skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Achieving Health Security and Threat Reduction through Sharing Sequence Data

Abstract

With the rapid development and broad applications of next-generation sequencing platforms and bioinformatic analytical tools, genomics has become a popular area for biosurveillance and international scientific collaboration. Governments from countries including the United States (US), Canada, Germany, and the United Kingdom have leveraged these advancements to support international cooperative programs that aim to reduce biological threats and build scientific capacity worldwide. A recent conference panel addressed the impacts of the enhancement of genomic sequencing capabilities through three major US bioengagement programs on international scientific engagement and biosecurity risk reduction. Here, the panel contrasted the risks and benefits of supporting the enhancement of genomic sequencing capabilities through international scientific engagement to achieve biological threat reduction and global health security. The lower costs and new bioinformatic tools available have led to the greater application of sequencing to biosurveillance. Strengthening sequencing capabilities globally for the diagnosis and detection of infectious diseases through mutual collaborations has a high return on investment for increasing global health security. International collaborations based on genomics and shared sequence data can build and leverage scientific networks and improve the timeliness and accuracy of disease surveillance reporting needed to identify and mitigate infectious disease outbreaks and comply with international norms.more » Further efforts to promote scientific transparency within international collaboration will improve trust, reduce threats, and promote global health security.« less

Authors:
ORCiD logo [1]; ORCiD logo [2];  [2];  [3];  [3];  [4];  [5];  [6];  [7];  [8];  [9]
  1. MRIGlobal, Gaithersburg, MD (United States)
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  3. Defense Threat Reduction Agency, Fort Belvoir, VA (United States)
  4. National Center for Disease Control and Public Health, Tbilisi (Georgia)
  5. Dept. of State, Washington, D.C. (United States)
  6. USAID, Arlington, VA (United States)
  7. Columbia Univ., New York, NY (United States)
  8. Univ. of California, Davis, CA (United States)
  9. Oklahoma State Univ., Stillwater, OK (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
Defense Threat Reduction Agency (DTRA); USDOE
OSTI Identifier:
1532731
Report Number(s):
LA-UR-19-24621
Journal ID: ISSN 2414-6366
Grant/Contract Number:  
89233218CNA000001
Resource Type:
Accepted Manuscript
Journal Name:
Tropical Medicine and Infectious Disease
Additional Journal Information:
Journal Volume: 4; Journal Issue: 2; Journal ID: ISSN 2414-6366
Publisher:
MDPIAG
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Biological Science; surveillance; biosecurity; global health security; sequencing; scientific engagement; threat reduction

Citation Formats

Yeh, Kenneth, Fair, Jeanne Marie, Cui, Helen Hong, Newman, Carl, Braunstein, Gavin, Chanturia, Gvantsa, Vora, Sapana, Chittenden, Kendra, Tseng, Ashley, Monagin, Corina, and Fletcher, Jacqueline. Achieving Health Security and Threat Reduction through Sharing Sequence Data. United States: N. p., 2019. Web. doi:10.3390/tropicalmed4020078.
Yeh, Kenneth, Fair, Jeanne Marie, Cui, Helen Hong, Newman, Carl, Braunstein, Gavin, Chanturia, Gvantsa, Vora, Sapana, Chittenden, Kendra, Tseng, Ashley, Monagin, Corina, & Fletcher, Jacqueline. Achieving Health Security and Threat Reduction through Sharing Sequence Data. United States. doi:10.3390/tropicalmed4020078.
Yeh, Kenneth, Fair, Jeanne Marie, Cui, Helen Hong, Newman, Carl, Braunstein, Gavin, Chanturia, Gvantsa, Vora, Sapana, Chittenden, Kendra, Tseng, Ashley, Monagin, Corina, and Fletcher, Jacqueline. Tue . "Achieving Health Security and Threat Reduction through Sharing Sequence Data". United States. doi:10.3390/tropicalmed4020078. https://www.osti.gov/servlets/purl/1532731.
@article{osti_1532731,
title = {Achieving Health Security and Threat Reduction through Sharing Sequence Data},
author = {Yeh, Kenneth and Fair, Jeanne Marie and Cui, Helen Hong and Newman, Carl and Braunstein, Gavin and Chanturia, Gvantsa and Vora, Sapana and Chittenden, Kendra and Tseng, Ashley and Monagin, Corina and Fletcher, Jacqueline},
abstractNote = {With the rapid development and broad applications of next-generation sequencing platforms and bioinformatic analytical tools, genomics has become a popular area for biosurveillance and international scientific collaboration. Governments from countries including the United States (US), Canada, Germany, and the United Kingdom have leveraged these advancements to support international cooperative programs that aim to reduce biological threats and build scientific capacity worldwide. A recent conference panel addressed the impacts of the enhancement of genomic sequencing capabilities through three major US bioengagement programs on international scientific engagement and biosecurity risk reduction. Here, the panel contrasted the risks and benefits of supporting the enhancement of genomic sequencing capabilities through international scientific engagement to achieve biological threat reduction and global health security. The lower costs and new bioinformatic tools available have led to the greater application of sequencing to biosurveillance. Strengthening sequencing capabilities globally for the diagnosis and detection of infectious diseases through mutual collaborations has a high return on investment for increasing global health security. International collaborations based on genomics and shared sequence data can build and leverage scientific networks and improve the timeliness and accuracy of disease surveillance reporting needed to identify and mitigate infectious disease outbreaks and comply with international norms. Further efforts to promote scientific transparency within international collaboration will improve trust, reduce threats, and promote global health security.},
doi = {10.3390/tropicalmed4020078},
journal = {Tropical Medicine and Infectious Disease},
number = 2,
volume = 4,
place = {United States},
year = {2019},
month = {5}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Figures / Tables:

Figure 1 Figure 1: The governments of the US, Canada, Germany, and the United Kingdom fund programs that engage with over 40 countries worldwide to reduce biological threats. The countries represented are not necessarily engaged in current program activities.

Save / Share:

Works referenced in this record:

Vital Signs : Trends in Reported Vectorborne Disease Cases — United States and Territories, 2004–2016
journal, May 2018

  • Rosenberg, Ronald; Lindsey, Nicole P.; Fischer, Marc
  • MMWR. Morbidity and Mortality Weekly Report, Vol. 67, Issue 17
  • DOI: 10.15585/mmwr.mm6717e1

Scientific Collaborations: How Do We Measure the Return on Relationships?
journal, February 2016

  • Fair, Jeanne M.; Stokes, Martha Mangum; Pennington, Deana
  • Frontiers in Public Health, Vol. 4
  • DOI: 10.3389/fpubh.2016.00009

Metagenomics: The Next Culture-Independent Game Changer
journal, July 2017

  • Forbes, Jessica D.; Knox, Natalie C.; Ronholm, Jennifer
  • Frontiers in Microbiology, Vol. 8
  • DOI: 10.3389/fmicb.2017.01069

Culture-Independent Diagnostics for Health Security
journal, June 2016

  • Doggett, Norman A.; Mukundan, Harshini; Lefkowitz, Elliot J.
  • Health Security, Vol. 14, Issue 3
  • DOI: 10.1089/hs.2015.0074

Biosurveillance in Central Asia: Successes and Challenges of Tick-Borne Disease Research in Kazakhstan and Kyrgyzstan
journal, February 2016


Implementation of the International Health Regulations (2005) Through Cooperative Bioengagement
journal, October 2015

  • Standley, Claire J.; Sorrell, Erin M.; Kornblet, Sarah
  • Frontiers in Public Health, Vol. 3
  • DOI: 10.3389/fpubh.2015.00231

Promoting Scientific Transparency to Facilitate the Safe and Open International Exchange of Biological Materials and Electronic Data
journal, October 2017

  • Yeh, Kenneth; Monagin, Corina; Fletcher, Jacqueline
  • Tropical Medicine and Infectious Disease, Vol. 2, Issue 4
  • DOI: 10.3390/tropicalmed2040057

Building International Genomics Collaboration for Global Health Security
journal, December 2015


Managing dangerous pathogens: challenges in the wake of the recent West African Ebola outbreak
journal, January 2016


The Convergence of High-Consequence Livestock and Human Pathogen Research and Development: A Paradox of Zoonotic Disease
journal, May 2018

  • Michelotti, Julia; Yeh, Kenneth; Beckham, Tammy
  • Tropical Medicine and Infectious Disease, Vol. 3, Issue 2
  • DOI: 10.3390/tropicalmed3020055

The challenge of diagnostic metagenomics
journal, June 2018


    Figures / Tables found in this record:

      Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.