Cytokinin Transporters: Multisite Players in Cytokinin Homeostasis and Signal Distribution

Liu, Chang -Jun; Zhao, Yunjun; Zhang, Kewei

doi:10.3389/fpls.2019.00693

Title: Cytokinin Transporters: Multisite Players in Cytokinin Homeostasis and Signal Distribution

Journal Article · 31 May 2019 · Frontiers in Plant Science

DOI: https://doi.org/10.3389/fpls.2019.00693 · OSTI ID:1542279

Liu, Chang -Jun ^[1]; Zhao, Yunjun ^[1]; Zhang, Kewei ^[2]

Brookhaven National Lab. (BNL), Upton, NY (United States)
Zhejiang Normal Univ., Jinhua (China)

Here, cytokinins are a group of mobile adenine derivatives that act as chemical signals regulating a variety of biological processes implicated in plant development and stress responses. Their synthesis, homeostasis, and signaling perception evoke complicated intracellular traffic, intercellular movement, and in short- and long-distance translocation. Over nearly two decades, subsets of membrane transporters have been recognized and implicated in the transport of cytokinins as well as the related adenylates. In this review, we aim to recapitulate the key progresses in the exploration of the transporter proteins involved in cytokinin traffic and translocation, discuss their functional implications in the cytokinin-mediated paracrine and long-distance communication, and highlight some knowledge gaps and open issues toward comprehensively understanding the molecular mechanism of membrane transporters in controlling spatiotemporal distribution of cytokinin species.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0012704

OSTI ID:: 1542279

Report Number(s):: BNL-211842-2019-JAAM

Journal Information:: Frontiers in Plant Science, Vol. 10; ISSN 1664-462X

Publisher:: Frontiers Research FoundationCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 25 works

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Shoot-derived cytokinins systemically regulate root nodulation Sasaki, Takema; Suzaki, Takuya; Soyano, Takashi Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms5983	journal	September 2014
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AtIPT3 is a Key Determinant of Nitrate-Dependent Cytokinin Biosynthesis in Arabidopsis Takei, Kentaro; Ueda, Nanae; Aoki, Koh Plant and Cell Physiology, Vol. 45, Issue 8 https://doi.org/10.1093/pcp/pch119	journal	August 2004
ARAMEMNON, a Novel Database for Arabidopsis Integral Membrane Proteins Schwacke, Rainer; Schneider, Anja; van der Graaff, Eric Plant Physiology, Vol. 131, Issue 1 https://doi.org/10.1104/pp.011577	journal	January 2003
Functional Characterization and Expression Analysis of a Gene, OsENT2 , Encoding an Equilibrative Nucleoside Transporter in Rice Suggest a Function in Cytokinin Transport Hirose, Naoya; Makita, Nobue; Yamaya, Tomoyuki Plant Physiology, Vol. 138, Issue 1 https://doi.org/10.1104/pp.105.060137	journal	April 2005
Farnesylation Directs AtIPT3 Subcellular Localization and Modulates Cytokinin Biosynthesis in Arabidopsis Galichet, Arnaud; Hoyerová, Klára; Kamínek, Miroslav Plant Physiology, Vol. 146, Issue 3 https://doi.org/10.1104/pp.107.107425	journal	January 2008
Characterization of Cytokinin and Adenine Transport in Arabidopsis Cell Cultures Cedzich, Anna; Stransky, Harald; Schulz, Burkhard Plant Physiology, Vol. 148, Issue 4 https://doi.org/10.1104/pp.108.128454	journal	October 2008
Proteome Analysis in Arabidopsis Reveals Shoot- and Root-Specific Targets of Cytokinin Action and Differential Regulation of Hormonal Homeostasis Žd'árská, Markéta; Zatloukalová, Pavlína; Benítez, Mariana Plant Physiology, Vol. 161, Issue 2 https://doi.org/10.1104/pp.112.202853	journal	December 2012
A Robust and Sensitive Synthetic Sensor to Monitor the Transcriptional Output of the Cytokinin Signaling Network in Planta Zürcher, Evelyne; Tavor-Deslex, Deborah; Lituiev, Dmytro Plant Physiology, Vol. 161, Issue 3 https://doi.org/10.1104/pp.112.211763	journal	January 2013
Structure and Function of Nucleoside Hydrolases from Physcomitrella patens and Maize Catalyzing the Hydrolysis of Purine, Pyrimidine, and Cytokinin Ribosides Kopecna, M.; Blaschke, H.; Kopecny, D. PLANT PHYSIOLOGY, Vol. 163, Issue 4 https://doi.org/10.1104/pp.113.228775	journal	October 2013
Metabolism of Benzyladenine is Impaired in a Mutant of Arabidopsis thaliana Lacking Adenine Phosphoribosyltransferase Activity Moffatt, Barbara; Pethe, Claude; Laloue, Michel Plant Physiology, Vol. 95, Issue 3 https://doi.org/10.1104/pp.95.3.900	journal	March 1991
A New Family of High-Affinity Transporters for Adenine, Cytosine, and Purine Derivatives in Arabidopsis Gillissen, Bernd; Bürkle, Lukas; André, Bruno The Plant Cell, Vol. 12, Issue 2 https://doi.org/10.1105/tpc.12.2.291	journal	February 2000
Responses to Systemic Nitrogen Signaling in Arabidopsis Roots Involve trans -Zeatin in Shoots Poitout, Arthur; Crabos, Amandine; Petřík, Ivan The Plant Cell, Vol. 30, Issue 6 https://doi.org/10.1105/tpc.18.00011	journal	May 2018
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Arabidopsis SOI33/AtENT8 Gene Encodes a Putative Equilibrative Nucleoside Transporter That Is Involved in Cytokinin Transport In Planta Sun, Jiaqiang; Hirose, Naoya; Wang, Xingchun Journal of Integrative Plant Biology, Vol. 47, Issue 5 https://doi.org/10.1111/j.1744-7909.2005.00104.x	journal	May 2005
Big Grain3, encoding a purine permease, regulates grain size via modulating cytokinin transport in rice Xiao, Yunhua; Liu, Dapu; Zhang, Guoxia Journal of Integrative Plant Biology, Vol. 61, Issue 5 https://doi.org/10.1111/jipb.12727	journal	December 2018
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Cytokinins, the Cinderella of plant growth regulators Márquez-López, Ruth E.; Quintana-Escobar, Ana O.; Loyola-Vargas, Víctor M. Phytochemistry Reviews, Vol. 18, Issue 6 https://doi.org/10.1007/s11101-019-09656-6	journal	November 2019
ABC transporter OsABCG18 controls the shootward transport of cytokinins and grain yield in rice Zhao, Jiangzhe; Yu, Ningning; Ju, Min Journal of Experimental Botany, Vol. 70, Issue 21 https://doi.org/10.1093/jxb/erz382	journal	August 2019
ABC transporter OsABCG18 controls the shootward transport of cytokinins and grain yield in rice Zhao, Jiangzhe; Yu, Ningning; Ju, Min Journal of Experimental Botany, Vol. 70, Issue 21 https://doi.org/10.1093/jxb/erz382	journal	August 2019

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