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Title: Methanobactins: Maintaining copper homeostasis in methanotrophs and beyond

Abstract

Methanobactins (Mbns) are ribosomally produced, post-translationally modified natural products that bind copper with high affinity and specificity. Originally identified in methanotrophic bacteria, which have a high need for copper, operons encoding these compounds have also been found in many non-methanotrophic bacteria. The proteins responsible for Mbn biosynthesis include several novel enzymes. Mbn transport involves export through a multidrug efflux pump and re-internalization via a TonB-dependent transporter. Release of copper from Mbn and the molecular basis for copper regulation of Mbn production remain to be elucidated. Future work is likely to result in the identification of new enzymatic chemistry, opportunities for bioengineering and drug targeting of copper metabolism, and an expanded understanding of microbial metal homeostasis.

Authors:
;
Publication Date:
Research Org.:
Northwestern Univ., Evanston, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1540313
Grant/Contract Number:  
SC0016284
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Biological Chemistry
Additional Journal Information:
Journal Volume: 293; Journal Issue: 13; Journal ID: ISSN 0021-9258
Publisher:
American Society for Biochemistry and Molecular Biology
Country of Publication:
United States
Language:
English
Subject:
Biochemistry & Molecular Biology

Citation Formats

Kenney, Grace E., and Rosenzweig, Amy C. Methanobactins: Maintaining copper homeostasis in methanotrophs and beyond. United States: N. p., 2018. Web. doi:10.1074/jbc.tm117.000185.
Kenney, Grace E., & Rosenzweig, Amy C. Methanobactins: Maintaining copper homeostasis in methanotrophs and beyond. United States. doi:10.1074/jbc.tm117.000185.
Kenney, Grace E., and Rosenzweig, Amy C. Thu . "Methanobactins: Maintaining copper homeostasis in methanotrophs and beyond". United States. doi:10.1074/jbc.tm117.000185. https://www.osti.gov/servlets/purl/1540313.
@article{osti_1540313,
title = {Methanobactins: Maintaining copper homeostasis in methanotrophs and beyond},
author = {Kenney, Grace E. and Rosenzweig, Amy C.},
abstractNote = {Methanobactins (Mbns) are ribosomally produced, post-translationally modified natural products that bind copper with high affinity and specificity. Originally identified in methanotrophic bacteria, which have a high need for copper, operons encoding these compounds have also been found in many non-methanotrophic bacteria. The proteins responsible for Mbn biosynthesis include several novel enzymes. Mbn transport involves export through a multidrug efflux pump and re-internalization via a TonB-dependent transporter. Release of copper from Mbn and the molecular basis for copper regulation of Mbn production remain to be elucidated. Future work is likely to result in the identification of new enzymatic chemistry, opportunities for bioengineering and drug targeting of copper metabolism, and an expanded understanding of microbial metal homeostasis.},
doi = {10.1074/jbc.tm117.000185},
journal = {Journal of Biological Chemistry},
number = 13,
volume = 293,
place = {United States},
year = {2018},
month = {1}
}

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