Mitochondrial DNA and temperature tolerance in lager yeasts

Baker, EmilyClare P.; Peris, David; Moriarty, Ryan V.; Li, Xueying C.; Fay, Justin C.; Hittinger, Chris Todd

doi:10.1126/sciadv.aav1869

Title: Mitochondrial DNA and temperature tolerance in lager yeasts

Journal Article · 29 January 2019 · Science Advances

DOI: https://doi.org/10.1126/sciadv.aav1869 · OSTI ID:1546622

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Univ. of Wisconsin, Madison, WI (United States); University of Wisconsin-Madison Department of Genetics
Univ. of Wisconsin, Madison, WI (United States); Institute of Agrochemistry and Food Technology (IATA), Valencia (Spain)
Univ. of Wisconsin, Madison, WI (United States)
Washington Univ., St. Louis, MO (United States); Univ. of Rochester, Rochester, NY (United States)

A growing body of research suggests that the mitochondrial genome (mtDNA) is important for temperature adaptation. In the yeast genus Saccharomyces, species have diverged in temperature tolerance, driving their use in high- or low-temperature fermentations. Here, we experimentally test the role of mtDNA in temperature tolerance in synthetic and industrial hybrids (Saccharomyces cerevisiae × Saccharomyces eubayanus or Saccharomyces pastorianus), which cold-brew lager beer. We find that the relative temperature tolerances of hybrids correspond to the parent donating mtDNA, allowing us to modulate lager strain temperature preferences. The strong influence of mitotype on the temperature tolerance of otherwise identical hybrid strains provides support for the mitochondrial climactic adaptation hypothesis in yeasts and demonstrates how mitotype has influenced the world’s most commonly fermented beverage.

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Research Organization:: Univ. of Wisconsin, Madison, WI (United States). Great Lakes Bioenergy Research Center

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0018409

OSTI ID:: 1546622

Journal Information:: Science Advances, Journal Name: Science Advances Journal Issue: 1 Vol. 5; ISSN 2375-2548

Publisher:: AAASCopyright Statement

Country of Publication:: United States

Language:: English

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Environmental Factors Can Influence Mitochondrial Inheritance in the Saccharomyces Yeast Hybrids Hsu, Yu-Yi; Chou, Jui-Yu PLOS ONE, Vol. 12, Issue 1 https://doi.org/10.1371/journal.pone.0169953	journal	January 2017
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Environmental Factors Can Influence Mitochondrial Inheritance in the Saccharomyces Yeast Hybrids Hsu, Yu-Yi; Chou, Jui-Yu PLOS ONE, Vol. 12, Issue 1 https://doi.org/10.1371/journal.pone.0169953	journal	January 2017
Sequence Diversity, Reproductive Isolation and Species Concepts in Saccharomyces Liti, Gianni; Barton, David B. H.; Louis, Edward J. Genetics, Vol. 174, Issue 2 https://doi.org/10.1534/genetics.106.062166	journal	September 2006
Mitochondrial-Nuclear Epistasis Contributes to Phenotypic Variation and Coadaptation in Natural Isolates of Saccharomyces cerevisiae Paliwal, Swati; Fiumera, Anthony C.; Fiumera, Heather L. Genetics, Vol. 198, Issue 3 https://doi.org/10.1534/genetics.114.168575	journal	August 2014
High-Efficiency Genome Editing and Allele Replacement in Prototrophic and Wild Strains of Saccharomyces Alexander, W. G.; Doering, D. T.; Hittinger, C. T. Genetics, Vol. 198, Issue 3, p. 859-866 https://doi.org/10.1534/genetics.114.170118	journal	September 2014
Mitochondrial Recombination Reveals Mito–Mito Epistasis in Yeast Wolters, John F.; Charron, Guillaume; Gaspary, Alec Genetics, Vol. 209, Issue 1 https://doi.org/10.1534/genetics.117.300660	journal	March 2018
CellProfiler™: free, versatile software for automated biological image analysis Lamprecht, Michael R.; Sabatini, David M.; Carpenter, Anne E. BioTechniques, Vol. 42, Issue 1 https://doi.org/10.2144/000112257	journal	January 2007
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Experimental support that natural selection has shaped the latitudinal distribution of mitochondrial haplotypes in Australian Drosophila melanogaster Camus, Florencia figshare https://doi.org/10.6084/m9.figshare.5140174	dataset	January 2017
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Temperature preference can bias parental genome retention during hybrid evolution Smukowski Heil, Caiti S.; Large, Christopher R. L.; Patterson, Kira PLOS Genetics, Vol. 15, Issue 9 https://doi.org/10.1371/journal.pgen.1008383	journal	September 2019
Interspecific hybridization facilitates niche adaptation in beer yeast Gallone, Brigida; Steensels, Jan; Mertens, Stijn Nature Ecology & Evolution, Vol. 3, Issue 11 https://doi.org/10.1038/s41559-019-0997-9	journal	October 2019
Fermentation innovation through complex hybridization of wild and domesticated yeasts Langdon, Quinn K.; Peris, David; Baker, EmilyClare P. Nature Ecology & Evolution, Vol. 3, Issue 11 https://doi.org/10.1038/s41559-019-0998-8	journal	October 2019
Lager-brewing yeasts in the era of modern genetics Gorter de Vries, Arthur R.; Pronk, Jack T.; Daran, Jean-Marc G. FEMS Yeast Research, Vol. 19, Issue 7 https://doi.org/10.1093/femsyr/foz063	journal	September 2019
Mitochondria-encoded genes contribute to evolution of heat and cold tolerance in yeast Li, Xueying C.; Peris, David; Hittinger, Chris Todd Science Advances, Vol. 5, Issue 1 https://doi.org/10.1126/sciadv.aav1848	journal	January 2019
Temperature preference can bias parental genome retention during hybrid evolution Smukowski Heil, Caiti S.; Large, Christopher R. L.; Patterson, Kira PLOS Genetics, Vol. 15, Issue 9 https://doi.org/10.1371/journal.pgen.1008383	journal	September 2019
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