https://doi.org/10.1093/femsyr/foz032
Opulente, Dana A., Langdon, Quinn K., Buh, Kelly V., Haase, Max A. B., Sylvester, Kayla, Moriarty, Ryan V., Jarzyna, Martin, Considine, Samantha L., Schneider, Rachel M., and Hittinger, Chris Todd. Wed .
"Pathogenic budding yeasts isolated outside of clinical settings". United States. https://doi.org/10.1093/femsyr/foz032. https://www.osti.gov/servlets/purl/1548305.
@article{osti_1548305,
title = {Pathogenic budding yeasts isolated outside of clinical settings},
author = {Opulente, Dana A. and Langdon, Quinn K. and Buh, Kelly V. and Haase, Max A. B. and Sylvester, Kayla and Moriarty, Ryan V. and Jarzyna, Martin and Considine, Samantha L. and Schneider, Rachel M. and Hittinger, Chris Todd},
abstractNote = {Budding yeasts are distributed across a wide range of habitats, including as human commensals. However, under some conditions, these commensals can cause superficial, invasive, and even lethal infections. Despite their importance to human health, little is known about the ecology of these opportunistic pathogens, aside from their associations with mammals and clinical environments. During a survey of approximately 1000 non-clinical samples across the United States of America, we isolated 54 strains of budding yeast species considered opportunistic pathogens, including Candida albicans and Candida (Nakaseomyces) glabrata. We report that, as a group, pathogenic yeasts were positively associated with fruits and soil environments, whereas the species Pichia kudriavzevii (syn. Candida krusei syn. Issatchenkia orientalis) had a significant association with plants. Of the four species that cause 95% of candidiasis, we found a positive association with soil. These results indicate that pathogenic yeast ecology is more complex and diverse than is currently appreciated and raises the possibility that these additional environments could be a point of contact for human infections.},
doi = {10.1093/femsyr/foz032},
journal = {FEMS Yeast Research},
number = 3,
volume = 19,
place = {United States},
year = {Wed Apr 24 00:00:00 EDT 2019},
month = {Wed Apr 24 00:00:00 EDT 2019}
}
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