Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes

Sanborn, Jeremy R.; Chen, Xi; Yao, Yun-Chiao; Hammons, Joshua A.; Tunuguntla, Ramya H.; Zhang, Yuliang; Newcomb, Christina C.; Soltis, Jennifer A.; De Yoreo, James J.; Van Buuren, Anthony; Parikh, Atul N.; Noy, Aleksandr

doi:10.1002/adma.201803355

Title: Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes

Journal Article · 16 October 2018 · Advanced Materials

DOI: https://doi.org/10.1002/adma.201803355 · OSTI ID:1542739

Sanborn, Jeremy R. ^[1]; Chen, Xi ^[2]; Yao, Yun-Chiao ^[2]; Hammons, Joshua A. ^[3]; Tunuguntla, Ramya H. ^[3]; Zhang, Yuliang ^[3]; Newcomb, Christina C. ^[4]; Soltis, Jennifer A. ^[4]; De Yoreo, James J. ^[5]; Van Buuren, Anthony ^[3]; Parikh, Atul N. ^[6];

^[2]

Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Univ. of California, Davis, CA (United States)
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Univ. of California Merced, Merced, CA (United States)
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Univ. of Washington, Seattle, WA (United States)
Univ. of California, Davis, CA (United States)

Biological membranes reflect a fascinating example of a separation system that is multifunctional, tunable, precise, and efficient. Biomimetic membranes, which mimic the architecture of cellular membranes, have the potential to deliver significant improvements in specificity and permeability. In this work, a fully synthetic biomimetic membrane is introduced that incorporates ultra-efficient 1.5 nm diameter carbon nanotube porin (CNTPs) channels in a block-copolymer matrix. It is demonstrated that CNTPs maintain high proton and water permeability in these membranes. CNTPs can also mimic the behavior of biological gap junctions by forming bridges between vesicular compartments that allow transport of small molecules.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: National Institute of General Medical Sciences; National Institutes of Health; USDOE; USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC02-05CH11231; AC02-76SF00515; AC05-76RL01830; AC52-07NA27344

OSTI ID:: 1542739

Report Number(s):: LLNL-JRNL--761054; 949988

Journal Information:: Advanced Materials, Journal Name: Advanced Materials Journal Issue: 51 Vol. 30; ISSN 0935-9648

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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