Jörg Langowski: his scientific legacy and the future it promises
Abstract
Background: With the passing of Jörg Langowski 6 May 2017 in a sailplane accident, the scientific community was deprived of a strident and effective voice for DNA and chromatin molecular and computational biophysics, for open access publishing and for the creation of effective scientific research networks.Methods: In this work, after reviewing some of Jörg’s key research contributions and ideas, we offer through the personal remembrance of his closest collaborators, a deep analysis of the major results of his research and the future directions they have engendered.Conclusions: The legacy of Jörg Langowski has been to propel a way of viewing biological function that considers living systems as dynamic and in three dimensions. This physical view of biology that he pioneered is now, finally, becoming established also because of his great effort.
- Authors:
-
- Universita di Milano-Bicocca, Milan (Italy)
- Deutsches Krebsforschungszentrum, Heidelberg (Germany)
- Univ. of Pittsburgh School of Medicine, Pittsburgh, PA (United States)
- Univ. of New England, Portland, ME (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
- Publication Date:
- Research Org.:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1523723
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- BMC Biophysics
- Additional Journal Information:
- Journal Volume: 11; Journal Issue: 1; Journal ID: ISSN 2046-1682
- Publisher:
- BioMed Central
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Chirico, Giuseppe, Gansen, Alexander, Leuba, Sanford H., Olins, Ada L., Smith, Jeremy C., and Toth, Katalin. Jörg Langowski: his scientific legacy and the future it promises. United States: N. p., 2018.
Web. doi:10.1186/s13628-018-0045-1.
Chirico, Giuseppe, Gansen, Alexander, Leuba, Sanford H., Olins, Ada L., Smith, Jeremy C., & Toth, Katalin. Jörg Langowski: his scientific legacy and the future it promises. United States. https://doi.org/10.1186/s13628-018-0045-1
Chirico, Giuseppe, Gansen, Alexander, Leuba, Sanford H., Olins, Ada L., Smith, Jeremy C., and Toth, Katalin. Mon .
"Jörg Langowski: his scientific legacy and the future it promises". United States. https://doi.org/10.1186/s13628-018-0045-1. https://www.osti.gov/servlets/purl/1523723.
@article{osti_1523723,
title = {Jörg Langowski: his scientific legacy and the future it promises},
author = {Chirico, Giuseppe and Gansen, Alexander and Leuba, Sanford H. and Olins, Ada L. and Smith, Jeremy C. and Toth, Katalin},
abstractNote = {Background: With the passing of Jörg Langowski 6 May 2017 in a sailplane accident, the scientific community was deprived of a strident and effective voice for DNA and chromatin molecular and computational biophysics, for open access publishing and for the creation of effective scientific research networks.Methods: In this work, after reviewing some of Jörg’s key research contributions and ideas, we offer through the personal remembrance of his closest collaborators, a deep analysis of the major results of his research and the future directions they have engendered.Conclusions: The legacy of Jörg Langowski has been to propel a way of viewing biological function that considers living systems as dynamic and in three dimensions. This physical view of biology that he pioneered is now, finally, becoming established also because of his great effort.},
doi = {10.1186/s13628-018-0045-1},
journal = {BMC Biophysics},
number = 1,
volume = 11,
place = {United States},
year = {2018},
month = {7}
}
Figures / Tables:

Works referenced in this record:
Effects of charge-modifying mutations in histone H2A α3-domain on nucleosome stability assessed by single-pair FRET and MD simulations
journal, October 2017
- Lehmann, Kathrin; Zhang, Ruihan; Schwarz, Nathalie
- Scientific Reports, Vol. 7, Issue 1
Regulation of the nucleosome unwrapping rate controls DNA accessibility
journal, September 2012
- North, Justin A.; Shimko, John C.; Javaid, Sarah
- Nucleic Acids Research, Vol. 40, Issue 20
Internal motion of supercoiled DNA: brownian dynamics simulations of site juxtaposition 1 1Edited by I. Tinoco
journal, November 1998
- Jian, Hongmei; Schlick, Tamar; Vologodskii, Alexander
- Journal of Molecular Biology, Vol. 284, Issue 2
The effect of DNA supercoiling on nucleosome structure and stability
journal, January 2015
- Elbel, Tabea; Langowski, Jörg
- Journal of Physics: Condensed Matter, Vol. 27, Issue 6
DNA bending potentials for loop-mediated nucleosome repositioning
journal, February 2012
- Biswas, M.; Wocjan, T.; Langowski, J.
- EPL (Europhysics Letters), Vol. 97, Issue 3
Sequence-Dependent Variations Associated with H2A/H2B Depletion of Nucleosomes
journal, January 2008
- Kelbauskas, L.; Chan, N.; Bash, R.
- Biophysical Journal, Vol. 94, Issue 1
Solution structure and dynamics of DNA topoisomers: Dynamic light scattering studies and Monte Carlo simulations
journal, May 1994
- Langowski, J�rg; Kapp, Ulrike; Klenin, Konstantin
- Biopolymers, Vol. 34, Issue 5
Dynamic Organization of Chromatin Domains Revealed by Super-Resolution Live-Cell Imaging
journal, July 2017
- Nozaki, Tadasu; Imai, Ryosuke; Tanbo, Mai
- Molecular Cell, Vol. 67, Issue 2
Computation of writhe in modeling of supercoiled DNA
journal, January 2000
- Klenin, Konstantin; Langowski, Jörg
- Biopolymers, Vol. 54, Issue 5
Histone Octamer Instability under Single Molecule Experiment Conditions
journal, March 2005
- Claudet, Cyril; Angelov, Dimitar; Bouvet, Philippe
- Journal of Biological Chemistry, Vol. 280, Issue 20
Polymer chain models of DNA and chromatin
journal, March 2006
- Langowski, J.
- The European Physical Journal E, Vol. 19, Issue 3
Trinucleosome Compaction Studied by Fluorescence Energy Transfer and Scanning Force Microscopy
journal, September 2006
- Bussiek, Malte; Tóth, Katalin; Schwarz, Nathalie
- Biochemistry, Vol. 45, Issue 36
Effects of core histone tail domains on the equilibrium constants for dynamic dna site accessibility in nucleosomes
journal, April 2000
- Polach, K. J.; Lowary, P. T.; Widom, J.
- Journal of Molecular Biology, Vol. 298, Issue 2
Torsional-bending infinitesimal dynamics of a DNA chain
journal, June 1996
- Chirico, Giuseppe
- Biopolymers, Vol. 38, Issue 6
Nucleosome Remodeling Induced by RNA Polymerase II
journal, March 2002
- Kireeva, Maria L.; Walter, Wendy; Tchernajenko, Vladimir
- Molecular Cell, Vol. 9, Issue 3
Opposing roles of H3- and H4-acetylation in the regulation of nucleosome structure—a FRET study
journal, January 2015
- Gansen, Alexander; Tóth, Katalin; Schwarz, Nathalie
- Nucleic Acids Research, Vol. 43, Issue 3
Clipping of Flexible Tails of Histones H3 and H4 Affects the Structure and Dynamics of the Nucleosome
journal, March 2013
- Nurse, Nathan P.; Jimenez-Useche, Isabel; Smith, Ian Tad
- Biophysical Journal, Vol. 104, Issue 5
Looping Dynamics of Linear DNA Molecules and the Effect of DNA Curvature: A Study by Brownian Dynamics Simulation
journal, February 1998
- Merlitz, Holger; Rippe, Karsten; Klenin, Konstantin V.
- Biophysical Journal, Vol. 74, Issue 2
Revealing transient structures of nucleosomes as DNA unwinds
journal, July 2014
- Chen, Yujie; Tokuda, Joshua M.; Topping, Traci
- Nucleic Acids Research, Vol. 42, Issue 13
A high-resolution map of the three-dimensional chromatin interactome in human cells
journal, October 2013
- Jin, Fulai; Li, Yan; Dixon, Jesse R.
- Nature, Vol. 503, Issue 7475
Trajectory of Nucleosomal Linker DNA Studied by Fluorescence Resonance Energy Transfer
journal, June 2001
- Tóth, Katalin; Brun, Nathalie; Langowski, Jörg
- Biochemistry, Vol. 40, Issue 23
Detection of Structural Dynamics by FRET: A Photon Distribution and Fluorescence Lifetime Analysis of Systems with Multiple States
journal, June 2010
- Kalinin, Stanislav; Valeri, Alessandro; Antonik, Matthew
- The Journal of Physical Chemistry B, Vol. 114, Issue 23
Histone and chromatin cross-talk
journal, April 2003
- Fischle, Wolfgang; Wang, Yanming; Allis, C. David
- Current Opinion in Cell Biology, Vol. 15, Issue 2
Unwrapping of Nucleosomal DNA Ends: A Multiscale Molecular Dynamics Study
journal, February 2012
- Voltz, Karine; Trylska, Joanna; Calimet, Nicolas
- Biophysical Journal, Vol. 102, Issue 4
Nucleosome disassembly intermediates characterized by single-molecule FRET
journal, August 2009
- Gansen, A.; Valeri, A.; Hauger, F.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 36
Kinetics of DNA supercoiling studied by Brownian dynamics simulation
journal, March 1994
- Chirico, Giuseppe; Langowski, J�rg
- Biopolymers, Vol. 34, Issue 3
DNA flexibility studied by covalent closure of short fragments into circles.
journal, August 1981
- Shore, D.; Langowski, J.; Baldwin, R. L.
- Proceedings of the National Academy of Sciences, Vol. 78, Issue 8
Histone Release during Transcription: Displacement of the Two H2A−H2B Dimers in the Nucleosome Is Dependent on Different Levels of Transcription-Induced Positive Stress †
journal, April 2005
- Levchenko, Vladislav; Jackson, Beverly; Jackson, Vaughn
- Biochemistry, Vol. 44, Issue 14
Role of Histone Tails in Structural Stability of the Nucleosome
journal, December 2011
- Biswas, Mithun; Voltz, Karine; Smith, Jeremy C.
- PLoS Computational Biology, Vol. 7, Issue 12
Coarse-grained force field for the nucleosome from self-consistent multiscaling
journal, January 2008
- Voltz, Karine; Trylska, Joanna; Tozzini, Valentina
- Journal of Computational Chemistry, Vol. 29, Issue 9
Brownian dynamics simulations of supercoiled DNA with bent sequences
journal, August 1996
- Chirico, G.; Langowski, J.
- Biophysical Journal, Vol. 71, Issue 2
Single-pair fluorescence resonance energy transfer of nucleosomes in free diffusion: Optimizing stability and resolution of subpopulations
journal, September 2007
- Gansen, Alexander; Hauger, Florian; Tóth, Katalin
- Analytical Biochemistry, Vol. 368, Issue 2
Dynamics and function of compact nucleosome arrays
journal, August 2009
- Poirier, Michael G.; Oh, Eugene; Tims, Hannah S.
- Nature Structural & Molecular Biology, Vol. 16, Issue 9
Deformational dynamics and nmr relaxation of supercoiled DNAs
journal, June 1985
- Langowski, Jörg; Fujimoto, Bryant S.; Wemmer, David E.
- Biopolymers, Vol. 24, Issue 6
Effect of Positive Supercoiling on DNA Compaction by Nucleosome Cores
journal, November 1993
- Clark, David J.; Ghirlando, Rodolfo; Felsenfeld, Gary
- Journal of Molecular Biology, Vol. 234, Issue 2
Supercoiled DNA energetics and dynamics by computer simulation
journal, February 1992
- Schlick, Tamar; Olson, Wilma K.
- Journal of Molecular Biology, Vol. 223, Issue 4
Torque modulates nucleosome stability and facilitates H2A/H2B dimer loss
journal, October 2013
- Sheinin, Maxim Y.; Li, Ming; Soltani, Mohammad
- Nature Communications, Vol. 4, Issue 1
Salt-Dependent DNA Superhelix Diameter Studied by Small Angle Neutron Scattering Measurements and Monte Carlo Simulations
journal, December 1998
- Hammermann, Markus; Brun, Nathalie; Klenin, Konstantin V.
- Biophysical Journal, Vol. 75, Issue 6
Nucleosomal Fluctuations Govern the Transcription Dynamics of RNA Polymerase II
journal, July 2009
- Hodges, C.; Bintu, L.; Lubkowska, L.
- Science, Vol. 325, Issue 5940
Salt effects on the structure and internal dynamics of superhelical DNAs studied by light scattering and Brownian dynamics
journal, November 1997
- Hammermann, M.; Steinmaier, C.; Merlitz, H.
- Biophysical Journal, Vol. 73, Issue 5
Trefoil Knotting Revealed by Molecular Dynamics Simulations of Supercoiled DNA
journal, August 1992
- Schlick, T.; Olson, W. K.
- Science, Vol. 257, Issue 5073
ELCS in ice: cryo-electron microscopy of nuclear envelope-limited chromatin sheets
journal, February 2014
- Eltsov, Mikhail; Sosnovski, Sergey; Olins, Ada L.
- Chromosoma, Vol. 123, Issue 3
Dynamics of the Interactions of Histones H2A,H2B and H3,H4 with Torsionally Stressed DNA
journal, May 1994
- Jackson, Shawn; Brooks, Wesley; Jackson, Vaughn
- Biochemistry, Vol. 33, Issue 18
Histone fold modifications control nucleosome unwrapping and disassembly
journal, July 2011
- Simon, M.; North, J. A.; Shimko, J. C.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 31
A Brownian Dynamics Program for the Simulation of Linear and Circular DNA and Other Wormlike Chain Polyelectrolytes
journal, February 1998
- Klenin, Konstantin; Merlitz, Holger; Langowski, Jörg
- Biophysical Journal, Vol. 74, Issue 2
The mechanics of DNA loops bridged by proteins unveiled by single-molecule experiments
journal, November 2017
- Tardin, Catherine
- Biochimie, Vol. 142
The Role of Histone Tails in the Nucleosome: A Computational Study
journal, December 2014
- Erler, Jochen; Zhang, Ruihan; Petridis, Loukas
- Biophysical Journal, Vol. 107, Issue 12
Closing the Gap between Single Molecule and Bulk FRET Analysis of Nucleosomes
journal, April 2013
- Gansen, Alexander; Hieb, Aaron R.; Böhm, Vera
- PLoS ONE, Vol. 8, Issue 4
Nucleosomes undergo slow spontaneous gaping
journal, March 2015
- Ngo, Thuy T. M.; Ha, Taekjip
- Nucleic Acids Research, Vol. 43, Issue 8
Spheroid Chromatin Units (ngr Bodies)
journal, January 1974
- Olins, A. L.; Olins, D. E.
- Science, Vol. 183, Issue 4122
Single-molecule analysis uncovers the difference between the kinetics of DNA decatenation by bacterial topoisomerases I and III
journal, September 2014
- Terekhova, Ksenia; Marko, John F.; Mondragón, Alfonso
- Nucleic Acids Research, Vol. 42, Issue 18
Nucleosome Core Particle Disassembly and Assembly Kinetics Studied Using Single-Molecule Fluorescence
journal, October 2015
- Hazan, Noa Plavner; Tomov, Toma E.; Tsukanov, Roman
- Biophysical Journal, Vol. 109, Issue 8
Histone- and DNA sequence-dependent stability of nucleosomes studied by single-pair FRET: spFRET Studies of Mononucleosome Stability
journal, July 2013
- Tóth, Katalin; Böhm, Vera; Sellmann, Carolin
- Cytometry Part A, Vol. 83, Issue 9
A nucleosome core is transferred out of the path of a transcribing polymerase
journal, October 1992
- Clark, David J.; Felsenfeld, Gary
- Cell, Vol. 71, Issue 1
Nuclear envelope-limited chromatin sheets (ELCS) and heterochromatin higher order structure
journal, June 2009
- Olins, Donald E.; Olins, Ada L.
- Chromosoma, Vol. 118, Issue 5
Dual-Color Fluorescence Cross-Correlation Spectroscopy on a Single Plane Illumination Microscope (SPIM-FCCS)
journal, January 2014
- Krieger, Jan Wolfgang; Singh, Anand Pratap; Garbe, Christoph S.
- Optics Express, Vol. 22, Issue 3
Fast, long-range, reversible conformational fluctuations in nucleosomes revealed by single-pair fluorescence resonance energy transfer
journal, February 2005
- Tomschik, M.; Zheng, H.; van Holde, K.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 9
Structural Analysis of the Hexasome, Lacking One Histone H2A/H2B Dimer from the Conventional Nucleosome
journal, April 2012
- Arimura, Yasuhiro; Tachiwana, Hiroaki; Oda, Takashi
- Biochemistry, Vol. 51, Issue 15
Nucleosome accessibility governed by the dimer/tetramer interface
journal, December 2010
- Böhm, Vera; Hieb, Aaron R.; Andrews, Andrew J.
- Nucleic Acids Research, Vol. 39, Issue 8
Monte Carlo simulations of supercoiling free energies for unknotted and trefoil knotted DNAs
journal, February 1995
- Gebe, J. A.; Allison, S. A.; Clendenning, J. B.
- Biophysical Journal, Vol. 68, Issue 2
Dynamics of superhelical DNA studied by photon correlation spectroscopy
journal, December 1986
- Langowski, Jörg; Giesen, Ursula; Lehmann, Christina
- Biophysical Chemistry, Vol. 25, Issue 2
Salt-induced release of DNA from nucleosome core particles
journal, March 1989
- Yager, Thomas D.; McMurray, Cynthia T.; Van Holde, K. E.
- Biochemistry, Vol. 28, Issue 5
Chromatin Compaction at the Mononucleosome Level
journal, February 2006
- Tóth, Katalin; Brun, Nathalie; Langowski, Jörg
- Biochemistry, Vol. 45, Issue 6
Change of conformation and internal dynamics of supercoiled DNA upon binding of Escherichia coli single-strand binding protein
journal, July 1985
- Langowski, Joerg; Benight, Albert S.; Fujimoto, Bryant S.
- Biochemistry, Vol. 24, Issue 15
Regulation of chromatin structure by site-specific histone H3 methyltransferases
journal, August 2000
- Rea, Stephen; Eisenhaber, Frank; O'Carroll, Dónal
- Nature, Vol. 406, Issue 6796
ELCS in Ice: Cryo-electron Microscopy of Nuclear Envelope-Limited Chromatin Sheets
journal, August 2014
- Eltsov, Mikhail; Sosnovski, Sergey; Olins, Ada L.
- Microscopy and Microanalysis, Vol. 20, Issue S3