Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model

Wang, Longmei; Tu, Zhixiao; Wang, Haibo; Wang, Shuhui; Wang, Xiuying; Zhu, Huiling; Hu, Chien-An Andy; Liu, Yulan

doi:10.1016/j.jff.2018.05.015

Title: Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model

Authors:: Wang, Longmei; Tu, Zhixiao; Wang, Haibo; Wang, Shuhui; Wang, Xiuying; Zhu, Huiling; Hu, Chien-An Andy; Liu, Yulan

Publication Date:: 2018-07-01

Sponsoring Org.:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI Identifier:: 1548112

Grant/Contract Number:: 2016YFD0501210

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Journal of Functional Foods (Print)

Additional Journal Information:: Journal Name: Journal of Functional Foods (Print) Journal Volume: 46 Journal Issue: C; Journal ID: ISSN 1756-4646

Publisher:: Elsevier

Country of Publication:: Netherlands

Language:: English

Citation Formats


                    Wang, Longmei, Tu, Zhixiao, Wang, Haibo, Wang, Shuhui, Wang, Xiuying, Zhu, Huiling, Hu, Chien-An Andy, and Liu, Yulan. Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model.  Netherlands: N. p., 2018. 
Web.  doi:10.1016/j.jff.2018.05.015.

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                    Wang, Longmei, Tu, Zhixiao, Wang, Haibo, Wang, Shuhui, Wang, Xiuying, Zhu, Huiling, Hu, Chien-An Andy, & Liu, Yulan. Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model.  Netherlands.  https://doi.org/10.1016/j.jff.2018.05.015

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                    Wang, Longmei, Tu, Zhixiao, Wang, Haibo, Wang, Shuhui, Wang, Xiuying, Zhu, Huiling, Hu, Chien-An Andy, and Liu, Yulan. Sun .  
"Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model".  Netherlands.  https://doi.org/10.1016/j.jff.2018.05.015.

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@article{osti_1548112,

  title        = {Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model},

  author       = {Wang, Longmei and Tu, Zhixiao and Wang, Haibo and Wang, Shuhui and Wang, Xiuying and Zhu, Huiling and Hu, Chien-An Andy and Liu, Yulan},

  abstractNote = {},

  doi          = {10.1016/j.jff.2018.05.015},

  journal      = {Journal of Functional Foods (Print)},

  number       = C,

  volume       = 46,

  place        = {Netherlands},

  year         = {2018},

  month        = {7}

}

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https://doi.org/10.1016/j.jff.2018.05.015

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Similar Records

Title: Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model

Citation Formats

Sensory evaluation of egg products and eggs laid from hens fed diets with different fatty acid composition and supplemented with antioxidants journal, January 2006

The role of tumour necrosis factor- and tumour necrosis factor receptor signalling in inflammation-associated systemic genotoxicity journal, October 2011

Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury journal, January 2016

Role of necroptosis in autophagy signaling during hepatic ischemia and reperfusion journal, October 2016

IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines journal, January 2002

Necroptosis and Inflammation journal, June 2016

Dietary Polyunsaturated Fatty Acids Improve Histological and Biochemical Alterations in Rats with Experimental Ulcerative Colitis journal, January 2002

Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury journal, July 2016

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis journal, July 2012

Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features journal, August 2014

Animal models to study neonatal nutrition in humans journal, January 2008

Pattern Recognition Receptors and Inflammation journal, March 2010

Flaxseed Oil Increases the Plasma Concentrations of Cardioprotective (n-3) Fatty Acids in Humans journal, January 2006

Dietary ALA from Spinach Enhances Liver n-3 Fatty Acid Content to Greater Extent than Linseed Oil in Mice Fed Equivalent Amounts of ALA journal, November 2015

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3 journal, April 2014

Relationship between endotoxaemia and protein concentration of ascites in cirrhotic patients. journal, March 1979

Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice journal, February 2017

Favorable Outcomes of Preterm Infants With Parenteral Nutrition–associated Liver Disease Treated With Intravenous Fish Oil–based Lipid Emulsion journal, January 2017

Preventive effect of α-linolenic acid-rich flaxseed oil against ethanol-induced liver injury is associated with ameliorating gut-derived endotoxin-mediated inflammation in mice journal, May 2016

Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. journal, June 1990

Hepatic tight junctions: From viral entry to cancer metastasis journal, January 2010

II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin journal, October 1998

AHA Dietary Guidelines: Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association journal, November 2000

Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard journal, January 2013

Flaxseed Oil Attenuates Nonalcoholic Fatty Liver of Hyperlipidemic Hamsters journal, June 2009

Ameliorative effect of flaxseed oil against thiacloprid-induced toxicity in rats: hematological, biochemical, and histopathological study journal, March 2016

Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways journal, January 2013

Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation journal, March 2017

α-Linolenic acid in health and disease journal, May 1999

A metabolic system-wide characterisation of the pig: a model for human physiology journal, January 2011

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance journal, October 2014

Flaxseed Oil Attenuates Intestinal Damage and Inflammation by Regulating Necroptosis and TLR4/NOD Signaling Pathways Following Lipopolysaccharide Challenge in a Piglet Model journal, April 2018

Warm ischemia time-dependent variation in liver damage, inflammation, and function in hepatic ischemia/reperfusion injury journal, February 2017

Activation of necroptosis in human and experimental cholestasis journal, September 2016

The Genetic Architecture of Liver Enzyme Levels: GGT, ALT and AST journal, April 2013

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis journal, July 2015

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method journal, December 2001

Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice journal, March 2017

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Architecture of the paracellular channels formed by claudins of the blood-brain barrier tight junctions: Blood-brain barrier tight junctions journal, June 2017

Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells journal, June 2012

Past and Present Insights on Alpha-linolenic Acid and the Omega-3 Fatty Acid Family journal, February 2015

Sensory evaluation of egg products and eggs laid from hens fed diets with different fatty acid composition and supplemented with antioxidants
journal, January 2006

The role of tumour necrosis factor- and tumour necrosis factor receptor signalling in inflammation-associated systemic genotoxicity
journal, October 2011

Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury
journal, January 2016

Role of necroptosis in autophagy signaling during hepatic ischemia and reperfusion
journal, October 2016

IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines
journal, January 2002

Necroptosis and Inflammation
journal, June 2016

Dietary Polyunsaturated Fatty Acids Improve Histological and Biochemical Alterations in Rats with Experimental Ulcerative Colitis
journal, January 2002

Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury
journal, July 2016

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis
journal, July 2012

Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features
journal, August 2014

Animal models to study neonatal nutrition in humans
journal, January 2008

Pattern Recognition Receptors and Inflammation
journal, March 2010

Flaxseed Oil Increases the Plasma Concentrations of Cardioprotective (n-3) Fatty Acids in Humans
journal, January 2006

Dietary ALA from Spinach Enhances Liver n-3 Fatty Acid Content to Greater Extent than Linseed Oil in Mice Fed Equivalent Amounts of ALA
journal, November 2015

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3
journal, April 2014

Relationship between endotoxaemia and protein concentration of ascites in cirrhotic patients.
journal, March 1979

Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice
journal, February 2017

Favorable Outcomes of Preterm Infants With Parenteral Nutrition–associated Liver Disease Treated With Intravenous Fish Oil–based Lipid Emulsion
journal, January 2017

Preventive effect of α-linolenic acid-rich flaxseed oil against ethanol-induced liver injury is associated with ameliorating gut-derived endotoxin-mediated inflammation in mice
journal, May 2016

Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.
journal, June 1990

Hepatic tight junctions: From viral entry to cancer metastasis
journal, January 2010

II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin
journal, October 1998

AHA Dietary Guidelines: Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association
journal, November 2000

Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard
journal, January 2013

Flaxseed Oil Attenuates Nonalcoholic Fatty Liver of Hyperlipidemic Hamsters
journal, June 2009

Ameliorative effect of flaxseed oil against thiacloprid-induced toxicity in rats: hematological, biochemical, and histopathological study
journal, March 2016

Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways
journal, January 2013

Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation
journal, March 2017

α-Linolenic acid in health and disease
journal, May 1999

A metabolic system-wide characterisation of the pig: a model for human physiology
journal, January 2011

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance
journal, October 2014

Flaxseed Oil Attenuates Intestinal Damage and Inflammation by Regulating Necroptosis and TLR4/NOD Signaling Pathways Following Lipopolysaccharide Challenge in a Piglet Model
journal, April 2018

Warm ischemia time-dependent variation in liver damage, inflammation, and function in hepatic ischemia/reperfusion injury
journal, February 2017

Activation of necroptosis in human and experimental cholestasis
journal, September 2016

The Genetic Architecture of Liver Enzyme Levels: GGT, ALT and AST
journal, April 2013

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis
journal, July 2015

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
journal, December 2001

Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice
journal, March 2017

Dietary Milled Flaxseed and Flaxseed Oil Improve N-3 Fatty Acid Status and Do Not Affect Glycemic Control in Individuals with Well-Controlled Type 2 Diabetes
journal, February 2010

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journal, June 2017

Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells
journal, June 2012

Past and Present Insights on Alpha-linolenic Acid and the Omega-3 Fatty Acid Family
journal, February 2015