Jörg Langowski: his scientific legacy and the future it promises

Chirico, Giuseppe; Gansen, Alexander; Leuba, Sanford H.; Olins, Ada L.; Smith, Jeremy C.; Toth, Katalin

doi:10.1186/s13628-018-0045-1

Title: Jörg Langowski: his scientific legacy and the future it promises

Journal Article · 16 July 2018 · BMC Biophysics

DOI: https://doi.org/10.1186/s13628-018-0045-1 · OSTI ID:1523723

^[1]; Gansen, Alexander ^[2]; Leuba, Sanford H. ^[3]; Olins, Ada L. ^[4];

^[5]; Toth, Katalin ^[2]

Universita di Milano-Bicocca, Milan (Italy)
Deutsches Krebsforschungszentrum, Heidelberg (Germany)
Univ. of Pittsburgh School of Medicine, Pittsburgh, PA (United States)
Univ. of New England, Portland, ME (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)

Background: With the passing of Jörg Langowski 6 May 2017 in a sailplane accident, the scientific community was deprived of a strident and effective voice for DNA and chromatin molecular and computational biophysics, for open access publishing and for the creation of effective scientific research networks.Methods: In this work, after reviewing some of Jörg’s key research contributions and ideas, we offer through the personal remembrance of his closest collaborators, a deep analysis of the major results of his research and the future directions they have engendered.Conclusions: The legacy of Jörg Langowski has been to propel a way of viewing biological function that considers living systems as dynamic and in three dimensions. This physical view of biology that he pioneered is now, finally, becoming established also because of his great effort.

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Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1523723

Journal Information:: BMC Biophysics, Journal Name: BMC Biophysics Journal Issue: 1 Vol. 11; ISSN 2046-1682

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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Histone fold modifications control nucleosome unwrapping and disassembly Simon, M.; North, J. A.; Shimko, J. C. Proceedings of the National Academy of Sciences, Vol. 108, Issue 31 https://doi.org/10.1073/pnas.1106264108	journal	July 2011
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Histone Octamer Instability under Single Molecule Experiment Conditions Claudet, Cyril; Angelov, Dimitar; Bouvet, Philippe Journal of Biological Chemistry, Vol. 280, Issue 20 https://doi.org/10.1074/jbc.M500121200	journal	March 2005
The effect of DNA supercoiling on nucleosome structure and stability Elbel, Tabea; Langowski, Jörg Journal of Physics: Condensed Matter, Vol. 27, Issue 6 https://doi.org/10.1088/0953-8984/27/6/064105	journal	January 2015
Nucleosome accessibility governed by the dimer/tetramer interface Böhm, Vera; Hieb, Aaron R.; Andrews, Andrew J. Nucleic Acids Research, Vol. 39, Issue 8 https://doi.org/10.1093/nar/gkq1279	journal	December 2010
Regulation of the nucleosome unwrapping rate controls DNA accessibility North, Justin A.; Shimko, John C.; Javaid, Sarah Nucleic Acids Research, Vol. 40, Issue 20 https://doi.org/10.1093/nar/gks747	journal	September 2012
Opposing roles of H3- and H4-acetylation in the regulation of nucleosome structure—a FRET study Gansen, Alexander; Tóth, Katalin; Schwarz, Nathalie Nucleic Acids Research, Vol. 43, Issue 3 https://doi.org/10.1093/nar/gku1354	journal	January 2015
Revealing transient structures of nucleosomes as DNA unwinds Chen, Yujie; Tokuda, Joshua M.; Topping, Traci Nucleic Acids Research, Vol. 42, Issue 13 https://doi.org/10.1093/nar/gku562	journal	July 2014
Single-molecule analysis uncovers the difference between the kinetics of DNA decatenation by bacterial topoisomerases I and III Terekhova, Ksenia; Marko, John F.; Mondragón, Alfonso Nucleic Acids Research, Vol. 42, Issue 18 https://doi.org/10.1093/nar/gku785	journal	September 2014
Nucleosomes undergo slow spontaneous gaping Ngo, Thuy T. M.; Ha, Taekjip Nucleic Acids Research, Vol. 43, Issue 8 https://doi.org/10.1093/nar/gkv276	journal	March 2015
Nucleosomal Fluctuations Govern the Transcription Dynamics of RNA Polymerase II Hodges, C.; Bintu, L.; Lubkowska, L. Science, Vol. 325, Issue 5940 https://doi.org/10.1126/science.1172926	journal	July 2009
Spheroid Chromatin Units (ngr Bodies) Olins, A. L.; Olins, D. E. Science, Vol. 183, Issue 4122 https://doi.org/10.1126/science.183.4122.330	journal	January 1974
Trefoil Knotting Revealed by Molecular Dynamics Simulations of Supercoiled DNA Schlick, T.; Olson, W. K. Science, Vol. 257, Issue 5073 https://doi.org/10.1126/science.257.5073.1110	journal	August 1992
Polymer chain models of DNA and chromatin Langowski, J. The European Physical Journal E, Vol. 19, Issue 3 https://doi.org/10.1140/epje/i2005-10067-9	journal	March 2006
DNA bending potentials for loop-mediated nucleosome repositioning Biswas, M.; Wocjan, T.; Langowski, J. EPL (Europhysics Letters), Vol. 97, Issue 3 https://doi.org/10.1209/0295-5075/97/38004	journal	February 2012
Dual-Color Fluorescence Cross-Correlation Spectroscopy on a Single Plane Illumination Microscope (SPIM-FCCS) Krieger, Jan Wolfgang; Singh, Anand Pratap; Garbe, Christoph S. Optics Express, Vol. 22, Issue 3 https://doi.org/10.1364/OE.22.002358	journal	January 2014
Role of Histone Tails in Structural Stability of the Nucleosome Biswas, Mithun; Voltz, Karine; Smith, Jeremy C. PLoS Computational Biology, Vol. 7, Issue 12 https://doi.org/10.1371/journal.pcbi.1002279	journal	December 2011
Closing the Gap between Single Molecule and Bulk FRET Analysis of Nucleosomes Gansen, Alexander; Hieb, Aaron R.; Böhm, Vera PLoS ONE, Vol. 8, Issue 4 https://doi.org/10.1371/journal.pone.0057018	journal	April 2013
Sequence-Dependent Variations Associated with H2A/H2B Depletion of Nucleosomes Kelbauskas, L.; Chan, N.; Bash, R. Biophysical Journal, Vol. 94, Issue 1 https://doi.org/10.1529/biophysj.107.111906	journal	January 2008

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