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Title: Effects of carotenoids on lipid bilayers

Abstract

Carotenoids have been found to be important in improving the integrity of biomembranes in eukaryotes. However, the molecular details of how carotenoids modulate the physical properties of biomembranes are unknown. To this end, we have conducted a series of molecular dynamics simulations of different biologically-relevant membranes in the presence of carotenoids. The carotenoid effect on the membrane was found to be specific to the identity of the carotenoid and the composition of the membrane itself. Therefore, different classes of carotenoids produce a different effect on the membrane, and different membrane phases are affected differently by carotenoids. It is apparent from our data that carotenoids do trigger the bilayer to become thinner. The mechanism by which this occurs depends on two competing factors, the ability of the lipid tails of opposing monolayers to either (1) compress or (2) interdigitate as the bilayer condenses. Indeed, carotenoids directly influence the physical properties via these two mechanisms, thus compacting the bilayer. Furthermore, the degree to which these competing mechanisms are utilized depends on the bilayer phase and the carotenoid identity.

Authors:
ORCiD logo [1];  [2];  [3]; ORCiD logo [4]; ORCiD logo [2]
  1. Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  3. Univ. of Tennessee, Knoxville, TN (United States)
  4. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
OSTI Identifier:
1531265
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Physical Chemistry Chemical Physics. PCCP
Additional Journal Information:
Journal Volume: 20; Journal Issue: 5; Journal ID: ISSN 1463-9076
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Johnson, Quentin R., Mostofian, Barmak, Gomez, Gabriel Fuente, Smith, Jeremy C., and Cheng, Xiaolin. Effects of carotenoids on lipid bilayers. United States: N. p., 2018. Web. doi:10.1039/C7CP07126D.
Johnson, Quentin R., Mostofian, Barmak, Gomez, Gabriel Fuente, Smith, Jeremy C., & Cheng, Xiaolin. Effects of carotenoids on lipid bilayers. United States. https://doi.org/10.1039/C7CP07126D
Johnson, Quentin R., Mostofian, Barmak, Gomez, Gabriel Fuente, Smith, Jeremy C., and Cheng, Xiaolin. Tue . "Effects of carotenoids on lipid bilayers". United States. https://doi.org/10.1039/C7CP07126D. https://www.osti.gov/servlets/purl/1531265.
@article{osti_1531265,
title = {Effects of carotenoids on lipid bilayers},
author = {Johnson, Quentin R. and Mostofian, Barmak and Gomez, Gabriel Fuente and Smith, Jeremy C. and Cheng, Xiaolin},
abstractNote = {Carotenoids have been found to be important in improving the integrity of biomembranes in eukaryotes. However, the molecular details of how carotenoids modulate the physical properties of biomembranes are unknown. To this end, we have conducted a series of molecular dynamics simulations of different biologically-relevant membranes in the presence of carotenoids. The carotenoid effect on the membrane was found to be specific to the identity of the carotenoid and the composition of the membrane itself. Therefore, different classes of carotenoids produce a different effect on the membrane, and different membrane phases are affected differently by carotenoids. It is apparent from our data that carotenoids do trigger the bilayer to become thinner. The mechanism by which this occurs depends on two competing factors, the ability of the lipid tails of opposing monolayers to either (1) compress or (2) interdigitate as the bilayer condenses. Indeed, carotenoids directly influence the physical properties via these two mechanisms, thus compacting the bilayer. Furthermore, the degree to which these competing mechanisms are utilized depends on the bilayer phase and the carotenoid identity.},
doi = {10.1039/C7CP07126D},
journal = {Physical Chemistry Chemical Physics. PCCP},
number = 5,
volume = 20,
place = {United States},
year = {Tue Jan 09 00:00:00 EST 2018},
month = {Tue Jan 09 00:00:00 EST 2018}
}

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