Analysis of TP53 gene in uterine myomas: No mutations but P72R polymorphism is associated with myoma development

Altinkaya, S. Ozlem; Avcioglu, Sumeyra N.; Sezer, Selda D.; Ceylaner, Serdar

doi:10.1111/jog.14071

Title: Analysis of TP53 gene in uterine myomas: No mutations but P72R polymorphism is associated with myoma development

Authors:

Altinkaya, S. Ozlem ^[1]; Avcioglu, Sumeyra N. ^[1]; Sezer, Selda D. ^[1]; Ceylaner, Serdar ^[2]

Department of Gynecology and Obstetrics Adnan Menderes University, Faculty of Medicine Aydin Turkey
Intergen Genetics Center Ankara Turkey

Publication Date:: 2019-07-29

Sponsoring Org.:: USDOE

OSTI Identifier:: 1545479

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Journal of Obstetrics and Gynaecology Research

Additional Journal Information:: Journal Name: Journal of Obstetrics and Gynaecology Research Journal Volume: 45 Journal Issue: 10; Journal ID: ISSN 1341-8076

Publisher:: Wiley-Blackwell

Country of Publication:: Country unknown/Code not available

Language:: English

Citation Formats


                    Altinkaya, S. Ozlem, Avcioglu, Sumeyra N., Sezer, Selda D., and Ceylaner, Serdar. Analysis of TP53 gene in uterine myomas: No mutations but P72R polymorphism is associated with myoma development.  Country unknown/Code not available: N. p., 2019. 
Web.  doi:10.1111/jog.14071.

Copy to clipboard


                    Altinkaya, S. Ozlem, Avcioglu, Sumeyra N., Sezer, Selda D., & Ceylaner, Serdar. Analysis of TP53 gene in uterine myomas: No mutations but P72R polymorphism is associated with myoma development.  Country unknown/Code not available.  https://doi.org/10.1111/jog.14071

Copy to clipboard


                    Altinkaya, S. Ozlem, Avcioglu, Sumeyra N., Sezer, Selda D., and Ceylaner, Serdar. Mon .  
"Analysis of TP53 gene in uterine myomas: No mutations but P72R polymorphism is associated with myoma development".  Country unknown/Code not available.  https://doi.org/10.1111/jog.14071.

Copy to clipboard


                    
@article{osti_1545479,

  title        = {Analysis of TP53 gene in uterine myomas: No mutations but P72R polymorphism is associated with myoma development},

  author       = {Altinkaya, S. Ozlem and Avcioglu, Sumeyra N. and Sezer, Selda D. and Ceylaner, Serdar},

  abstractNote = {},

  doi          = {10.1111/jog.14071},

  journal      = {Journal of Obstetrics and Gynaecology Research},

  number       = 10,

  volume       = 45,

  place        = {Country unknown/Code not available},

  year         = {2019},

  month        = {7}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (Publisher)

Publisher's Version of Record
https://doi.org/10.1111/jog.14071

Other availability

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Tumor necrosis factor-α-308 promoter and p53 codon 72 gene polymorphisms in women with leiomyomas
journal, October 2004

Hsieh, Yao-Yuan; Chang, Chi-Chen; Tsai, Fuu-Jen
Fertility and Sterility, Vol. 82
DOI: 10.1016/j.fertnstert.2004.03.035

Rearrangement of the p53 gene in human osteogenic sarcomas.
journal, November 1987

Masuda, H.; Miller, C.; Koeffler, H. P.
Proceedings of the National Academy of Sciences, Vol. 84, Issue 21
DOI: 10.1073/pnas.84.21.7716

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
journal, December 2014

Wong, Terrence N.; Ramsingh, Giridharan; Young, Andrew L.
Nature, Vol. 518, Issue 7540
DOI: 10.1038/nature13968

Epidemiologic Contributions to Understanding the Etiology of Uterine Leiomyomata
journal, October 2000

Schwartz, Stephen M.; Marshall, Lynn M.; Baird, Donna D.
Environmental Health Perspectives, Vol. 108, Issue s5
DOI: 10.1289/ehp.00108s5821

Polymorphism of the p53 tumor suppressor gene is associated with susceptibility to uterine leiomyoma
journal, July 2005

Denschlag, Dominik; Bettendorf, Herta; Watermann, Dirk
Fertility and Sterility, Vol. 84, Issue 1
DOI: 10.1016/j.fertnstert.2005.01.103

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction
journal, March 2016

Kung, Che-Pei; Leu, Julia I-Ju; Basu, Subhasree
Cell Reports, Vol. 14, Issue 10
DOI: 10.1016/j.celrep.2016.02.037

A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
journal, September 2011

Stacey, Simon N.; Sulem, Patrick; Jonasdottir, Aslaug
Nature Genetics, Vol. 43, Issue 11
DOI: 10.1038/ng.926

Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 expression
journal, September 2013

Ortega, F. J.; Moreno-Navarrete, J. M.; Mayas, D.
International Journal of Obesity, Vol. 38, Issue 5
DOI: 10.1038/ijo.2013.163

Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer.
journal, May 1991

Chen, L. C.; Neubauer, A.; Kurisu, W.
Proceedings of the National Academy of Sciences, Vol. 88, Issue 9
DOI: 10.1073/pnas.88.9.3847

Germline Mutations of the p53 Tumor-Suppressor Gene in Children and Young Adults with Second Malignant Neoplasms
journal, May 1992

Malkin, David; Jolly, Kent W.; Barbier, Noële
New England Journal of Medicine, Vol. 326, Issue 20
DOI: 10.1056/NEJM199205143262002

The role of p53 in cancer drug resistance and targeted chemotherapy
journal, November 2016

Hientz, Karin; Mohr, André; Bhakta-Guha, Dipita
Oncotarget, Vol. 8, Issue 5
DOI: 10.18632/oncotarget.13475

Putting p53 in Context
journal, September 2017

Kastenhuber, Edward R.; Lowe, Scott W.
Cell, Vol. 170, Issue 6
DOI: 10.1016/j.cell.2017.08.028

Apoptosis and aging: breast cells and apoptosis
journal, February 2001

Gompel, Anne; Levy, D.; Chaouat, M.
Maturitas, Vol. 38, Issue 1
DOI: 10.1016/S0378-5122(00)00190-0

Analysis of Ki-ras, p53, and MDM2 Genes in Uterine Leiomyomas and Leiomyosarcomas
journal, May 1997

Hall, Kevin L.; Teneriello, Michael G.; Taylor, Robert R.
Gynecologic Oncology, Vol. 65, Issue 2
DOI: 10.1006/gyno.1997.4653

An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma.
journal, July 1992

Sun, Y.; Hegamyer, G.; Cheng, Y. J.
Proceedings of the National Academy of Sciences, Vol. 89, Issue 14
DOI: 10.1073/pnas.89.14.6516

Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines
journal, January 2006

Liu, Y.; Bodmer, W. F.
Proceedings of the National Academy of Sciences, Vol. 103, Issue 4
DOI: 10.1073/pnas.0510146103

Gene and protein expression of progesterone receptor isoforms A and B, p53 and p21 in myometrium and uterine leiomyoma
journal, February 2012

Lora, Vanessa; Grings, Anelise Olmos; Capp, Edison
Archives of Gynecology and Obstetrics, Vol. 286, Issue 1
DOI: 10.1007/s00404-012-2245-2

Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyoma: Analysis of Uterine Smooth Muscle Tumors
journal, July 2014

Zhang, Qing; Ubago, Julianne; Li, Li
Cancer, Vol. 120, Issue 20
DOI: 10.1002/cncr.28900

TP53 polymorphism in plasma cell myeloma
journal, February 2018

Zmorzynski, Szymon Andrzej; Korszen-Pilecka, Iwona; Wojcierowska-Litwin, Magdalena
Folia Histochemica et Cytobiologica, Vol. 55, Issue 4
DOI: 10.5603/FHC.a2017.0022

Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis
journal, December 2006

Tang, Yi; Luo, Jianyuan; Zhang, Wenzhu
Molecular Cell, Vol. 24, Issue 6
DOI: 10.1016/j.molcel.2006.11.021

Four novel single nucleotide polymorphisms within the promoter region of p53 gene and their associations with uterine leiomyoma
journal, January 2007

Hsieh, Yao-Yuan; Wang, Jui-Ping; Lin, Chich-Sheng
Molecular Reproduction and Development, Vol. 74, Issue 7
DOI: 10.1002/mrd.20464

Apoptosis in Human Uterine Leiomyomas
journal, May 2004

,
Seminars in Reproductive Medicine, Vol. 22, Issue 2
DOI: 10.1055/s-2004-828615

Melanoma arising in a Giant congenital melanocytic nevus: two case reports
journal, February 2019

Belysheva, Tatiana S.; Vishnevskaya, Yana V.; Nasedkina, Tatiana V.
Diagnostic Pathology, Vol. 14, Issue 1
DOI: 10.1186/s13000-019-0797-1

Unicellular histogenesis of uterine leiomyomas as determined by electrophoresis of glucose-6-phosphate dehydrogenase
journal, January 1970

Townsend, Duane E.; Sparkes, Roberts.; Baluda, Maryellen C.
American Journal of Obstetrics and Gynecology, Vol. 107, Issue 8
DOI: 10.1016/S0002-9378(15)30365-3

Why are there hotspot mutations in the TP53 gene in human cancers?
journal, November 2017

Baugh, Evan H.; Ke, Hua; Levine, Arnold J.
Cell Death & Differentiation, Vol. 25, Issue 1
DOI: 10.1038/cdd.2017.180

Association of XRCC1 Arg399GIn and Tp53 Arg72Pro polymorphisms and increased risk of uterine leiomyoma - A case-control study
journal, November 2015

Yaghmaei, Minoo; Salimi, Saeedeh; Namazi, Lida
Genetics and Molecular Biology, Vol. 38, Issue 4
DOI: 10.1590/S1415-475738420140359

p53 Mutations are common in pancreatic cancer and are absent in chronic pancreatitis
journal, May 1993

Casey, Graham; Yamanaka, Yoichiro; Friess, Helmut
Cancer Letters, Vol. 69, Issue 3
DOI: 10.1016/0304-3835(93)90168-9

Mutation analysis ofCDP,TP53, andKRAS in uterine leiomyomas
journal, May 2003

Patrikis, Maria I.; Bryan, Emma J.; Thomas, Nicola A.
Molecular Carcinogenesis, Vol. 37, Issue 2
DOI: 10.1002/mc.10127

Tp53 gene p72R polymorphism in chronic lymphocytic leukemia: incidence and clinical significance amongst cases with unmutated immunoglobulin receptors
journal, August 2016

Gemenetzi, Katerina; Galigalidou, Chrysi; Vlachonikola, Elisavet
Leukemia & Lymphoma, Vol. 58, Issue 3
DOI: 10.1080/10428194.2016.1211276

Mutational hot spot in the p53 gene in human hepatocellular carcinomas
journal, April 1991

Hsu, I. C.; Metcalf, R. A.; Sun, T.
Nature, Vol. 350, Issue 6317
DOI: 10.1038/350427a0

Prognostic Significance of TP53 Mutations and Single Nucleotide Polymorphisms in Acute Myeloid Leukemia: A case Series and Literature Review
journal, February 2014

Zeichner, Simon Blechman; Alghamdi, Sarah; Elhammady, Gina
Asian Pacific Journal of Cancer Prevention, Vol. 15, Issue 4
DOI: 10.7314/APJCP.2014.15.4.1603

Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis
journal, October 2018

Yogosawa, Satomi; Yoshida, Kiyotsugu
Cancer Science, Vol. 109, Issue 11
DOI: 10.1111/cas.13792

Identification of a novel TP53 germline mutation E285V in a rare case of paediatric adrenocortical carcinoma and choroid plexus carcinoma
journal, June 2008

Russell-Swetek, A.; West, A. N.; Mintern, J. E.
Journal of Medical Genetics, Vol. 45, Issue 9
DOI: 10.1136/jmg.2008.059568

A crucial role for adipose tissue p53 in the regulation of insulin resistance
journal, August 2009

Minamino, Tohru; Orimo, Masayuki; Shimizu, Ippei
Nature Medicine, Vol. 15, Issue 9
DOI: 10.1038/nm.2014

Absence of p53-Dependent Apoptosis Combined With Nonhomologous End-Joining Deficiency Leads to a Severe Diabetic Phenotype in Mice
journal, October 2009

Tavana, O.; Puebla-Osorio, N.; Sang, M.
Diabetes, Vol. 59, Issue 1
DOI: 10.2337/db09-0792

Similar Records in DOE PAGES and OSTI.GOV collections:

Association of the widespread A149P hereditary fructose intolerance mutation with newly identified sequence polymorphisms in the aldolase B gene

Journal Article Brooks, C C ; Tolan, D R - American Journal of Human Genetics; (United States)

Hereditary fructose intolerance (HFI) is a potentially fatal autosomal recessive disease resulting from the catalytic deficiency of fructose 1-phosphate aldolase (aldolase B) in fructose-metabolizing tissues. The A149P mutation in exon 5 of the aldolase B gene, located on chromosome 9q2l.3-q22.2, is widespread and the most common HFI mutation, accounting for 57% of HFI chromosomes. The possible origin of this mutation was studied by linkage to polymorphisms within the aldolase B gene. DNA fragments of the aldolase B gene containing the polymorphic marker loci from HFI patients homozygous for the A149P allele were amplified by PCR. Absolute linkage to a commonmore »« less
Teenage-onset non-syndromic deafness associated with a mutation and a polymorphism in the mitochondrial 12S ribsomal RNA gene in a large Zairese pedigree

Journal Article Matthijs, G ; Claes, S ; Cassiman, J J - American Journal of Human Genetics

Non-syndromic deafness has been described as both an autosomal dominant and a recessive trait. Recently, Prezant et al. have identified a 1555 A to G substitution in the mitcohondrial 12S rRNA gene associated with deafness, either in an early-onset form with a postulated recessive nuclear defect for phenotypic expression, or after treatment with aminoglycosides. We have analyzed samples from a large pedigree originating from the village KAI SINGINI in Bas-Zaire. Patients have a maternally inherited, sudden-onset and bilateral sensineuronal deafness before the age of 20. To the best of our knowledge, no aminoglycosides have been given to these individuals. Sequencingmore »« less
Pst I restriction fragment length polymorphism of human placental alkaline phosphatase gene: Mendelian in segregation and localization of mutation site in the gene

Journal Article Tsavaler, L ; Penhallow, R C ; Sussman, H H - Proceedings of the National Academy of Sciences of the United States of America; (USA)

The pattern of inheritance of a Pst I restriction fragment length polymorphism (RFLP) of the human placental alkaline phosphatase gene was studied in nine nuclear families by Southern blot hybridization analysis of genomic DNA. The dimorphic RFLP is defined by the presence of allelic fragments 1.0 kilobase and 0.8 kilobase long. The results of this study show that the two alleles of the Pst I RFLP of the placental alkaline phosphatase gene segregate as codominant traits according to Mendelian expectations. For a polymorphism to be useful as a genetic marker the probability that an offspring is informative (PIC) must bemore »« less
https://doi.org/10.1073/pnas.85.20.7680
TP53 Mutational Status and ROS Effect the Expression of the Survivin-Associated Radio-Adaptive Response

Journal Article Murley, Jeffrey S. ; Miller, Richard C. ; Weichselbaum, Ralph R. ; ... - Radiation Research

Not provided.
https://doi.org/10.1667/rr14831.1
Posterior Reversible Encephalopathy Syndrome Occurring After Uterine Artery Embolization for Uterine Myoma

Journal Article Suzuki, Satoshi ; Tanigawa, Noboru ; Kariya, Syuji ; ... - Cardiovascular and Interventional Radiology

This case report describes posterior reversible encephalopathy syndrome (PRES) occurring after uterine artery embolization (UAE) for uterine myoma. This is the first report of PRES occurring after uterine vascular radiologic intervention. The mechanism by which UAE induced PRES is unclear.
https://doi.org/10.1007/S00270-010-9817-Y

Similar Records

Title: Analysis of TP53 gene in uterine myomas: No mutations but P72R polymorphism is associated with myoma development

Citation Formats

Tumor necrosis factor-α-308 promoter and p53 codon 72 gene polymorphisms in women with leiomyomas journal, October 2004

Rearrangement of the p53 gene in human osteogenic sarcomas. journal, November 1987

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia journal, December 2014

Epidemiologic Contributions to Understanding the Etiology of Uterine Leiomyomata journal, October 2000

Polymorphism of the p53 tumor suppressor gene is associated with susceptibility to uterine leiomyoma journal, July 2005

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction journal, March 2016

A germline variant in the TP53 polyadenylation signal confers cancer susceptibility journal, September 2011

Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 expression journal, September 2013

Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer. journal, May 1991

Germline Mutations of the p53 Tumor-Suppressor Gene in Children and Young Adults with Second Malignant Neoplasms journal, May 1992

The role of p53 in cancer drug resistance and targeted chemotherapy journal, November 2016

Putting p53 in Context journal, September 2017

Apoptosis and aging: breast cells and apoptosis journal, February 2001

Analysis of Ki-ras, p53, and MDM2 Genes in Uterine Leiomyomas and Leiomyosarcomas journal, May 1997

An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma. journal, July 1992

Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines journal, January 2006

Gene and protein expression of progesterone receptor isoforms A and B, p53 and p21 in myometrium and uterine leiomyoma journal, February 2012

Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyoma: Analysis of Uterine Smooth Muscle Tumors journal, July 2014

TP53 polymorphism in plasma cell myeloma journal, February 2018

Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis journal, December 2006

Four novel single nucleotide polymorphisms within the promoter region of p53 gene and their associations with uterine leiomyoma journal, January 2007

Apoptosis in Human Uterine Leiomyomas journal, May 2004

Melanoma arising in a Giant congenital melanocytic nevus: two case reports journal, February 2019

Unicellular histogenesis of uterine leiomyomas as determined by electrophoresis of glucose-6-phosphate dehydrogenase journal, January 1970

Why are there hotspot mutations in the TP53 gene in human cancers? journal, November 2017

Association of XRCC1 Arg399GIn and Tp53 Arg72Pro polymorphisms and increased risk of uterine leiomyoma - A case-control study journal, November 2015

p53 Mutations are common in pancreatic cancer and are absent in chronic pancreatitis journal, May 1993

Mutation analysis ofCDP,TP53, andKRAS in uterine leiomyomas journal, May 2003

Tp53 gene p72R polymorphism in chronic lymphocytic leukemia: incidence and clinical significance amongst cases with unmutated immunoglobulin receptors journal, August 2016

Mutational hot spot in the p53 gene in human hepatocellular carcinomas journal, April 1991

Prognostic Significance of TP53 Mutations and Single Nucleotide Polymorphisms in Acute Myeloid Leukemia: A case Series and Literature Review journal, February 2014

Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis journal, October 2018

Identification of a novel TP53 germline mutation E285V in a rare case of paediatric adrenocortical carcinoma and choroid plexus carcinoma journal, June 2008

A crucial role for adipose tissue p53 in the regulation of insulin resistance journal, August 2009

Absence of p53-Dependent Apoptosis Combined With Nonhomologous End-Joining Deficiency Leads to a Severe Diabetic Phenotype in Mice journal, October 2009

Tumor necrosis factor-α-308 promoter and p53 codon 72 gene polymorphisms in women with leiomyomas
journal, October 2004

Rearrangement of the p53 gene in human osteogenic sarcomas.
journal, November 1987

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
journal, December 2014

Epidemiologic Contributions to Understanding the Etiology of Uterine Leiomyomata
journal, October 2000

Polymorphism of the p53 tumor suppressor gene is associated with susceptibility to uterine leiomyoma
journal, July 2005

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction
journal, March 2016

A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
journal, September 2011

Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 expression
journal, September 2013

Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer.
journal, May 1991

Germline Mutations of the p53 Tumor-Suppressor Gene in Children and Young Adults with Second Malignant Neoplasms
journal, May 1992

The role of p53 in cancer drug resistance and targeted chemotherapy
journal, November 2016

Putting p53 in Context
journal, September 2017

Apoptosis and aging: breast cells and apoptosis
journal, February 2001

Analysis of Ki-ras, p53, and MDM2 Genes in Uterine Leiomyomas and Leiomyosarcomas
journal, May 1997

An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma.
journal, July 1992

Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines
journal, January 2006

Gene and protein expression of progesterone receptor isoforms A and B, p53 and p21 in myometrium and uterine leiomyoma
journal, February 2012

Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyoma: Analysis of Uterine Smooth Muscle Tumors
journal, July 2014

TP53 polymorphism in plasma cell myeloma
journal, February 2018

Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis
journal, December 2006

Four novel single nucleotide polymorphisms within the promoter region of p53 gene and their associations with uterine leiomyoma
journal, January 2007

Apoptosis in Human Uterine Leiomyomas
journal, May 2004

Melanoma arising in a Giant congenital melanocytic nevus: two case reports
journal, February 2019

Unicellular histogenesis of uterine leiomyomas as determined by electrophoresis of glucose-6-phosphate dehydrogenase
journal, January 1970

Why are there hotspot mutations in the TP53 gene in human cancers?
journal, November 2017

Association of XRCC1 Arg399GIn and Tp53 Arg72Pro polymorphisms and increased risk of uterine leiomyoma - A case-control study
journal, November 2015

p53 Mutations are common in pancreatic cancer and are absent in chronic pancreatitis
journal, May 1993

Mutation analysis ofCDP,TP53, andKRAS in uterine leiomyomas
journal, May 2003

Tp53 gene p72R polymorphism in chronic lymphocytic leukemia: incidence and clinical significance amongst cases with unmutated immunoglobulin receptors
journal, August 2016

Mutational hot spot in the p53 gene in human hepatocellular carcinomas
journal, April 1991

Prognostic Significance of TP53 Mutations and Single Nucleotide Polymorphisms in Acute Myeloid Leukemia: A case Series and Literature Review
journal, February 2014

Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis
journal, October 2018

Identification of a novel TP53 germline mutation E285V in a rare case of paediatric adrenocortical carcinoma and choroid plexus carcinoma
journal, June 2008

A crucial role for adipose tissue p53 in the regulation of insulin resistance
journal, August 2009

Absence of p53-Dependent Apoptosis Combined With Nonhomologous End-Joining Deficiency Leads to a Severe Diabetic Phenotype in Mice
journal, October 2009