A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway

doi:10.1016/j.bcp.2018.07.020

Title: A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway

Full Record
Other Related Research

Authors:: Tu, Tingyue; Yu, Mao; Zhang, Yanping; Shi, Xiafei; Xu, Jinhao; Hu, Junqing; Gan, Jingjing; He, Wei; Dong, Lei; Han, Jianlin; Huang, Zhen; Pan, Yi; Zhang, Junfeng

Publication Date:: 2018-09-01

Sponsoring Org.:: USDOE Office of Electricity Delivery and Energy Reliability (OE), Power Systems Engineering Research and Development (R&D) (OE-10)

OSTI Identifier:: 1548065

Grant/Contract Number:: 2017YFC0909700

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Biochemical Pharmacology

Additional Journal Information:: Journal Name: Biochemical Pharmacology Journal Volume: 155 Journal Issue: C; Journal ID: ISSN 0006-2952

Publisher:: Elsevier

Country of Publication:: United Kingdom

Language:: English

Citation Formats


                    Tu, Tingyue, Yu, Mao, Zhang, Yanping, Shi, Xiafei, Xu, Jinhao, Hu, Junqing, Gan, Jingjing, He, Wei, Dong, Lei, Han, Jianlin, Huang, Zhen, Pan, Yi, and Zhang, Junfeng. A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway.  United Kingdom: N. p., 2018. 
        Web.  doi:10.1016/j.bcp.2018.07.020.

Copy to clipboard


                    Tu, Tingyue, Yu, Mao, Zhang, Yanping, Shi, Xiafei, Xu, Jinhao, Hu, Junqing, Gan, Jingjing, He, Wei, Dong, Lei, Han, Jianlin, Huang, Zhen, Pan, Yi, & Zhang, Junfeng. A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway.  United Kingdom.  doi:10.1016/j.bcp.2018.07.020.

Copy to clipboard


                    Tu, Tingyue, Yu, Mao, Zhang, Yanping, Shi, Xiafei, Xu, Jinhao, Hu, Junqing, Gan, Jingjing, He, Wei, Dong, Lei, Han, Jianlin, Huang, Zhen, Pan, Yi, and Zhang, Junfeng. Sat .  
        "A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway".  United Kingdom.  doi:10.1016/j.bcp.2018.07.020.

Copy to clipboard


                    
@article{osti_1548065,

  title        = {A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway},

  author       = {Tu, Tingyue and Yu, Mao and Zhang, Yanping and Shi, Xiafei and Xu, Jinhao and Hu, Junqing and Gan, Jingjing and He, Wei and Dong, Lei and Han, Jianlin and Huang, Zhen and Pan, Yi and Zhang, Junfeng},

  abstractNote = {},

  doi          = {10.1016/j.bcp.2018.07.020},

  journal      = {Biochemical Pharmacology},

  number       = C,

  volume       = 155,

  place        = {United Kingdom},

  year         = {2018},

  month        = {9}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (Publisher)

Publisher's Version of Record
DOI: 10.1016/j.bcp.2018.07.020

Other availability

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone

Journal Article Wu, Xue-Feng ; Ouyang, Zi-Jun ; Feng, Li-Li ; ... - Toxicology and Applied Pharmacology

Inflammatory bowel disease (IBD) affects millions of people worldwide. Although the etiology of this disease is uncertain, accumulating evidence indicates a key role for the activated mucosal immune system. In the present study, we examined the effects of the natural compound fraxinellone on dextran sulfate sodium (DSS)-induced colitis in mice, an animal model that mimics IBD. Treatment with fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. In addition, the activities of myeloperoxidase and alkaline phosphatase were markedly suppressed, while the levels of glutathione were increased in colitis tissues followingmore »« less
DOI: 10.1016/J.TAAP.2014.10.002
Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption

Journal Article Srivastava, Ritesh K. ; Li, Changzhao ; Chaudhary, Sandeep C. ; ... - Toxicology and Applied Pharmacology

Arsenic exposure is known to disrupt innate immune functions in humans and in experimental animals. In this study, we provide a mechanism by which arsenic trioxide (ATO) disrupts macrophage functions. ATO treatment of murine macrophage cells diminished internalization of FITC-labeled latex beads, impaired clearance of phagocytosed fluorescent bacteria and reduced secretion of pro-inflammatory cytokines. These impairments in macrophage functions are associated with ATO-induced unfolded protein response (UPR) signaling pathway characterized by the enhancement in proteins such as GRP78, p-PERK, p-eIF2α, ATF4 and CHOP. The expression of these proteins is altered both at transcriptional and translational levels. Pretreatment with chemical chaperon,more »« less
DOI: 10.1016/J.TAAP.2013.08.004
CPT-11 activates NLRP3 inflammasome through JNK and NF-κB signalings

Journal Article Li, Qian ; Zhang, Xiong ; Wang, Weicheng ; ... - Toxicology and Applied Pharmacology

CPT-11 is widely used for cancer therapy as a chemotherapeutic agent. Despite its good efficacy, a large number of side effects appeared during decades of clinical application. Delayed diarrhea, at dose limiting toxicity, happens after 24 h of treatment and the rate of occurrence is up to 90%. Although many investments have been made on this negative impact, the real molecular mechanism of delayed diarrhea is poorly understood. In this study, we have discovered that CPT-11 promotes macrophage infiltration into intestinal tissues and activates the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, resulting in a robust IL-1β responsemore »« less
DOI: 10.1016/J.TAAP.2015.09.025
Cerebroside D, a glycoceramide compound, improves experimental colitis in mice with multiple targets against activated T lymphocytes

Journal Article Wu, Xue-Feng ; Wu, Xing-Xin ; Guo, Wen-Jie ; ... - Toxicology and Applied Pharmacology

In the present paper, we aimed to examine the novel effects of cerebroside D, a glycoceramide compound, on murine experimental colitis. Cerebroside D significantly reduced the weight loss, mortality rate and alleviated the macroscopic and microscopic appearances of colitis induced by dexran sulfate sodium. This compound also decreased the levels of TNF-α, IFN-γ and IL-1β in intestinal tissue of mice with experimental colitis in a concentration-dependent manner, accompanied with markedly increased serum level of IL-10. Cerebroside D inhibited proliferation and induced apoptosis of T cells activated by concanavalin A or anti-CD3 plus anti-CD28 antibodies. The compound did not show anmore »« less
DOI: 10.1016/J.TAAP.2012.07.001
A novel synthetic derivative of melatonin, 5-hydroxy-2’-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation

Journal Article Shim, Do-Wan ; Shin, Hee Jae ; Han, Ji-Won ; ... - Toxicology and Applied Pharmacology

Melatonin is substantially reported to possess anti-inflammatory properties. In the present study, we synthesized a novel melatonin derivative, 5-hydroxy-2′-isobutyl-streptochlorin (HIS), which displayed superior anti-inflammatory properties to its parent compound. Further, we explored its underlying mechanisms in cellular and experimental animal models. Lipopolysaccharide was used to induce in vitro inflammatory responses in RAW 264.7 macrophages. LPS-primed macrophages were pulsed with biologically unrelated toxic molecules to evaluate the role of HIS on inflammasome activation. In vivo verifications were carried out using acute lung injury (ALI) and Escherichia coli-induced septic shock mouse models. HIS inhibited the production of proinflammatory mediators and cytokines suchmore »« less
DOI: 10.1016/J.TAAP.2015.02.006

Similar Records