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Title: Terahertz hyperspectral imaging with dual chip-scale combs

Abstract

Hyperspectral imaging is a spectroscopic imaging technique that allows for the creation of images with pixels containing information from multiple spectral bands. At terahertz wavelengths, it has emerged as a prominent tool for a number of applications, ranging from nonionizing cancer diagnosis and pharmaceutical characterization to nondestructive artifact testing. Contemporary terahertz imaging systems typically rely on nonlinear optical downconversion of a fiber-based near-infrared femtosecond laser, requiring complex optical systems. In this work, we show hyperspectral imaging with chip-scale frequency combs based on terahertz quantum cascade lasers. The dual combs are free-running and emit coherent terahertz radiation that covers a bandwidth of 220 GHz at 3.4 THz with ~10 μW per line. The combination of the fast acquisition rate of dual-comb spectroscopy with the monolithic design, scalability, and chip-scale size of the combs is highly appealing for future imaging applications in biomedicine and the pharmaceutical industry.

Authors:
ORCiD logo; ORCiD logo; ; ORCiD logo; ; ; ORCiD logo
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division; Defense Advanced Research Projects Agency (DARPA)
OSTI Identifier:
1523699
Alternate Identifier(s):
OSTI ID: 1529134
Report Number(s):
SAND-2019-0534J
Journal ID: ISSN 2334-2536
Grant/Contract Number:  
NA-0003525; AC04-94AL85000; W31P4Q-16-1-0001
Resource Type:
Published Article
Journal Name:
Optica
Additional Journal Information:
Journal Name: Optica Journal Volume: 6 Journal Issue: 6; Journal ID: ISSN 2334-2536
Publisher:
Optical Society of America
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING

Citation Formats

Sterczewski, Lukasz A., Westberg, Jonas, Yang, Yang, Burghoff, David, Reno, John, Hu, Qing, and Wysocki, Gerard. Terahertz hyperspectral imaging with dual chip-scale combs. United States: N. p., 2019. Web. doi:10.1364/OPTICA.6.000766.
Sterczewski, Lukasz A., Westberg, Jonas, Yang, Yang, Burghoff, David, Reno, John, Hu, Qing, & Wysocki, Gerard. Terahertz hyperspectral imaging with dual chip-scale combs. United States. https://doi.org/10.1364/OPTICA.6.000766
Sterczewski, Lukasz A., Westberg, Jonas, Yang, Yang, Burghoff, David, Reno, John, Hu, Qing, and Wysocki, Gerard. Fri . "Terahertz hyperspectral imaging with dual chip-scale combs". United States. https://doi.org/10.1364/OPTICA.6.000766.
@article{osti_1523699,
title = {Terahertz hyperspectral imaging with dual chip-scale combs},
author = {Sterczewski, Lukasz A. and Westberg, Jonas and Yang, Yang and Burghoff, David and Reno, John and Hu, Qing and Wysocki, Gerard},
abstractNote = {Hyperspectral imaging is a spectroscopic imaging technique that allows for the creation of images with pixels containing information from multiple spectral bands. At terahertz wavelengths, it has emerged as a prominent tool for a number of applications, ranging from nonionizing cancer diagnosis and pharmaceutical characterization to nondestructive artifact testing. Contemporary terahertz imaging systems typically rely on nonlinear optical downconversion of a fiber-based near-infrared femtosecond laser, requiring complex optical systems. In this work, we show hyperspectral imaging with chip-scale frequency combs based on terahertz quantum cascade lasers. The dual combs are free-running and emit coherent terahertz radiation that covers a bandwidth of 220 GHz at 3.4 THz with ~10 μW per line. The combination of the fast acquisition rate of dual-comb spectroscopy with the monolithic design, scalability, and chip-scale size of the combs is highly appealing for future imaging applications in biomedicine and the pharmaceutical industry.},
doi = {10.1364/OPTICA.6.000766},
journal = {Optica},
number = 6,
volume = 6,
place = {United States},
year = {2019},
month = {5}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1364/OPTICA.6.000766

Citation Metrics:
Cited by: 9 works
Citation information provided by
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Works referencing / citing this record:

Nondestructive Analysis of Tablet Coating Thicknesses Using Terahertz Pulsed Imaging
journal, January 2005

  • Fitzgerald, Anthony J.; Cole, Bryan E.; Taday, Philip F.
  • Journal of Pharmaceutical Sciences, Vol. 94, Issue 1
  • DOI: 10.1002/jps.20225

Analysis of Coating Structures and Interfaces in Solid Oral Dosage Forms by Three Dimensional Terahertz Pulsed Imaging
journal, February 2007

  • Zeitler, J. Axel; Shen, Yaochun; Baker, Colin
  • Journal of Pharmaceutical Sciences, Vol. 96, Issue 2
  • DOI: 10.1002/jps.20789

Non-invasive investigation of art paintings by terahertz imaging
journal, March 2010


Optically pumped far infrared lasers
journal, July 1989


The HITRAN2016 molecular spectroscopic database
journal, December 2017

  • Gordon, I. E.; Rothman, L. S.; Hill, C.
  • Journal of Quantitative Spectroscopy and Radiative Transfer, Vol. 203
  • DOI: 10.1016/j.jqsrt.2017.06.038

Terahertz time-domain spectroscopy of l-histidine hydrochloride monohydrate
journal, April 2018


Terahertz imaging for non-destructive evaluation of mural paintings
journal, February 2008


Temperature dependent terahertz pulsed spectroscopy of carbamazepine
journal, October 2005

  • Zeitler, J. Axel; Newnham, David A.; Taday, Philip F.
  • Thermochimica Acta, Vol. 436, Issue 1-2
  • DOI: 10.1016/j.tca.2005.07.006

Single-Shot Sub-microsecond Mid-infrared Spectroscopy on Protein Reactions with Quantum Cascade Laser Frequency Combs
journal, August 2018


Lateral Heterogeneous Integration of Quantum Cascade Lasers
journal, December 2017


Mid-infrared frequency comb based on a quantum cascade laser
journal, December 2012

  • Hugi, Andreas; Villares, Gustavo; Blaser, Stéphane
  • Nature, Vol. 492, Issue 7428
  • DOI: 10.1038/nature11620

Dual-comb spectroscopy based on quantum-cascade-laser frequency combs
journal, October 2014

  • Villares, Gustavo; Hugi, Andreas; Blaser, Stéphane
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms6192

Terahertz quantum-cascade lasers
journal, September 2007


Cutting-edge terahertz technology
journal, February 2007


Terahertz quantum-cascade-laser source based on intracavity difference-frequency generation
journal, May 2007

  • Belkin, Mikhail A.; Capasso, Federico; Belyanin, Alexey
  • Nature Photonics, Vol. 1, Issue 5
  • DOI: 10.1038/nphoton.2007.70

Octave-spanning semiconductor laser
journal, November 2014


Terahertz laser frequency combs
journal, May 2014


Silicon-chip-based mid-infrared dual-comb spectroscopy
journal, May 2018


High-coherence mid-infrared dual-comb spectroscopy spanning 2.6 to 5.2 μm
journal, March 2018


Massively parallel sensing of trace molecules and their isotopologues with broadband subharmonic mid-infrared frequency combs
journal, March 2018


Adaptive sampling dual terahertz comb spectroscopy using dual free-running femtosecond lasers
journal, June 2015

  • Yasui, Takeshi; Ichikawa, Ryuji; Hsieh, Yi-Da
  • Scientific Reports, Vol. 5, Issue 1
  • DOI: 10.1038/srep10786

Real-time terahertz imaging over a standoff distance (>25meters)
journal, October 2006

  • Lee, Alan W. M.; Qin, Qi; Kumar, Sushil
  • Applied Physics Letters, Vol. 89, Issue 14
  • DOI: 10.1063/1.2360210

Mid-infrared multiheterodyne spectroscopy with phase-locked quantum cascade lasers
journal, April 2017

  • Westberg, J.; Sterczewski, L. A.; Wysocki, G.
  • Applied Physics Letters, Vol. 110, Issue 14
  • DOI: 10.1063/1.4979825

Dual comb operation of λ ∼ 8.2 μ m quantum cascade laser frequency comb with 1 W optical power
journal, October 2017

  • Jouy, P.; Wolf, J. M.; Bidaux, Y.
  • Applied Physics Letters, Vol. 111, Issue 14
  • DOI: 10.1063/1.4985102

Terahertz Pulsed Imaging of Human Breast Tumors
journal, May 2006

  • Fitzgerald, Anthony J.; Wallace, Vincent P.; Jimenez-Linan, Mercedes
  • Radiology, Vol. 239, Issue 2
  • DOI: 10.1148/radiol.2392041315

Dual-comb spectroscopy
journal, January 2016


Terahertz multiheterodyne spectroscopy using laser frequency combs
journal, January 2016


Mid-infrared dual-comb spectroscopy of volatile organic compounds across long open-air paths
journal, January 2019


Recent advances in terahertz technology for biomedical applications
journal, June 2017

  • Sun, Qiushuo; He, Yuezhi; Liu, Kai
  • Quantitative Imaging in Medicine and Surgery, Vol. 7, Issue 3
  • DOI: 10.21037/qims.2017.06.02

Microelectromechanical control of the state of quantum cascade laser frequency combs
journal, July 2019

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Direct hyperspectral dual-comb imaging
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RF Injection of THz QCL Combs at 80 K Emitting over 700 GHz Spectral Bandwidth
journal, January 2020