skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

This content will become publicly available on June 4, 2020

Title: Gadolinium vanadate nanocrystals as carriers of α-emitters ( 225Ac, 227Th) and contrast agents

Abstract

Gadolinium vanadate (GdVO 4) core and core +2 shell nanocrystals (NCs) were evaluated for in vitro retention of 225Ac, 227Th, and their first decay daughters, 221Fr and 223Ra, respectively. GdVO 4 NCs with a tetragonal crystal system (zircon-type) and spherical morphology were obtained by precipitation of GdCl 3 and Na 3VO 4 using sodium citrate as a complexing agent. The growth of two nonradioactive GdVO 4 shells on both Gd( 225Ac)VO 4 and Gd( 227Th)VO 4 core NCs was demonstrated by an increase of 0.7 nm and 2 nm in the crystallite size, respectively. The maximum leakage of 225Ac was 15% and 2.4% from core and core + 2 shells, whereas the leakage of 227Th was 3% and 1.5%, respectively. The presence of two nonradioactive GdVO 4 shells increased the retention of 221Fr and 223Ra by 20% and 15% with respect to core NCs. Furthermore, a longitudinal proton relaxivity, r 1 = 0.9289 s –1 mM –1, confirmed their potential application as contrast agents for magnetic resonance imaging. In summary, GdVO 4 NCs show promising capabilities as radionuclide carriers with partial retention of decay daughters and as contrast agents for theranostic applications.

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [2]; ORCiD logo [3]
  1. Virginia Commonwealth Univ., Richmond, VA (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  3. Virginia Commonwealth Univ., Richmond, VA (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1524884
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Applied Physics
Additional Journal Information:
Journal Volume: 125; Journal Issue: 21; Journal ID: ISSN 0021-8979
Publisher:
American Institute of Physics (AIP)
Country of Publication:
United States
Language:
English
Subject:
73 NUCLEAR PHYSICS AND RADIATION PHYSICS; Actinium-225; thorium-227; radionuclide retention; multifunctional nanocrystals; gadolinium vanadate

Citation Formats

Toro-González, Miguel, Dame, Ashley N., Mirzadeh, Saed, and Rojas, Jessika V. Gadolinium vanadate nanocrystals as carriers of α-emitters (225Ac,227Th) and contrast agents. United States: N. p., 2019. Web. doi:10.1063/1.5096880.
Toro-González, Miguel, Dame, Ashley N., Mirzadeh, Saed, & Rojas, Jessika V. Gadolinium vanadate nanocrystals as carriers of α-emitters (225Ac,227Th) and contrast agents. United States. doi:10.1063/1.5096880.
Toro-González, Miguel, Dame, Ashley N., Mirzadeh, Saed, and Rojas, Jessika V. Tue . "Gadolinium vanadate nanocrystals as carriers of α-emitters (225Ac,227Th) and contrast agents". United States. doi:10.1063/1.5096880.
@article{osti_1524884,
title = {Gadolinium vanadate nanocrystals as carriers of α-emitters (225Ac,227Th) and contrast agents},
author = {Toro-González, Miguel and Dame, Ashley N. and Mirzadeh, Saed and Rojas, Jessika V.},
abstractNote = {Gadolinium vanadate (GdVO4) core and core +2 shell nanocrystals (NCs) were evaluated for in vitro retention of 225Ac, 227Th, and their first decay daughters, 221Fr and 223Ra, respectively. GdVO4 NCs with a tetragonal crystal system (zircon-type) and spherical morphology were obtained by precipitation of GdCl3 and Na3VO4 using sodium citrate as a complexing agent. The growth of two nonradioactive GdVO4 shells on both Gd(225Ac)VO4 and Gd(227Th)VO4 core NCs was demonstrated by an increase of 0.7 nm and 2 nm in the crystallite size, respectively. The maximum leakage of 225Ac was 15% and 2.4% from core and core + 2 shells, whereas the leakage of 227Th was 3% and 1.5%, respectively. The presence of two nonradioactive GdVO4 shells increased the retention of 221Fr and 223Ra by 20% and 15% with respect to core NCs. Furthermore, a longitudinal proton relaxivity, r1 = 0.9289 s–1 mM–1, confirmed their potential application as contrast agents for magnetic resonance imaging. In summary, GdVO4 NCs show promising capabilities as radionuclide carriers with partial retention of decay daughters and as contrast agents for theranostic applications.},
doi = {10.1063/1.5096880},
journal = {Journal of Applied Physics},
number = 21,
volume = 125,
place = {United States},
year = {2019},
month = {6}
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on June 4, 2020
Publisher's Version of Record

Save / Share:

Works referenced in this record:

In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia
journal, August 2016


Europium-doped GdVO4 nanocrystals as a luminescent probe for hydrogen peroxide and for enzymatic sensing of glucose
journal, March 2017


Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy
journal, January 2013



journal, June 2014


Targeted Alpha-Particle Therapy with 227Th-Labeled Antibodies
journal, September 2008


Lanthanide-based nanocrystals as dual-modal probes for SPECT and X-ray CT imaging
journal, May 2014


Paramagnetic nanoparticles as potential MRI contrast agents: characterization, NMR relaxation, simulations and theory
journal, July 2012

  • Vuong, Quoc Lam; Van Doorslaer, Sabine; Bridot, Jean-Luc
  • Magnetic Resonance Materials in Physics, Biology and Medicine, Vol. 25, Issue 6
  • DOI: 10.1007/s10334-012-0326-7

Radiation resistance of LaPO4 (monazite structure) and YbPO4 (zircon structure) from data of computer simulation
journal, September 2013

  • Grechanovsky, A. E.; Eremin, N. N.; Urusov, V. S.
  • Physics of the Solid State, Vol. 55, Issue 9
  • DOI: 10.1134/S1063783413090138

Synthesis and targeting of gold-coated 177 Lu-containing lanthanide phosphate nanoparticles—A potential theranostic agent for pulmonary metastatic disease
journal, March 2018

  • Sobol, Nicholas; Sutherlin, Logan; Cedrowska, Edyta
  • APL Bioengineering, Vol. 2, Issue 1
  • DOI: 10.1063/1.5018165

Preparation of TH 227 -Labeled Radioimmunoconjugates, Assessment of Serum Stability and Antigen Binding Ability
journal, June 2007

  • Larsen, Roy H.; Borrebaek, Jorgen; Dahle, Jostein
  • Cancer Biotherapy and Radiopharmaceuticals, Vol. 22, Issue 3
  • DOI: 10.1089/cbr.2006.321

An overview of targeted alpha therapy
journal, December 2011


Improved 225 Ac daughter retention in InPO 4 containing polymersomes
journal, October 2017


Radionuclide carriers for targeting of cancer
journal, June 2008


Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications
journal, July 2013


Multifunctional Rare-Earth Vanadate Nanoparticles: Luminescent Labels, Oxidant Sensors, and MRI Contrast Agents
journal, October 2014

  • Abdesselem, Mouna; Schoeffel, Markus; Maurin, Isabelle
  • ACS Nano, Vol. 8, Issue 11
  • DOI: 10.1021/nn504170x

SRIM – The stopping and range of ions in matter (2010)
journal, June 2010

  • Ziegler, James F.; Ziegler, M. D.; Biersack, J. P.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 268, Issue 11-12
  • DOI: 10.1016/j.nimb.2010.02.091

LaPO 4 Nanoparticles Doped with Actinium-225 that Partially Sequester Daughter Radionuclides
journal, April 2011

  • Woodward, Jonathan; Kennel, Stephen J.; Stuckey, Alan
  • Bioconjugate Chemistry, Vol. 22, Issue 4
  • DOI: 10.1021/bc100574f

Multifunctional GdVO 4 :Eu core–shell nanoparticles containing 225 Ac for targeted alpha therapy and molecular imaging
journal, January 2018

  • Toro-González, M.; Copping, R.; Mirzadeh, S.
  • Journal of Materials Chemistry B, Vol. 6, Issue 47
  • DOI: 10.1039/C8TB02173B

LnPO 4 Nanoparticles Doped with Ac-225 and Sequestered Daughters for Targeted Alpha Therapy
journal, February 2014

  • McLaughlin, Mark F.; Robertson, David; Pevsner, Paul H.
  • Cancer Biotherapy and Radiopharmaceuticals, Vol. 29, Issue 1
  • DOI: 10.1089/cbr.2013.1546

The green upconversion emission mechanism investigation of GdVO4:Yb3+, Er3+ via tuning of the sensitizer concentration
journal, April 2015


Alpha self-irradiation effects in ternary oxides of actinides elements: The zircon-like phases AmIIIVO4 and AIINpIV(VO4)2 (A=Sr, Pb)
journal, June 2005


Functionalized NaA nanozeolites labeled with 224,225Ra for targeted alpha therapy
journal, October 2013

  • Piotrowska, Agata; Leszczuk, Edyta; Bruchertseifer, Frank
  • Journal of Nanoparticle Research, Vol. 15, Issue 11
  • DOI: 10.1007/s11051-013-2082-7

Targeted alpha therapy using a novel CD70 targeted thorium-227 conjugate in <i>in vitro</i> and <i>in vivo</i> models of renal cell carcinoma
journal, April 2017


Enhanced Retention of the α-Particle-Emitting Daughters of Actinium-225 by Liposome Carriers
journal, November 2007

  • Sofou, Stavroula; Kappel, Barry J.; Jaggi, Jaspreet S.
  • Bioconjugate Chemistry, Vol. 18, Issue 6
  • DOI: 10.1021/bc070075t

The therapeutic potential of polymersomes loaded with 225Ac evaluated in 2D and 3D in vitro glioma models
journal, June 2018

  • de Kruijff, R. M.; van der Meer, A. J. G. M.; Windmeijer, C. A. A.
  • European Journal of Pharmaceutics and Biopharmaceutics, Vol. 127
  • DOI: 10.1016/j.ejpb.2018.02.008

Synthesis, structure and spectroscopic properties of luminescent GdVO 4 :Dy 3+ and DyVO 4 particles
journal, February 2018


Ultra-wide range field-dependent measurements of the relaxivity of Gd1−xEuxVO4 nanoparticle contrast agents using a mechanical sample-shuttling relaxometer
journal, March 2017

  • Chou, Ching-Yu; Abdesselem, Mouna; Bouzigues, Cedric
  • Scientific Reports, Vol. 7, Issue 1
  • DOI: 10.1038/srep44770

Functionalized TiO2 nanoparticles labelled with 225Ac for targeted alpha radionuclide therapy
journal, March 2018

  • Cędrowska, Edyta; Pruszynski, Marek; Majkowska-Pilip, Agnieszka
  • Journal of Nanoparticle Research, Vol. 20, Issue 3
  • DOI: 10.1007/s11051-018-4181-y

Lanthanides: Applications in Cancer Diagnosis and Therapy: Miniperspective
journal, February 2016


Synthesis and Characterizations of YVO 4 :Eu Colloids
journal, May 2002

  • Huignard, A.; Buissette, V.; Laurent, G.
  • Chemistry of Materials, Vol. 14, Issue 5
  • DOI: 10.1021/cm011263a

Surface modified Eu:GdVO4 nanocrystals for optical and MRI imaging
journal, January 2013

  • Nuñez, Nuria O.; Rivera, Sara; Alcantara, David
  • Dalton Transactions, Vol. 42, Issue 30
  • DOI: 10.1039/c3dt50676b

The Scherrer equation versus the 'Debye-Scherrer equation'
journal, August 2011



journal, March 2015


Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications
journal, June 2017

  • Escudero, Alberto; Becerro, Ana I.; Carrillo-Carrión, Carolina
  • Nanophotonics, Vol. 6, Issue 5
  • DOI: 10.1515/nanoph-2017-0007

A Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters?
journal, June 2015

  • de Kruijff, Robin; Wolterbeek, Hubert; Denkova, Antonia
  • Pharmaceuticals, Vol. 8, Issue 2
  • DOI: 10.3390/ph8020321

Production of actinium-225 for alpha particle mediated radioimmunotherapy
journal, May 2005


A random walk approach to estimate the confinement of α-particle emitters in nanoparticles for targeted radionuclide therapy
journal, May 2018

  • Holzwarth, Uwe; Ojea Jimenez, Isaac; Calzolai, Luigi
  • EJNMMI Radiopharmacy and Chemistry, Vol. 3, Issue 1
  • DOI: 10.1186/s41181-018-0042-3

Biological Applications of Rare-Earth Based Nanoparticles
journal, October 2011

  • Bouzigues, Cedric; Gacoin, Thierry; Alexandrou, Antigoni
  • ACS Nano, Vol. 5, Issue 11
  • DOI: 10.1021/nn202378b

Gadolinium-based contrast agents: A comprehensive risk assessment: Gadolinium Risk Assessment
journal, January 2017

  • Fraum, Tyler J.; Ludwig, Daniel R.; Bashir, Mustafa R.
  • Journal of Magnetic Resonance Imaging, Vol. 46, Issue 2
  • DOI: 10.1002/jmri.25625

Mesoporous silica-coated luminescent Eu 3+ doped GdVO 4 nanoparticles for multimodal imaging and drug delivery
journal, January 2014

  • Kim, Taeho; Lee, Nohyun; Park, Yong Il
  • RSC Adv., Vol. 4, Issue 86
  • DOI: 10.1039/C4RA06628F

Radium Ra 223 Dichloride Injection: U.S. Food and Drug Administration Drug Approval Summary
journal, November 2013


Re-dispersion and film formation of GdVO4 :  Ln3+ (Ln3+ = Dy3+, Eu3+, Sm3+, Tm3+) nanoparticles: particle size and luminescence studies
journal, January 2012

  • Shanta Singh, N.; Ningthoujam, R. S.; Phaomei, Ganngam
  • Dalton Transactions, Vol. 41, Issue 15
  • DOI: 10.1039/c2dt12190e

Synthesis and characterization of intrinsically radiolabeled lanthanide phosphate nanoparticles toward biomedical and environmental applications
journal, September 2018

  • Toro-González, M.; Clifford, D. M.; Copping, R.
  • Journal of Nanoparticle Research, Vol. 20, Issue 9
  • DOI: 10.1007/s11051-018-4338-8

Nanozeolite bioconjugates labeled with 223 Ra for targeted alpha therapy
journal, April 2017


Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy
journal, July 2015


The theory of Ostwald ripening
journal, January 1985

  • Voorhees, P. W.
  • Journal of Statistical Physics, Vol. 38, Issue 1-2
  • DOI: 10.1007/BF01017860

In Vitro Cytotoxicity of Low-Dose-Rate Radioimmunotherapy by the Alpha-Emitting Radioimmunoconjugate Thorium-227–DOTA–Rituximab
journal, November 2009

  • Dahle, Jostein; Krogh, Cecilie; Melhus, Katrine B.
  • International Journal of Radiation Oncology*Biology*Physics, Vol. 75, Issue 3
  • DOI: 10.1016/j.ijrobp.2009.04.062

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy
journal, April 2015


Multifunctional Eu3+- and Er3+/Yb3+-doped GdVO4 nanoparticles synthesized by reverse micelle method
journal, February 2014

  • Gavrilović, Tamara V.; Jovanović, Dragana J.; Lojpur, Vesna
  • Scientific Reports, Vol. 4, Issue 1
  • DOI: 10.1038/srep04209

Radioimmunotherapy of Breast Cancer Metastases with  -Particle Emitter 225Ac: Comparing Efficacy with 213Bi and 90Y
journal, November 2009


Relative Biologic Effects of Low-Dose-Rate α-Emitting 227Th-Rituximab and β-Emitting 90Y-Tiuexetan-Ibritumomab Versus External Beam X-Radiation
journal, September 2008

  • Dahle, Jostein; Bruland, Øyvind S.; Larsen, Roy H.
  • International Journal of Radiation Oncology*Biology*Physics, Vol. 72, Issue 1
  • DOI: 10.1016/j.ijrobp.2008.05.029

Evaluation of 225 Ac for Vascular Targeted Radioimmunotherapy of Lung Tumors
journal, June 2000

  • Kennel, Stephen J.; Chappell, Lara L.; Dadachova, Kate
  • Cancer Biotherapy and Radiopharmaceuticals, Vol. 15, Issue 3
  • DOI: 10.1089/108497800414329

Initial evaluation of 227Th-p-benzyl-DOTA-rituximab for low-dose rate α-particle radioimmunotherapy
journal, February 2006


Engineering lanthanide-based materials for nanomedicine
journal, September 2014


Targeted cancer therapy with a novel low-dose rate α-emitting radioimmunoconjugate
journal, September 2007


Displacive radiation effects in the monazite- and zircon-structure orthophosphates
journal, December 1997


Multicolor upconversion luminescence of GdVO 4 :Ln 3+ /Yb 3+ (Ln 3+  = Ho 3+ , Er 3+ , Tm 3+ , Ho 3+ /Er 3+ /Tm 3+ ) nanorods
journal, March 2016


Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles
journal, February 2014