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Title: Microfluidics-based separation of actinium-225 from radium-225 for medical applications

Abstract

Separation of 225Ra (t1/2 = 15 d) from its daughter isotope 225Ac (t1/2 = 10 d) is necessary to obtain pure 225Ac for cancer alpha-therapy. In this study, microscale separation of 225Ra from its daughter 225Ac using BioRad AG50X4 cation exchange resin was achieved with good reproducibility across microdevices, and ≥90% purity was achieved for 225Ac, which is comparable to conventional chromatography. These results indicate the potential for greater use of microfluidics for biomedical radiochemistry. The modularity of the system and its compatibility with different resins allows for quick and easy adaptation to the various needs of a separation campaign.

Authors:
ORCiD logo [1];  [2];  [3];  [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. Oak Ridge Associated Univ., Oak Ridge, TN (United States)
  3. Oak Ridge Associated Univ., Oak Ridge, TN (United States); Arizona State Univ., Tempe, AZ (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)
OSTI Identifier:
1546530
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Separation Science and Technology
Additional Journal Information:
Journal Volume: 54; Journal Issue: 12; Journal ID: ISSN 0149-6395
Publisher:
Taylor & Francis
Country of Publication:
United States
Language:
English
Subject:
29 ENERGY PLANNING, POLICY, AND ECONOMY; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; Microfluidics; Actinium-225; Radium-225; Ion chromatography; Targeted-Alpha-Therapy

Citation Formats

Davern, Sandra, O’Neil, David, Hallikainen, Hannah, O’Neil, Kathleen, Allman, Steve, Millet, Larry J., Retterer, Scott, Doktycz, Mitchel, Standaert, Robert, Boll, Rose Ann, Van Cleve, Shelley, DePaoli, David, and Mirzadeh, Saed. Microfluidics-based separation of actinium-225 from radium-225 for medical applications. United States: N. p., 2019. Web. doi:10.1080/01496395.2019.1614956.
Davern, Sandra, O’Neil, David, Hallikainen, Hannah, O’Neil, Kathleen, Allman, Steve, Millet, Larry J., Retterer, Scott, Doktycz, Mitchel, Standaert, Robert, Boll, Rose Ann, Van Cleve, Shelley, DePaoli, David, & Mirzadeh, Saed. Microfluidics-based separation of actinium-225 from radium-225 for medical applications. United States. doi:10.1080/01496395.2019.1614956.
Davern, Sandra, O’Neil, David, Hallikainen, Hannah, O’Neil, Kathleen, Allman, Steve, Millet, Larry J., Retterer, Scott, Doktycz, Mitchel, Standaert, Robert, Boll, Rose Ann, Van Cleve, Shelley, DePaoli, David, and Mirzadeh, Saed. Mon . "Microfluidics-based separation of actinium-225 from radium-225 for medical applications". United States. doi:10.1080/01496395.2019.1614956. https://www.osti.gov/servlets/purl/1546530.
@article{osti_1546530,
title = {Microfluidics-based separation of actinium-225 from radium-225 for medical applications},
author = {Davern, Sandra and O’Neil, David and Hallikainen, Hannah and O’Neil, Kathleen and Allman, Steve and Millet, Larry J. and Retterer, Scott and Doktycz, Mitchel and Standaert, Robert and Boll, Rose Ann and Van Cleve, Shelley and DePaoli, David and Mirzadeh, Saed},
abstractNote = {Separation of 225Ra (t1/2 = 15 d) from its daughter isotope 225Ac (t1/2 = 10 d) is necessary to obtain pure 225Ac for cancer alpha-therapy. In this study, microscale separation of 225Ra from its daughter 225Ac using BioRad AG50X4 cation exchange resin was achieved with good reproducibility across microdevices, and ≥90% purity was achieved for 225Ac, which is comparable to conventional chromatography. These results indicate the potential for greater use of microfluidics for biomedical radiochemistry. The modularity of the system and its compatibility with different resins allows for quick and easy adaptation to the various needs of a separation campaign.},
doi = {10.1080/01496395.2019.1614956},
journal = {Separation Science and Technology},
number = 12,
volume = 54,
place = {United States},
year = {2019},
month = {5}
}

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    Works referencing / citing this record:

    Alpha-particles for targeted therapy
    journal, September 2008


    Production of actinium-225 for alpha particle mediated radioimmunotherapy
    journal, May 2005


    Microfluidic reactor for the radiosynthesis of PET radiotracers
    journal, March 2006


    Microfluidic technology for PET radiochemistry
    journal, March 2006


    Microfluidic reactor geometries for radiolysis reduction in radiopharmaceuticals
    journal, August 2012


    Large scale accelerator production of 225Ac: Effective cross sections for 78–192 MeV protons incident on 232Th targets
    journal, December 2016


    Selective etching of PDMS: Etching as a negative tone resist
    journal, July 2018


    Selective etching of PDMS: Etching technique for application as a positive tone resist
    journal, November 2018


    Targeting the DNA Damage Response in Cancer
    journal, November 2015


    Regulation of ATM in DNA double strand break repair accounts for the radiosensitivity in human cells exposed to high linear energy transfer ionizing radiation
    journal, November 2009

    • Xue, Lian; Yu, Dong; Furusawa, Yoshiya
    • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 670, Issue 1-2
    • DOI: 10.1016/j.mrfmmm.2009.06.016

    Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation
    journal, June 2011

    • Asaithamby, Aroumougame; Chen, David J.
    • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 711, Issue 1-2
    • DOI: 10.1016/j.mrfmmm.2010.11.002

    Actinide targets for the synthesis of super-heavy elements
    journal, December 2015


    Separation of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins
    journal, April 2018


    Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix
    journal, August 2017


    Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals
    journal, January 2013

    • Arima, Valentina; Pascali, Giancarlo; Lade, Oliver
    • Lab on a Chip, Vol. 13, Issue 12
    • DOI: 10.1039/c3lc00055a

    A solvent resistant lab-on-chip platform for radiochemistry applications
    journal, January 2014

    • Rensch, Christian; Lindner, Simon; Salvamoser, Ruben
    • Lab Chip, Vol. 14, Issue 14
    • DOI: 10.1039/c4lc00076e

    Synthesis and targeting of gold-coated 177 Lu-containing lanthanide phosphate nanoparticles—A potential theranostic agent for pulmonary metastatic disease
    journal, March 2018

    • Sobol, Nicholas; Sutherlin, Logan; Cedrowska, Edyta
    • APL Bioengineering, Vol. 2, Issue 1
    • DOI: 10.1063/1.5018165

    Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
    journal, April 2003

    • Rothkamm, K.; Lobrich, M.
    • Proceedings of the National Academy of Sciences, Vol. 100, Issue 9, p. 5057-5062
    • DOI: 10.1073/pnas.0830918100

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    • Asaithamby, A.; Hu, B.; Chen, D. J.
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    • DOI: 10.1073/pnas.1016045108

    Patterning PDMS using a combination of wet and dry etching
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    • Balakrisnan, B; Patil, S; Smela, E
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    Bismuth-213 and Actinium-225 – Generator Performance and Evolving Therapeutic Applications of Two Generator-Derived Alpha-Emitting Radioisotopes
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    • Current Radiopharmaceuticals, Vol. 5, Issue 3
    • DOI: 10.2174/1874471011205030221

    German Multicenter Study Investigating 177 Lu-PSMA-617 Radioligand Therapy in Advanced Prostate Cancer Patients
    journal, October 2016

    • Rahbar, Kambiz; Ahmadzadehfar, Hojjat; Kratochwil, Clemens
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    • DOI: 10.2967/jnumed.116.183194

    α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies—Part 1
    journal, March 2018

    • Poty, Sophie; Francesconi, Lynn C.; McDevitt, Michael R.
    • Journal of Nuclear Medicine, Vol. 59, Issue 6
    • DOI: 10.2967/jnumed.116.186338

    α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies—Part 2
    journal, March 2018

    • Poty, Sophie; Francesconi, Lynn C.; McDevitt, Michael R.
    • Journal of Nuclear Medicine, Vol. 59, Issue 7
    • DOI: 10.2967/jnumed.117.204651

    Microfluidics: A Groundbreaking Technology for PET Tracer Production?
    journal, July 2013