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Title: The influence of curvature on domain distribution in binary mixture membranes

Abstract

Curvature-induced domain sorting, a strategy exploited by cells to organize membrane components, is a promising mechanism to control self-assembly of materials. To comprehend this phenomenon, we explore the effects of curvature on component rearrangement in thin polymer films and lipid bilayers supported on sinusoidal substrates. Self-consistent field theory (SCFT), specifically, was used to study the spatial distribution of polymers in blends containing conformationally asymmetric chains. In addition, coarse-grained molecular dynamics (MD) simulations were used to probe the arrangement of rigid lipid domains in a relatively soft lipid matrix. Besides the expected preference of rigid species localizing in regions with low mean curvature, both systems exhibit unexpected localization of rigid components in comparatively high curvature regions. The origins of this unexpected sorting are discussed in terms of entropic and enthalpic contributions. In summary, this study demonstrates that domain distribution strongly depends on local topography and further highlights the collective effects that thermodynamic forces have on the morphological behavior of membranes.

Authors:
ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [1]; ORCiD logo [3]; ORCiD logo [1]
+ Show Author Affiliations
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
  3. Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1543203
Alternate Identifier(s):
OSTI ID: 1543356
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Soft Matter
Additional Journal Information:
Journal Volume: 15; Journal Issue: 33; Journal ID: ISSN 1744-683X
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 36 MATERIALS SCIENCE

Citation Formats

Li, Wei, Carrillo, Jan-Michael Y., Katsaras, John, Sumpter, Bobby G., Ashkar, Rana, and Kumar, Rajeev. The influence of curvature on domain distribution in binary mixture membranes. United States: N. p., 2019. Web. doi:10.1039/C9SM01262A.
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Li, Wei, Carrillo, Jan-Michael Y., Katsaras, John, Sumpter, Bobby G., Ashkar, Rana, & Kumar, Rajeev. The influence of curvature on domain distribution in binary mixture membranes. United States. doi:10.1039/C9SM01262A.
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Li, Wei, Carrillo, Jan-Michael Y., Katsaras, John, Sumpter, Bobby G., Ashkar, Rana, and Kumar, Rajeev. Fri . "The influence of curvature on domain distribution in binary mixture membranes". United States. doi:10.1039/C9SM01262A. https://www.osti.gov/servlets/purl/1543203.
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@article{osti_1543203,
title = {The influence of curvature on domain distribution in binary mixture membranes},
author = {Li, Wei and Carrillo, Jan-Michael Y. and Katsaras, John and Sumpter, Bobby G. and Ashkar, Rana and Kumar, Rajeev},
abstractNote = {Curvature-induced domain sorting, a strategy exploited by cells to organize membrane components, is a promising mechanism to control self-assembly of materials. To comprehend this phenomenon, we explore the effects of curvature on component rearrangement in thin polymer films and lipid bilayers supported on sinusoidal substrates. Self-consistent field theory (SCFT), specifically, was used to study the spatial distribution of polymers in blends containing conformationally asymmetric chains. In addition, coarse-grained molecular dynamics (MD) simulations were used to probe the arrangement of rigid lipid domains in a relatively soft lipid matrix. Besides the expected preference of rigid species localizing in regions with low mean curvature, both systems exhibit unexpected localization of rigid components in comparatively high curvature regions. The origins of this unexpected sorting are discussed in terms of entropic and enthalpic contributions. In summary, this study demonstrates that domain distribution strongly depends on local topography and further highlights the collective effects that thermodynamic forces have on the morphological behavior of membranes.},
doi = {10.1039/C9SM01262A},
journal = {Soft Matter},
number = 33,
volume = 15,
place = {United States},
year = {2019},
month = {7}
}
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DOI:  10.1039/C9SM01262A
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