Single-Molecule Chemistry with Surface- and Tip-Enhanced Raman Spectroscopy

Zrimsek, Alyssa B.; Chiang, Naihao; Mattei, Michael; Zaleski, Stephanie; McAnally, Michael O.; Chapman, Craig T.; Henry, Anne-Isabelle; Schatz, George C.; Van Duyne, Richard P.

doi:10.1021/acs.chemrev.6b00552

Title: Single-Molecule Chemistry with Surface- and Tip-Enhanced Raman Spectroscopy

Journal Article · 08 December 2016 · Chemical Reviews

DOI: https://doi.org/10.1021/acs.chemrev.6b00552 · OSTI ID:1534472

Zrimsek, Alyssa B. ^[1]; Chiang, Naihao ^[1]; Mattei, Michael ^[1]; Zaleski, Stephanie ^[1];

^[1];

^[1]; Henry, Anne-Isabelle ^[1]; Schatz, George C. ^[1];

^[1]

Northwestern Univ., Evanston, IL (United States)

Single-molecule (SM) surface-enhanced Raman spectroscopy (SERS) and tip-enhanced Raman spectroscopy (TERS) have emerged as analytical techniques for characterizing molecular systems in nanoscale environments. SERS and TERS use plasmonically enhanced Raman scattering to characterize the chemical information on single molecules. Additionally, TERS can image single molecules with subnanometer spatial resolution. Here, we cover the development and history of SERS and TERS, including the concept of SERS hot spots and the plasmonic nanostructures necessary for SM detection, the past and current methodologies for verifying SMSERS, and investigations into understanding the signal heterogeneities observed with SMSERS. Moving on to TERS, we cover tip fabrication and the physical origins of the subnanometer spatial resolution. Then, we highlight recent advances of SMSERS and TERS in fields such as electrochemistry, catalysis, and SM electronics, which all benefit from the vibrational characterization of single molecules. SMSERS and TERS provide new insights on molecular behavior that would otherwise be obscured in an ensemble-averaged measurement.

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Research Organization:: Northwestern Univ., Evanston, IL (United States)

Sponsoring Organization:: National Science Foundation (NSF); US Air Force Office of Scientific Research (AFOSR); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0001785; CHE-1414466; FG02-09ER16109; DGE-0824162

OSTI ID:: 1534472

Journal Information:: Chemical Reviews, Vol. 117, Issue 11; ISSN 0009-2665

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 468 works

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Studying the local character of Raman features of single-walled carbon nanotubes along a bundle using TERS Peica, Niculina; Thomsen, Christian; Maultzsch, Janina Nanoscale Research Letters, Vol. 6, Issue 1 https://doi.org/10.1186/1556-276X-6-174	journal	February 2011
Plasmonic Materials for Surface-Enhanced Sensing and Spectroscopy Haes, Amanda J.; Haynes, Christy L.; McFarland, Adam D. MRS Bulletin, Vol. 30, Issue 5 https://doi.org/10.1557/mrs2005.100	journal	May 2005
Fabrication of silver tips for scanning tunneling microscope induced luminescence Zhang, C.; Gao, B.; Chen, L. G. Review of Scientific Instruments, Vol. 82, Issue 8 https://doi.org/10.1063/1.3617456	journal	August 2011
Structure and Composition of Insulin Fibril Surfaces Probed by TERS Kurouski, Dmitry; Deckert-Gaudig, Tanja; Deckert, Volker Journal of the American Chemical Society, Vol. 134, Issue 32 https://doi.org/10.1021/ja303263y	journal	August 2012
Chemical mapping of a single molecule by plasmon-enhanced Raman scattering Zhang, R.; Zhang, Y.; Dong, Z. C. Nature, Vol. 498, Issue 7452 https://doi.org/10.1038/nature12151	journal	June 2013
Localized enhancement of electric field in tip-enhanced Raman spectroscopy using radially and linearly polarized light Kazemi-Zanjani, Nastaran; Vedraine, Sylvain; Lagugné-Labarthet, François Optics Express, Vol. 21, Issue 21 https://doi.org/10.1364/OE.21.025271	journal	January 2013
Evidence of Natural Isotopic Distribution from Single-Molecule SERS Etchegoin, Pablo G.; Le Ru, Eric C.; Meyer, Matthias Journal of the American Chemical Society, Vol. 131, Issue 7 https://doi.org/10.1021/ja808934d	journal	February 2009
Ultrafast Nonradiative Decay Rates on Metallic Surfaces by Comparing Surface-Enhanced Raman and Fluorescence Signals of Single Molecules Galloway, C. M.; Etchegoin, P. G.; Le Ru, E. C. Physical Review Letters, Vol. 103, Issue 6 https://doi.org/10.1103/PhysRevLett.103.063003	journal	August 2009
Surface Enhanced Raman Spectroscopy: Towards Single Molecule Spectroscopy Pettinger, Bruno; Picardi, Gennaro; Schuster, Rolf Electrochemistry, Vol. 68, Issue 12 https://doi.org/10.5796/electrochemistry.68.942	journal	January 2000

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