skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Genome-Wide Analysis of Corynespora cassiicola Leaf Fall Disease Putative Effectors

Abstract

Corynespora cassiicola is an Ascomycetes fungus with a broad host range and diverse life styles. Mostly known as a necrotrophic plant pathogen, it has also been associated with rare cases of human infection. In the rubber tree, this fungus causes the Corynespora leaf fall (CLF) disease, which increasingly affects natural rubber production in Asia and Africa. It has also been found as an endophyte in South American rubber plantations where no CLF outbreak has yet occurred. The C. cassiicola species is genetically highly diverse, but no clear relationship has been evidenced between phylogenetic lineage and pathogenicity. Cassiicolin, a small glycosylated secreted protein effector, is thought to be involved in the necrotrophic interaction with the rubber tree but some virulent C. cassiicola isolates do not have a cassiicolin gene. This study set out to identify other putative effectors involved in CLF. The genome of a highly virulent C. cassiicola isolate from the rubber tree (CCP) was sequenced and assembled. In silico prediction revealed 2870 putative effectors, comprising CAZymes, lipases, peptidases, secreted proteins and enzymes associated with secondary metabolism. Comparison with the genomes of 44 other fungal species, focusing on effector content, revealed a striking proximity with phylogenetically unrelated species ( Colletotrichummore » acutatum, Colletotrichum gloesporioides, Fusarium oxysporum, nectria hematococca, and Botrosphaeria dothidea) sharing life style plasticity and broad host range. Candidate effectors involved in the compatible interaction with the rubber tree were identified by transcriptomic analysis. Differentially expressed genes included 92 putative effectors, among which cassiicolin and two other secreted singleton proteins. Finally, the genomes of 35 C. cassiicola isolates representing the genetic diversity of the species were sequenced and assembled, and putative effectors identified. At the intraspecific level, effector-based classification was found to be highly consistent with the phylogenomic trees. Identification of lineage-specific effectors is a key step toward understanding C. cassiicola virulence and host specialization mechanisms.« less

Authors:
 [1];  [2];  [1];  [1];  [1];  [3];  [4];  [5];  [5];  [5];  [5];  [6];  [5];  [7];  [8];  [9];  [2]
  1. Univ. Clermont Auvergne, Clermont-Ferrand (France)
  2. Univ. Clermont Auvergne, Clermont-Ferrand (France); CIRAD, UMR AGAP, Clermont-Ferrand (France); Univ. Montpellier, Montpellier (France)
  3. UMR INRA-Univ. de Lorraine “Interaction Arbres/Microorganismes,” Champenoux (France)
  4. Univ. Estadual de Maringá, Maringá (Brazil)
  5. USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States)
  6. USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Utrecht Univ., Utrecht (Netherlands)
  7. Oregon State Univ., Corvallis, OR (United States)
  8. USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Univ. of California, Berkeley, CA (United States)
  9. Université de Lorraine, Champenoux (France)
Publication Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC); Univ. of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1544038
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
Frontiers in Microbiology
Additional Journal Information:
Journal Volume: 9; Journal ID: ISSN 1664-302X
Publisher:
Frontiers Research Foundation
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Microbiology; Corynespora cassiicola; Hevea brasiliensis; plant-pathogens interaction; effectors; cassiicolin; genomics; gene expression

Citation Formats

Lopez, David, Ribeiro, Sébastien, Label, Philippe, Fumanal, Boris, Venisse, Jean -Stéphane, Kohler, Annegret, de Oliveira, Ricardo R., Labutti, Kurt, Lipzen, Anna, Lail, Kathleen, Bauer, Diane, Ohm, Robin A., Barry, Kerrie W., Spatafora, Joseph, Grigoriev, Igor V., Martin, Francis M., and Pujade-Renaud, Valérie. Genome-Wide Analysis of Corynespora cassiicola Leaf Fall Disease Putative Effectors. United States: N. p., 2018. Web. doi:10.3389/fmicb.2018.00276.
Lopez, David, Ribeiro, Sébastien, Label, Philippe, Fumanal, Boris, Venisse, Jean -Stéphane, Kohler, Annegret, de Oliveira, Ricardo R., Labutti, Kurt, Lipzen, Anna, Lail, Kathleen, Bauer, Diane, Ohm, Robin A., Barry, Kerrie W., Spatafora, Joseph, Grigoriev, Igor V., Martin, Francis M., & Pujade-Renaud, Valérie. Genome-Wide Analysis of Corynespora cassiicola Leaf Fall Disease Putative Effectors. United States. doi:10.3389/fmicb.2018.00276.
Lopez, David, Ribeiro, Sébastien, Label, Philippe, Fumanal, Boris, Venisse, Jean -Stéphane, Kohler, Annegret, de Oliveira, Ricardo R., Labutti, Kurt, Lipzen, Anna, Lail, Kathleen, Bauer, Diane, Ohm, Robin A., Barry, Kerrie W., Spatafora, Joseph, Grigoriev, Igor V., Martin, Francis M., and Pujade-Renaud, Valérie. Fri . "Genome-Wide Analysis of Corynespora cassiicola Leaf Fall Disease Putative Effectors". United States. doi:10.3389/fmicb.2018.00276. https://www.osti.gov/servlets/purl/1544038.
@article{osti_1544038,
title = {Genome-Wide Analysis of Corynespora cassiicola Leaf Fall Disease Putative Effectors},
author = {Lopez, David and Ribeiro, Sébastien and Label, Philippe and Fumanal, Boris and Venisse, Jean -Stéphane and Kohler, Annegret and de Oliveira, Ricardo R. and Labutti, Kurt and Lipzen, Anna and Lail, Kathleen and Bauer, Diane and Ohm, Robin A. and Barry, Kerrie W. and Spatafora, Joseph and Grigoriev, Igor V. and Martin, Francis M. and Pujade-Renaud, Valérie},
abstractNote = {Corynespora cassiicola is an Ascomycetes fungus with a broad host range and diverse life styles. Mostly known as a necrotrophic plant pathogen, it has also been associated with rare cases of human infection. In the rubber tree, this fungus causes the Corynespora leaf fall (CLF) disease, which increasingly affects natural rubber production in Asia and Africa. It has also been found as an endophyte in South American rubber plantations where no CLF outbreak has yet occurred. The C. cassiicola species is genetically highly diverse, but no clear relationship has been evidenced between phylogenetic lineage and pathogenicity. Cassiicolin, a small glycosylated secreted protein effector, is thought to be involved in the necrotrophic interaction with the rubber tree but some virulent C. cassiicola isolates do not have a cassiicolin gene. This study set out to identify other putative effectors involved in CLF. The genome of a highly virulent C. cassiicola isolate from the rubber tree (CCP) was sequenced and assembled. In silico prediction revealed 2870 putative effectors, comprising CAZymes, lipases, peptidases, secreted proteins and enzymes associated with secondary metabolism. Comparison with the genomes of 44 other fungal species, focusing on effector content, revealed a striking proximity with phylogenetically unrelated species (Colletotrichum acutatum, Colletotrichum gloesporioides, Fusarium oxysporum, nectria hematococca, and Botrosphaeria dothidea) sharing life style plasticity and broad host range. Candidate effectors involved in the compatible interaction with the rubber tree were identified by transcriptomic analysis. Differentially expressed genes included 92 putative effectors, among which cassiicolin and two other secreted singleton proteins. Finally, the genomes of 35 C. cassiicola isolates representing the genetic diversity of the species were sequenced and assembled, and putative effectors identified. At the intraspecific level, effector-based classification was found to be highly consistent with the phylogenomic trees. Identification of lineage-specific effectors is a key step toward understanding C. cassiicola virulence and host specialization mechanisms.},
doi = {10.3389/fmicb.2018.00276},
journal = {Frontiers in Microbiology},
number = ,
volume = 9,
place = {United States},
year = {2018},
month = {3}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Citation Metrics:
Cited by: 6 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Basic local alignment search tool
journal, October 1990

  • Altschul, Stephen F.; Gish, Warren; Miller, Webb
  • Journal of Molecular Biology, Vol. 215, Issue 3, p. 403-410
  • DOI: 10.1016/S0022-2836(05)80360-2

De novo genome assembly of the soil-borne fungus and tomato pathogen Pyrenochaeta lycopersici
journal, January 2014


Structural Analysis of Cassiicolin, a Host-selective Protein Toxin from Corynespora cassiicola
journal, March 2007

  • Barthe, Philippe; Pujade-Renaud, Valérie; Breton, Frédéric
  • Journal of Molecular Biology, Vol. 367, Issue 1
  • DOI: 10.1016/j.jmb.2006.11.086

under dependency
journal, August 2001


Closely related fungi employ diverse enzymatic strategies to degrade plant biomass
journal, August 2015

  • Benoit, Isabelle; Culleton, Helena; Zhou, Miaomiao
  • Biotechnology for Biofuels, Vol. 8, Issue 1
  • DOI: 10.1186/s13068-015-0285-0

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers
journal, May 2013

  • Blin, Kai; Medema, Marnix H.; Kazempour, Daniyal
  • Nucleic Acids Research, Vol. 41, Issue W1
  • DOI: 10.1093/nar/gkt449

Pathogenicity of Colletotrichum acutatum and C. gloeosporioides on leaves of Hevea spp.
journal, March 1994


Advances in the proteomic investigation of the cell secretome
journal, June 2012

  • Brown, Kristy J.; Formolo, Catherine A.; Seol, Haeri
  • Expert Review of Proteomics, Vol. 9, Issue 3
  • DOI: 10.1586/epr.12.21

Variation between freshwater and terrestrial fungal communities on decaying bamboo culms
journal, April 2006


BLAST+: architecture and applications
journal, January 2009

  • Camacho, Christiam; Coulouris, George; Avagyan, Vahram
  • BMC Bioinformatics, Vol. 10, Issue 1
  • DOI: 10.1186/1471-2105-10-421

Colletotrichum – current status and future directions
journal, September 2012

  • Cannon, P. F.; Damm, U.; Johnston, P. R.
  • Studies in Mycology, Vol. 73
  • DOI: 10.3114/sim0014

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics
journal, January 2009

  • Cantarel, B. L.; Coutinho, P. M.; Rancurel, C.
  • Nucleic Acids Research, Vol. 37, Issue Database
  • DOI: 10.1093/nar/gkn663

Characterization of SNP1, a Cell Wall-Degrading Trypsin, Produced During Infection by Stagonospora nodorum
journal, May 2000

  • Carlile, A. J.; Bindschedler, L. V.; Bailey, A. M.
  • Molecular Plant-Microbe Interactions, Vol. 13, Issue 5
  • DOI: 10.1094/MPMI.2000.13.5.538

Isolation of the Soybean Pathogens Corynespora cassiicola and Phialophora gregata from Cysts of Heterodera glycines in Illinois
journal, May 1986

  • Carris, L. M.; Glawe, D. A.; Gray, L. E.
  • Mycologia, Vol. 78, Issue 3
  • DOI: 10.2307/3793061

Selection of Conserved Blocks from Multiple Alignments for Their Use in Phylogenetic Analysis
journal, April 2000


Cupin: A candidate molecular structure for the Nep1-like protein family
journal, January 2008

  • Cechin, Adelmo L.; Sinigaglia, Marialva; Lemke, Ney
  • BMC Plant Biology, Vol. 8, Issue 1
  • DOI: 10.1186/1471-2229-8-50

Assembling the Fungal Tree of Life: constructing the Structural and Biochemical Database
journal, November 2006


A simple and efficient method for isolating RNA from pine trees
journal, June 1993

  • Chang, Shujun; Puryear, Jeff; Cairney, John
  • Plant Molecular Biology Reporter, Vol. 11, Issue 2
  • DOI: 10.1007/BF02670468

The powdery mildew resistance gene REN1 co-segregates with an NBS-LRR gene cluster in two Central Asian grapevines
journal, January 2009


Geographical and seasonal influences on the distribution of fungal endophytes in Quercus ilex
journal, December 1999


Antilipase antibodies prevent infection of tomato leaves byBotrytis cinerea
journal, January 1998

  • Comménil, P.; Belingheri, L.; Dehorter, B.
  • Physiological and Molecular Plant Pathology, Vol. 52, Issue 1
  • DOI: 10.1006/pmpp.1997.0130

ProtTest 3: fast selection of best-fit models of protein evolution
journal, February 2011


Evidence for a role of cutinase in pathogenicity of Pyrenopeziza brassicae on brassicas
journal, August 2000

  • Davies, K. A.; De Lorono, I.; Foster, S. J.
  • Physiological and Molecular Plant Pathology, Vol. 57, Issue 2
  • DOI: 10.1006/pmpp.2000.0282

Purification and characterization of cassiicolin, the toxin produced by Corynespora cassiicola, causal agent of the leaf fall disease of rubber tree
journal, April 2007

  • de Lamotte, Frédéric; Duviau, Marie-Pierre; Sanier, Christine
  • Journal of Chromatography B, Vol. 849, Issue 1-2
  • DOI: 10.1016/j.jchromb.2006.10.051

Characterization of a cassiicolin-encoding gene from Corynespora cassiicola, pathogen of rubber tree (Hevea brasiliensis)
journal, April 2012


Diversity of the cassiicolin gene in Corynespora cassiicola and relation with the pathogenicity in Hevea brasiliensis
journal, January 2014


First characterization of endophytic Corynespora cassiicola isolates with variant cassiicolin genes recovered from rubber trees in Brazil
journal, April 2012


Host Specialization and Phylogenetic Diversity of Corynespora cassiicola
journal, September 2009


Cupins: A New Superfamily of Functionally Diverse Proteins that Include Germins and Plant Storage Proteins
journal, April 1998


An efficient algorithm for large-scale detection of protein families
journal, April 2002


NPP1, a Phytophthora -associated trigger of plant defense in parsley and Arabidopsis
journal, November 2002


A role for random, humidity-dependent epiphytic growth prior to invasion of wheat by Zymoseptoria tritici
journal, September 2017


Fusarium oxysporum and its biocontrol
journal, March 2003


Diversity of fungal endophytes in leaves and stems of wild rubber trees (Hevea brasiliensis) in Peru
journal, August 2010


High-quality draft assemblies of mammalian genomes from massively parallel sequence data
journal, December 2010

  • Gnerre, S.; MacCallum, I.; Przybylski, D.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 4
  • DOI: 10.1073/pnas.1017351108

Study of endophytic fungal community from different parts of Aegle marmelos Correae (Rutaceae) from Varanasi (India)
journal, March 2007

  • Gond, S. K.; Verma, V. C.; Kumar, A.
  • World Journal of Microbiology and Biotechnology, Vol. 23, Issue 10
  • DOI: 10.1007/s11274-007-9375-x

MycoCosm portal: gearing up for 1000 fungal genomes
journal, December 2013

  • Grigoriev, Igor V.; Nikitin, Roman; Haridas, Sajeet
  • Nucleic Acids Research, Vol. 42, Issue D1
  • DOI: 10.1093/nar/gkt1183

A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood
journal, October 2003


Estimating Gene Gain and Loss Rates in the Presence of Error in Genome Assembly and Annotation Using CAFE 3
journal, May 2013

  • Han, Mira V.; Thomas, Gregg W. C.; Lugo-Martinez, Jose
  • Molecular Biology and Evolution, Vol. 30, Issue 8
  • DOI: 10.1093/molbev/mst100

Root Endophyte Colletotrichum tofieldiae Confers Plant Fitness Benefits that Are Phosphate Status Dependent
journal, April 2016


Subcutaneous infection caused by Corynespora cassiicola, a plant pathogen
journal, February 2010


Tools to kill: Genome of one of the most destructive plant pathogenic fungi Macrophomina phaseolina
journal, January 2012


Secretome analysis of virulent Pyrenophora teres f . teres isolates
journal, September 2016


Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
journal, November 2006

  • Kämper, Jörg; Kahmann, Regine; Bölker, Michael
  • Nature, Vol. 444, Issue 7115
  • DOI: 10.1038/nature05248

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
journal, January 2013

  • Katoh, K.; Standley, D. M.
  • Molecular Biology and Evolution, Vol. 30, Issue 4
  • DOI: 10.1093/molbev/mst010

Dissecting the fungal biology of Bipolaris papendorfii: from phylogenetic to comparative genomic analysis
journal, April 2015


Plant Cell Wall–Degrading Enzymes and Their Secretion in Plant-Pathogenic Fungi
journal, August 2014


FactoMineR : An R Package for Multivariate Analysis
journal, January 2008

  • Lê, Sébastien; Josse, Julie; Husson, François
  • Journal of Statistical Software, Vol. 25, Issue 1
  • DOI: 10.18637/jss.v025.i01

Expansion of the enzymatic repertoire of the CAZy database to integrate auxiliary redox enzymes
journal, January 2013

  • Levasseur, Anthony; Drula, Elodie; Lombard, Vincent
  • Biotechnology for Biofuels, Vol. 6, Issue 1, Article No. 41
  • DOI: 10.1186/1754-6834-6-41

Fast and accurate short read alignment with Burrows-Wheeler transform
journal, May 2009


OrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes
journal, September 2003


The carbohydrate-active enzymes database (CAZy) in 2013
journal, November 2013

  • Lombard, Vincent; Golaconda Ramulu, Hemalatha; Drula, Elodie
  • Nucleic Acids Research, Vol. 42, Issue D1
  • DOI: 10.1093/nar/gkt1178

Genomic insight into pathogenicity of dematiaceous fungus Corynespora cassiicola
journal, January 2017


Insights into Populus XIP aquaporins: evolutionary expansion, protein functionality, and environmental regulation
journal, January 2012

  • Lopez, D.; Bronner, G.; Brunel, N.
  • Journal of Experimental Botany, Vol. 63, Issue 5
  • DOI: 10.1093/jxb/err404

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
journal, December 2014


Extracellular peptidases of the cereal pathogen Fusarium graminearum
journal, November 2015

  • Lowe, Rohan G. T.; McCorkelle, Owen; Bleackley, Mark
  • Frontiers in Plant Science, Vol. 6
  • DOI: 10.3389/fpls.2015.00962

Rnnotator: an automated de novo transcriptome assembly pipeline from stranded RNA-Seq reads
journal, January 2010


The diversity of fungal genome
journal, April 2015


An overview of mannan structure and mannan-degrading enzyme systems
journal, April 2008


Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses
journal, August 2012

  • O'Connell, Richard J.; Thon, Michael R.; Hacquard, Stéphane
  • Nature Genetics, Vol. 44, Issue 9
  • DOI: 10.1038/ng.2372

Diverse Lifestyles and Strategies of Plant Pathogenesis Encoded in the Genomes of Eighteen Dothideomycetes Fungi
journal, December 2012


SNP-sites: rapid efficient extraction of SNPs from multi-FASTA alignments
journal, April 2016

  • Page, Andrew J.; Taylor, Ben; Delaney, Aidan J.
  • Microbial Genomics, Vol. 2, Issue 4
  • DOI: 10.1099/mgen.0.000056

CAZymes Analysis Toolkit (CAT): Web service for searching and analyzing carbohydrate-active enzymes in a newly sequenced organism using CAZy database
journal, August 2010

  • Park, Byung H.; Karpinets, Tatiana V.; Syed, Mustafa H.
  • Glycobiology, Vol. 20, Issue 12
  • DOI: 10.1093/glycob/cwq106

SignalP 4.0: discriminating signal peptides from transmembrane regions
journal, September 2011

  • Petersen, Thomas Nordahl; Brunak, Søren; von Heijne, Gunnar
  • Nature Methods, Vol. 8, Issue 10
  • DOI: 10.1038/nmeth.1701

A Phylogenetic Evaluation of Whether Endophytes Become Saprotrophs at Host Senescence
journal, April 2007

  • Promputtha, Itthayakorn; Lumyong, Saisamorn; Dhanasekaran, Vijaykrishna
  • Microbial Ecology, Vol. 53, Issue 4
  • DOI: 10.1007/s00248-006-9117-x

Molecular and Pathogenic Variation Identified Among Isolates of Corynespora cassiicola
journal, October 2008


Morphological and molecular analysis of genetic variability within isolates of Corynespora cassiicola from different hosts
journal, January 2011

  • Qi, Yan-Xiang; Zhang, Xin; Pu, Jin-Ji
  • European Journal of Plant Pathology, Vol. 130, Issue 1
  • DOI: 10.1007/s10658-010-9734-6

Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components
journal, August 2011

  • Quinlan, R. J.; Sweeney, M. D.; Lo Leggio, L.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 37, p. 15079-15084
  • DOI: 10.1073/pnas.1105776108

MEROPS : the database of proteolytic enzymes, their substrates and inhibitors
journal, October 2013

  • Rawlings, Neil D.; Waller, Matthew; Barrett, Alan J.
  • Nucleic Acids Research, Vol. 42, Issue D1
  • DOI: 10.1093/nar/gkt953

Molecular and functional characterization of a secreted lipase from Botrytis cinerea
journal, May 2005


Softening-up mannan-rich cell walls
journal, May 2012

  • Rodríguez-Gacio, María del Carmen; Iglesias-Fernández, Raquel; Carbonero, Pilar
  • Journal of Experimental Botany, Vol. 63, Issue 11
  • DOI: 10.1093/jxb/ers096

A bacterial cysteine protease effector protein interferes with photosynthesis to suppress plant innate immune responses: P. syringae HopN1 targets photosynthesis
journal, February 2012


A class-wide phylogenetic assessment of Dothideomycetes
journal, January 2009


Genetic variation in Corynespora cassiicola: a possible relationship between host origin and virulence
journal, May 2003

  • Silva, Watudura P. K.; Karunanayake, Eric H.; Wijesundera, Ravi L. C.
  • Mycological Research, Vol. 107, Issue 5
  • DOI: 10.1017/S0953756203007755

Molecular, physiological and pathological characterization of Corynespora leaf spot fungi from rubber plantations in Sri Lanka
journal, June 1998


Against the grain: safeguarding rice from rice blast disease
journal, March 2009


Botryosphaeriaceae as endophytes and latent pathogens of woody plants: diversity, ecology and impact
journal, May 2007


RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies
journal, January 2014


Endophytic fungal communities in woody perennials of three tropical forest types of the Western Ghats, southern India
journal, February 2011

  • Suryanarayanan, T. S.; Murali, T. S.; Thirunavukkarasu, N.
  • Biodiversity and Conservation, Vol. 20, Issue 5
  • DOI: 10.1007/s10531-011-0004-5

A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning
journal, July 2002

  • Takahashi-Ando, Naoko; Kimura, Makoto; Kakeya, Hideaki
  • Biochemical Journal, Vol. 365, Issue 1
  • DOI: 10.1042/bj20020450

Genetic Determinism of Sensitivity to Corynespora cassiicola Exudates in Rubber Tree (Hevea brasiliensis)
journal, October 2016


Purification and Characterization of Chitin Deacetylase from Colletotrichum lindemuthianum
journal, November 1995


Cutinase A of Botrytis cinerea is Expressed, but not Essential, During Penetration of Gerbera and Tomato
journal, January 1997

  • van Kan, J. A. L.; van 't Klooster, J. W.; Wagemakers, C. A. M.
  • Molecular Plant-Microbe Interactions, Vol. 10, Issue 1
  • DOI: 10.1094/MPMI.1997.10.1.30

Dfam: a database of repetitive DNA based on profile hidden Markov models
journal, November 2012

  • Wheeler, Travis J.; Clements, Jody; Eddy, Sean R.
  • Nucleic Acids Research, Vol. 41, Issue D1
  • DOI: 10.1093/nar/gks1265

Rare case of fungal keratitis caused by Corynespora cassiicola
journal, January 2013

  • Yamada, Hiroki; Takahashi, Nobumichi; Hori, Nobuhide
  • Journal of Infection and Chemotherapy, Vol. 19, Issue 6
  • DOI: 10.1007/s10156-013-0579-8

CARD 9 mutation linked to Corynespora cassiicola infection in a Chinese patient
journal, November 2015

  • Yan, X. X.; Yu, C. P.; Fu, X. A.
  • British Journal of Dermatology, Vol. 174, Issue 1
  • DOI: 10.1111/bjd.14082

Velvet: Algorithms for de novo short read assembly using de Bruijn graphs
journal, February 2008


Chromone Derivatives from a Sponge-Derived Strain of the Fungus Corynespora cassiicola
journal, January 2015

  • Zhao, Dong-Lin; Shao, Chang-Lun; Gan, Li-She
  • Journal of Natural Products, Vol. 78, Issue 2
  • DOI: 10.1021/np5009152

Correction: Comparative analysis of fungal genomes reveals different plant cell wall degrading capacity in fungi
journal, January 2014


    Works referencing / citing this record:

    Effects of early‐season insect herbivory on subsequent pathogen infection and ant abundance on wild cotton ( Gossypium hirsutum )
    journal, November 2018

    • Abdala‐Roberts, Luis; Pérez Niño, Biiniza; Moreira, Xoaquín
    • Journal of Ecology, Vol. 107, Issue 3
    • DOI: 10.1111/1365-2745.13131