Current concepts on epilepsy management in tuberous sclerosis complex
Abstract
Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease affecting approximately 1 in 6,000 people, and represents one of the most common genetic causes of epilepsy. Epilepsy affects 90% of the patients and appears in the first 2 years of life in the majority of them. Early onset of epilepsy in the first 12 months of life is associated with high risk of cognitive decline and neuropsychiatric problems including autism. Prenatal or early infantile diagnosis of TSC, before the onset of epilepsy, provides a unique opportunity to monitor EEG before the onset of clinical seizures, thus enabling early intervention in the process of epileptogenesis. In this review, we discuss the current status of knowledge on epileptogenesis in TSC, and present recommendations of American and European experts in the field of epilepsy.
- Authors:
-
- Child Neuropsychiatry Unit ‐ Epilepsy Center, San Paolo Hospital, Department of Health Sciences Università degli Studi di Milano Milan Italy
- Department of Neurology and Epileptology The Children's Memorial Health Institute Warsaw Poland
- Department of Pediatric Neuropsychiatry Tor Vergata University Rome Italy
- Child Neuropsychiatry Unit ‐ Epilepsy Center, San Paolo Hospital, Department of Health Sciences Università degli Studi di Milano Milan Italy, Division of Medical Genetics, Department of Pediatrics University of Utah Salt Lake City Utah
- Department of Neurology and Epileptology The Children's Memorial Health Institute Warsaw Poland, Department of Pediatric Neurology Warsaw Medical University Warsaw Poland
- Department of Pediatric Neurology Warsaw Medical University Warsaw Poland
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1524464
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- American Journal of Medical Genetics Part C: Seminars in Medical Genetics
- Additional Journal Information:
- Journal Name: American Journal of Medical Genetics Part C: Seminars in Medical Genetics Journal Volume: 178 Journal Issue: 3; Journal ID: ISSN 1552-4868
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Citation Formats
Canevini, Maria Paola, Kotulska‐Jozwiak, Katarzyna, Curatolo, Paolo, La Briola, Francesca, Peron, Angela, Słowińska, Monika, Strzelecka, Jolanta, Vignoli, Aglaia, and Jóźwiak, Sergiusz. Current concepts on epilepsy management in tuberous sclerosis complex. Country unknown/Code not available: N. p., 2018.
Web. doi:10.1002/ajmg.c.31652.
Canevini, Maria Paola, Kotulska‐Jozwiak, Katarzyna, Curatolo, Paolo, La Briola, Francesca, Peron, Angela, Słowińska, Monika, Strzelecka, Jolanta, Vignoli, Aglaia, & Jóźwiak, Sergiusz. Current concepts on epilepsy management in tuberous sclerosis complex. Country unknown/Code not available. https://doi.org/10.1002/ajmg.c.31652
Canevini, Maria Paola, Kotulska‐Jozwiak, Katarzyna, Curatolo, Paolo, La Briola, Francesca, Peron, Angela, Słowińska, Monika, Strzelecka, Jolanta, Vignoli, Aglaia, and Jóźwiak, Sergiusz. Wed .
"Current concepts on epilepsy management in tuberous sclerosis complex". Country unknown/Code not available. https://doi.org/10.1002/ajmg.c.31652.
@article{osti_1524464,
title = {Current concepts on epilepsy management in tuberous sclerosis complex},
author = {Canevini, Maria Paola and Kotulska‐Jozwiak, Katarzyna and Curatolo, Paolo and La Briola, Francesca and Peron, Angela and Słowińska, Monika and Strzelecka, Jolanta and Vignoli, Aglaia and Jóźwiak, Sergiusz},
abstractNote = {Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease affecting approximately 1 in 6,000 people, and represents one of the most common genetic causes of epilepsy. Epilepsy affects 90% of the patients and appears in the first 2 years of life in the majority of them. Early onset of epilepsy in the first 12 months of life is associated with high risk of cognitive decline and neuropsychiatric problems including autism. Prenatal or early infantile diagnosis of TSC, before the onset of epilepsy, provides a unique opportunity to monitor EEG before the onset of clinical seizures, thus enabling early intervention in the process of epileptogenesis. In this review, we discuss the current status of knowledge on epileptogenesis in TSC, and present recommendations of American and European experts in the field of epilepsy.},
doi = {10.1002/ajmg.c.31652},
journal = {American Journal of Medical Genetics Part C: Seminars in Medical Genetics},
number = 3,
volume = 178,
place = {Country unknown/Code not available},
year = {Wed Sep 26 00:00:00 EDT 2018},
month = {Wed Sep 26 00:00:00 EDT 2018}
}
https://doi.org/10.1002/ajmg.c.31652
Web of Science
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