Gadolinium vanadate nanocrystals as carriers of α-emitters (225Ac,227Th) and contrast agents

Toro-González, Miguel; Dame, Ashley N.; Mirzadeh, Saed; Rojas, Jessika V.

doi:10.1063/1.5096880

Title: Gadolinium vanadate nanocrystals as carriers of α-emitters (²²⁵Ac,²²⁷Th) and contrast agents

Journal Article · 04 June 2019 · Journal of Applied Physics

DOI: https://doi.org/10.1063/1.5096880 · OSTI ID:1524884

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Virginia Commonwealth Univ., Richmond, VA (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Virginia Commonwealth Univ., Richmond, VA (United States)

Gadolinium vanadate (GdVO₄) core and core +2 shell nanocrystals (NCs) were evaluated for in vitro retention of ²²⁵Ac, ²²⁷Th, and their first decay daughters, ²²¹Fr and ²²³Ra, respectively. GdVO₄ NCs with a tetragonal crystal system (zircon-type) and spherical morphology were obtained by precipitation of GdCl₃ and Na₃VO₄ using sodium citrate as a complexing agent. The growth of two nonradioactive GdVO₄ shells on both Gd(²²⁵Ac)VO₄ and Gd(²²⁷Th)VO₄ core NCs was demonstrated by an increase of 0.7 nm and 2 nm in the crystallite size, respectively. The maximum leakage of ²²⁵Ac was 15% and 2.4% from core and core + 2 shells, whereas the leakage of ²²⁷Th was 3% and 1.5%, respectively. The presence of two nonradioactive GdVO₄ shells increased the retention of ²²¹Fr and ²²³Ra by 20% and 15% with respect to core NCs. Furthermore, a longitudinal proton relaxivity, r₁ = 0.9289 s^–1 mM^–1, confirmed their potential application as contrast agents for magnetic resonance imaging. In summary, GdVO₄ NCs show promising capabilities as radionuclide carriers with partial retention of decay daughters and as contrast agents for theranostic applications.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1524884

Journal Information:: Journal of Applied Physics, Vol. 125, Issue 21; ISSN 0021-8979

Publisher:: American Institute of Physics (AIP)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 18 works

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Title: Gadolinium vanadate nanocrystals as carriers of α-emitters (²²⁵Ac,²²⁷Th) and contrast agents