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Title: Nanoparticle diffusion in sheared cellular blood flow

Abstract

Using a multiscale blood flow solver, the complete diffusion tensor of nanoparticles (NPs) in sheared cellular blood flow is calculated over a wide range of shear rate and haematocrit. In the short-time regime, NPs exhibit anomalous dispersive behaviors under high shear and high haematocrit due to the transient elongation and alignment of the red blood cells (RBCs). In the long-time regime, the NP diffusion tensor features high anisotropy. Particularly, there exists a critical shear rate ($${\sim}100~\text{s}^{-1}$$) around which the shear-rate dependence of the diffusivity tensor changes from linear to nonlinear scale. Above the critical shear rate, the cross-stream diffusivity terms vary sublinearly with shear rate, while the longitudinal term varies superlinearly. The dependence on haematocrit is linear in general except at high shear rates, where a sublinear scale is found for the vorticity term and a quadratic scale for the longitudinal term. Through analysis of the suspension microstructure and numerical experiments, the nonlinear haemorheological dependence of the NP diffusion tensor is attributed to the streamwise elongation and cross-stream contraction of RBCs under high shear, quantified by a capillary number. The RBC size is shown to be the characteristic length scale affecting the RBC-enhanced shear-induced diffusion (RESID), while the NP submicrometre size exhibits negligible influence on the RESID. Based on the observed scaling behaviours, empirical correlations are proposed to bridge the NP diffusion tensor to specific shear rate and haematocrit. As a result, the characterized NP diffusion tensor provides a constitutive relation that can lead to more effective continuum models to tackle large-scale NP biotransport applications.

Authors:
ORCiD logo [1];  [2];  [2]; ORCiD logo [1]
  1. Georgia Inst. of Technology, Atlanta, GA (United States)
  2. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1529001
Report Number(s):
SAND-2019-3969J
Journal ID: ISSN 0022-1120; 674532
Grant/Contract Number:  
AC04-94AL85000
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Fluid Mechanics
Additional Journal Information:
Journal Volume: 871; Journal ID: ISSN 0022-1120
Publisher:
Cambridge University Press
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; 60 APPLIED LIFE SCIENCES; Blood flow; Suspensions; Particle/fluid flows

Citation Formats

Liu, Zixiang, Clausen, Jonathan R., Rao, Rekha R., and Aidun, Cyrus K. Nanoparticle diffusion in sheared cellular blood flow. United States: N. p., 2019. Web. doi:10.1017/jfm.2019.320.
Liu, Zixiang, Clausen, Jonathan R., Rao, Rekha R., & Aidun, Cyrus K. Nanoparticle diffusion in sheared cellular blood flow. United States. doi:10.1017/jfm.2019.320.
Liu, Zixiang, Clausen, Jonathan R., Rao, Rekha R., and Aidun, Cyrus K. Fri . "Nanoparticle diffusion in sheared cellular blood flow". United States. doi:10.1017/jfm.2019.320. https://www.osti.gov/servlets/purl/1529001.
@article{osti_1529001,
title = {Nanoparticle diffusion in sheared cellular blood flow},
author = {Liu, Zixiang and Clausen, Jonathan R. and Rao, Rekha R. and Aidun, Cyrus K.},
abstractNote = {Using a multiscale blood flow solver, the complete diffusion tensor of nanoparticles (NPs) in sheared cellular blood flow is calculated over a wide range of shear rate and haematocrit. In the short-time regime, NPs exhibit anomalous dispersive behaviors under high shear and high haematocrit due to the transient elongation and alignment of the red blood cells (RBCs). In the long-time regime, the NP diffusion tensor features high anisotropy. Particularly, there exists a critical shear rate (${\sim}100~\text{s}^{-1}$) around which the shear-rate dependence of the diffusivity tensor changes from linear to nonlinear scale. Above the critical shear rate, the cross-stream diffusivity terms vary sublinearly with shear rate, while the longitudinal term varies superlinearly. The dependence on haematocrit is linear in general except at high shear rates, where a sublinear scale is found for the vorticity term and a quadratic scale for the longitudinal term. Through analysis of the suspension microstructure and numerical experiments, the nonlinear haemorheological dependence of the NP diffusion tensor is attributed to the streamwise elongation and cross-stream contraction of RBCs under high shear, quantified by a capillary number. The RBC size is shown to be the characteristic length scale affecting the RBC-enhanced shear-induced diffusion (RESID), while the NP submicrometre size exhibits negligible influence on the RESID. Based on the observed scaling behaviours, empirical correlations are proposed to bridge the NP diffusion tensor to specific shear rate and haematocrit. As a result, the characterized NP diffusion tensor provides a constitutive relation that can lead to more effective continuum models to tackle large-scale NP biotransport applications.},
doi = {10.1017/jfm.2019.320},
journal = {Journal of Fluid Mechanics},
number = ,
volume = 871,
place = {United States},
year = {2019},
month = {5}
}

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