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Title: Shedding light on a Group IV (ECF11) alternative σ factor

Abstract

This year marks the 50 th anniversary of the discovery of σ 70 as a protein factor that was needed for bacterial RNA polymerase to accurately transcribe a promoter in vitro. It was 25 years later that the Group IV alternative σs were described as a distinct family of proteins related to σ 70. In the intervening time, there has been an ever-growing list of Group IV σs, numbers of genes they transcribe, insight into the diverse suite of processes they control, and appreciation for their impact on bacterial lifestyles. This work summarizes knowledge of the Rhodobacter sphaeroides σ E-ChrR pair, a member of the ECF11 subfamily of Group IV alternative σs, in protecting cells from the reactive oxygen species, singlet oxygen. It describes lessons learned from analyzing ChrR, a zinc-dependent anti-σ factor, that are generally applicable to Group IV σs and relevant to the response to single oxygen. This MicroReview also illustrates insights into stress responses in this and other bacteria that have been acquired by analyzing or modeling the activity of the σ E-ChrR across the bacterial phylogeny.

Authors:
ORCiD logo [1]
  1. Univ. of Wisconsin, Madison, WI (United States). Bacteriology Dept., Great Lakes Bioenergy Research Center Wisconsin Energy Inst.
Publication Date:
Research Org.:
Univ. of Wisconsin, Madison, WI (United States). Great Lakes Bioenergy Research Center
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1546720
Grant/Contract Number:  
SC0018409
Resource Type:
Accepted Manuscript
Journal Name:
Molecular microbiology
Additional Journal Information:
Journal Volume: 112; Journal Issue: 2; Journal ID: ISSN 0950-382X
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Donohue, Timothy J. Shedding light on a Group IV (ECF11) alternative σ factor. United States: N. p., 2019. Web. doi:10.1111/mmi.14280.
Donohue, Timothy J. Shedding light on a Group IV (ECF11) alternative σ factor. United States. doi:10.1111/mmi.14280.
Donohue, Timothy J. Mon . "Shedding light on a Group IV (ECF11) alternative σ factor". United States. doi:10.1111/mmi.14280. https://www.osti.gov/servlets/purl/1546720.
@article{osti_1546720,
title = {Shedding light on a Group IV (ECF11) alternative σ factor},
author = {Donohue, Timothy J.},
abstractNote = {This year marks the 50th anniversary of the discovery of σ70 as a protein factor that was needed for bacterial RNA polymerase to accurately transcribe a promoter in vitro. It was 25 years later that the Group IV alternative σs were described as a distinct family of proteins related to σ70. In the intervening time, there has been an ever-growing list of Group IV σs, numbers of genes they transcribe, insight into the diverse suite of processes they control, and appreciation for their impact on bacterial lifestyles. This work summarizes knowledge of the Rhodobacter sphaeroides σE-ChrR pair, a member of the ECF11 subfamily of Group IV alternative σs, in protecting cells from the reactive oxygen species, singlet oxygen. It describes lessons learned from analyzing ChrR, a zinc-dependent anti-σ factor, that are generally applicable to Group IV σs and relevant to the response to single oxygen. This MicroReview also illustrates insights into stress responses in this and other bacteria that have been acquired by analyzing or modeling the activity of the σE-ChrR across the bacterial phylogeny.},
doi = {10.1111/mmi.14280},
journal = {Molecular microbiology},
number = 2,
volume = 112,
place = {United States},
year = {2019},
month = {5}
}

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