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Title: Terahertz hyperspectral imaging with dual chip-scale combs

Abstract

Hyperspectral imaging is a spectroscopic imaging technique that allows for the creation of images with pixels containing information from multiple spectral bands. At terahertz wavelengths, it has emerged as a prominent tool for a number of applications, ranging from nonionizing cancer diagnosis and pharmaceutical characterization to nondestructive artifact testing. Contemporary terahertz imaging systems typically rely on nonlinear optical downconversion of a fiber-based near-infrared femtosecond laser, requiring complex optical systems. In this work, we show hyperspectral imaging with chip-scale frequency combs based on terahertz quantum cascade lasers. The dual combs are free-running and emit coherent terahertz radiation that covers a bandwidth of 220 GHz at 3.4 THz with ~10 μW per line. The combination of the fast acquisition rate of dual-comb spectroscopy with the monolithic design, scalability, and chip-scale size of the combs is highly appealing for future imaging applications in biomedicine and the pharmaceutical industry.

Authors:
ORCiD logo [1]; ORCiD logo [2];  [3]; ORCiD logo [4];  [5];  [3]; ORCiD logo [2]
  1. Princeton Univ., NJ (United States); Univ. of Wroclaw (Poland)
  2. Princeton Univ., NJ (United States)
  3. Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
  4. Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Univ. of Notre Dame, IN (United States)
  5. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22). Scientific User Facilities Division; USDOE National Nuclear Security Administration (NNSA); Defense Advanced Research Projects Agency (DARPA)
OSTI Identifier:
1523699
Alternate Identifier(s):
OSTI ID: 1529134
Report Number(s):
SAND-2019-0534J
Journal ID: ISSN 2334-2536; 671637
Grant/Contract Number:  
AC04-94AL85000; W31P4Q-16-1-0001; NA-0003525
Resource Type:
Published Article
Journal Name:
Optica
Additional Journal Information:
Journal Volume: 6; Journal Issue: 6; Journal ID: ISSN 2334-2536
Publisher:
Optical Society of America
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING

Citation Formats

Sterczewski, Lukasz A., Westberg, Jonas, Yang, Yang, Burghoff, David, Reno, John, Hu, Qing, and Wysocki, Gerard. Terahertz hyperspectral imaging with dual chip-scale combs. United States: N. p., 2019. Web. doi:10.1364/OPTICA.6.000766.
Sterczewski, Lukasz A., Westberg, Jonas, Yang, Yang, Burghoff, David, Reno, John, Hu, Qing, & Wysocki, Gerard. Terahertz hyperspectral imaging with dual chip-scale combs. United States. doi:10.1364/OPTICA.6.000766.
Sterczewski, Lukasz A., Westberg, Jonas, Yang, Yang, Burghoff, David, Reno, John, Hu, Qing, and Wysocki, Gerard. Fri . "Terahertz hyperspectral imaging with dual chip-scale combs". United States. doi:10.1364/OPTICA.6.000766.
@article{osti_1523699,
title = {Terahertz hyperspectral imaging with dual chip-scale combs},
author = {Sterczewski, Lukasz A. and Westberg, Jonas and Yang, Yang and Burghoff, David and Reno, John and Hu, Qing and Wysocki, Gerard},
abstractNote = {Hyperspectral imaging is a spectroscopic imaging technique that allows for the creation of images with pixels containing information from multiple spectral bands. At terahertz wavelengths, it has emerged as a prominent tool for a number of applications, ranging from nonionizing cancer diagnosis and pharmaceutical characterization to nondestructive artifact testing. Contemporary terahertz imaging systems typically rely on nonlinear optical downconversion of a fiber-based near-infrared femtosecond laser, requiring complex optical systems. In this work, we show hyperspectral imaging with chip-scale frequency combs based on terahertz quantum cascade lasers. The dual combs are free-running and emit coherent terahertz radiation that covers a bandwidth of 220 GHz at 3.4 THz with ~10 μW per line. The combination of the fast acquisition rate of dual-comb spectroscopy with the monolithic design, scalability, and chip-scale size of the combs is highly appealing for future imaging applications in biomedicine and the pharmaceutical industry.},
doi = {10.1364/OPTICA.6.000766},
journal = {Optica},
number = 6,
volume = 6,
place = {United States},
year = {2019},
month = {5}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1364/OPTICA.6.000766

Citation Metrics:
Cited by: 2 works
Citation information provided by
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Works referenced in this record:

All-fiber terahertz time-domain spectrometer operating at 1.5 μm telecom wavelengths
journal, January 2008

  • Sartorius, B.; Roehle, H.; Künzel, H.
  • Optics Express, Vol. 16, Issue 13
  • DOI: 10.1364/OE.16.009565

Dual-comb spectroscopy based on quantum-cascade-laser frequency combs
journal, October 2014

  • Villares, Gustavo; Hugi, Andreas; Blaser, Stéphane
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms6192

Terahertz time-domain spectroscopy of l-histidine hydrochloride monohydrate
journal, April 2018


Real-time terahertz imaging over a standoff distance (>25meters)
journal, October 2006

  • Lee, Alan W. M.; Qin, Qi; Kumar, Sushil
  • Applied Physics Letters, Vol. 89, Issue 14
  • DOI: 10.1063/1.2360210

Terahertz Pulsed Imaging of Human Breast Tumors
journal, May 2006

  • Fitzgerald, Anthony J.; Wallace, Vincent P.; Jimenez-Linan, Mercedes
  • Radiology, Vol. 239, Issue 2
  • DOI: 10.1148/radiol.2392041315

Time-domain mid-infrared frequency-comb spectrometer
journal, January 2004

  • Keilmann, Fritz; Gohle, Christoph; Holzwarth, Ronald
  • Optics Letters, Vol. 29, Issue 13
  • DOI: 10.1364/OL.29.001542

Mid-infrared frequency comb based on a quantum cascade laser
journal, December 2012

  • Hugi, Andreas; Villares, Gustavo; Blaser, Stéphane
  • Nature, Vol. 492, Issue 7428
  • DOI: 10.1038/nature11620

The limits of signal averaging in atmospheric trace-gas monitoring by tunable diode-laser absorption spectroscopy (TDLAS)
journal, August 1993

  • Werle, P.; M�cke, R.; Slemr, F.
  • Applied Physics B Photophysics and Laser Chemistry, Vol. 57, Issue 2
  • DOI: 10.1007/BF00425997

Dual-frequency imaging using an electrically tunable terahertz quantum cascade laser
journal, January 2009

  • Dean, Paul; Saat, Nor Kamila; Khanna, Suraj P.
  • Optics Express, Vol. 17, Issue 23
  • DOI: 10.1364/OE.17.020631

Recent advances in terahertz technology for biomedical applications
journal, June 2017

  • Sun, Qiushuo; He, Yuezhi; Liu, Kai
  • Quantitative Imaging in Medicine and Surgery, Vol. 7, Issue 3
  • DOI: 10.21037/qims.2017.06.02

Massively parallel sensing of trace molecules and their isotopologues with broadband subharmonic mid-infrared frequency combs
journal, March 2018


Real-time imaging using a 4.3-THz quantum cascade laser and a 320 /spl times/ 240 microbolometer focal-plane array
journal, July 2006

  • Lee, A. W. M.; Wil, B. S.; Kumar, S.
  • IEEE Photonics Technology Letters, Vol. 18, Issue 13
  • DOI: 10.1109/LPT.2006.877220

Optically pumped far infrared lasers
journal, July 1989


Temperature dependent terahertz pulsed spectroscopy of carbamazepine
journal, October 2005

  • Zeitler, J. Axel; Newnham, David A.; Taday, Philip F.
  • Thermochimica Acta, Vol. 436, Issue 1-2
  • DOI: 10.1016/j.tca.2005.07.006

Cutting-edge terahertz technology
journal, February 2007


Analysis of Coating Structures and Interfaces in Solid Oral Dosage Forms by Three Dimensional Terahertz Pulsed Imaging
journal, February 2007

  • Zeitler, J. Axel; Shen, Yaochun; Baker, Colin
  • Journal of Pharmaceutical Sciences, Vol. 96, Issue 2
  • DOI: 10.1002/jps.20789

Nondestructive Analysis of Tablet Coating Thicknesses Using Terahertz Pulsed Imaging
journal, January 2005

  • Fitzgerald, Anthony J.; Cole, Bryan E.; Taday, Philip F.
  • Journal of Pharmaceutical Sciences, Vol. 94, Issue 1
  • DOI: 10.1002/jps.20225

Terahertz multiheterodyne spectroscopy using laser frequency combs
journal, January 2016


Adaptive sampling dual terahertz comb spectroscopy using dual free-running femtosecond lasers
journal, June 2015

  • Yasui, Takeshi; Ichikawa, Ryuji; Hsieh, Yi-Da
  • Scientific Reports, Vol. 5, Issue 1
  • DOI: 10.1038/srep10786

Lateral Heterogeneous Integration of Quantum Cascade Lasers
journal, December 2017


Terahertz quantum-cascade-laser source based on intracavity difference-frequency generation
journal, May 2007

  • Belkin, Mikhail A.; Capasso, Federico; Belyanin, Alexey
  • Nature Photonics, Vol. 1, Issue 5
  • DOI: 10.1038/nphoton.2007.70

Octave-spanning semiconductor laser
journal, November 2014


Terahertz quantum-cascade lasers
journal, September 2007


High-coherence mid-infrared dual-comb spectroscopy spanning 2.6 to 5.2 μm
journal, March 2018


Mid-infrared dual-comb spectroscopy of volatile organic compounds across long open-air paths
journal, January 2019


Single-Shot Sub-microsecond Mid-infrared Spectroscopy on Protein Reactions with Quantum Cascade Laser Frequency Combs
journal, August 2018


The HITRAN2016 molecular spectroscopic database
journal, December 2017

  • Gordon, I. E.; Rothman, L. S.; Hill, C.
  • Journal of Quantitative Spectroscopy and Radiative Transfer, Vol. 203
  • DOI: 10.1016/j.jqsrt.2017.06.038

Silicon-chip-based mid-infrared dual-comb spectroscopy
journal, May 2018


Twenty years of terahertz imaging [Invited]
journal, January 2018


Mid-infrared multiheterodyne spectroscopy with phase-locked quantum cascade lasers
journal, April 2017

  • Westberg, J.; Sterczewski, L. A.; Wysocki, G.
  • Applied Physics Letters, Vol. 110, Issue 14
  • DOI: 10.1063/1.4979825

Non-invasive investigation of art paintings by terahertz imaging
journal, March 2010


Terahertz imaging for non-destructive evaluation of mural paintings
journal, February 2008


Dual comb operation of λ ∼ 8.2 μ m quantum cascade laser frequency comb with 1 W optical power
journal, October 2017

  • Jouy, P.; Wolf, J. M.; Bidaux, Y.
  • Applied Physics Letters, Vol. 111, Issue 14
  • DOI: 10.1063/1.4985102

Terahertz laser frequency combs
journal, May 2014


Quantum cascade lasers: 20 years of challenges
journal, January 2015

  • Vitiello, Miriam Serena; Scalari, Giacomo; Williams, Benjamin
  • Optics Express, Vol. 23, Issue 4
  • DOI: 10.1364/OE.23.005167

    Works referencing / citing this record:

    High-coherence mid-infrared dual-comb spectroscopy spanning 2.6 to 5.2 μm
    journal, March 2018


    Cutting-edge terahertz technology
    journal, February 2007


    Terahertz laser frequency combs
    journal, May 2014


    The HITRAN2016 molecular spectroscopic database
    journal, December 2017

    • Gordon, I. E.; Rothman, L. S.; Hill, C.
    • Journal of Quantitative Spectroscopy and Radiative Transfer, Vol. 203
    • DOI: 10.1016/j.jqsrt.2017.06.038

    Optically pumped far infrared lasers
    journal, July 1989


    Adaptive sampling dual terahertz comb spectroscopy using dual free-running femtosecond lasers
    journal, June 2015

    • Yasui, Takeshi; Ichikawa, Ryuji; Hsieh, Yi-Da
    • Scientific Reports, Vol. 5, Issue 1
    • DOI: 10.1038/srep10786

    Mid-infrared multiheterodyne spectroscopy with phase-locked quantum cascade lasers
    journal, April 2017

    • Westberg, J.; Sterczewski, L. A.; Wysocki, G.
    • Applied Physics Letters, Vol. 110, Issue 14
    • DOI: 10.1063/1.4979825

    Octave-spanning semiconductor laser
    journal, November 2014


    Terahertz quantum-cascade-laser source based on intracavity difference-frequency generation
    journal, May 2007

    • Belkin, Mikhail A.; Capasso, Federico; Belyanin, Alexey
    • Nature Photonics, Vol. 1, Issue 5
    • DOI: 10.1038/nphoton.2007.70

    Dual comb operation of λ ∼ 8.2 μ m quantum cascade laser frequency comb with 1 W optical power
    journal, October 2017

    • Jouy, P.; Wolf, J. M.; Bidaux, Y.
    • Applied Physics Letters, Vol. 111, Issue 14
    • DOI: 10.1063/1.4985102

    Single-Shot Sub-microsecond Mid-infrared Spectroscopy on Protein Reactions with Quantum Cascade Laser Frequency Combs
    journal, August 2018


    Non-invasive investigation of art paintings by terahertz imaging
    journal, March 2010


    Terahertz quantum-cascade lasers
    journal, September 2007


    Real-time terahertz imaging over a standoff distance (>25meters)
    journal, October 2006

    • Lee, Alan W. M.; Qin, Qi; Kumar, Sushil
    • Applied Physics Letters, Vol. 89, Issue 14
    • DOI: 10.1063/1.2360210

    Mid-infrared frequency comb based on a quantum cascade laser
    journal, December 2012

    • Hugi, Andreas; Villares, Gustavo; Blaser, Stéphane
    • Nature, Vol. 492, Issue 7428
    • DOI: 10.1038/nature11620

    Silicon-chip-based mid-infrared dual-comb spectroscopy
    journal, May 2018


    Terahertz Pulsed Imaging of Human Breast Tumors
    journal, May 2006

    • Fitzgerald, Anthony J.; Wallace, Vincent P.; Jimenez-Linan, Mercedes
    • Radiology, Vol. 239, Issue 2
    • DOI: 10.1148/radiol.2392041315

    Dual-comb spectroscopy based on quantum-cascade-laser frequency combs
    journal, October 2014

    • Villares, Gustavo; Hugi, Andreas; Blaser, Stéphane
    • Nature Communications, Vol. 5, Issue 1
    • DOI: 10.1038/ncomms6192

    Terahertz imaging for non-destructive evaluation of mural paintings
    journal, February 2008


    Lateral Heterogeneous Integration of Quantum Cascade Lasers
    journal, December 2017


    Terahertz time-domain spectroscopy of l-histidine hydrochloride monohydrate
    journal, April 2018


    Nondestructive Analysis of Tablet Coating Thicknesses Using Terahertz Pulsed Imaging
    journal, January 2005

    • Fitzgerald, Anthony J.; Cole, Bryan E.; Taday, Philip F.
    • Journal of Pharmaceutical Sciences, Vol. 94, Issue 1
    • DOI: 10.1002/jps.20225

    Analysis of Coating Structures and Interfaces in Solid Oral Dosage Forms by Three Dimensional Terahertz Pulsed Imaging
    journal, February 2007

    • Zeitler, J. Axel; Shen, Yaochun; Baker, Colin
    • Journal of Pharmaceutical Sciences, Vol. 96, Issue 2
    • DOI: 10.1002/jps.20789

    Dual-comb spectroscopy
    journal, January 2016


    Temperature dependent terahertz pulsed spectroscopy of carbamazepine
    journal, October 2005

    • Zeitler, J. Axel; Newnham, David A.; Taday, Philip F.
    • Thermochimica Acta, Vol. 436, Issue 1-2
    • DOI: 10.1016/j.tca.2005.07.006

    Recent advances in terahertz technology for biomedical applications
    journal, June 2017

    • Sun, Qiushuo; He, Yuezhi; Liu, Kai
    • Quantitative Imaging in Medicine and Surgery, Vol. 7, Issue 3
    • DOI: 10.21037/qims.2017.06.02

    Massively parallel sensing of trace molecules and their isotopologues with broadband subharmonic mid-infrared frequency combs
    journal, March 2018