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Title: Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science

Abstract

This review summarizes recent developments in radiocarbon tracer technology and applications. Technologies covered include accelerator mass spectrometry (AMS), including conversion of samples to graphite, and rapid combustion to carbon dioxide to enable direct liquid sample analysis, coupling to HPLC for real-time AMS analysis, and combined molecular mass spectrometry and AMS for analyte identification and quantitation. Laser-based alternatives, such as cavity ring down spectrometry, are emerging to enable lower cost, higher throughput measurements of biological samples. Applications covered include radiocarbon dating, use of environmental atomic bomb pulse radiocarbon content for cell and protein age determination and turnover studies, and carbon source identification. Low dose toxicology applications reviewed include studies of naphthalene-DNA adduct formation, benzo[a]pyrene pharmacokinetics in humans, and triclocarban exposure and risk assessment. Cancer-related studies covered include the use of radiocarbon-labeled cells for better defining mechanisms of metastasis and the use of drug-DNA adducts as predictive biomarkers of response to chemotherapy.

Authors:
; ORCiD logo; ; ; ; ; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1529655
Alternate Identifier(s):
OSTI ID: 1559419
Report Number(s):
LLNL-JRNL-768802
Journal ID: ISSN 2305-6304; TOXIC8; PII: toxics7020027
Grant/Contract Number:  
LDRD 08-LW-100; AC52-07NA27344
Resource Type:
Published Article
Journal Name:
Toxics
Additional Journal Information:
Journal Name: Toxics Journal Volume: 7 Journal Issue: 2; Journal ID: ISSN 2305-6304
Publisher:
MDPI AG
Country of Publication:
Country unknown/Code not available
Language:
English
Subject:
70 PLASMA PHYSICS AND FUSION TECHNOLOGY

Citation Formats

Malfatti, Michael A., Buchholz, Bruce A., Enright, Heather A., Stewart, Benjamin J., Ognibene, Ted J., McCartt, A. Daniel, Loots, Gabriela G., Zimmermann, Maike, Scharadin, Tiffany M., Cimino, George D., Jonas, Brian A., Pan, Chong-Xian, Bench, Graham, Henderson, Paul T., and Turteltaub, Kenneth W. Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science. Country unknown/Code not available: N. p., 2019. Web. doi:10.3390/toxics7020027.
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Malfatti, Michael A., Buchholz, Bruce A., Enright, Heather A., Stewart, Benjamin J., Ognibene, Ted J., McCartt, A. Daniel, Loots, Gabriela G., Zimmermann, Maike, Scharadin, Tiffany M., Cimino, George D., Jonas, Brian A., Pan, Chong-Xian, Bench, Graham, Henderson, Paul T., & Turteltaub, Kenneth W. Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science. Country unknown/Code not available. https://doi.org/10.3390/toxics7020027
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Malfatti, Michael A., Buchholz, Bruce A., Enright, Heather A., Stewart, Benjamin J., Ognibene, Ted J., McCartt, A. Daniel, Loots, Gabriela G., Zimmermann, Maike, Scharadin, Tiffany M., Cimino, George D., Jonas, Brian A., Pan, Chong-Xian, Bench, Graham, Henderson, Paul T., and Turteltaub, Kenneth W. Thu . "Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science". Country unknown/Code not available. https://doi.org/10.3390/toxics7020027.
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@article{osti_1529655,
title = {Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science},
author = {Malfatti, Michael A. and Buchholz, Bruce A. and Enright, Heather A. and Stewart, Benjamin J. and Ognibene, Ted J. and McCartt, A. Daniel and Loots, Gabriela G. and Zimmermann, Maike and Scharadin, Tiffany M. and Cimino, George D. and Jonas, Brian A. and Pan, Chong-Xian and Bench, Graham and Henderson, Paul T. and Turteltaub, Kenneth W.},
abstractNote = {This review summarizes recent developments in radiocarbon tracer technology and applications. Technologies covered include accelerator mass spectrometry (AMS), including conversion of samples to graphite, and rapid combustion to carbon dioxide to enable direct liquid sample analysis, coupling to HPLC for real-time AMS analysis, and combined molecular mass spectrometry and AMS for analyte identification and quantitation. Laser-based alternatives, such as cavity ring down spectrometry, are emerging to enable lower cost, higher throughput measurements of biological samples. Applications covered include radiocarbon dating, use of environmental atomic bomb pulse radiocarbon content for cell and protein age determination and turnover studies, and carbon source identification. Low dose toxicology applications reviewed include studies of naphthalene-DNA adduct formation, benzo[a]pyrene pharmacokinetics in humans, and triclocarban exposure and risk assessment. Cancer-related studies covered include the use of radiocarbon-labeled cells for better defining mechanisms of metastasis and the use of drug-DNA adducts as predictive biomarkers of response to chemotherapy.},
doi = {10.3390/toxics7020027},
journal = {Toxics},
number = 2,
volume = 7,
place = {Country unknown/Code not available},
year = {2019},
month = {5}
}
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https://doi.org/10.3390/toxics7020027
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    Works referencing / citing this record:

    Retrospective Birth Dating of Cells in Humans
    journal, July 2005

    Ultrahigh Efficiency Moving Wire Combustion Interface for Online Coupling of High-Performance Liquid Chromatography (HPLC)
    journal, December 2011

    • Thomas, Avi T.; Ognibene, Ted; Daley, Paul
    • Analytical Chemistry, Vol. 83, Issue 24
    • DOI: 10.1021/ac202013s

    The antimicrobial agents triclocarban and triclosan as potent modulators of reproduction in Potamopyrgus antipodarum (Mollusca: Hydrobiidae)
    journal, July 2016

    • Geiß, Cornelia; Ruppert, Katharina; Heidelbach, Tanja
    • Journal of Environmental Science and Health, Part A, Vol. 51, Issue 13
    • DOI: 10.1080/10934529.2016.1206388

    Free flow electrophoresis separation and AMS quantitation of 14C–naphthalene–protein adducts
    journal, April 2010

    • Buchholz, Bruce A.; Haack, Kurt W.; Sporty, Jennifer L.
    • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 268, Issue 7-8
    • DOI: 10.1016/j.nimb.2009.10.164

    Dynamics of Hippocampal Neurogenesis in Adult Humans
    journal, June 2013

    Dynamics of human adipose lipid turnover in health and metabolic disease
    journal, September 2011

    • Arner, Peter; Bernard, Samuel; Salehpour, Mehran
    • Nature, Vol. 478, Issue 7367
    • DOI: 10.1038/nature10426

    Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity
    journal, November 2015

    Optical Measurement of Radiocarbon below Unity Fraction Modern by Linear Absorption Spectroscopy
    journal, September 2017

    • Fleisher, Adam J.; Long, David A.; Liu, Qingnan
    • The Journal of Physical Chemistry Letters, Vol. 8, Issue 18
    • DOI: 10.1021/acs.jpclett.7b02105

    Biochemical paths in humans and cells: Frontiers of AMS bioanalysis
    journal, June 2007

    • Vogel, J. S.; Palmblad, N. M.; Ognibene, T.
    • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 259, Issue 1
    • DOI: 10.1016/j.nimb.2007.01.215

    Lethality of human myeloblasts correlates with the incorporation of arabinofuranosylcytosine into DNA.
    journal, May 1981

    • Major, P. P.; Egan, E. M.; Beardsley, G. P.
    • Proceedings of the National Academy of Sciences, Vol. 78, Issue 5
    • DOI: 10.1073/pnas.78.5.3235

    Snail Bioaccumulation of Triclocarban, Triclosan, and Methyltriclosan in a North Texas, usa, Stream Affected by Wastewater Treatment Plant Runoff
    journal, January 2008

    • Coogan, Melinda A.; La Point, Thomas W.
    • Environmental Toxicology and Chemistry, Vol. 27, Issue 8
    • DOI: 10.1897/07-374.1

    Elemental Speciation by Parallel Elemental and Molecular Mass Spectrometry and Peak Profile Matching
    journal, December 2006

    • Sacks, Gavin L.; Derry, Louis A.; Brenna, J. Thomas
    • Analytical Chemistry, Vol. 78, Issue 24
    • DOI: 10.1021/ac0612170

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