skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science

Abstract

This review summarizes recent developments in radiocarbon tracer technology and applications. Technologies covered include accelerator mass spectrometry (AMS), including conversion of samples to graphite, and rapid combustion to carbon dioxide to enable direct liquid sample analysis, coupling to HPLC for real-time AMS analysis, and combined molecular mass spectrometry and AMS for analyte identification and quantitation. Laser-based alternatives, such as cavity ring down spectrometry, are emerging to enable lower cost, higher throughput measurements of biological samples. Applications covered include radiocarbon dating, use of environmental atomic bomb pulse radiocarbon content for cell and protein age determination and turnover studies, and carbon source identification. Low dose toxicology applications reviewed include studies of naphthalene-DNA adduct formation, benzo[a]pyrene pharmacokinetics in humans, and triclocarban exposure and risk assessment. Cancer-related studies covered include the use of radiocarbon-labeled cells for better defining mechanisms of metastasis and the use of drug-DNA adducts as predictive biomarkers of response to chemotherapy.

Authors:
; ORCiD logo; ; ; ; ; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1529655
Alternate Identifier(s):
OSTI ID: 1559419
Report Number(s):
LLNL-JRNL-768802
Journal ID: ISSN 2305-6304; TOXIC8; PII: toxics7020027
Grant/Contract Number:  
LDRD 08-LW-100; AC52-07NA27344
Resource Type:
Published Article
Journal Name:
Toxics
Additional Journal Information:
Journal Name: Toxics Journal Volume: 7 Journal Issue: 2; Journal ID: ISSN 2305-6304
Publisher:
MDPI AG
Country of Publication:
Country unknown/Code not available
Language:
English
Subject:
70 PLASMA PHYSICS AND FUSION TECHNOLOGY

Citation Formats

Malfatti, Michael A., Buchholz, Bruce A., Enright, Heather A., Stewart, Benjamin J., Ognibene, Ted J., McCartt, A. Daniel, Loots, Gabriela G., Zimmermann, Maike, Scharadin, Tiffany M., Cimino, George D., Jonas, Brian A., Pan, Chong-Xian, Bench, Graham, Henderson, Paul T., and Turteltaub, Kenneth W. Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science. Country unknown/Code not available: N. p., 2019. Web. doi:10.3390/toxics7020027.
Malfatti, Michael A., Buchholz, Bruce A., Enright, Heather A., Stewart, Benjamin J., Ognibene, Ted J., McCartt, A. Daniel, Loots, Gabriela G., Zimmermann, Maike, Scharadin, Tiffany M., Cimino, George D., Jonas, Brian A., Pan, Chong-Xian, Bench, Graham, Henderson, Paul T., & Turteltaub, Kenneth W. Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science. Country unknown/Code not available. doi:10.3390/toxics7020027.
Malfatti, Michael A., Buchholz, Bruce A., Enright, Heather A., Stewart, Benjamin J., Ognibene, Ted J., McCartt, A. Daniel, Loots, Gabriela G., Zimmermann, Maike, Scharadin, Tiffany M., Cimino, George D., Jonas, Brian A., Pan, Chong-Xian, Bench, Graham, Henderson, Paul T., and Turteltaub, Kenneth W. Thu . "Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science". Country unknown/Code not available. doi:10.3390/toxics7020027.
@article{osti_1529655,
title = {Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science},
author = {Malfatti, Michael A. and Buchholz, Bruce A. and Enright, Heather A. and Stewart, Benjamin J. and Ognibene, Ted J. and McCartt, A. Daniel and Loots, Gabriela G. and Zimmermann, Maike and Scharadin, Tiffany M. and Cimino, George D. and Jonas, Brian A. and Pan, Chong-Xian and Bench, Graham and Henderson, Paul T. and Turteltaub, Kenneth W.},
abstractNote = {This review summarizes recent developments in radiocarbon tracer technology and applications. Technologies covered include accelerator mass spectrometry (AMS), including conversion of samples to graphite, and rapid combustion to carbon dioxide to enable direct liquid sample analysis, coupling to HPLC for real-time AMS analysis, and combined molecular mass spectrometry and AMS for analyte identification and quantitation. Laser-based alternatives, such as cavity ring down spectrometry, are emerging to enable lower cost, higher throughput measurements of biological samples. Applications covered include radiocarbon dating, use of environmental atomic bomb pulse radiocarbon content for cell and protein age determination and turnover studies, and carbon source identification. Low dose toxicology applications reviewed include studies of naphthalene-DNA adduct formation, benzo[a]pyrene pharmacokinetics in humans, and triclocarban exposure and risk assessment. Cancer-related studies covered include the use of radiocarbon-labeled cells for better defining mechanisms of metastasis and the use of drug-DNA adducts as predictive biomarkers of response to chemotherapy.},
doi = {10.3390/toxics7020027},
journal = {Toxics},
number = 2,
volume = 7,
place = {Country unknown/Code not available},
year = {2019},
month = {5}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.3390/toxics7020027

Save / Share:

Works referenced in this record:

The v 3 band of 14 C 16 O 2 molecule measured by optical-frequency-comb-assisted cavity ring-down spectroscopy
journal, September 2011


Towards biomarker-dependent individualized chemotherapy: Exploring cell-specific differences in oxaliplatin–DNA adduct distribution using accelerator mass spectrometry
journal, April 2010

  • Hah, Sang Soo; Henderson, Paul T.; Turteltaub, Kenneth W.
  • Bioorganic & Medicinal Chemistry Letters, Vol. 20, Issue 8
  • DOI: 10.1016/j.bmcl.2010.03.020

DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine
journal, December 2016


Spectroscopic detection of radiocarbon dioxide at parts-per-quadrillion sensitivity
journal, January 2016


Collagen turnover in the adult femoral mid-shaft: Modeled from anthropogenic radiocarbon tracer measurements
journal, January 2007

  • Hedges, Robert E. M.; Clement, John G.; Thomas, C. David L.
  • American Journal of Physical Anthropology, Vol. 133, Issue 2
  • DOI: 10.1002/ajpa.20598

Automated Combustion Accelerator Mass Spectrometry for the Analysis of Biomedical Samples in the Low Attomole Range
journal, July 2014

  • van Duijn, Esther; Sandman, Hugo; Grossouw, Dimitri
  • Analytical Chemistry, Vol. 86, Issue 15
  • DOI: 10.1021/ac5015035

Age of Collagen in Intracranial Saccular Aneurysms
journal, June 2014


Radioisotopic labels for blood cell survival studies: a review
journal, October 1993


Radiocarbon Dating of the Human Eye Lens Crystallines Reveal Proteins without Carbon Turnover throughout Life
journal, January 2008


Evidence for Cardiomyocyte Renewal in Humans
journal, April 2009


Gemcitabine Causes Minimal Modulation of Carboplatin-DNA Monoadduct Formation and Repair in Bladder Cancer Cells
journal, November 2010

  • Wang, Sisi; Zhang, Hongyong; Malfatti, Michael
  • Chemical Research in Toxicology, Vol. 23, Issue 11
  • DOI: 10.1021/tx1003547

Human Microdosing with Carcinogenic Polycyclic Aromatic Hydrocarbons: In Vivo Pharmacokinetics of Dibenzo[ def,p ]chrysene and Metabolites by UPLC Accelerator Mass Spectrometry
journal, September 2016


Measurements of carbon-14 with cavity ring-down spectroscopy
journal, October 2015

  • McCartt, A. D.; Ognibene, T.; Bench, G.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 361
  • DOI: 10.1016/j.nimb.2015.05.036

Antibody-secreting plasma cells persist for decades in human intestine
journal, January 2017

  • Landsverk, Ole J. B.; Snir, Omri; Casado, Raquel Bartolomé
  • The Journal of Experimental Medicine, Vol. 214, Issue 2
  • DOI: 10.1084/jem.20161590

Characterization of Oxaliplatin−DNA Adduct Formation in DNA and Differentiation of Cancer Cell Drug Sensitivity at Microdose Concentrations
journal, December 2007

  • Hah, Sang Soo; Sumbad, Rhoda A.; de Vere White, Ralph W.
  • Chemical Research in Toxicology, Vol. 20, Issue 12
  • DOI: 10.1021/tx700376a

A Simple Technique for Converting CO 2 to AMS Target Graphite
journal, January 1992


Microdose-Induced Drug–DNA Adducts as Biomarkers of Chemotherapy Resistance in Humans and Mice
journal, November 2016


Dynamics of fat cell turnover in humans
journal, May 2008

  • Spalding, Kirsty L.; Arner, Erik; Westermark, Pål O.
  • Nature, Vol. 453, Issue 7196
  • DOI: 10.1038/nature06902

Activation of clinically used anthracyclines by the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate
journal, April 2007


Critical Role of Histone Turnover in Neuronal Transcription and Plasticity
journal, July 2015


Luminescent Labels?More than Just an Alternative to Radioisotopes?
journal, June 1994

  • Mayer, Andreas; Neuenhofer, Stephan
  • Angewandte Chemie International Edition in English, Vol. 33, Issue 10
  • DOI: 10.1002/anie.199410441

COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin
journal, December 2017


A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the “Metabolites in Safety Testing” Regulatory Guidance
journal, February 2018

  • Schadt, Simone; Bister, Bojan; Chowdhury, Swapan K.
  • Drug Metabolism and Disposition, Vol. 46, Issue 6
  • DOI: 10.1124/dmd.117.079848

Time from diagnosis to treatment initiation predicts survival in younger, but not older, acute myeloid leukemia patients
journal, January 2009


The status of platinum anticancer drugs in the clinic and in clinical trials
journal, January 2010

  • Wheate, Nial J.; Walker, Shonagh; Craig, Gemma E.
  • Dalton Transactions, Vol. 39, Issue 35
  • DOI: 10.1039/c0dt00292e

Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry
journal, April 2009


CRIMS: Chemical reaction interface mass spectrometry
journal, July 1994


Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing
journal, February 2019


An interface for the direct coupling of small liquid samples to AMS
journal, October 2015

  • Ognibene, T. J.; Thomas, A. T.; Daley, P. F.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 361
  • DOI: 10.1016/j.nimb.2015.05.018

A diagnostic microdosing approach to investigate platinum sensitivity in non-small cell lung cancer: Diagnostic microdosing approach
journal, May 2017

  • Wang, Si-Si; Zimmermann, Maike; Zhang, Hongyong
  • International Journal of Cancer, Vol. 141, Issue 3
  • DOI: 10.1002/ijc.30747

High-dose cytosine arabinoside in the treatment of acute myeloid leukemia: Review of three randomized trials
journal, January 2006


Lethality of human myeloblasts correlates with the incorporation of arabinofuranosylcytosine into DNA.
journal, May 1981

  • Major, P. P.; Egan, E. M.; Beardsley, G. P.
  • Proceedings of the National Academy of Sciences, Vol. 78, Issue 5
  • DOI: 10.1073/pnas.78.5.3235

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain
journal, November 2014


Biochemical paths in humans and cells: Frontiers of AMS bioanalysis
journal, June 2007

  • Vogel, J. S.; Palmblad, N. M.; Ognibene, T.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 259, Issue 1
  • DOI: 10.1016/j.nimb.2007.01.215

Retrospective Birth Dating of Cells in Humans
journal, July 2005


Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer’s disease
journal, March 2002


Acute Myeloid Leukemia
journal, September 1999

  • Lowenberg, Bob; Downing, James R.; Burnett, Alan
  • New England Journal of Medicine, Vol. 341, Issue 14
  • DOI: 10.1056/NEJM199909303411407

Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies
journal, October 2018


Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity
journal, November 2015


Optical Measurement of Radiocarbon below Unity Fraction Modern by Linear Absorption Spectroscopy
journal, September 2017

  • Fleisher, Adam J.; Long, David A.; Liu, Qingnan
  • The Journal of Physical Chemistry Letters, Vol. 8, Issue 18
  • DOI: 10.1021/acs.jpclett.7b02105

Performance of catalytically condensed carbon for use in accelerator mass spectrometry
journal, November 1984

  • Vogel, J. S.; Southon, J. R.; Nelson, D. E.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 5, Issue 2
  • DOI: 10.1016/0168-583X(84)90529-9

Tamoxifen Forms DNA Adducts in Human Colon after Administration of a Single [ 14 C]-Labeled Therapeutic Dose
journal, July 2007


Doxorubicin-DNA Adducts Induce a Non-Topoisomerase II–Mediated Form of Cell Death
journal, May 2006


A validation study comparing accelerator MS and liquid scintillation counting for analysis of 14C-labelled drugs in plasma, urine and faecal extracts
journal, December 2000


Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon.
journal, May 1991

  • Shapiro, S. D.; Endicott, S. K.; Province, M. A.
  • Journal of Clinical Investigation, Vol. 87, Issue 5
  • DOI: 10.1172/JCI115204

Platinum-based drugs: past, present and future
journal, February 2016


Contemporary carbon content of bis (2-ethylhexyl) phthalate in butter
journal, January 2016


The impact of early human data on clinical development: there is time to win
journal, June 2016


Ultrahigh Efficiency Moving Wire Combustion Interface for Online Coupling of High-Performance Liquid Chromatography (HPLC)
journal, December 2011

  • Thomas, Avi T.; Ognibene, Ted; Daley, Paul
  • Analytical Chemistry, Vol. 83, Issue 24
  • DOI: 10.1021/ac202013s

14 C Background Levels in An Accelerator Mass Spectrometry System
journal, January 1987


Radiocarbon dating by infrared laser spectroscopy: A reasibility study
journal, April 1981

  • Labrie, D.; Reid, J.
  • Applied Physics, Vol. 24, Issue 4, p. 381-386
  • DOI: 10.1007/BF00899738

On the Need and Speed of Regulating Triclosan and Triclocarban in the United States
journal, March 2014

  • Halden, Rolf U.
  • Environmental Science & Technology, Vol. 48, Issue 7
  • DOI: 10.1021/es500495p

Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry
journal, October 2018


Compiled records of carbon isotopes in atmospheric CO 2 for historical simulations in CMIP6
journal, January 2017

  • Graven, Heather; Allison, Colin E.; Etheridge, David M.
  • Geoscientific Model Development, Vol. 10, Issue 12
  • DOI: 10.5194/gmd-10-4405-2017

Profiling of dalcetrapib metabolites in human plasma by accelerator mass spectrometry and investigation of the free phenothiol by derivatisation with methylacrylate
journal, April 2018

  • Husser, Christophe; Pähler, Axel; Seymour, Mark
  • Journal of Pharmaceutical and Biomedical Analysis, Vol. 152
  • DOI: 10.1016/j.jpba.2018.01.022

Elemental Speciation by Parallel Elemental and Molecular Mass Spectrometry and Peak Profile Matching
journal, December 2006

  • Sacks, Gavin L.; Derry, Louis A.; Brenna, J. Thomas
  • Analytical Chemistry, Vol. 78, Issue 24
  • DOI: 10.1021/ac0612170

Systems biology of cisplatin resistance: past, present and future
journal, May 2014


Catalyst and binder effects in the use of filamentous graphite for AMS
journal, November 1987

  • Vogel, John S.; Southon, John R.; Nelson, D. Erle
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 29, Issue 1-2
  • DOI: 10.1016/0168-583X(87)90202-3

The Age of Olfactory Bulb Neurons in Humans
journal, May 2012


Quantifying Carbon-14 for Biology Using Cavity Ring-Down Spectroscopy
journal, August 2016


Exploring the Age of Intracranial Aneurysms Using Carbon Birth Dating: Preliminary Results
journal, March 2013


Neocortical neurogenesis in humans is restricted to development
journal, August 2006

  • Bhardwaj, R. D.; Curtis, M. A.; Spalding, K. L.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 33
  • DOI: 10.1073/pnas.0605177103

Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations
journal, August 2008

  • Coldwell, K. E.; Cutts, S. M.; Ognibene, T. J.
  • Nucleic Acids Research, Vol. 36, Issue 16
  • DOI: 10.1093/nar/gkn439

Naphthalene DNA adduct formation and tolerance in the lung
journal, January 2019

  • Buchholz, Bruce A.; Carratt, Sarah A.; Kuhn, Edward A.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 438
  • DOI: 10.1016/j.nimb.2018.07.004

Naphthalene: A Respiratory Tract Toxicant and Carcinogen for Mice
journal, January 1992


A microdosing approach for characterizing formation and repair of carboplatin-DNA monoadducts and chemoresistance
journal, March 2011

  • Henderson, Paul T.; Li, Tao; He, Miaoling
  • International Journal of Cancer, Vol. 129, Issue 6
  • DOI: 10.1002/ijc.25814

Bioanalytical Applications of Accelerator Mass Spectrometry for Pharmaceutical Research
journal, July 2000


Installation of hybrid ion source on the 1-MV LLNL BioAMS spectrometer
journal, January 2013

  • Ognibene, T. J.; Salazar, G. A.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 294
  • DOI: 10.1016/j.nimb.2011.11.029

Carotid Plaque Age Is a Feature of Plaque Stability Inversely Related to Levels of Plasma Insulin
journal, April 2011


A review of whole animal bioassays of the carcinogenic potential of naphthalene
journal, July 2008

  • North, D. Warner; Abdo, Kamal M.; Benson, Janet M.
  • Regulatory Toxicology and Pharmacology, Vol. 51, Issue 2
  • DOI: 10.1016/j.yrtph.2007.09.022

Discussion Reporting of 14 C Data
journal, January 1977


Rapid Production of Graphite Without Contamination for Biomedical AMS
journal, January 1992


Preparation of Specific Compartments of the Lungs for Pathologic and Biochemical Analysis of Toxicologic Responses
journal, February 2017

  • Winkle, Laura S.; Kelty, Jacklyn S.; Plopper, Charles G.
  • Current Protocols in Toxicology, Vol. 71, Issue 1
  • DOI: 10.1002/cptx.18

Snail Bioaccumulation of Triclocarban, Triclosan, and Methyltriclosan in a North Texas, usa, Stream Affected by Wastewater Treatment Plant Runoff
journal, January 2008

  • Coogan, Melinda A.; La Point, Thomas W.
  • Environmental Toxicology and Chemistry, Vol. 27, Issue 8
  • DOI: 10.1897/07-374.1

The resurgence of platinum-based cancer chemotherapy
journal, July 2007

  • Kelland, Lloyd
  • Nature Reviews Cancer, Vol. 7, Issue 8
  • DOI: 10.1038/nrc2167

Urinary Naphthol Metabolites and Chromosomal Aberrations in 5-Year-Old Children
journal, May 2012


Lack of tissue renewal in human adult Achilles tendon is revealed by nuclear bomb 14 C
journal, May 2013

  • Heinemeier, Katja Maria; Schjerling, Peter; Heinemeier, Jan
  • The FASEB Journal, Vol. 27, Issue 5
  • DOI: 10.1096/fj.12-225599

Radiocarbon dioxide detection based on cavity ring-down spectroscopy and a quantum cascade laser
journal, January 2015


Dynamics of Hippocampal Neurogenesis in Adult Humans
journal, June 2013


Dynamics of human adipose lipid turnover in health and metabolic disease
journal, September 2011

  • Arner, Peter; Bernard, Samuel; Salehpour, Mehran
  • Nature, Vol. 478, Issue 7367
  • DOI: 10.1038/nature10426

Directly Coupled High-Performance Liquid Chromatography–Accelerator Mass Spectrometry Measurement of Chemically Modified Protein and Peptides
journal, March 2013

  • Thomas, Avi T.; Stewart, Benjamin J.; Ognibene, Ted J.
  • Analytical Chemistry, Vol. 85, Issue 7
  • DOI: 10.1021/ac303609n

Accelerator Mass Spectrometry
journal, June 1995

  • Vogel, John S.; Turteltaub, Kenneth W.; Finkel, Robert
  • Analytical Chemistry, Vol. 67, Issue 11
  • DOI: 10.1021/ac00107a714

Free flow electrophoresis separation and AMS quantitation of 14C–naphthalene–protein adducts
journal, April 2010

  • Buchholz, Bruce A.; Haack, Kurt W.; Sporty, Jennifer L.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 268, Issue 7-8
  • DOI: 10.1016/j.nimb.2009.10.164

Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage
journal, July 2016

  • Heinemeier, Katja M.; Schjerling, Peter; Heinemeier, Jan
  • Science Translational Medicine, Vol. 8, Issue 346
  • DOI: 10.1126/scitranslmed.aad8335

The antimicrobial agents triclocarban and triclosan as potent modulators of reproduction in Potamopyrgus antipodarum (Mollusca: Hydrobiidae)
journal, July 2016

  • Geiß, Cornelia; Ruppert, Katharina; Heidelbach, Tanja
  • Journal of Environmental Science and Health, Part A, Vol. 51, Issue 13
  • DOI: 10.1080/10934529.2016.1206388

Intracavity Optogalvanic Spectroscopy. An Analytical Technique for 14 C Analysis with Subattomole Sensitivity
journal, July 2008

  • Murnick, Daniel E.; Dogru, Ozgur; Ilkmen, Erhan
  • Analytical Chemistry, Vol. 80, Issue 13
  • DOI: 10.1021/ac800751y

Cellular processing of platinum anticancer drugs
journal, March 2005

  • Wang, Dong; Lippard, Stephen J.
  • Nature Reviews Drug Discovery, Vol. 4, Issue 4
  • DOI: 10.1038/nrd1691

Toward Predicting Acute Myeloid Leukemia Patient Response to 7 + 3 Induction Chemotherapy via Diagnostic Microdosing
journal, August 2018


Diagnostic Microdosing Approach to Study Gemcitabine Resistance
journal, October 2016


Contemporary Fraction of bis(2–ethylhexyl) Phthalate in Stilton Cheese by Accelerator Mass Spectrometry
journal, January 2013


Dating Techniques in Archaeology and Paleoanthropology
journal, February 1987


Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined by in Vivo Thymidine Analog Incorporation and Radiocarbon Dating
journal, October 2010

  • Perl, S.; Kushner, J. A.; Buchholz, B. A.
  • The Journal of Clinical Endocrinology & Metabolism, Vol. 95, Issue 10
  • DOI: 10.1210/jc.2010-0932

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
journal, January 2009


Isotopes in nutrition research
journal, February 1999

  • Young, Vernon R.; Ajami, Alfred
  • Proceedings of the Nutrition Society, Vol. 58, Issue 1
  • DOI: 10.1079/PNS19990004

Treatment of acute myelocytic leukemia: a study by cancer and leukemia group B
journal, December 1981


A randomized study of high-dose cytarabine in induction in acute myeloid leukemia [see comments]
journal, March 1996


    Works referencing / citing this record:

    Retrospective Birth Dating of Cells in Humans
    journal, July 2005


    Ultrahigh Efficiency Moving Wire Combustion Interface for Online Coupling of High-Performance Liquid Chromatography (HPLC)
    journal, December 2011

    • Thomas, Avi T.; Ognibene, Ted; Daley, Paul
    • Analytical Chemistry, Vol. 83, Issue 24
    • DOI: 10.1021/ac202013s

    The antimicrobial agents triclocarban and triclosan as potent modulators of reproduction in Potamopyrgus antipodarum (Mollusca: Hydrobiidae)
    journal, July 2016

    • Geiß, Cornelia; Ruppert, Katharina; Heidelbach, Tanja
    • Journal of Environmental Science and Health, Part A, Vol. 51, Issue 13
    • DOI: 10.1080/10934529.2016.1206388

    Free flow electrophoresis separation and AMS quantitation of 14C–naphthalene–protein adducts
    journal, April 2010

    • Buchholz, Bruce A.; Haack, Kurt W.; Sporty, Jennifer L.
    • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 268, Issue 7-8
    • DOI: 10.1016/j.nimb.2009.10.164

    Dynamics of Hippocampal Neurogenesis in Adult Humans
    journal, June 2013


    Dynamics of human adipose lipid turnover in health and metabolic disease
    journal, September 2011

    • Arner, Peter; Bernard, Samuel; Salehpour, Mehran
    • Nature, Vol. 478, Issue 7367
    • DOI: 10.1038/nature10426

    Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity
    journal, November 2015


    Optical Measurement of Radiocarbon below Unity Fraction Modern by Linear Absorption Spectroscopy
    journal, September 2017

    • Fleisher, Adam J.; Long, David A.; Liu, Qingnan
    • The Journal of Physical Chemistry Letters, Vol. 8, Issue 18
    • DOI: 10.1021/acs.jpclett.7b02105

    Biochemical paths in humans and cells: Frontiers of AMS bioanalysis
    journal, June 2007

    • Vogel, J. S.; Palmblad, N. M.; Ognibene, T.
    • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 259, Issue 1
    • DOI: 10.1016/j.nimb.2007.01.215

    Lethality of human myeloblasts correlates with the incorporation of arabinofuranosylcytosine into DNA.
    journal, May 1981

    • Major, P. P.; Egan, E. M.; Beardsley, G. P.
    • Proceedings of the National Academy of Sciences, Vol. 78, Issue 5
    • DOI: 10.1073/pnas.78.5.3235

    Snail Bioaccumulation of Triclocarban, Triclosan, and Methyltriclosan in a North Texas, usa, Stream Affected by Wastewater Treatment Plant Runoff
    journal, January 2008

    • Coogan, Melinda A.; La Point, Thomas W.
    • Environmental Toxicology and Chemistry, Vol. 27, Issue 8
    • DOI: 10.1897/07-374.1

    Elemental Speciation by Parallel Elemental and Molecular Mass Spectrometry and Peak Profile Matching
    journal, December 2006

    • Sacks, Gavin L.; Derry, Louis A.; Brenna, J. Thomas
    • Analytical Chemistry, Vol. 78, Issue 24
    • DOI: 10.1021/ac0612170

    Profiling of dalcetrapib metabolites in human plasma by accelerator mass spectrometry and investigation of the free phenothiol by derivatisation with methylacrylate
    journal, April 2018

    • Husser, Christophe; Pähler, Axel; Seymour, Mark
    • Journal of Pharmaceutical and Biomedical Analysis, Vol. 152
    • DOI: 10.1016/j.jpba.2018.01.022

    The Age of Olfactory Bulb Neurons in Humans
    journal, May 2012


    The impact of early human data on clinical development: there is time to win
    journal, June 2016


    Platinum-based drugs: past, present and future
    journal, February 2016


    Dating Techniques in Archaeology and Paleoanthropology
    journal, February 1987


    Naphthalene DNA adduct formation and tolerance in the lung
    journal, January 2019

    • Buchholz, Bruce A.; Carratt, Sarah A.; Kuhn, Edward A.
    • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 438
    • DOI: 10.1016/j.nimb.2018.07.004

    Neocortical neurogenesis in humans is restricted to development
    journal, August 2006

    • Bhardwaj, R. D.; Curtis, M. A.; Spalding, K. L.
    • Proceedings of the National Academy of Sciences, Vol. 103, Issue 33
    • DOI: 10.1073/pnas.0605177103

    Toward Predicting Acute Myeloid Leukemia Patient Response to 7 + 3 Induction Chemotherapy via Diagnostic Microdosing
    journal, August 2018


    Systems biology of cisplatin resistance: past, present and future
    journal, May 2014


    Human Microdosing with Carcinogenic Polycyclic Aromatic Hydrocarbons: In Vivo Pharmacokinetics of Dibenzo[ def,p ]chrysene and Metabolites by UPLC Accelerator Mass Spectrometry
    journal, September 2016


    Compiled records of carbon isotopes in atmospheric CO 2 for historical simulations in CMIP6
    journal, January 2017

    • Graven, Heather; Allison, Colin E.; Etheridge, David M.
    • Geoscientific Model Development, Vol. 10, Issue 12
    • DOI: 10.5194/gmd-10-4405-2017

    Intracavity Optogalvanic Spectroscopy. An Analytical Technique for 14 C Analysis with Subattomole Sensitivity
    journal, July 2008

    • Murnick, Daniel E.; Dogru, Ozgur; Ilkmen, Erhan
    • Analytical Chemistry, Vol. 80, Issue 13
    • DOI: 10.1021/ac800751y

    Critical Role of Histone Turnover in Neuronal Transcription and Plasticity
    journal, July 2015


    Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage
    journal, July 2016

    • Heinemeier, Katja M.; Schjerling, Peter; Heinemeier, Jan
    • Science Translational Medicine, Vol. 8, Issue 346
    • DOI: 10.1126/scitranslmed.aad8335

    Preparation of Specific Compartments of the Lungs for Pathologic and Biochemical Analysis of Toxicologic Responses
    journal, February 2017

    • Winkle, Laura S.; Kelty, Jacklyn S.; Plopper, Charles G.
    • Current Protocols in Toxicology, Vol. 71, Issue 1
    • DOI: 10.1002/cptx.18

    DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine
    journal, December 2016


    Accelerator Mass Spectrometry
    journal, June 1995

    • Vogel, John S.; Turteltaub, Kenneth W.; Finkel, Robert
    • Analytical Chemistry, Vol. 67, Issue 11
    • DOI: 10.1021/ac00107a714

    Characterization of Oxaliplatin−DNA Adduct Formation in DNA and Differentiation of Cancer Cell Drug Sensitivity at Microdose Concentrations
    journal, December 2007

    • Hah, Sang Soo; Sumbad, Rhoda A.; de Vere White, Ralph W.
    • Chemical Research in Toxicology, Vol. 20, Issue 12
    • DOI: 10.1021/tx700376a

    Installation of hybrid ion source on the 1-MV LLNL BioAMS spectrometer
    journal, January 2013

    • Ognibene, T. J.; Salazar, G. A.
    • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 294
    • DOI: 10.1016/j.nimb.2011.11.029

    Collagen turnover in the adult femoral mid-shaft: Modeled from anthropogenic radiocarbon tracer measurements
    journal, January 2007

    • Hedges, Robert E. M.; Clement, John G.; Thomas, C. David L.
    • American Journal of Physical Anthropology, Vol. 133, Issue 2
    • DOI: 10.1002/ajpa.20598

    Radiocarbon Dating of the Human Eye Lens Crystallines Reveal Proteins without Carbon Turnover throughout Life
    journal, January 2008


    A microdosing approach for characterizing formation and repair of carboplatin-DNA monoadducts and chemoresistance
    journal, March 2011

    • Henderson, Paul T.; Li, Tao; He, Miaoling
    • International Journal of Cancer, Vol. 129, Issue 6
    • DOI: 10.1002/ijc.25814

    Contemporary carbon content of bis (2-ethylhexyl) phthalate in butter
    journal, January 2016


    Directly Coupled High-Performance Liquid Chromatography–Accelerator Mass Spectrometry Measurement of Chemically Modified Protein and Peptides
    journal, March 2013

    • Thomas, Avi T.; Stewart, Benjamin J.; Ognibene, Ted J.
    • Analytical Chemistry, Vol. 85, Issue 7
    • DOI: 10.1021/ac303609n

    Time from diagnosis to treatment initiation predicts survival in younger, but not older, acute myeloid leukemia patients
    journal, January 2009


    A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the “Metabolites in Safety Testing” Regulatory Guidance
    journal, February 2018

    • Schadt, Simone; Bister, Bojan; Chowdhury, Swapan K.
    • Drug Metabolism and Disposition, Vol. 46, Issue 6
    • DOI: 10.1124/dmd.117.079848

    Cellular processing of platinum anticancer drugs
    journal, March 2005

    • Wang, Dong; Lippard, Stephen J.
    • Nature Reviews Drug Discovery, Vol. 4, Issue 4
    • DOI: 10.1038/nrd1691

    The status of platinum anticancer drugs in the clinic and in clinical trials
    journal, January 2010

    • Wheate, Nial J.; Walker, Shonagh; Craig, Gemma E.
    • Dalton Transactions, Vol. 39, Issue 35
    • DOI: 10.1039/c0dt00292e

    The resurgence of platinum-based cancer chemotherapy
    journal, July 2007

    • Kelland, Lloyd
    • Nature Reviews Cancer, Vol. 7, Issue 8
    • DOI: 10.1038/nrc2167

    Antibody-secreting plasma cells persist for decades in human intestine
    journal, January 2017

    • Landsverk, Ole J. B.; Snir, Omri; Casado, Raquel Bartolomé
    • The Journal of Experimental Medicine, Vol. 214, Issue 2
    • DOI: 10.1084/jem.20161590

    Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry
    journal, October 2018


    New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
    journal, January 2009


    Diagnostic Microdosing Approach to Study Gemcitabine Resistance
    journal, October 2016


    Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined by in Vivo Thymidine Analog Incorporation and Radiocarbon Dating
    journal, October 2010

    • Perl, S.; Kushner, J. A.; Buchholz, B. A.
    • The Journal of Clinical Endocrinology & Metabolism, Vol. 95, Issue 10
    • DOI: 10.1210/jc.2010-0932

    Evidence for Cardiomyocyte Renewal in Humans
    journal, April 2009


    A diagnostic microdosing approach to investigate platinum sensitivity in non-small cell lung cancer: Diagnostic microdosing approach
    journal, May 2017

    • Wang, Si-Si; Zimmermann, Maike; Zhang, Hongyong
    • International Journal of Cancer, Vol. 141, Issue 3
    • DOI: 10.1002/ijc.30747

    Lack of tissue renewal in human adult Achilles tendon is revealed by nuclear bomb 14 C
    journal, May 2013

    • Heinemeier, Katja Maria; Schjerling, Peter; Heinemeier, Jan
    • The FASEB Journal, Vol. 27, Issue 5
    • DOI: 10.1096/fj.12-225599

    The v 3 band of 14 C 16 O 2 molecule measured by optical-frequency-comb-assisted cavity ring-down spectroscopy
    journal, September 2011


    High-dose cytosine arabinoside in the treatment of acute myeloid leukemia: Review of three randomized trials
    journal, January 2006


    Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies
    journal, October 2018


    Towards biomarker-dependent individualized chemotherapy: Exploring cell-specific differences in oxaliplatin–DNA adduct distribution using accelerator mass spectrometry
    journal, April 2010

    • Hah, Sang Soo; Henderson, Paul T.; Turteltaub, Kenneth W.
    • Bioorganic & Medicinal Chemistry Letters, Vol. 20, Issue 8
    • DOI: 10.1016/j.bmcl.2010.03.020

    Luminescent Labels?More than Just an Alternative to Radioisotopes?
    journal, June 1994

    • Mayer, Andreas; Neuenhofer, Stephan
    • Angewandte Chemie International Edition in English, Vol. 33, Issue 10
    • DOI: 10.1002/anie.199410441

    Automated Combustion Accelerator Mass Spectrometry for the Analysis of Biomedical Samples in the Low Attomole Range
    journal, July 2014

    • van Duijn, Esther; Sandman, Hugo; Grossouw, Dimitri
    • Analytical Chemistry, Vol. 86, Issue 15
    • DOI: 10.1021/ac5015035

    Bioanalytical Applications of Accelerator Mass Spectrometry for Pharmaceutical Research
    journal, July 2000


    Carotid Plaque Age Is a Feature of Plaque Stability Inversely Related to Levels of Plasma Insulin
    journal, April 2011


    Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations
    journal, August 2008

    • Coldwell, K. E.; Cutts, S. M.; Ognibene, T. J.
    • Nucleic Acids Research, Vol. 36, Issue 16
    • DOI: 10.1093/nar/gkn439

    Gemcitabine Causes Minimal Modulation of Carboplatin-DNA Monoadduct Formation and Repair in Bladder Cancer Cells
    journal, November 2010

    • Wang, Sisi; Zhang, Hongyong; Malfatti, Michael
    • Chemical Research in Toxicology, Vol. 23, Issue 11
    • DOI: 10.1021/tx1003547

    On the Need and Speed of Regulating Triclosan and Triclocarban in the United States
    journal, March 2014

    • Halden, Rolf U.
    • Environmental Science & Technology, Vol. 48, Issue 7
    • DOI: 10.1021/es500495p

    Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry
    journal, April 2009


    Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing
    journal, February 2019


    Dynamics of fat cell turnover in humans
    journal, May 2008

    • Spalding, Kirsty L.; Arner, Erik; Westermark, Pål O.
    • Nature, Vol. 453, Issue 7196
    • DOI: 10.1038/nature06902

    An interface for the direct coupling of small liquid samples to AMS
    journal, October 2015

    • Ognibene, T. J.; Thomas, A. T.; Daley, P. F.
    • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 361
    • DOI: 10.1016/j.nimb.2015.05.018

    Quantifying Carbon-14 for Biology Using Cavity Ring-Down Spectroscopy
    journal, August 2016


    CRIMS: Chemical reaction interface mass spectrometry
    journal, July 1994


    Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain
    journal, November 2014