DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Cisplatin protects mice from challenge of Cryptococcus neoformans by targeting the Prp8 intein

Journal Article · · Emerging Microbes & Infections
ORCiD logo [1];  [2];  [3];  [1];  [1];  [1];  [4];  [5];  [2]; ORCiD logo [4]
  1. New York State Department of Health, Wadsworth Center, Albany, NY, USA
  2. College of Pharmaceutical Sciences, Southwest University, Chongqing, People’s Republic of China
  3. Department of Biological Sciences and RNA Institute, University at Albany, Albany, NY, USA
  4. New York State Department of Health, Wadsworth Center, Albany, NY, USA, Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY, USA
  5. Department of Biological Sciences and RNA Institute, University at Albany, Albany, NY, USA, Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY, USA

Not Available

Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
OSTI ID:
1529025
Journal Information:
Emerging Microbes & Infections, Journal Name: Emerging Microbes & Infections Journal Issue: 1 Vol. 8; ISSN 2222-1751
Publisher:
Informa UK LimitedCopyright Statement
Country of Publication:
United Kingdom
Language:
English

References (66)

Structural basis of pre-mRNA splicing journal August 2015
Antifungal Drug Resistance: Mechanisms, Epidemiology, and Consequences for Treatment journal January 2012
An in Vitro Screening System for Protein Splicing Inhibitors Based on Green Fluorescent Protein as an Indicator journal May 2003
Clinical Issues Regarding Relapsing Aspergillosis and the Efficacy of Secondary Antifungal Prophylaxis in Patients with Hematological Malignancies journal June 2006
High-frequency Triazole Resistance Found In Nonculturable Aspergillus fumigatus from Lungs of Patients with Chronic Fungal Disease journal May 2011
Emergence and Pathogenicity of Highly Virulent Cryptococcus gattii Genotypes in the Northwest United States journal April 2010
Features and development of Coot journal March 2010
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Cryptococcus neoformans Infection in Organ Transplant Recipients: Variables Influencing Clinical Characteristics and Outcome journal June 2001
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Cryptococcosis diagnosis and treatment: What do we know now journal May 2015
The resurgence of platinum-based cancer chemotherapy journal July 2007
Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America journal February 2010
Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation journal June 2002
A nuclear-encoded intein in the fungal pathogenCryptococcus neoformans journal January 2001
PAS Domain Protein Pas3 Interacts with the Chromatin Modifier Bre1 in Regulating Cryptococcal Morphogenesis journal November 2018
Invasive Fungal Infections: The Challenge Continues journal January 2009
Protein splicing inhibitors as a new class of antimycobacterial agents journal January 2007
Cisplatin Inhibits Protein Splicing, Suggesting Inteins as Therapeutic Targets in Mycobacteria journal November 2010
Protein splicing of a recombinase intein induced by ssDNA and DNA damage journal December 2016
Spread of Cryptococcus gattii in British Columbia, Canada, and Detection in the Pacific Northwest, USA journal January 2007
Cryptococcal Disease in Patients with the Acquired Immunodeficiency Syndrome: Diagnostic Features and Outcome of Treatment journal February 1986
Evolution and Application of Inteins in Candida species: A Review journal October 2016
Cisplatin in cancer therapy: Molecular mechanisms of action journal October 2014
Inteins as targets for potential antimycobacterial drugs journal January 2003
A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease journal May 2017
Exploring Intein Inhibition by Platinum Compounds as an Antimicrobial Strategy journal September 2016
Structure of a yeast spliceosome at 3.6-angstrom resolution journal August 2015
Split Renilla Luciferase Protein Fragment-assisted Complementation (SRL-PFAC) to Characterize Hsp90-Cdc37 Complex and Identify Critical Residues in Protein/Protein Interactions journal April 2010
Preceding hydrophobic and β-branched amino acids attenuate splicing by the CnePRP8 intein journal August 2007
Enigmatic Distribution, Evolution, and Function of Inteins journal April 2014
Protein Splicing of the Saccharomyces cerevisiae VMA Intein without the Endonuclease Motifs journal June 1997
Split-luciferase complementary assay: applications, recent developments, and future perspectives journal July 2014
Nature's recipe for splitting inteins journal August 2014
Fungal Infections journal March 2006
The Cryptococcus neoformans Transcriptome at the Site of Human Meningitis journal February 2014
Genetic definition of a protein-splicing domain: Functional mini-inteins support structure predictions and a model for intein evolution journal October 1997
Frequency and Evolution of Azole Resistance in Aspergillus fumigatus Associated with Treatment Failure1 journal July 2009
Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial journal May 2004
Crystallographic and Mutational Studies of Mycobacterium tuberculosis recA Mini-inteins Suggest a Pivotal Role for a Highly Conserved Aspartate Residue journal March 2007
Prp8 intein in fungal pathogens: target for potential antifungal drugs journal July 2004
Cryptococcal Meningitis Treatment Strategies in Resource-Limited Settings: A Cost-Effectiveness Analysis journal September 2012
Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America journal February 2008
Global burden of chronic pulmonary aspergillosis complicating sarcoidosis journal June 2012
Liposomal Amphotericin B: A Review of its Use as Empirical Therapy in Febrile Neutropenia and in the Treatment of Invasive Fungal Infections journal January 2009
Prp8 protein: At the heart of the spliceosome journal May 2005
Sequence requirements for splicing by the Cne PRP8 intein journal May 2007
Protein Splicing: How Inteins Escape from Precursor Proteins journal April 2014
Practice Guidelines for the Management of Cryptococcal Disease journal April 2000
Fungal diagnosis: how do we do it and can we do better? journal April 2013
Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction journal July 2017
Minimization and stabilization of the Mycobacterium tuberculosis recA intein journal December 2005
Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance journal October 1999
SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses journal August 2015
Relapsing meningitis caused by persistent cryptococcal antigens and immune reconstitution after the initiation of highly active antiretroviral therapy journal January 2004
Crystal Structure of a Mini-intein Reveals a Conserved Catalytic Module Involved in Side Chain Cyclization of Asparagine during Protein Splicing journal July 2003
A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions journal January 1988
High resolution crystal structure of domain I of the Saccharomyces cerevisiae homing endonuclease PI-SceI journal September 2002
Evaluation of Endpoints for Antifungal Susceptibility Determinations with LY303366 journal June 1998
Monitoring Protein−Protein Interactions Using Split Synthetic Renilla Luciferase Protein-Fragment-Assisted Complementation journal April 2003
Zygomycosis in a Tertiary‐Care Cancer Center in the Era of Aspergillus‐ Active Antifungal Therapy: A Case‐Control Observational Study of 27 Recent Cases
  • Kontoyiannis, Dimitrios P.; Lionakis, Michail S.; Lewis, Russell E.
  • The Journal of Infectious Diseases, Vol. 191, Issue 8 https://doi.org/10.1086/428780
journal April 2005
The PRP8 inteins in Cryptococcus are a source of phylogenetic and epidemiological information journal May 2005
Structural and Dynamical Features of Inteins and Implications on Protein Splicing journal April 2014
A Diverse Population of Cryptococcus gattii Molecular Type VGIII in Southern Californian HIV/AIDS Patients journal September 2011
Hidden Killers: Human Fungal Infections journal December 2012
Mycobacterial DnaB helicase intein as oxidative stress sensor journal October 2018