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Title: Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model

Authors:
; ; ; ; ; ; ;
Publication Date:
Sponsoring Org.:
USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research
OSTI Identifier:
1548112
Grant/Contract Number:  
2016YFD0501210
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Journal of Functional Foods (Print)
Additional Journal Information:
Journal Name: Journal of Functional Foods (Print) Journal Volume: 46 Journal Issue: C; Journal ID: ISSN 1756-4646
Publisher:
Elsevier
Country of Publication:
Netherlands
Language:
English

Citation Formats

Wang, Longmei, Tu, Zhixiao, Wang, Haibo, Wang, Shuhui, Wang, Xiuying, Zhu, Huiling, Hu, Chien-An Andy, and Liu, Yulan. Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model. Netherlands: N. p., 2018. Web. doi:10.1016/j.jff.2018.05.015.
Wang, Longmei, Tu, Zhixiao, Wang, Haibo, Wang, Shuhui, Wang, Xiuying, Zhu, Huiling, Hu, Chien-An Andy, & Liu, Yulan. Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model. Netherlands. https://doi.org/10.1016/j.jff.2018.05.015
Wang, Longmei, Tu, Zhixiao, Wang, Haibo, Wang, Shuhui, Wang, Xiuying, Zhu, Huiling, Hu, Chien-An Andy, and Liu, Yulan. Sun . "Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model". Netherlands. https://doi.org/10.1016/j.jff.2018.05.015.
@article{osti_1548112,
title = {Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model},
author = {Wang, Longmei and Tu, Zhixiao and Wang, Haibo and Wang, Shuhui and Wang, Xiuying and Zhu, Huiling and Hu, Chien-An Andy and Liu, Yulan},
abstractNote = {},
doi = {10.1016/j.jff.2018.05.015},
journal = {Journal of Functional Foods (Print)},
number = C,
volume = 46,
place = {Netherlands},
year = {2018},
month = {7}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1016/j.jff.2018.05.015

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Cited by: 1 work
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Works referenced in this record:

Sensory evaluation of egg products and eggs laid from hens fed diets with different fatty acid composition and supplemented with antioxidants
journal, January 2006


Role of necroptosis in autophagy signaling during hepatic ischemia and reperfusion
journal, October 2016


IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines
journal, January 2002

  • Diehl, Anna Mae
  • American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 282, Issue 1
  • DOI: 10.1152/ajpgi.00384.2001

Necroptosis and Inflammation
journal, June 2016


Dietary Polyunsaturated Fatty Acids Improve Histological and Biochemical Alterations in Rats with Experimental Ulcerative Colitis
journal, January 2002

  • Nieto, Natalia; Torres, María Isabel; Ríos, Antonio
  • The Journal of Nutrition, Vol. 132, Issue 1
  • DOI: 10.1093/jn/132.1.11

Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury
journal, July 2016

  • Roychowdhury, Sanjoy; McCullough, Rebecca L.; Sanz-Garcia, Carlos
  • Hepatology, Vol. 64, Issue 5
  • DOI: 10.1002/hep.28676

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis
journal, July 2012


Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features
journal, August 2014

  • Pacheco, Fabio J.; Almaguel, Frankis G.; Evans, Whitney
  • Inflammation Research, Vol. 63, Issue 10
  • DOI: 10.1007/s00011-014-0760-2

Animal models to study neonatal nutrition in humans
journal, January 2008

  • Puiman, Patrycja; Stoll, Barbara
  • Current Opinion in Clinical Nutrition & Metabolic Care, Vol. 11, Issue 5
  • DOI: 10.1097/MCO.0b013e32830b5b15

Pattern Recognition Receptors and Inflammation
journal, March 2010


Flaxseed Oil Increases the Plasma Concentrations of Cardioprotective (n-3) Fatty Acids in Humans
journal, January 2006

  • Harper, Charles R.; Edwards, Megan J.; DeFilipis, Andrew P.
  • The Journal of Nutrition, Vol. 136, Issue 1
  • DOI: 10.1093/jn/136.1.83

Dietary ALA from Spinach Enhances Liver n-3 Fatty Acid Content to Greater Extent than Linseed Oil in Mice Fed Equivalent Amounts of ALA
journal, November 2015


Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3
journal, April 2014


Relationship between endotoxaemia and protein concentration of ascites in cirrhotic patients.
journal, March 1979


Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice
journal, February 2017


Favorable Outcomes of Preterm Infants With Parenteral Nutrition–associated Liver Disease Treated With Intravenous Fish Oil–based Lipid Emulsion
journal, January 2017

  • Sorrell, Michael; Moreira, Alvaro; Green, Kay
  • Journal of Pediatric Gastroenterology & Nutrition, Vol. 64, Issue 5
  • DOI: 10.1097/MPG.0000000000001397

Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.
journal, June 1990

  • Colletti, L. M.; Remick, D. G.; Burtch, G. D.
  • Journal of Clinical Investigation, Vol. 85, Issue 6
  • DOI: 10.1172/JCI114656

Hepatic tight junctions: From viral entry to cancer metastasis
journal, January 2010


II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin
journal, October 1998


Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard
journal, January 2013


Flaxseed Oil Attenuates Nonalcoholic Fatty Liver of Hyperlipidemic Hamsters
journal, June 2009

  • Yang, Shun-Fa; Tseng, Jung-Kai; Chang, Yuan-Yen
  • Journal of Agricultural and Food Chemistry, Vol. 57, Issue 11
  • DOI: 10.1021/jf900499v

Ameliorative effect of flaxseed oil against thiacloprid-induced toxicity in rats: hematological, biochemical, and histopathological study
journal, March 2016

  • Hendawi, Mohamed Y.; Alam, Rasha T. M.; Abdellatief, Suhair A.
  • Environmental Science and Pollution Research, Vol. 23, Issue 12
  • DOI: 10.1007/s11356-016-6376-z

Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation
journal, March 2017


α-Linolenic acid in health and disease
journal, May 1999

  • Connor, William E.
  • The American Journal of Clinical Nutrition, Vol. 69, Issue 5
  • DOI: 10.1093/ajcn/69.5.827

A metabolic system-wide characterisation of the pig: a model for human physiology
journal, January 2011

  • Merrifield, Claire A.; Lewis, Marie; Claus, Sandrine P.
  • Molecular BioSystems, Vol. 7, Issue 9
  • DOI: 10.1039/c1mb05023k

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance
journal, October 2014


Warm ischemia time-dependent variation in liver damage, inflammation, and function in hepatic ischemia/reperfusion injury
journal, February 2017

  • Olthof, Pim B.; van Golen, Rowan F.; Meijer, Ben
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1863, Issue 2
  • DOI: 10.1016/j.bbadis.2016.10.022

Activation of necroptosis in human and experimental cholestasis
journal, September 2016

  • Afonso, Marta B.; Rodrigues, Pedro M.; Simão, André L.
  • Cell Death & Disease, Vol. 7, Issue 9
  • DOI: 10.1038/cddis.2016.280

The Genetic Architecture of Liver Enzyme Levels: GGT, ALT and AST
journal, April 2013

  • van Beek, Jenny H. D. A.; de Moor, Marleen H. M.; de Geus, Eco J. C.
  • Behavior Genetics, Vol. 43, Issue 4
  • DOI: 10.1007/s10519-013-9593-y

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis
journal, July 2015

  • Afonso, Marta B.; Rodrigues, Pedro M.; Carvalho, Tânia
  • Clinical Science, Vol. 129, Issue 8
  • DOI: 10.1042/CS20140732

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
journal, December 2001


Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice
journal, March 2017


Dietary Milled Flaxseed and Flaxseed Oil Improve N-3 Fatty Acid Status and Do Not Affect Glycemic Control in Individuals with Well-Controlled Type 2 Diabetes
journal, February 2010

  • Taylor, Carla G.; Noto, Amy D.; Stringer, Danielle M.
  • Journal of the American College of Nutrition, Vol. 29, Issue 1
  • DOI: 10.1080/07315724.2010.10719819

Architecture of the paracellular channels formed by claudins of the blood-brain barrier tight junctions: Blood-brain barrier tight junctions
journal, June 2017

  • Irudayanathan, Flaviyan Jerome; Wang, Nan; Wang, Xiaoyi
  • Annals of the New York Academy of Sciences, Vol. 1405, Issue 1
  • DOI: 10.1111/nyas.13378

Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells
journal, June 2012

  • Khan, Muhammad Jadoon; Rizwan Alam, Muhammad; Waldeck-Weiermair, Markus
  • Journal of Biological Chemistry, Vol. 287, Issue 25
  • DOI: 10.1074/jbc.M111.319129

Past and Present Insights on Alpha-linolenic Acid and the Omega-3 Fatty Acid Family
journal, February 2015

  • Stark, Aliza H.; Reifen, Ram; Crawford, Michael A.
  • Critical Reviews in Food Science and Nutrition, Vol. 56, Issue 14
  • DOI: 10.1080/10408398.2013.828678