Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model

Wang, Longmei; Tu, Zhixiao; Wang, Haibo; Wang, Shuhui; Wang, Xiuying; Zhu, Huiling; Hu, Chien-An Andy; Liu, Yulan

doi:10.1016/j.jff.2018.05.015

Title: Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model

Journal Article · 30 June 2018 · Journal of Functional Foods

DOI: https://doi.org/10.1016/j.jff.2018.05.015 · OSTI ID:1548112

Wang, Longmei; Tu, Zhixiao; Wang, Haibo; Wang, Shuhui; Wang, Xiuying; Zhu, Huiling; Hu, Chien-An Andy; Liu, Yulan

Not Available

View Accepted Manuscript (Publisher)

Cite

Export

Save

Sponsoring Organization:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI ID:: 1548112

Journal Information:: Journal of Functional Foods, Journal Name: Journal of Functional Foods Journal Issue: C Vol. 46; ISSN 1756-4646

Publisher:: ElsevierCopyright Statement

Country of Publication:: Netherlands

Language:: English

References (42)

Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. Colletti, L. M.; Remick, D. G.; Burtch, G. D. Journal of Clinical Investigation, Vol. 85, Issue 6 https://doi.org/10.1172/JCI114656	journal	June 1990
II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin Thurman, R. G. American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 275, Issue 4 https://doi.org/10.1152/ajpgi.1998.275.4.G605	journal	October 1998
A metabolic system-wide characterisation of the pig: a model for human physiology Merrifield, Claire A.; Lewis, Marie; Claus, Sandrine P. Molecular BioSystems, Vol. 7, Issue 9 https://doi.org/10.1039/c1mb05023k	journal	January 2011
Relationship between endotoxaemia and protein concentration of ascites in cirrhotic patients. Tarao, K.; Moroi, T.; Nagakura, Y. Gut, Vol. 20, Issue 3 https://doi.org/10.1136/gut.20.3.205	journal	March 1979
Architecture of the paracellular channels formed by claudins of the blood-brain barrier tight junctions: Blood-brain barrier tight junctions Irudayanathan, Flaviyan Jerome; Wang, Nan; Wang, Xiaoyi Annals of the New York Academy of Sciences, Vol. 1405, Issue 1 https://doi.org/10.1111/nyas.13378	journal	June 2017
Flaxseed Oil Increases the Plasma Concentrations of Cardioprotective (n-3) Fatty Acids in Humans Harper, Charles R.; Edwards, Megan J.; DeFilipis, Andrew P. The Journal of Nutrition, Vol. 136, Issue 1 https://doi.org/10.1093/jn/136.1.83	journal	January 2006
Dietary Milled Flaxseed and Flaxseed Oil Improve N-3 Fatty Acid Status and Do Not Affect Glycemic Control in Individuals with Well-Controlled Type 2 Diabetes Taylor, Carla G.; Noto, Amy D.; Stringer, Danielle M. Journal of the American College of Nutrition, Vol. 29, Issue 1 https://doi.org/10.1080/07315724.2010.10719819	journal	February 2010
Warm ischemia time-dependent variation in liver damage, inflammation, and function in hepatic ischemia/reperfusion injury Olthof, Pim B.; van Golen, Rowan F.; Meijer, Ben Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1863, Issue 2 https://doi.org/10.1016/j.bbadis.2016.10.022	journal	February 2017
Favorable Outcomes of Preterm Infants With Parenteral Nutrition–associated Liver Disease Treated With Intravenous Fish Oil–based Lipid Emulsion Sorrell, Michael; Moreira, Alvaro; Green, Kay Journal of Pediatric Gastroenterology & Nutrition, Vol. 64, Issue 5 https://doi.org/10.1097/MPG.0000000000001397	journal	January 2017
Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3 Wang, Huayi; Sun, Liming; Su, Lijing Molecular Cell, Vol. 54, Issue 1 https://doi.org/10.1016/j.molcel.2014.03.003	journal	April 2014
Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells Khan, Muhammad Jadoon; Rizwan Alam, Muhammad; Waldeck-Weiermair, Markus Journal of Biological Chemistry, Vol. 287, Issue 25 https://doi.org/10.1074/jbc.M111.319129	journal	June 2012
The Genetic Architecture of Liver Enzyme Levels: GGT, ALT and AST van Beek, Jenny H. D. A.; de Moor, Marleen H. M.; de Geus, Eco J. C. Behavior Genetics, Vol. 43, Issue 4 https://doi.org/10.1007/s10519-013-9593-y	journal	April 2013
The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis Li, Jixi; McQuade, Thomas; Siemer, Ansgar B. Cell, Vol. 150, Issue 2 https://doi.org/10.1016/j.cell.2012.06.019	journal	July 2012
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method Livak, Kenneth J.; Schmittgen, Thomas D. Methods, Vol. 25, Issue 4 https://doi.org/10.1006/meth.2001.1262	journal	December 2001
The role of tumour necrosis factor- and tumour necrosis factor receptor signalling in inflammation-associated systemic genotoxicity Westbrook, A. M.; Wei, B.; Hacke, K. Mutagenesis, Vol. 27, Issue 1 https://doi.org/10.1093/mutage/ger063	journal	October 2011
Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard Xu, Jiqu; Gao, Hui; Song, Lin Lipids in Health and Disease, Vol. 12, Issue 1 https://doi.org/10.1186/1476-511X-12-58	journal	January 2013
Pattern Recognition Receptors and Inflammation Takeuchi, Osamu; Akira, Shizuo Cell, Vol. 140, Issue 6 https://doi.org/10.1016/j.cell.2010.01.022	journal	March 2010
Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice Shang, Tingting; Liu, Liang; Zhou, Jia Lipids in Health and Disease, Vol. 16, Issue 1 https://doi.org/10.1186/s12944-017-0461-2	journal	March 2017
Animal models to study neonatal nutrition in humans Puiman, Patrycja; Stoll, Barbara Current Opinion in Clinical Nutrition & Metabolic Care, Vol. 11, Issue 5 https://doi.org/10.1097/MCO.0b013e32830b5b15	journal	January 2008
Necroptosis and Inflammation Newton, Kim; Manning, Gerard Annual Review of Biochemistry, Vol. 85, Issue 1 https://doi.org/10.1146/annurev-biochem-060815-014830	journal	June 2016
α-Linolenic acid in health and disease Connor, William E. The American Journal of Clinical Nutrition, Vol. 69, Issue 5 https://doi.org/10.1093/ajcn/69.5.827	journal	May 1999
Past and Present Insights on Alpha-linolenic Acid and the Omega-3 Fatty Acid Family Stark, Aliza H.; Reifen, Ram; Crawford, Michael A. Critical Reviews in Food Science and Nutrition, Vol. 56, Issue 14 https://doi.org/10.1080/10408398.2013.828678	journal	February 2015
IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines Diehl, Anna Mae American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 282, Issue 1 https://doi.org/10.1152/ajpgi.00384.2001	journal	January 2002
Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury Wang, Shaogui; Ni, Hong-Min; Dorko, Kenneth Oncotarget, Vol. 7, Issue 14 https://doi.org/10.18632/oncotarget.6893	journal	January 2016
Dietary Polyunsaturated Fatty Acids Improve Histological and Biochemical Alterations in Rats with Experimental Ulcerative Colitis Nieto, Natalia; Torres, María Isabel; Ríos, Antonio The Journal of Nutrition, Vol. 132, Issue 1 https://doi.org/10.1093/jn/132.1.11	journal	January 2002
Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation Rani, Meenakshi; Nicholson, Susannah E.; Zhang, Qiong Burns, Vol. 43, Issue 2 https://doi.org/10.1016/j.burns.2016.10.001	journal	March 2017
Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features Pacheco, Fabio J.; Almaguel, Frankis G.; Evans, Whitney Inflammation Research, Vol. 63, Issue 10 https://doi.org/10.1007/s00011-014-0760-2	journal	August 2014
Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis Afonso, Marta B.; Rodrigues, Pedro M.; Carvalho, Tânia Clinical Science, Vol. 129, Issue 8 https://doi.org/10.1042/CS20140732	journal	July 2015
Activation of necroptosis in human and experimental cholestasis Afonso, Marta B.; Rodrigues, Pedro M.; Simão, André L. Cell Death & Disease, Vol. 7, Issue 9 https://doi.org/10.1038/cddis.2016.280	journal	September 2016
Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance Luedde, Tom; Kaplowitz, Neil; Schwabe, Robert F. Gastroenterology, Vol. 147, Issue 4 https://doi.org/10.1053/j.gastro.2014.07.018	journal	October 2014
Preventive effect of α-linolenic acid-rich flaxseed oil against ethanol-induced liver injury is associated with ameliorating gut-derived endotoxin-mediated inflammation in mice Wang, Meng; Zhang, Xiao-Jing; Yan, Chunyan Journal of Functional Foods, Vol. 23 https://doi.org/10.1016/j.jff.2016.03.012	journal	May 2016
Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice Zhang, Xiaoxia; Wang, Hao; Yin, Peipei Lipids in Health and Disease, Vol. 16, Issue 1 https://doi.org/10.1186/s12944-017-0431-8	journal	February 2017
Dietary ALA from Spinach Enhances Liver n-3 Fatty Acid Content to Greater Extent than Linseed Oil in Mice Fed Equivalent Amounts of ALA Kuroe, Miho; Kamogawa, Hiroyuki; Hosokawa, Masashi Lipids, Vol. 51, Issue 1 https://doi.org/10.1007/s11745-015-4086-9	journal	November 2015
Hepatic tight junctions: From viral entry to cancer metastasis Lee, Nikki P. World Journal of Gastroenterology, Vol. 16, Issue 3 https://doi.org/10.3748/wjg.v16.i3.289	journal	January 2010
Flaxseed Oil Attenuates Intestinal Damage and Inflammation by Regulating Necroptosis and TLR4/NOD Signaling Pathways Following Lipopolysaccharide Challenge in a Piglet Model Zhu, Huiling; Wang, Haibo; Wang, Shuhui Molecular Nutrition & Food Research, Vol. 62, Issue 9 https://doi.org/10.1002/mnfr.201700814	journal	April 2018
Flaxseed Oil Attenuates Nonalcoholic Fatty Liver of Hyperlipidemic Hamsters Yang, Shun-Fa; Tseng, Jung-Kai; Chang, Yuan-Yen Journal of Agricultural and Food Chemistry, Vol. 57, Issue 11 https://doi.org/10.1021/jf900499v	journal	June 2009
Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury Roychowdhury, Sanjoy; McCullough, Rebecca L.; Sanz-Garcia, Carlos Hepatology, Vol. 64, Issue 5 https://doi.org/10.1002/hep.28676	journal	July 2016
Role of necroptosis in autophagy signaling during hepatic ischemia and reperfusion Hong, Jeong-Min; Kim, Seok-Joo; Lee, Sun-Mee Toxicology and Applied Pharmacology, Vol. 308 https://doi.org/10.1016/j.taap.2016.08.010	journal	October 2016
Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways Chen, Feng; Liu, Yulan; Zhu, Huiling Innate Immunity, Vol. 19, Issue 5 https://doi.org/10.1177/1753425912472003	journal	January 2013
Sensory evaluation of egg products and eggs laid from hens fed diets with different fatty acid composition and supplemented with antioxidants Parpinello, G. P.; Meluzzi, A.; Sirri, F. Food Research International, Vol. 39, Issue 1 https://doi.org/10.1016/j.foodres.2005.05.010	journal	January 2006
AHA Dietary Guidelines: Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association Krauss, Ronald M.; Eckel, Robert H.; Howard, Barbara Stroke, Vol. 31, Issue 11 https://doi.org/10.1161/01.STR.31.11.2751	journal	November 2000
Ameliorative effect of flaxseed oil against thiacloprid-induced toxicity in rats: hematological, biochemical, and histopathological study Hendawi, Mohamed Y.; Alam, Rasha T. M.; Abdellatief, Suhair A. Environmental Science and Pollution Research, Vol. 23, Issue 12 https://doi.org/10.1007/s11356-016-6376-z	journal	March 2016

Similar Records

Overexpression of the Mas1 gene mitigated LPS-induced inflammatory injury in mammary epithelial cells by inhibiting the NF-κB/MAPKs signaling pathways

Journal Article · 2024 · Frontiers in Veterinary Science · OSTI ID:2397364

Yan, Shuping; Ju, Xianghong; Lao, Jianlong; +4 more

Corn oligopeptides inhibit Akt/ NF‐κB signaling pathway and inflammatory factors to ameliorate CCl ₄ ‐induced hepatic fibrosis in mice

Journal Article · 2022 · Journal of Food Biochemistry · OSTI ID:1862585

Feng, Xiao‐Wen; Cheng, Qing‐Li; Fang, Lei; +6 more

Hydrogen sulfide ameliorated lipopolysaccharide-induced acute lung injury by inhibiting autophagy through PI3K/Akt/mTOR pathway in mice

Journal Article · 2018 · Biochemical and Biophysical Research Communications · OSTI ID:23134294

Xu, Xiaolin; Li, Hao; Gong, Yuan; +2 more

Title: Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model

Citation Formats

References (42)

Similar Records

Related Subjects