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Title: The application of poorly crystalline silicotitanate in production of 225Ac

Abstract

Actinium-225 ( 225Ac) can be produced from a Thorium-229/Radium-225 ( 229Th/ 225Ra) generator, from high/low energy proton irradiated natural Thorium or Radium-226 target. Titanium based ion exchanger were evaluated for purification of 225Ac. Poorly crystalline silicotitanate (PCST) ion exchanger had high selectivity for Ba, Ag and Th. 225Ac was received with trace amounts of 227Ac, 227Th and 223Ra, and the solution was used to evaluate the retention of the isotopes on PCST ion exchanger. Over 90% of the 225Ac was recovered from PCST, and the radiopurity was >99% (calculated based on 225Ac, 227Th, and 223Ra). The capacity of the PCST inorganic ion exchange for Barium and 232Th was determined to be 24.19 mg/mL for Barium and 5.05 mg/mL for Thorium. PCST ion exchanger could separate 225Ac from isotopes of Ra and Th, and the process represents an interesting one step separation that could be used in an 225Ac generator from 225Ra and/or 229Th. Capacity studies indicated PCST could be used to separate 225Ac produced on small 226Ra targets (0.3–1 g), but PCST did not have a high enough capacity for production scale Th targets (50–100 g).

Authors:
 [1];  [2];  [3];  [1];  [1];  [1]
  1. Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Division, Medical Isotope Research & Production Lab.
  2. Stony Brook Univ., Stony Brook, NY (United States). Chemistry Dept.
  3. Stony Brook Univ., Stony Brook, NY (United States). Biochemistry Dept.
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)
OSTI Identifier:
1547020
Report Number(s):
BNL-211944-2019-JAAM
Journal ID: ISSN 2045-2322
Grant/Contract Number:  
SC0012704
Resource Type:
Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 9; Journal Issue: 1; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
43 PARTICLE ACCELERATORS; Actinium-225; Thorium; Titanium based ion exchangers; PCST; inorganic ion exchangers; Thorium-229/Radium-225 generator; Radium; spallation; irradiation

Citation Formats

Fitzsimmons, Jonathan, Abraham, Alyson, Catalano, Demetra, Younes, Ali, Cutler, Cathy S., and Medvedev, Dmitri. The application of poorly crystalline silicotitanate in production of 225Ac. United States: N. p., 2019. Web. doi:10.1038/s41598-019-48021-7.
Fitzsimmons, Jonathan, Abraham, Alyson, Catalano, Demetra, Younes, Ali, Cutler, Cathy S., & Medvedev, Dmitri. The application of poorly crystalline silicotitanate in production of 225Ac. United States. doi:10.1038/s41598-019-48021-7.
Fitzsimmons, Jonathan, Abraham, Alyson, Catalano, Demetra, Younes, Ali, Cutler, Cathy S., and Medvedev, Dmitri. Wed . "The application of poorly crystalline silicotitanate in production of 225Ac". United States. doi:10.1038/s41598-019-48021-7. https://www.osti.gov/servlets/purl/1547020.
@article{osti_1547020,
title = {The application of poorly crystalline silicotitanate in production of 225Ac},
author = {Fitzsimmons, Jonathan and Abraham, Alyson and Catalano, Demetra and Younes, Ali and Cutler, Cathy S. and Medvedev, Dmitri},
abstractNote = {Actinium-225 (225Ac) can be produced from a Thorium-229/Radium-225 (229Th/225Ra) generator, from high/low energy proton irradiated natural Thorium or Radium-226 target. Titanium based ion exchanger were evaluated for purification of 225Ac. Poorly crystalline silicotitanate (PCST) ion exchanger had high selectivity for Ba, Ag and Th. 225Ac was received with trace amounts of 227Ac, 227Th and 223Ra, and the solution was used to evaluate the retention of the isotopes on PCST ion exchanger. Over 90% of the 225Ac was recovered from PCST, and the radiopurity was >99% (calculated based on 225Ac, 227Th, and 223Ra). The capacity of the PCST inorganic ion exchange for Barium and 232Th was determined to be 24.19 mg/mL for Barium and 5.05 mg/mL for Thorium. PCST ion exchanger could separate 225Ac from isotopes of Ra and Th, and the process represents an interesting one step separation that could be used in an 225Ac generator from 225Ra and/or 229Th. Capacity studies indicated PCST could be used to separate 225Ac produced on small 226Ra targets (0.3–1 g), but PCST did not have a high enough capacity for production scale Th targets (50–100 g).},
doi = {10.1038/s41598-019-48021-7},
journal = {Scientific Reports},
number = 1,
volume = 9,
place = {United States},
year = {2019},
month = {8}
}

Journal Article:
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Figures / Tables:

Figure 1 Figure 1: Flow chart illustrating the sequence of studies reported in the manuscript.

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