Dynamic and programmable morphology and size evolution via a living hierarchical self-assembly strategy

Wang, Xing; Gao, Peiyuan; Yang, Yanyu; Guo, Hongxia; Wu, Decheng

doi:10.1038/s41467-018-05142-3

Title: Dynamic and programmable morphology and size evolution via a living hierarchical self-assembly strategy

Journal Article · 17 July 2018 · Nature Communications

DOI: https://doi.org/10.1038/s41467-018-05142-3 · OSTI ID:1531348

Wang, Xing ^[1]; Gao, Peiyuan ^[2]; Yang, Yanyu ^[3]; Guo, Hongxia ^[4]; Wu, Decheng ^[4]

Chinese Academy of Sciences (CAS), Beijing (China)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Chinese Academy of Sciences (CAS), Beijing (China); Zhengzhou Univ., Henan (China)
Chinese Academy of Sciences (CAS), Beijing (China); Univ. of Chinese Academy of Sciences, Beijing (China)

Recent advances in the preparation of shape-shifting and size-growing nanostructures are hot topics in development of nanoscience, because many intelligent functions are always relied on their shape and dimension. Here we report a tunable manipulation of sequential self-assembled transformation in situ via a hierarchical assembly strategy based on a living thiol–disulfide exchange reaction. By tailoring the external stimuli, the reactive points can be generated at the ends of initially unimolecular micelles, which subsequently drive the pre-assemblies to periodically proceed into the hierarchically micellar connection, axial growth, bending, and cyclization processes from nanoscopic assemblies to macroscopic particles. Of particular interest would be systems that acquired the shape control and size adjustment of self-assemblies after termination or reactivation of disulfide reshuffling reaction by regulating external stimuli whenever needed. Such a hierarchical strategy for self-assembled evolution is universally applicable not only for other disulfide-linked dendritic polymers but also for exploitation of biological applications.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1531348

Report Number(s):: PNNL-SA--136487

Journal Information:: Nature Communications, Journal Name: Nature Communications Journal Issue: 1 Vol. 9; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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POSS-based supramolecular amphiphilic zwitterionic complexes for drug delivery Fan, Linfeng; Wang, Xing; Cao, Qingchen Biomaterials Science, Vol. 7, Issue 5 https://doi.org/10.1039/c9bm00125e	journal	January 2019
In situ bone regeneration enabled by a biodegradable hybrid double-network hydrogel Zhang, Yuanhao; Chen, Mingjiao; Tian, Jia Biomaterials Science, Vol. 7, Issue 8 https://doi.org/10.1039/c9bm00561g	journal	January 2019
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