skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Dynamical nonlinear memory capacitance in biomimetic membranes

Abstract

Two-terminal memory elements, or memelements, capable of co-locating signal processing and memory via history-dependent reconfigurability at the nanoscale are vital for next-generation computing materials striving to match the brain’s efficiency and flexible cognitive capabilities. While memory resistors, or memristors, have been widely reported, other types of memelements remain underexplored or undiscovered. Here we report the first example of a volatile, voltage-controlled memcapacitor in which capacitive memory arises from reversible and hysteretic geometrical changes in a lipid bilayer that mimics the composition and structure of biomembranes. We demonstrate that the nonlinear dynamics and memory are governed by two implicitly-coupled, voltage-dependent state variables—membrane radius and thickness. Further, our system is capable of tuneable signal processing and learning via synapse-like, short-term capacitive plasticity. These findings will accelerate the development of low-energy, biomolecular neuromorphic memelements, which, in turn, could also serve as models to study capacitive memory and signal processing in neuronal membranes.

Authors:
ORCiD logo [1];  [2]; ORCiD logo [3];  [2];  [2]; ORCiD logo [4];  [4];  [5]
  1. Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. Univ. of Tennessee, Knoxville, TN (United States
  3. Texas A & M Univ., College Station, TX (United States)
  4. Univ. of Tennessee, Knoxville, TN (United States)
  5. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE; National Science Foundation (NSF)
OSTI Identifier:
1546523
Grant/Contract Number:  
AC05-00OR22725; NSF ECCS-1631472
Resource Type:
Accepted Manuscript
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 10; Journal Issue: 1; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Najem, Joseph S., Hasan, Md Sakib, Williams, R. Stanley, Weiss, Ryan J., Rose, Garrett S., Taylor, Graham J., Sarles, Stephen A., and Collier, C. Patrick. Dynamical nonlinear memory capacitance in biomimetic membranes. United States: N. p., 2019. Web. doi:10.1038/s41467-019-11223-8.
Najem, Joseph S., Hasan, Md Sakib, Williams, R. Stanley, Weiss, Ryan J., Rose, Garrett S., Taylor, Graham J., Sarles, Stephen A., & Collier, C. Patrick. Dynamical nonlinear memory capacitance in biomimetic membranes. United States. doi:10.1038/s41467-019-11223-8.
Najem, Joseph S., Hasan, Md Sakib, Williams, R. Stanley, Weiss, Ryan J., Rose, Garrett S., Taylor, Graham J., Sarles, Stephen A., and Collier, C. Patrick. Fri . "Dynamical nonlinear memory capacitance in biomimetic membranes". United States. doi:10.1038/s41467-019-11223-8. https://www.osti.gov/servlets/purl/1546523.
@article{osti_1546523,
title = {Dynamical nonlinear memory capacitance in biomimetic membranes},
author = {Najem, Joseph S. and Hasan, Md Sakib and Williams, R. Stanley and Weiss, Ryan J. and Rose, Garrett S. and Taylor, Graham J. and Sarles, Stephen A. and Collier, C. Patrick},
abstractNote = {Two-terminal memory elements, or memelements, capable of co-locating signal processing and memory via history-dependent reconfigurability at the nanoscale are vital for next-generation computing materials striving to match the brain’s efficiency and flexible cognitive capabilities. While memory resistors, or memristors, have been widely reported, other types of memelements remain underexplored or undiscovered. Here we report the first example of a volatile, voltage-controlled memcapacitor in which capacitive memory arises from reversible and hysteretic geometrical changes in a lipid bilayer that mimics the composition and structure of biomembranes. We demonstrate that the nonlinear dynamics and memory are governed by two implicitly-coupled, voltage-dependent state variables—membrane radius and thickness. Further, our system is capable of tuneable signal processing and learning via synapse-like, short-term capacitive plasticity. These findings will accelerate the development of low-energy, biomolecular neuromorphic memelements, which, in turn, could also serve as models to study capacitive memory and signal processing in neuronal membranes.},
doi = {10.1038/s41467-019-11223-8},
journal = {Nature Communications},
number = 1,
volume = 10,
place = {United States},
year = {2019},
month = {7}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Citation Metrics:
Cited by: 2 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

The parallel approach
journal, April 2013

  • Di Ventra, Massimiliano; Pershin, Yuriy V.
  • Nature Physics, Vol. 9, Issue 4
  • DOI: 10.1038/nphys2566

Adapting to Thrive in a New Economy of Memory Abundance
journal, December 2015

  • Bresniker, Kirk M.; Singhal, Sharad; Williams, R. Stanley
  • Computer, Vol. 48, Issue 12
  • DOI: 10.1109/MC.2015.368

What's Next? [The end of Moore's law]
journal, March 2017

  • Williams, R. Stanley
  • Computing in Science & Engineering, Vol. 19, Issue 2
  • DOI: 10.1109/MCSE.2017.31

Neuromorphic electronic systems
journal, January 1990


A million spiking-neuron integrated circuit with a scalable communication network and interface
journal, August 2014


Large-scale neuromorphic computing systems
journal, August 2016


The SpiNNaker Project
journal, May 2014


How We Found The Missing Memristor
journal, December 2008


The chips are down for Moore’s law
journal, February 2016


Nonlinear circuit foundations for nanodevices, part I: the four-element torus
journal, November 2003


Memristor-The missing circuit element
journal, January 1971


The missing memristor found
journal, May 2008

  • Strukov, Dmitri B.; Snider, Gregory S.; Stewart, Duncan R.
  • Nature, Vol. 453, Issue 7191
  • DOI: 10.1038/nature06932

Memristive Ion Channel-Doped Biomembranes as Synaptic Mimics
journal, March 2018


Two centuries of memristors
journal, May 2012

  • Prodromakis, Themistoklis; Toumazou, Christofer; Chua, Leon
  • Nature Materials, Vol. 11, Issue 6
  • DOI: 10.1038/nmat3338

Review of memristor devices in neuromorphic computing: materials sciences and device challenges
journal, September 2018

  • Li, Yibo; Wang, Zhongrui; Midya, Rivu
  • Journal of Physics D: Applied Physics, Vol. 51, Issue 50
  • DOI: 10.1088/1361-6463/aade3f

Layered memristive and memcapacitive switches for printable electronics
journal, November 2014

  • Bessonov, Alexander A.; Kirikova, Marina N.; Petukhov, Dmitrii I.
  • Nature Materials, Vol. 14, Issue 2
  • DOI: 10.1038/nmat4135

Exploration and characterization of the memcapacitor and memristor properties of Ni–DNA nanowire devices
journal, September 2017

  • Chu, Hsueh-Liang; Lai, Jian-Jhong; Wu, Li-Ying
  • NPG Asia Materials, Vol. 9, Issue 9
  • DOI: 10.1038/am.2017.157

Coexistence of high performance resistance and capacitance memory based on multilayered metal-oxide structures
journal, August 2013


Analog reversible nonvolatile memcapacitance in metal-oxide-semiconductor memcapacitor with ITO/HfO x /Si structure
journal, October 2018

  • Park, Daehoon; Yang, Paul; Kim, Hyung Jun
  • Applied Physics Letters, Vol. 113, Issue 16
  • DOI: 10.1063/1.5043275

Transmembrane Potential across Single Conical Nanopores and Resulting Memristive and Memcapacitive Ion Transport
journal, February 2012

  • Wang, Dengchao; Kvetny, Maksim; Liu, Juan
  • Journal of the American Chemical Society, Vol. 134, Issue 8
  • DOI: 10.1021/ja211142e

Analog memory capacitor based on field-configurable ion-doped polymers
journal, November 2009

  • Lai, Qianxi; Zhang, Lei; Li, Zhiyong
  • Applied Physics Letters, Vol. 95, Issue 21
  • DOI: 10.1063/1.3268433

Memory Impedance in TiO2 based Metal-Insulator-Metal Devices
journal, March 2014

  • Qingjiang, Li; Khiat, Ali; Salaoru, Iulia
  • Scientific Reports, Vol. 4, Issue 1
  • DOI: 10.1038/srep04522

Nanobatteries in redox-based resistive switches require extension of memristor theory
journal, April 2013

  • Valov, I.; Linn, E.; Tappertzhofen, S.
  • Nature Communications, Vol. 4, Issue 1
  • DOI: 10.1038/ncomms2784

Multilevel Nonvolatile Memristive and Memcapacitive Switching in Stacked Graphene Sheets
journal, May 2016

  • Park, Minji; Park, Sungjin; Yoo, Kyung-Hwa
  • ACS Applied Materials & Interfaces, Vol. 8, Issue 22
  • DOI: 10.1021/acsami.6b01962

Coexistence of memristive and memcapacitive effects in oxide thin films
journal, November 2018

  • Shuai, Yao; Peng, Yun; Pan, Xinqiang
  • Japanese Journal of Applied Physics, Vol. 57, Issue 12
  • DOI: 10.7567/JJAP.57.121502

Memcapacitive properties of poly(3,4-ethylenedioxythiophene) modified electrodes
journal, March 2013


Memory effects in complex materials and nanoscale systems
journal, April 2011


Capacitive neural network with neuro-transistors
journal, August 2018


Everything You Wish to Know About Memristors But Are Afraid to Ask
journal, June 2015


Lipids on the frontier: a century of cell-membrane bilayers
journal, May 2003

  • Edidin, Michael
  • Nature Reviews Molecular Cell Biology, Vol. 4, Issue 5
  • DOI: 10.1038/nrm1102

Regulated Attachment Method for Reconstituting Lipid Bilayers of Prescribed Size within Flexible Substrates
journal, February 2010

  • Sarles, Stephen A.; Leo, Donald J.
  • Analytical Chemistry, Vol. 82, Issue 3
  • DOI: 10.1021/ac902555z

Direct in situ measurement of specific capacitance, monolayer tension, and bilayer tension in a droplet interface bilayer
journal, January 2015

  • Taylor, Graham J.; Venkatesan, Guru A.; Collier, C. Patrick
  • Soft Matter, Vol. 11, Issue 38
  • DOI: 10.1039/C5SM01005E

Calculations of the electrostatic potential adjacent to model phospholipid bilayers
journal, March 1995


Vesicle and bilayer formation of diphytanoylphosphatidylcholine (DPhPC) and diphytanoylphosphatidylethanolamine (DPhPE) mixtures and their bilayers’ electrical stability
journal, February 2011


Capacitive Detection of Low-Enthalpy, Higher-Order Phase Transitions in Synthetic and Natural Composition Lipid Membranes
journal, August 2017


Heating-Enabled Formation of Droplet Interface Bilayers Using Escherichia coli Total Lipid Extract
journal, December 2014

  • Taylor, Graham J.; Sarles, Stephen A.
  • Langmuir, Vol. 31, Issue 1
  • DOI: 10.1021/la503471m

Reversible, voltage-activated formation of biomimetic membranes between triblock copolymer-coated aqueous droplets in good solvents
journal, January 2016

  • Tamaddoni, Nima; Taylor, Graham; Hepburn, Trevor
  • Soft Matter, Vol. 12, Issue 23
  • DOI: 10.1039/C6SM00400H

Densities, Viscosities, and Refractive Indices of Binary Liquid Mixtures of Hexane, Decane, Hexadecane, and Squalane with Benzene at 298.15 K
journal, September 2000

  • Lal, Krishan; Tripathi, Neelima; Dubey, Gyan P.
  • Journal of Chemical & Engineering Data, Vol. 45, Issue 5
  • DOI: 10.1021/je000103x

The organization of n-alkanes in lipid bilayers
journal, April 1980

  • McIntosh, T. J.; Simon, S. A.; MacDonald, R. C.
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 597, Issue 3
  • DOI: 10.1016/0005-2736(80)90219-9

Determining Membrane Capacitance by Dynamic Control of Droplet Interface Bilayer Area
journal, December 2011

  • Gross, Linda C. M.; Heron, Andrew J.; Baca, Sylvan C.
  • Langmuir, Vol. 27, Issue 23
  • DOI: 10.1021/la203081v

Direct Measurement of Specific Membrane Capacitance in Neurons
journal, July 2000


The lippmann equation and the characterization of black lipid films
journal, May 1975


Poisson’s Ratio and Young’s Modulus of Lipid Bilayers in Different Phases
journal, April 2014

  • Jadidi, Tayebeh; Seyyed-Allaei, Hamid; Tabar, M. Reza Rahimi
  • Frontiers in Bioengineering and Biotechnology, Vol. 2
  • DOI: 10.3389/fbioe.2014.00008

Physical origin of dynamic ion transport features through single conical nanopores at different bias frequencies
journal, January 2014

  • Wang, Dengchao; Liu, Juan; Kvetny, Maksim
  • Chemical Science, Vol. 5, Issue 5
  • DOI: 10.1039/c3sc52187g

A quantitative description of membrane current and its application to conduction and excitation in nerve
journal, August 1952


The voltage-dependence of MscL has dipolar and dielectric contributions and is governed by local intramembrane electric field
journal, September 2018


The Mechanisms and Functions of Synaptic Facilitation
journal, May 2017


Short-term synaptic plasticity as a temporal filter
journal, July 2001


Squeeze film damping and stiffening in circular CMUT with air-filled cavity: Influence of the lateral venting boundary conditions and the bias voltage
journal, October 2017

  • Galisultanov, Ayrat; Le Moal, Patrice; Bourbon, Gilles
  • Sensors and Actuators A: Physical, Vol. 266
  • DOI: 10.1016/j.sna.2017.09.003

Memcapacitive neural networks
journal, January 2014


A Tissue-Like Printed Material
journal, April 2013