Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science

Malfatti, Michael A.; Buchholz, Bruce A.; Enright, Heather A.; Stewart, Benjamin J.; Ognibene, Ted J.; McCartt, A. Daniel; Loots, Gabriela G.; Zimmermann, Maike; Scharadin, Tiffany M.; Cimino, George D.; Jonas, Brian A.; Pan, Chong-Xian; Bench, Graham; Henderson, Paul T.; Turteltaub, Kenneth W.

doi:10.3390/toxics7020027

Title: Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science

Journal Article · 08 May 2019 · Toxics

DOI: https://doi.org/10.3390/toxics7020027 · OSTI ID:1529655

Malfatti, Michael A.;

; Enright, Heather A.; Stewart, Benjamin J.; Ognibene, Ted J.; McCartt, A. Daniel; Loots, Gabriela G.; Zimmermann, Maike; Scharadin, Tiffany M.; Cimino, George D.; Jonas, Brian A.; Pan, Chong-Xian; Bench, Graham; Henderson, Paul T.; Turteltaub, Kenneth W.

This review summarizes recent developments in radiocarbon tracer technology and applications. Technologies covered include accelerator mass spectrometry (AMS), including conversion of samples to graphite, and rapid combustion to carbon dioxide to enable direct liquid sample analysis, coupling to HPLC for real-time AMS analysis, and combined molecular mass spectrometry and AMS for analyte identification and quantitation. Laser-based alternatives, such as cavity ring down spectrometry, are emerging to enable lower cost, higher throughput measurements of biological samples. Applications covered include radiocarbon dating, use of environmental atomic bomb pulse radiocarbon content for cell and protein age determination and turnover studies, and carbon source identification. Low dose toxicology applications reviewed include studies of naphthalene-DNA adduct formation, benzo[a]pyrene pharmacokinetics in humans, and triclocarban exposure and risk assessment. Cancer-related studies covered include the use of radiocarbon-labeled cells for better defining mechanisms of metastasis and the use of drug-DNA adducts as predictive biomarkers of response to chemotherapy.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE; USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 1529655

Report Number(s):: LLNL--JRNL-768802; PII: toxics7020027

Journal Information:: Toxics, Journal Name: Toxics Journal Issue: 2 Vol. 7; ISSN TOXIC8; ISSN 2305-6304

Publisher:: MDPI AGCopyright Statement

Country of Publication:: Switzerland

Language:: English

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Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies Kratochwil, Nicole A.; Dueker, Stephen R.; Muri, Dieter PLOS ONE, Vol. 13, Issue 10 https://doi.org/10.1371/journal.pone.0205435	journal	October 2018
Snail Bioaccumulation of Triclocarban, Triclosan, and Methyltriclosan in a North Texas, usa, Stream Affected by Wastewater Treatment Plant Runoff Coogan, Melinda A.; La Point, Thomas W. Environmental Toxicology and Chemistry, Vol. 27, Issue 8 https://doi.org/10.1897/07-374.1	journal	January 2008
Bioanalytical Applications of Accelerator Mass Spectrometry for Pharmaceutical Research Turteltaub, Kenneth; Vogel, John Current Pharmaceutical Design, Vol. 6, Issue 10 https://doi.org/10.2174/1381612003400047	journal	July 2000
Naphthalene: A Respiratory Tract Toxicant and Carcinogen for Mice Abdo, K. M.; Eustis, S. L.; McDonald, M. Inhalation Toxicology, Vol. 4, Issue 4 https://doi.org/10.3109/08958379209145317	journal	January 1992
Compiled records of carbon isotopes in atmospheric CO ₂ for historical simulations in CMIP6 Graven, Heather; Allison, Colin E.; Etheridge, David M. Geoscientific Model Development, Vol. 10, Issue 12 https://doi.org/10.5194/gmd-10-4405-2017	journal	January 2017

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