Edit at will: Genotype independent plant transformation in the era of advanced genomics and genome editing

Kausch, Albert P.; Nelson-Vasilchik, Kimberly; Hague, Joel; Mookkan, Muruganantham; Quemada, Hector; Dellaporta, Stephen; Fragoso, Christopher; Zhang, Zhanyuan J.

doi:10.1016/j.plantsci.2019.01.006

Title: Edit at will: Genotype independent plant transformation in the era of advanced genomics and genome editing

Journal Article · 13 January 2019 · Plant Science

DOI: https://doi.org/10.1016/j.plantsci.2019.01.006 · OSTI ID:1532520

Kausch, Albert P. ^[1]; Nelson-Vasilchik, Kimberly ^[2]; Hague, Joel ^[2]; Mookkan, Muruganantham ^[3];

^[4]; Dellaporta, Stephen ^[5]; Fragoso, Christopher ^[6];

^[3]

University of Rhode Island, Kingston, RI (United States); University of Rhode Island
University of Rhode Island, Kingston, RI (United States)
University of Missouri, Columbia, MO (United States)
Western Michigan University, Kalamazoo MI (United States)
Yale University, New Haven, CT (United States); Veroniomics Inc., New Haven, CT (United States)
Veroniomics Inc., New Haven, CT (United States)

The combination of advanced genomics, genome editing and plant transformation biology presents a powerful platform for basic plant research and crop improvement. Together these advances provide the tools to identify genes as targets for direct editing as single base pair changes, deletions, insertions and site specific homologous recombination. Recent breakthrough technologies using morphogenic regulators in plant transformation creates the ability to introduce reagents specific toward their identified targets and recover stably transformed and/or edited plants which are genotype independent. These technologies enable the possibility to alter a trait in any variety, without genetic disruption which would require subsequent extensive breeding, but rather to deliver the same variety with one trait changed. Regulatory issues regarding this technology will predicate how broadly these technologies will be implemented. In addition, education will play a crucial role for positive public acceptance. Taken together these technologies comprise a platform for advanced breeding which is an imperative for future world food security.

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Research Organization:: University of Rhode Island, Kingston, RI (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); National Science Foundation (NSF)

Grant/Contract Number:: SC0018277

OSTI ID:: 1532520

Journal Information:: Plant Science, Journal Name: Plant Science Journal Issue: C Vol. 281; ISSN 0168-9452

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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