Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate
Abstract
Lower glycolysis involves a series of reversible reactions, which interconvert intermediates that also feed anabolic pathways. 3-phosphoglycerate (3-PG) is an abundant lower glycolytic intermediate that feeds serine biosynthesis via the enzyme phosphoglycerate dehydrogenase, which is genomically amplified in several cancers. Phosphoglycerate mutase 1 (PGAM1) catalyzes the isomerization of 3-PG into the downstream glycolytic intermediate 2-phosphoglycerate (2-PG). PGAM1 needs to be histidine phosphorylated to become catalytically active. Here, this work shows that the primary PGAM1 histidine phosphate donor is 2,3-bisphosphoglycerate (2,3-BPG), which is made from the glycolytic intermediate 1,3-bisphosphoglycerate (1,3-BPG) by bisphosphoglycerate mutase (BPGM). When BPGM is knocked out, 1,3-BPG can directly phosphorylate PGAM1. In this case, PGAM1 phosphorylation and activity are decreased, but nonetheless sufficient to maintain normal glycolytic flux and cellular growth rate. 3-PG, however, accumulates, leading to increased serine synthesis. Hence, one biological function of BPGM is controlling glycolytic intermediate levels and thereby serine biosynthetic flux.
- Authors:
-
[1];
- Princeton Univ., NJ (United States); Merck Research Lab., Cambridge, MA (United States); Rutgers Univ., New Brunswick, NJ (United States); Ulsan National Institute of Science and Technology (UNIST) (Korea); Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
- Princeton Univ., NJ (United States)
- Princeton Univ., NJ (United States); Merck Research Lab., Cambridge, MA (United States); Rutgers Univ., New Brunswick, NJ (United States); Ulsan National Institute of Science and Technology (UNIST) (Korea); Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Rockefeller Univ., New York, NY (United States)
- Publication Date:
- Research Org.:
- Princeton Univ., NJ (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER); National Institutes of Health (NIH); Damon Runyon Cancer Research Foundation
- OSTI Identifier:
- 1546615
- Grant/Contract Number:
- SC0012461
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nature Chemical Biology
- Additional Journal Information:
- Journal Volume: 13; Journal Issue: 10; Journal ID: ISSN 1552-4450
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Oslund, Rob C., Su, Xiaoyang, Haugbro, Michael, Kee, Jung-Min, Esposito, Mark, David, Yael, Wang, Boyuan, Ge, Eva, Perlman, David H., Kang, Yibin, Muir, Tom W., and Rabinowitz, Joshua D. Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. United States: N. p., 2017.
Web. doi:10.1038/nchembio.2453.
Oslund, Rob C., Su, Xiaoyang, Haugbro, Michael, Kee, Jung-Min, Esposito, Mark, David, Yael, Wang, Boyuan, Ge, Eva, Perlman, David H., Kang, Yibin, Muir, Tom W., & Rabinowitz, Joshua D. Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. United States. https://doi.org/10.1038/nchembio.2453
Oslund, Rob C., Su, Xiaoyang, Haugbro, Michael, Kee, Jung-Min, Esposito, Mark, David, Yael, Wang, Boyuan, Ge, Eva, Perlman, David H., Kang, Yibin, Muir, Tom W., and Rabinowitz, Joshua D. Mon .
"Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate". United States. https://doi.org/10.1038/nchembio.2453. https://www.osti.gov/servlets/purl/1546615.
@article{osti_1546615,
title = {Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate},
author = {Oslund, Rob C. and Su, Xiaoyang and Haugbro, Michael and Kee, Jung-Min and Esposito, Mark and David, Yael and Wang, Boyuan and Ge, Eva and Perlman, David H. and Kang, Yibin and Muir, Tom W. and Rabinowitz, Joshua D.},
abstractNote = {Lower glycolysis involves a series of reversible reactions, which interconvert intermediates that also feed anabolic pathways. 3-phosphoglycerate (3-PG) is an abundant lower glycolytic intermediate that feeds serine biosynthesis via the enzyme phosphoglycerate dehydrogenase, which is genomically amplified in several cancers. Phosphoglycerate mutase 1 (PGAM1) catalyzes the isomerization of 3-PG into the downstream glycolytic intermediate 2-phosphoglycerate (2-PG). PGAM1 needs to be histidine phosphorylated to become catalytically active. Here, this work shows that the primary PGAM1 histidine phosphate donor is 2,3-bisphosphoglycerate (2,3-BPG), which is made from the glycolytic intermediate 1,3-bisphosphoglycerate (1,3-BPG) by bisphosphoglycerate mutase (BPGM). When BPGM is knocked out, 1,3-BPG can directly phosphorylate PGAM1. In this case, PGAM1 phosphorylation and activity are decreased, but nonetheless sufficient to maintain normal glycolytic flux and cellular growth rate. 3-PG, however, accumulates, leading to increased serine synthesis. Hence, one biological function of BPGM is controlling glycolytic intermediate levels and thereby serine biosynthetic flux.},
doi = {10.1038/nchembio.2453},
journal = {Nature Chemical Biology},
number = 10,
volume = 13,
place = {United States},
year = {Mon Aug 07 00:00:00 EDT 2017},
month = {Mon Aug 07 00:00:00 EDT 2017}
}
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