Optimization of Cation Exchange for the Separation of Actinium-225 from Radioactive Thorium, Radium-223 and Other Metals
Abstract
Actinium-225 (225Ac) can be produced with a linear accelerator by proton irradiation of a thorium (Th) target, but the Th also underdoes fission and produces 400 other radioisotopes. No research exists on optimization of the cation step for the purification. The research herein examines the optimization of the cation exchange step for the purification of 225Ac. The following variables were tested: pH of load solution (1.5–4.6); rinse steps with various concentrations of HCl, HNO3, H2SO4, and combinations of HCl and HNO3; various thorium chelators to block retention; MP50 and AG50 resins; and retention of 20–45 elements with different rinse sequences. The research indicated that HCl removes more isotopes earlier than HNO3, but that some elements, such as barium and radium, could be eluted with ≥2.5 M HNO3. The optimal pH of the load solution was 1.5–2.0, and the optimized rinse sequence was five bed volumes (BV) of 1 M citric acid pH 2.0, 3 BV of water, 3 BV of 2 M HNO3, 6 BV of 2.5 M HNO3 and 20 BV of 6 M HNO3. The sequence recovered >90% of 225Ac with minimal 223Ra and thorium present.
- Authors:
- Publication Date:
- Research Org.:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Nuclear Physics (NP)
- OSTI Identifier:
- 1529689
- Alternate Identifier(s):
- OSTI ID: 1542283
- Report Number(s):
- BNL-211829-2019-JAAM
Journal ID: ISSN 1420-3049; MOLEFW; PII: molecules24101921
- Grant/Contract Number:
- Core funding; Workforce development; SC0012704
- Resource Type:
- Published Article
- Journal Name:
- Molecules
- Additional Journal Information:
- Journal Name: Molecules Journal Volume: 24 Journal Issue: 10; Journal ID: ISSN 1420-3049
- Publisher:
- MDPI AG
- Country of Publication:
- Switzerland
- Language:
- English
- Subject:
- 43 PARTICLE ACCELERATORS; Lanthanum; Rhodium; AG50; MP50; fission products; Actinium-225; 225Ac; 223Ra; 227Th; thorium
Citation Formats
Fitzsimmons, Jonathan, Foley, Bryan, Torre, Bryna, Wilken, Megan, Cutler, Cathy S., Mausner, Leonard, and Medvedev, Dmitri. Optimization of Cation Exchange for the Separation of Actinium-225 from Radioactive Thorium, Radium-223 and Other Metals. Switzerland: N. p., 2019.
Web. doi:10.3390/molecules24101921.
Fitzsimmons, Jonathan, Foley, Bryan, Torre, Bryna, Wilken, Megan, Cutler, Cathy S., Mausner, Leonard, & Medvedev, Dmitri. Optimization of Cation Exchange for the Separation of Actinium-225 from Radioactive Thorium, Radium-223 and Other Metals. Switzerland. https://doi.org/10.3390/molecules24101921
Fitzsimmons, Jonathan, Foley, Bryan, Torre, Bryna, Wilken, Megan, Cutler, Cathy S., Mausner, Leonard, and Medvedev, Dmitri. Sat .
"Optimization of Cation Exchange for the Separation of Actinium-225 from Radioactive Thorium, Radium-223 and Other Metals". Switzerland. https://doi.org/10.3390/molecules24101921.
@article{osti_1529689,
title = {Optimization of Cation Exchange for the Separation of Actinium-225 from Radioactive Thorium, Radium-223 and Other Metals},
author = {Fitzsimmons, Jonathan and Foley, Bryan and Torre, Bryna and Wilken, Megan and Cutler, Cathy S. and Mausner, Leonard and Medvedev, Dmitri},
abstractNote = {Actinium-225 (225Ac) can be produced with a linear accelerator by proton irradiation of a thorium (Th) target, but the Th also underdoes fission and produces 400 other radioisotopes. No research exists on optimization of the cation step for the purification. The research herein examines the optimization of the cation exchange step for the purification of 225Ac. The following variables were tested: pH of load solution (1.5–4.6); rinse steps with various concentrations of HCl, HNO3, H2SO4, and combinations of HCl and HNO3; various thorium chelators to block retention; MP50 and AG50 resins; and retention of 20–45 elements with different rinse sequences. The research indicated that HCl removes more isotopes earlier than HNO3, but that some elements, such as barium and radium, could be eluted with ≥2.5 M HNO3. The optimal pH of the load solution was 1.5–2.0, and the optimized rinse sequence was five bed volumes (BV) of 1 M citric acid pH 2.0, 3 BV of water, 3 BV of 2 M HNO3, 6 BV of 2.5 M HNO3 and 20 BV of 6 M HNO3. The sequence recovered >90% of 225Ac with minimal 223Ra and thorium present.},
doi = {10.3390/molecules24101921},
journal = {Molecules},
number = 10,
volume = 24,
place = {Switzerland},
year = {Sat May 18 00:00:00 EDT 2019},
month = {Sat May 18 00:00:00 EDT 2019}
}
https://doi.org/10.3390/molecules24101921
Web of Science
Figures / Tables:
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