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Title: Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes

Abstract

Biological membranes reflect a fascinating example of a separation system that is multifunctional, tunable, precise, and efficient. Biomimetic membranes, which mimic the architecture of cellular membranes, have the potential to deliver significant improvements in specificity and permeability. In this work, a fully synthetic biomimetic membrane is introduced that incorporates ultra-efficient 1.5 nm diameter carbon nanotube porin (CNTPs) channels in a block-copolymer matrix. It is demonstrated that CNTPs maintain high proton and water permeability in these membranes. CNTPs can also mimic the behavior of biological gap junctions by forming bridges between vesicular compartments that allow transport of small molecules.

Authors:
 [1];  [2];  [2];  [3];  [3];  [3];  [4];  [4];  [5];  [3];  [6]; ORCiD logo [2]
+ Show Author Affiliations
  1. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Univ. of California, Davis, CA (United States)
  2. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Univ. of California Merced, Merced, CA (United States)
  3. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
  4. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  5. Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Univ. of Washington, Seattle, WA (United States)
  6. Univ. of California, Davis, CA (United States)
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA); National Institutes of Health (NIH); National Institute of General Medical Sciences
OSTI Identifier:
1542739
Alternate Identifier(s):
OSTI ID: 1479554
Report Number(s):
LLNL-JRNL-761054
Journal ID: ISSN 0935-9648; 949988
Grant/Contract Number:  
AC52-07NA27344; SCW0972; AC02‐05CH11231; AC02‐76SF00515; AC05–76RL01830; DE‐AC52‐07NA27344; DE‐AC02‐05CH11231; DE‐AC02‐76SF00515
Resource Type:
Accepted Manuscript
Journal Name:
Advanced Materials
Additional Journal Information:
Journal Volume: 30; Journal Issue: 51; Journal ID: ISSN 0935-9648
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; artificial membranes; carbon nanotube porins; carbon nanotubes; fast transport; polymersomes

Citation Formats

Sanborn, Jeremy R., Chen, Xi, Yao, Yun-Chiao, Hammons, Joshua A., Tunuguntla, Ramya H., Zhang, Yuliang, Newcomb, Christina C., Soltis, Jennifer A., De Yoreo, James J., Van Buuren, Anthony, Parikh, Atul N., and Noy, Aleksandr. Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes. United States: N. p., 2018. Web. doi:10.1002/adma.201803355.
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Sanborn, Jeremy R., Chen, Xi, Yao, Yun-Chiao, Hammons, Joshua A., Tunuguntla, Ramya H., Zhang, Yuliang, Newcomb, Christina C., Soltis, Jennifer A., De Yoreo, James J., Van Buuren, Anthony, Parikh, Atul N., & Noy, Aleksandr. Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes. United States. https://doi.org/10.1002/adma.201803355
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Sanborn, Jeremy R., Chen, Xi, Yao, Yun-Chiao, Hammons, Joshua A., Tunuguntla, Ramya H., Zhang, Yuliang, Newcomb, Christina C., Soltis, Jennifer A., De Yoreo, James J., Van Buuren, Anthony, Parikh, Atul N., and Noy, Aleksandr. Wed . "Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes". United States. https://doi.org/10.1002/adma.201803355. https://www.osti.gov/servlets/purl/1542739.
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@article{osti_1542739,
title = {Carbon Nanotube Porins in Amphiphilic Block Copolymers as Fully Synthetic Mimics of Biological Membranes},
author = {Sanborn, Jeremy R. and Chen, Xi and Yao, Yun-Chiao and Hammons, Joshua A. and Tunuguntla, Ramya H. and Zhang, Yuliang and Newcomb, Christina C. and Soltis, Jennifer A. and De Yoreo, James J. and Van Buuren, Anthony and Parikh, Atul N. and Noy, Aleksandr},
abstractNote = {Biological membranes reflect a fascinating example of a separation system that is multifunctional, tunable, precise, and efficient. Biomimetic membranes, which mimic the architecture of cellular membranes, have the potential to deliver significant improvements in specificity and permeability. In this work, a fully synthetic biomimetic membrane is introduced that incorporates ultra-efficient 1.5 nm diameter carbon nanotube porin (CNTPs) channels in a block-copolymer matrix. It is demonstrated that CNTPs maintain high proton and water permeability in these membranes. CNTPs can also mimic the behavior of biological gap junctions by forming bridges between vesicular compartments that allow transport of small molecules.},
doi = {10.1002/adma.201803355},
journal = {Advanced Materials},
number = 51,
volume = 30,
place = {United States},
year = {2018},
month = {10}
}
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Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1002/adma.201803355
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Cited by: 2 works
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Figures / Tables:

Figure 1 Figure 1: CNTPs in polymersome membranes. a. Schematic of the CNTP incorporation into PB-PEO 1800 polymersomes. b. Cryogenic TEM image of a polymersome wall with CNTPs. Inset highlights the location of the CNTPs in the image. c. A frame from a HS-AFM movie of the CNTP/polymersome membrane fused onto amore » mica surface. Image shows several CNTPs protruding above the polymersome membrane plane.« less
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Works referenced in this record:

Rekonstitution von Kanalproteinen in (polymerisierten) ABA-Triblockcopolymer-Membranen
journal, December 2000

Bilayer-Spanning DNA Nanopores with Voltage-Switching between Open and Closed State
journal, December 2014

  • Seifert, Astrid; Göpfrich, Kerstin; Burns, Jonathan R.
  • ACS Nano, Vol. 9, Issue 2
  • DOI: 10.1021/nn5039433

Biomimetic membranes: A review
journal, March 2014

Polymersome Shape Transformation at the Nanoscale
journal, September 2013

  • Salva, Romain; Le Meins, Jean-François; Sandre, Olivier
  • ACS Nano, Vol. 7, Issue 10
  • DOI: 10.1021/nn4039589

Influence of transbilayer area asymmetry on the morphology of large unilamellar vesicles
journal, September 1995

Osmotic shrinkage of giant egg-lecithin vesicles
journal, April 1981

Which Density Functional Should Be Used to Describe Protonated Water Clusters?
journal, April 2017

  • Shi, Ruili; Huang, Xiaoming; Su, Yan
  • The Journal of Physical Chemistry A, Vol. 121, Issue 16
  • DOI: 10.1021/acs.jpca.7b00058

Cytomimetic Organic Chemistry: Early Developments
journal, October 1995

  • Menger, Fredric M.; Gabrielson, Kurt D.
  • Angewandte Chemie International Edition in English, Vol. 34, Issue 19
  • DOI: 10.1002/anie.199520911

Budding transitions of fluid-bilayer vesicles: The effect of area-difference elasticity
journal, June 1994

Polymersomes: Tough Vesicles Made from Diblock Copolymers
journal, May 1999

Real-time dynamics of carbon nanotube porins in supported lipid membranes visualized by high-speed atomic force microscopy
journal, June 2017

  • Zhang, Yuliang; Tunuguntla, Ramya H.; Choi, Pyung-On
  • Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 372, Issue 1726
  • DOI: 10.1098/rstb.2016.0226

Assembly of a photosynthetic reaction center with ABA tri-block polymersomes: highlights on protein localization
journal, January 2015

  • Tangorra, R. R.; Operamolla, A.; Milano, F.
  • Photochemical & Photobiological Sciences, Vol. 14, Issue 10
  • DOI: 10.1039/C5PP00189G

Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding
journal, September 2009

  • Christian, David A.; Tian, Aiwei; Ellenbroek, Wouter G.
  • Nature Materials, Vol. 8, Issue 10
  • DOI: 10.1038/nmat2512

Stochastic transport through carbon nanotubes in lipid bilayers and live cell membranes
journal, October 2014

  • Geng, Jia; Kim, Kyunghoon; Zhang, Jianfei
  • Nature, Vol. 514, Issue 7524
  • DOI: 10.1038/nature13817

Polymer Vesicles
journal, August 2002

Morphology Transformations of DODAB Vesicles Reminiscent of Endocytosis and Vesicular Traffic †
journal, November 2000

  • Hubert, Dominicus H. W.; Jung, Martin; Frederik, Peter M.
  • Langmuir, Vol. 16, Issue 23
  • DOI: 10.1021/la000221i

In Vitro Expressed GPCR Inserted in Polymersome Membranes for Ligand-Binding Studies
journal, November 2012

  • May, Sylvia; Andreasson-Ochsner, Mirjam; Fu, Zhikang
  • Angewandte Chemie International Edition, Vol. 52, Issue 2
  • DOI: 10.1002/anie.201204645

High-Density Reconstitution of Functional Water Channels into Vesicular and Planar Block Copolymer Membranes
journal, November 2012

  • Kumar, Manish; Habel, Joachim E. O.; Shen, Yue-xiao
  • Journal of the American Chemical Society, Vol. 134, Issue 45
  • DOI: 10.1021/ja304721r

The minimum energy of bending as a possible explanation of the biconcave shape of the human red blood cell
journal, January 1970

Membrane bending energy and shape determination of phospholipid vesicles and red blood cells
journal, June 1989

  • Svetina, S.; Žekš, B.
  • European Biophysics Journal, Vol. 17, Issue 2
  • DOI: 10.1007/BF00257107

Synthesis, lipid membrane incorporation, and ion permeability testing of carbon nanotube porins
journal, September 2016

  • Tunuguntla, Ramya H.; Escalada, Artur; A. Frolov, Vadim
  • Nature Protocols, Vol. 11, Issue 10
  • DOI: 10.1038/nprot.2016.119

Carbon Nanotubes Mediate Fusion of Lipid Vesicles
journal, January 2017

  • Bhaskara, Ramachandra M.; Linker, Stephanie M.; Vögele, Martin
  • ACS Nano, Vol. 11, Issue 2
  • DOI: 10.1021/acsnano.6b05434

From Natural to Bioassisted and Biomimetic Artificial Water Channel Systems
journal, January 2013

  • Barboiu, Mihail; Gilles, Arnaud
  • Accounts of Chemical Research, Vol. 46, Issue 12
  • DOI: 10.1021/ar400025e

Self-assembly of amphiphilic dendritic dipeptides into helical pores
journal, August 2004

  • Percec, Virgil; Dulcey, Andrés E.; Balagurusamy, Venkatachalapathy S. K.
  • Nature, Vol. 430, Issue 7001
  • DOI: 10.1038/nature02770

Artificial Organelle:  ATP Synthesis from Cellular Mimetic Polymersomes
journal, December 2005

  • Choi, Hyo-Jick; Montemagno, Carlo D.
  • Nano Letters, Vol. 5, Issue 12
  • DOI: 10.1021/nl051896e

Free-floating ultrathin two-dimensional crystals from sequence-specific peptoid polymers
journal, April 2010

  • Nam, Ki Tae; Shelby, Sarah A.; Choi, Philip H.
  • Nature Materials, Vol. 9, Issue 5
  • DOI: 10.1038/nmat2742

Colorimetric determination of phospholipids with ammonium ferrothiocyanate
journal, May 1980

Block Copolymer Vesicle Permeability Measured by Osmotic Swelling and Shrinking
journal, April 2011

  • Carlsen, Autumn; Glaser, Nicolas; Le Meins, Jean-François
  • Langmuir, Vol. 27, Issue 8
  • DOI: 10.1021/la105045m

Antimicrobial and cell-penetrating peptides induce lipid vesicle fusion by folding and aggregation
journal, November 2011

  • Wadhwani, Parvesh; Reichert, Johannes; Bürck, Jochen
  • European Biophysics Journal, Vol. 41, Issue 2
  • DOI: 10.1007/s00249-011-0771-7

Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures
journal, November 2012

Shape Deformation of Ternary Vesicles Coupled with Phase Separation
journal, April 2008

Osmotically-Driven Transport in Carbon Nanotube Porins
journal, November 2014

  • Kim, Kyunghoon; Geng, Jia; Tunuguntla, Ramya
  • Nano Letters, Vol. 14, Issue 12
  • DOI: 10.1021/nl5034446

Enhanced water permeability and tunable ion selectivity in subnanometer carbon nanotube porins
journal, August 2017

  • Tunuguntla, Ramya H.; Henley, Robert Y.; Yao, Yun-Chiao
  • Science, Vol. 357, Issue 6353
  • DOI: 10.1126/science.aan2438

Budding and fission of vesicles
journal, October 1993

Sorting Single-Walled Carbon Nanotubes by Electronic Type Using Nonionic, Biocompatible Block Copolymers
journal, July 2010

  • Antaris, Alexander L.; Seo, Jung-Woo T.; Green, Alexander A.
  • ACS Nano, Vol. 4, Issue 8
  • DOI: 10.1021/nn101363m

Mixing, Diffusion, and Percolation in Binary Supported Membranes Containing Mixtures of Lipids and Amphiphilic Block Copolymers
journal, July 2014

  • Gettel, Douglas L.; Sanborn, Jeremy; Patel, Mira A.
  • Journal of the American Chemical Society, Vol. 136, Issue 29
  • DOI: 10.1021/ja5037308

Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages
journal, May 2017

  • Benke, Bahiru Punja; Aich, Pulakesh; Kim, Younghoon
  • Journal of the American Chemical Society, Vol. 139, Issue 22
  • DOI: 10.1021/jacs.7b02708

Building membrane nanopores
journal, July 2017

Ultrafast proton transport in sub-1-nm diameter carbon nanotube porins
journal, April 2016

  • Tunuguntla, Ramya H.; Allen, Frances I.; Kim, Kyunghoon
  • Nature Nanotechnology, Vol. 11, Issue 7
  • DOI: 10.1038/nnano.2016.43

Polymersomes
journal, August 2006

Biological small-angle X-ray scattering facility at the Stanford Synchrotron Radiation Laboratory
journal, April 2007

  • Smolsky, Igor L.; Liu, Ping; Niebuhr, Marc
  • Journal of Applied Crystallography, Vol. 40, Issue s1
  • DOI: 10.1107/S0021889807009624

Reversibly Triggered Protein-Ligand Assemblies in Giant Vesicles
journal, June 2015

  • Peters, Ruud J. R. W.; Nijemeisland, Marlies; van Hest, Jan C. M.
  • Angewandte Chemie International Edition, Vol. 54, Issue 33
  • DOI: 10.1002/anie.201502920

Highly permeable artificial water channels that can self-assemble into two-dimensional arrays
journal, July 2015

  • Shen, Yue-xiao; Si, Wen; Erbakan, Mustafa
  • Proceedings of the National Academy of Sciences, Vol. 112, Issue 32
  • DOI: 10.1073/pnas.1508575112

Nanostructured Lipid-Based Films for Substrate-Mediated Applications in Biotechnology
journal, January 2018

  • Kang, Minjee; Tuteja, Mohit; Centrone, Andrea
  • Advanced Functional Materials, Vol. 28, Issue 9
  • DOI: 10.1002/adfm.201704356

Science and technology for water purification in the coming decades
journal, March 2008

  • Shannon, Mark A.; Bohn, Paul W.; Elimelech, Menachem
  • Nature, Vol. 452, Issue 7185, p. 301-310
  • DOI: 10.1038/nature06599

Materials for next-generation desalination and water purification membranes
journal, April 2016

  • Werber, Jay R.; Osuji, Chinedum O.; Elimelech, Menachem
  • Nature Reviews Materials, Vol. 1, Issue 5
  • DOI: 10.1038/natrevmats.2016.18

Supramolecular Materials: Self-Organized Nanostructures
journal, April 1997

Reversibly Triggered Protein-Ligand Assemblies in Giant Vesicles
journal, June 2015

  • Peters, Ruud J. R. W.; Nijemeisland, Marlies; van Hest, Jan C. M.
  • Angewandte Chemie, Vol. 127, Issue 33
  • DOI: 10.1002/ange.201502920

Synthetic Lipid Membrane Channels formed by Designed DNA Nanostructures
journal, January 2013

Molecular Biology of the Cell
journal, January 1973

Molecular biology of the cell
journal, October 1983

Basic principles of membrane technology
journal, February 1993

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