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Title: Microfluidics-based separation of actinium-225 from radium-225 for medical applications

Abstract

Separation of 225Ra (t 1/2 = 15 d) from its daughter isotope 225Ac (t 1/2 = 10 d) is necessary to obtain pure 225Ac for cancer alpha-therapy. In this study, microscale separation of 225Ra from its daughter 225Ac using BioRad AG50X4 cation exchange resin was achieved with good reproducibility across microdevices, and ≥90% purity was achieved for 225Ac, which is comparable to conventional chromatography. These results indicate the potential for greater use of microfluidics for biomedical radiochemistry. The modularity of the system and its compatibility with different resins allows for quick and easy adaptation to the various needs of a separation campaign.

Authors:
ORCiD logo [1];  [2];  [3];  [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. Oak Ridge Associated Univ., Oak Ridge, TN (United States)
  3. Oak Ridge Associated Univ., Oak Ridge, TN (United States); Arizona State Univ., Tempe, AZ (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)
OSTI Identifier:
1546530
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Separation Science and Technology
Additional Journal Information:
Journal Volume: 54; Journal Issue: 12; Journal ID: ISSN 0149-6395
Publisher:
Taylor & Francis
Country of Publication:
United States
Language:
English
Subject:
29 ENERGY PLANNING, POLICY, AND ECONOMY; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; Microfluidics; Actinium-225; Radium-225; Ion chromatography; Targeted-Alpha-Therapy

Citation Formats

Davern, Sandra, O’Neil, David, Hallikainen, Hannah, O’Neil, Kathleen, Allman, Steve, Millet, Larry J., Retterer, Scott, Doktycz, Mitchel, Standaert, Robert, Boll, Rose Ann, Van Cleve, Shelley, DePaoli, David, and Mirzadeh, Saed. Microfluidics-based separation of actinium-225 from radium-225 for medical applications. United States: N. p., 2019. Web. doi:10.1080/01496395.2019.1614956.
Davern, Sandra, O’Neil, David, Hallikainen, Hannah, O’Neil, Kathleen, Allman, Steve, Millet, Larry J., Retterer, Scott, Doktycz, Mitchel, Standaert, Robert, Boll, Rose Ann, Van Cleve, Shelley, DePaoli, David, & Mirzadeh, Saed. Microfluidics-based separation of actinium-225 from radium-225 for medical applications. United States. doi:10.1080/01496395.2019.1614956.
Davern, Sandra, O’Neil, David, Hallikainen, Hannah, O’Neil, Kathleen, Allman, Steve, Millet, Larry J., Retterer, Scott, Doktycz, Mitchel, Standaert, Robert, Boll, Rose Ann, Van Cleve, Shelley, DePaoli, David, and Mirzadeh, Saed. Mon . "Microfluidics-based separation of actinium-225 from radium-225 for medical applications". United States. doi:10.1080/01496395.2019.1614956.
@article{osti_1546530,
title = {Microfluidics-based separation of actinium-225 from radium-225 for medical applications},
author = {Davern, Sandra and O’Neil, David and Hallikainen, Hannah and O’Neil, Kathleen and Allman, Steve and Millet, Larry J. and Retterer, Scott and Doktycz, Mitchel and Standaert, Robert and Boll, Rose Ann and Van Cleve, Shelley and DePaoli, David and Mirzadeh, Saed},
abstractNote = {Separation of 225Ra (t1/2 = 15 d) from its daughter isotope 225Ac (t1/2 = 10 d) is necessary to obtain pure 225Ac for cancer alpha-therapy. In this study, microscale separation of 225Ra from its daughter 225Ac using BioRad AG50X4 cation exchange resin was achieved with good reproducibility across microdevices, and ≥90% purity was achieved for 225Ac, which is comparable to conventional chromatography. These results indicate the potential for greater use of microfluidics for biomedical radiochemistry. The modularity of the system and its compatibility with different resins allows for quick and easy adaptation to the various needs of a separation campaign.},
doi = {10.1080/01496395.2019.1614956},
journal = {Separation Science and Technology},
number = 12,
volume = 54,
place = {United States},
year = {2019},
month = {5}
}

Journal Article:
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Works referenced in this record:

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
journal, April 2003

  • Rothkamm, K.; Lobrich, M.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 9, p. 5057-5062
  • DOI: 10.1073/pnas.0830918100

Microfluidic reactor for the radiosynthesis of PET radiotracers
journal, March 2006


Patterning PDMS using a combination of wet and dry etching
journal, March 2009

  • Balakrisnan, B; Patil, S; Smela, E
  • Journal of Micromechanics and Microengineering, Vol. 19, Issue 4, Article No. 047002
  • DOI: 10.1088/0960-1317/19/4/047002