Cisplatin protects mice from challenge of Cryptococcus neoformans by targeting the Prp8 intein

Li, Zhong; Fu, Bin; Green, Cathleen M.; Liu, Binbin; Zhang, Jing; Lang, Yuekun; Chaturvedi, Sudha; Belfort, Marlene; Liao, Guojian; Li, Hongmin

doi:10.1080/22221751.2019.1625727

Title: Cisplatin protects mice from challenge of Cryptococcus neoformans by targeting the Prp8 intein

Journal Article · 20 June 2019 · Emerging Microbes & Infections

DOI: https://doi.org/10.1080/22221751.2019.1625727 · OSTI ID:1529025

^[1]; Fu, Bin ^[2]; Green, Cathleen M. ^[3]; Liu, Binbin ^[1]; Zhang, Jing ^[1]; Lang, Yuekun ^[1]; Chaturvedi, Sudha ^[4]; Belfort, Marlene ^[5]; Liao, Guojian ^[2];

^[4]

New York State Department of Health, Wadsworth Center, Albany, NY, USA
College of Pharmaceutical Sciences, Southwest University, Chongqing, People’s Republic of China
Department of Biological Sciences and RNA Institute, University at Albany, Albany, NY, USA
New York State Department of Health, Wadsworth Center, Albany, NY, USA, Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY, USA
Department of Biological Sciences and RNA Institute, University at Albany, Albany, NY, USA, Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY, USA

Not Available

View Journal Article

Cite

Export

Save

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

OSTI ID:: 1529025

Journal Information:: Emerging Microbes & Infections, Journal Name: Emerging Microbes & Infections Journal Issue: 1 Vol. 8; ISSN 2222-1751

Publisher:: Informa UK LimitedCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (66)

Structural basis of pre-mRNA splicing Hang, Jing; Wan, Ruixue; Yan, Chuangye Science, Vol. 349, Issue 6253 https://doi.org/10.1126/science.aac8159	journal	August 2015
Antifungal Drug Resistance: Mechanisms, Epidemiology, and Consequences for Treatment Pfaller, Michael A. The American Journal of Medicine, Vol. 125, Issue 1 https://doi.org/10.1016/j.amjmed.2011.11.001	journal	January 2012
An in Vitro Screening System for Protein Splicing Inhibitors Based on Green Fluorescent Protein as an Indicator Gangopadhyay, Jaya Pal; Jiang, Shu-qin; Paulus, Henry Analytical Chemistry, Vol. 75, Issue 10 https://doi.org/10.1021/ac020756b	journal	May 2003
Clinical Issues Regarding Relapsing Aspergillosis and the Efficacy of Secondary Antifungal Prophylaxis in Patients with Hematological Malignancies Sipsas, N. V.; Kontoyiannis, D. P. Clinical Infectious Diseases, Vol. 42, Issue 11 https://doi.org/10.1086/503844	journal	June 2006
High-frequency Triazole Resistance Found In Nonculturable Aspergillus fumigatus from Lungs of Patients with Chronic Fungal Disease Denning, David W.; Park, Steven; Lass-Florl, Cornelia Clinical Infectious Diseases, Vol. 52, Issue 9 https://doi.org/10.1093/cid/cir179	journal	May 2011
Emergence and Pathogenicity of Highly Virulent Cryptococcus gattii Genotypes in the Northwest United States Byrnes, Edmond J.; Li, Wenjun; Lewit, Yonathan PLoS Pathogens, Vol. 6, Issue 4 https://doi.org/10.1371/journal.ppat.1000850	journal	April 2010
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
[20] Processing of X-ray diffraction data collected in oscillation mode Otwinowski, Zbyszek; Minor, Wladek Macromolecular Crystallography Part A, 307-326 https://doi.org/10.1016/S0076-6879(97)76066-X	book	January 1997
Cryptococcus neoformans Infection in Organ Transplant Recipients: Variables Influencing Clinical Characteristics and Outcome Husain, Shahid; Wagener, Marilyn M.; Singh, Nina Emerging Infectious Diseases, Vol. 7, Issue 3 https://doi.org/10.3201/eid0703.017302	journal	June 2001
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
Cryptococcosis diagnosis and treatment: What do we know now Perfect, John R.; Bicanic, Tihana Fungal Genetics and Biology, Vol. 78 https://doi.org/10.1016/j.fgb.2014.10.003	journal	May 2015
The resurgence of platinum-based cancer chemotherapy Kelland, Lloyd Nature Reviews Cancer, Vol. 7, Issue 8 https://doi.org/10.1038/nrc2167	journal	July 2007
Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America Perfect, John R.; Dismukes, William E.; Dromer, Francoise Clinical Infectious Diseases, Vol. 50, Issue 3 https://doi.org/10.1086/649858	journal	February 2010
Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation Kuhn, A. N.; Reichl, E. M.; Brow, D. A. Proceedings of the National Academy of Sciences, Vol. 99, Issue 14 https://doi.org/10.1073/pnas.102304299	journal	June 2002
A nuclear-encoded intein in the fungal pathogenCryptococcus neoformans Butler, Margaret I.; Goodwin, Timothy J. D.; M. Poulter, Russell T. Yeast, Vol. 18, Issue 15 https://doi.org/10.1002/yea.781	journal	January 2001
PAS Domain Protein Pas3 Interacts with the Chromatin Modifier Bre1 in Regulating Cryptococcal Morphogenesis Zhao, Youbao; Upadhyay, Srijana; Lin, Xiaorong mBio, Vol. 9, Issue 6 https://doi.org/10.1128/mBio.02135-18	journal	November 2018
Invasive Fungal Infections: The Challenge Continues Gullo, Antonino Drugs, Vol. 69, Issue Supplement 1 https://doi.org/10.2165/11315530-000000000-00000	journal	January 2009
Protein splicing inhibitors as a new class of antimycobacterial agents Paulus, H. Drugs of the Future, Vol. 32, Issue 11 https://doi.org/10.1358/dof.2007.032.11.1140690	journal	January 2007
Cisplatin Inhibits Protein Splicing, Suggesting Inteins as Therapeutic Targets in Mycobacteria Zhang, Liyun; Zheng, Yuchuan; Callahan, Brian Journal of Biological Chemistry, Vol. 286, Issue 2 https://doi.org/10.1074/jbc.M110.171124	journal	November 2010
Protein splicing of a recombinase intein induced by ssDNA and DNA damage Lennon, Christopher W.; Stanger, Matthew; Belfort, Marlene Genes & Development, Vol. 30, Issue 24 https://doi.org/10.1101/gad.289280.116	journal	December 2016
Spread of Cryptococcus gattii in British Columbia, Canada, and Detection in the Pacific Northwest, USA MacDougall, Laura; Kidd, Sarah E.; Galanis, Eleni Emerging Infectious Diseases, Vol. 13, Issue 1 https://doi.org/10.3201/eid1301.060827	journal	January 2007
Cryptococcal Disease in Patients with the Acquired Immunodeficiency Syndrome: Diagnostic Features and Outcome of Treatment Zuger, Abigail Annals of Internal Medicine, Vol. 104, Issue 2 https://doi.org/10.7326/0003-4819-104-2-234	journal	February 1986
Evolution and Application of Inteins in Candida species: A Review Fernandes, José A. L.; Prandini, Tâmara H. R.; Castro, Maria da Conceiçao A. Frontiers in Microbiology, Vol. 7 https://doi.org/10.3389/fmicb.2016.01585	journal	October 2016
Cisplatin in cancer therapy: Molecular mechanisms of action Dasari, Shaloam; Bernard Tchounwou, Paul European Journal of Pharmacology, Vol. 740 https://doi.org/10.1016/j.ejphar.2014.07.025	journal	October 2014
Inteins as targets for potential antimycobacterial drugs Paulus, Henry Frontiers in Bioscience, Vol. 8, Issue 6 https://doi.org/10.2741/1195	journal	January 2003
A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease Brecher, Matthew; Li, Zhong; Liu, Binbin PLOS Pathogens, Vol. 13, Issue 5 https://doi.org/10.1371/journal.ppat.1006411	journal	May 2017
Exploring Intein Inhibition by Platinum Compounds as an Antimicrobial Strategy Chan, Hon; Pearson, C. Seth; Green, Cathleen M. Journal of Biological Chemistry, Vol. 291, Issue 43 https://doi.org/10.1074/jbc.M116.747824	journal	September 2016
Structure of a yeast spliceosome at 3.6-angstrom resolution Yan, Chuangye; Hang, Jing; Wan, Ruixue Science, Vol. 349, Issue 6253 https://doi.org/10.1126/science.aac7629	journal	August 2015
Split Renilla Luciferase Protein Fragment-assisted Complementation (SRL-PFAC) to Characterize Hsp90-Cdc37 Complex and Identify Critical Residues in Protein/Protein Interactions Jiang, Yiqun; Bernard, Denzil; Yu, Yanke Journal of Biological Chemistry, Vol. 285, Issue 27 https://doi.org/10.1074/jbc.M110.103390	journal	April 2010
Preceding hydrophobic and β-branched amino acids attenuate splicing by the CnePRP8 intein Pearl, Esther J.; Bokor, Annika A. M.; Butler, Margi I. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1774, Issue 8 https://doi.org/10.1016/j.bbapap.2007.05.015	journal	August 2007
Enigmatic Distribution, Evolution, and Function of Inteins Novikova, Olga; Topilina, Natalya; Belfort, Marlene Journal of Biological Chemistry, Vol. 289, Issue 21 https://doi.org/10.1074/jbc.R114.548255	journal	April 2014
Protein Splicing of the Saccharomyces cerevisiae VMA Intein without the Endonuclease Motifs Chong, Shaorong; Xu, Ming-Qun Journal of Biological Chemistry, Vol. 272, Issue 25 https://doi.org/10.1074/jbc.272.25.15587	journal	June 1997
Split-luciferase complementary assay: applications, recent developments, and future perspectives Azad, Taha; Tashakor, Amin; Hosseinkhani, Saman Analytical and Bioanalytical Chemistry, Vol. 406, Issue 23 https://doi.org/10.1007/s00216-014-7980-8	journal	July 2014
Nature's recipe for splitting inteins Aranko, A. S.; Wlodawer, A.; Iwai, H. Protein Engineering Design and Selection, Vol. 27, Issue 8 https://doi.org/10.1093/protein/gzu028	journal	August 2014
Fungal Infections Kauffman, C. A. Proceedings of the American Thoracic Society, Vol. 3, Issue 1 https://doi.org/10.1513/pats.200510-110JH	journal	March 2006
The Cryptococcus neoformans Transcriptome at the Site of Human Meningitis Chen, Yuan; Toffaletti, Dena L.; Tenor, Jennifer L. mBio, Vol. 5, Issue 1 https://doi.org/10.1128/mBio.01087-13	journal	February 2014
Genetic definition of a protein-splicing domain: Functional mini-inteins support structure predictions and a model for intein evolution Derbyshire, V.; Wood, D. W.; Wu, W. Proceedings of the National Academy of Sciences, Vol. 94, Issue 21 https://doi.org/10.1073/pnas.94.21.11466	journal	October 1997
Frequency and Evolution of Azole Resistance in Aspergillus fumigatus Associated with Treatment Failure1 Howard, Susan J.; Cerar, Dasa; Anderson, Michael J. Emerging Infectious Diseases, Vol. 15, Issue 7 https://doi.org/10.3201/eid1507.090043	journal	July 2009
Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial Brouwer, Annemarie E.; Rajanuwong, Adul; Chierakul, Wirongrong The Lancet, Vol. 363, Issue 9423 https://doi.org/10.1016/S0140-6736(04)16301-0	journal	May 2004
Crystallographic and Mutational Studies of Mycobacterium tuberculosis recA Mini-inteins Suggest a Pivotal Role for a Highly Conserved Aspartate Residue Van Roey, Patrick; Pereira, Brian; Li, Zhong Journal of Molecular Biology, Vol. 367, Issue 1 https://doi.org/10.1016/j.jmb.2006.12.050	journal	March 2007
Prp8 intein in fungal pathogens: target for potential antifungal drugs Liu, Xiang-Qin; Yang, Jing FEBS Letters, Vol. 572, Issue 1-3 https://doi.org/10.1016/j.febslet.2004.07.016	journal	July 2004
Cryptococcal Meningitis Treatment Strategies in Resource-Limited Settings: A Cost-Effectiveness Analysis Rajasingham, Radha; Rolfes, Melissa A.; Birkenkamp, Kate E. PLoS Medicine, Vol. 9, Issue 9 https://doi.org/10.1371/journal.pmed.1001316	journal	September 2012
Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America Walsh, Thomas J.; Anaissie, Elias J.; Denning, David W. Clinical Infectious Diseases, Vol. 46, Issue 3 https://doi.org/10.1086/525258	journal	February 2008
Global burden of chronic pulmonary aspergillosis complicating sarcoidosis Denning, David W.; Pleuvry, Alex; Cole, Donald C. European Respiratory Journal, Vol. 41, Issue 3 https://doi.org/10.1183/09031936.00226911	journal	June 2012
Liposomal Amphotericin B: A Review of its Use as Empirical Therapy in Febrile Neutropenia and in the Treatment of Invasive Fungal Infections Moen, Marit D.; Lyseng-Williamson, Katherine A.; Scott, Lesley J. Drugs, Vol. 69, Issue 3 https://doi.org/10.2165/00003495-200969030-00010	journal	January 2009
Prp8 protein: At the heart of the spliceosome Grainger, R. J. RNA, Vol. 11, Issue 5 https://doi.org/10.1261/rna.2220705	journal	May 2005
Sequence requirements for splicing by the Cne PRP8 intein Pearl, Esther J.; Tyndall, Joel D. A.; Poulter, Russell T. M. FEBS Letters, Vol. 581, Issue 16 https://doi.org/10.1016/j.febslet.2007.05.060	journal	May 2007
Protein Splicing: How Inteins Escape from Precursor Proteins Mills, Kenneth V.; Johnson, Margaret A.; Perler, Francine B. Journal of Biological Chemistry, Vol. 289, Issue 21 https://doi.org/10.1074/jbc.R113.540310	journal	April 2014
Practice Guidelines for the Management of Cryptococcal Disease Saag, M. S.; Graybill, R. J.; Larsen, R. A. Clinical Infectious Diseases, Vol. 30, Issue 4 https://doi.org/10.1086/313757	journal	April 2000
Fungal diagnosis: how do we do it and can we do better? Perfect, John R. Current Medical Research and Opinion, Vol. 29, Issue sup4 https://doi.org/10.1185/03007995.2012.761134	journal	April 2013
Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction Li, Zhong; Brecher, Matthew; Deng, Yong-Qiang Cell Research, Vol. 27, Issue 8 https://doi.org/10.1038/cr.2017.88	journal	July 2017
Minimization and stabilization of the Mycobacterium tuberculosis recA intein Hiraga, Kaori; Derbyshire, Victoria; Dansereau, John T. Journal of Molecular Biology, Vol. 354, Issue 4 https://doi.org/10.1016/j.jmb.2005.09.088	journal	December 2005
Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance Ghannoum, Mahmoud A.; Rice, Louis B. Clinical Microbiology Reviews, Vol. 12, Issue 4 https://doi.org/10.1128/CMR.12.4.501	journal	October 1999
SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses Topilina, Natalya I.; Green, Cathleen M.; Jayachandran, Pradeepa Proceedings of the National Academy of Sciences, Vol. 112, Issue 33 https://doi.org/10.1073/pnas.1512777112	journal	August 2015
Relapsing meningitis caused by persistent cryptococcal antigens and immune reconstitution after the initiation of highly active antiretroviral therapy Boelaert, Johan R.; Goddeeris, Karel H.; Vanopdenbosch, Ludo J. AIDS, Vol. 18, Issue 8 https://doi.org/10.1097/00002030-200405210-00023	journal	January 2004
Crystal Structure of a Mini-intein Reveals a Conserved Catalytic Module Involved in Side Chain Cyclization of Asparagine during Protein Splicing Ding, Yi; Xu, Ming-Qun; Ghosh, Inca Journal of Biological Chemistry, Vol. 278, Issue 40 https://doi.org/10.1074/jbc.M306197200	journal	July 2003
A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions Higuchi, Russell; Krummel, Barbara; Saiki, Randall Nucleic Acids Research, Vol. 16, Issue 15 https://doi.org/10.1093/nar/16.15.7351	journal	January 1988
High resolution crystal structure of domain I of the Saccharomyces cerevisiae homing endonuclease PI-SceI Werner, E. Nucleic Acids Research, Vol. 30, Issue 18 https://doi.org/10.1093/nar/gkf523	journal	September 2002
Evaluation of Endpoints for Antifungal Susceptibility Determinations with LY303366 Klepser, Michael E.; Ernst, Erika J.; Ernst, Michael E. Antimicrobial Agents and Chemotherapy, Vol. 42, Issue 6 https://doi.org/10.1128/AAC.42.6.1387	journal	June 1998
Monitoring Protein−Protein Interactions Using Split Synthetic Renilla Luciferase Protein-Fragment-Assisted Complementation Paulmurugan, R.; Gambhir, S. S. Analytical Chemistry, Vol. 75, Issue 7 https://doi.org/10.1021/ac020731c	journal	April 2003
Zygomycosis in a Tertiary‐Care Cancer Center in the Era of Aspergillus‐ Active Antifungal Therapy: A Case‐Control Observational Study of 27 Recent Cases Kontoyiannis, Dimitrios P.; Lionakis, Michail S.; Lewis, Russell E. The Journal of Infectious Diseases, Vol. 191, Issue 8 https://doi.org/10.1086/428780	journal	April 2005
The PRP8 inteins in Cryptococcus are a source of phylogenetic and epidemiological information Butler, Margaret I.; Poulter, Russell T. M. Fungal Genetics and Biology, Vol. 42, Issue 5 https://doi.org/10.1016/j.fgb.2005.01.011	journal	May 2005
Structural and Dynamical Features of Inteins and Implications on Protein Splicing Eryilmaz, Ertan; Shah, Neel H.; Muir, Tom W. Journal of Biological Chemistry, Vol. 289, Issue 21 https://doi.org/10.1074/jbc.R113.540302	journal	April 2014
A Diverse Population of Cryptococcus gattii Molecular Type VGIII in Southern Californian HIV/AIDS Patients Byrnes, Edmond J.; Li, Wenjun; Ren, Ping PLoS Pathogens, Vol. 7, Issue 9 https://doi.org/10.1371/journal.ppat.1002205	journal	September 2011
Hidden Killers: Human Fungal Infections Brown, G. D.; Denning, D. W.; Gow, N. A. R. Science Translational Medicine, Vol. 4, Issue 165 https://doi.org/10.1126/scitranslmed.3004404	journal	December 2012
Mycobacterial DnaB helicase intein as oxidative stress sensor Kelley, Danielle S.; Lennon, Christopher W.; Li, Zhong Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-06554-x	journal	October 2018

Similar Records

Natural cellular resistance of beige mice against Cryptococcus neoformans

Journal Article · 1986 · J. Immunol.; (United States) · OSTI ID:6830070

Hidore, M R; Murphy, J W

The Structure of Cryptococcus Neoformans Thymidylate Synthase Suggests Strategies for Using Target Dynamics for Species-Specific Inhibition

Journal Article · 2006 · Acta Crystallogr.D Biol.Crystallogr.61:1320,2005 · OSTI ID:892583

Finer-Moore, J S; Anderson, A C; O'Neil, R H; +4 more

Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens

Journal Article · 2012 · J. Biol. Chem. · OSTI ID:1041325

Hast, Michael A; Nichols, Connie B; Armstrong, Stephanie M; +4 more

Title: Cisplatin protects mice from challenge of Cryptococcus neoformans by targeting the Prp8 intein

Citation Formats

References (66)

Similar Records

Related Subjects