skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

This content will become publicly available on May 10, 2020

Title: A proof-of-concept application of water-soluble ytterbium( iii ) molecular probes in in vivo NIR-II whole body bioimaging

Abstract

Lanthanide complexes are firstly applied for in vivo NIR-II high resolution whole body bioimaging.

Authors:
ORCiD logo [1];  [2];  [2];  [1];  [2];  [1]; ORCiD logo [2]; ORCiD logo [1]
  1. Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871
  2. Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1523295
Grant/Contract Number:  
SC0008397
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Inorganic Chemistry Frontiers (Online)
Additional Journal Information:
Journal Name: Inorganic Chemistry Frontiers (Online) Journal Volume: 6 Journal Issue: 8; Journal ID: ISSN 2052-1553
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Ning, Yingying, Chen, Si, Chen, Hao, Wang, Jing-Xiang, He, Shuqing, Liu, Yi-Wei, Cheng, Zhen, and Zhang, Jun-Long. A proof-of-concept application of water-soluble ytterbium( iii ) molecular probes in in vivo NIR-II whole body bioimaging. United Kingdom: N. p., 2019. Web. doi:10.1039/C9QI00157C.
Ning, Yingying, Chen, Si, Chen, Hao, Wang, Jing-Xiang, He, Shuqing, Liu, Yi-Wei, Cheng, Zhen, & Zhang, Jun-Long. A proof-of-concept application of water-soluble ytterbium( iii ) molecular probes in in vivo NIR-II whole body bioimaging. United Kingdom. doi:10.1039/C9QI00157C.
Ning, Yingying, Chen, Si, Chen, Hao, Wang, Jing-Xiang, He, Shuqing, Liu, Yi-Wei, Cheng, Zhen, and Zhang, Jun-Long. Tue . "A proof-of-concept application of water-soluble ytterbium( iii ) molecular probes in in vivo NIR-II whole body bioimaging". United Kingdom. doi:10.1039/C9QI00157C.
@article{osti_1523295,
title = {A proof-of-concept application of water-soluble ytterbium( iii ) molecular probes in in vivo NIR-II whole body bioimaging},
author = {Ning, Yingying and Chen, Si and Chen, Hao and Wang, Jing-Xiang and He, Shuqing and Liu, Yi-Wei and Cheng, Zhen and Zhang, Jun-Long},
abstractNote = {Lanthanide complexes are firstly applied for in vivo NIR-II high resolution whole body bioimaging.},
doi = {10.1039/C9QI00157C},
journal = {Inorganic Chemistry Frontiers (Online)},
number = 8,
volume = 6,
place = {United Kingdom},
year = {2019},
month = {8}
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on May 10, 2020
Publisher's Version of Record

Citation Metrics:
Cited by: 2 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Highly near-IR emissive ytterbium( iii ) complexes with unprecedented quantum yields
journal, January 2017

  • Hu, Ji-Yun; Ning, Yingying; Meng, Yin-Shan
  • Chemical Science, Vol. 8, Issue 4
  • DOI: 10.1039/C6SC05021B

Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window
journal, July 2017


Near-Infrared-Emitting Two-Dimensional Codes Based on Lattice-Strained Core/(Doped) Shell Quantum Dots with Long Fluorescence Lifetime
journal, July 2014


Lifetime-engineered NIR-II nanoparticles unlock multiplexed in vivo imaging
journal, August 2018


Near-Infrared Optical Imaging of Necrotic Cells by Photostable Lanthanide-Based Metallacrowns
journal, June 2017

  • Martinić, Ivana; Eliseeva, Svetlana V.; Nguyen, Tu N.
  • Journal of the American Chemical Society, Vol. 139, Issue 25
  • DOI: 10.1021/jacs.7b01587

Lanthanide light for biology and medical diagnosis
journal, February 2016


Understanding the Quenching Effects of Aromatic C–H- and C–D-Oscillators in Near-IR Lanthanoid Luminescence
journal, September 2012

  • Doffek, Christine; Alzakhem, Nicola; Bischof, Caroline
  • Journal of the American Chemical Society, Vol. 134, Issue 39
  • DOI: 10.1021/ja307339f

Lanthanide near infrared imaging in living cells with Yb3+ nano metal organic frameworks
journal, October 2013

  • Foucault-Collet, A.; Gogick, K. A.; White, K. A.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 43
  • DOI: 10.1073/pnas.1305910110

Time-resolved luminescent biosensing based on inorganic lanthanide-doped nanoprobes
journal, January 2015

  • Zheng, Wei; Tu, Datao; Huang, Ping
  • Chemical Communications, Vol. 51, Issue 20
  • DOI: 10.1039/C4CC10432C

Flavylium Polymethine Fluorophores for Near- and Shortwave Infrared Imaging
journal, September 2017

  • Cosco, Emily D.; Caram, Justin R.; Bruns, Oliver T.
  • Angewandte Chemie International Edition, Vol. 56, Issue 42
  • DOI: 10.1002/anie.201706974

On-the-fly decoding luminescence lifetimes in the microsecond region for lanthanide-encoded suspension arrays
journal, May 2014

  • Lu, Yiqing; Lu, Jie; Zhao, Jiangbo
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms4741

Two-Photon Luminescent Bone Imaging Using Europium Nanoagents
journal, September 2016


Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics
journal, January 2018

  • He, Shuqing; Song, Jun; Qu, Junle
  • Chemical Society Reviews, Vol. 47, Issue 12
  • DOI: 10.1039/C8CS00234G

β-Fluorinated porpholactones and metal complexes: synthesis, characterization and some spectroscopic studies
journal, January 2017

  • Hu, Ji-Yun; Wu, Zhuo-Yan; Chai, Ke
  • Inorganic Chemistry Frontiers, Vol. 4, Issue 9
  • DOI: 10.1039/C7QI00375G

Carbon nanotubes for biomedical imaging: The recent advances
journal, December 2013


Excitation- and Emission-Wavelength-Based Multiplex Spectroscopy Using Red-Absorbing Near-Infrared-Emitting Lanthanide Complexes
journal, August 2018

  • Xiong, Ruisheng; Mara, Dimitrije; Liu, Jing
  • Journal of the American Chemical Society, Vol. 140, Issue 35
  • DOI: 10.1021/jacs.8b07609

Lanthanide-based luminescence biolabelling
journal, January 2016

  • Sy, Mohamadou; Nonat, Aline; Hildebrandt, Niko
  • Chemical Communications, Vol. 52, Issue 29
  • DOI: 10.1039/C6CC00922K

A small-molecule dye for NIR-II imaging
journal, November 2015

  • Antaris, Alexander L.; Chen, Hao; Cheng, Kai
  • Nature Materials, Vol. 15, Issue 2
  • DOI: 10.1038/nmat4476

Polynuclear Sm III Polyamidoamine-Based Dendrimer: A Single Probe for Combined Visible and Near-Infrared Live-Cell Imaging
journal, February 2014

  • Foucault-Collet, Alexandra; Shade, Chad M.; Nazarenko, Iuliia
  • Angewandte Chemie International Edition, Vol. 53, Issue 11
  • DOI: 10.1002/anie.201311028

Review of Long-Wavelength Optical and NIR Imaging Materials: Contrast Agents, Fluorophores, and Multifunctional Nano Carriers
journal, December 2011

  • Pansare, Vikram J.; Hejazi, Shahram; Faenza, William J.
  • Chemistry of Materials, Vol. 24, Issue 5
  • DOI: 10.1021/cm2028367

Enantioselective cellular localisation of europium( iii ) coordination complexes
journal, January 2018

  • Frawley, Andrew T.; Linford, Holly V.; Starck, Matthieu
  • Chemical Science, Vol. 9, Issue 4
  • DOI: 10.1039/C7SC04422D

Development of responsive visibly and NIR luminescent and supramolecular coordination self-assemblies using lanthanide ion directed synthesis
journal, August 2014

  • Bradberry, Samuel J.; Savyasachi, Aramballi Jayant; Martinez-Calvo, Miguel
  • Coordination Chemistry Reviews, Vol. 273-274
  • DOI: 10.1016/j.ccr.2014.03.023

Biological Imaging Using Nanoparticles of Small Organic Molecules with Fluorescence Emission at Wavelengths Longer than 1000 nm
journal, October 2013

  • Tao, Zhimin; Hong, Guosong; Shinji, Chihiro
  • Angewandte Chemie International Edition, Vol. 52, Issue 49
  • DOI: 10.1002/anie.201307346

Shortwave-infrared (SWIR) emitters for biological imaging: a review of challenges and opportunities
journal, June 2017


Preferential accumulation within tumors and in vivo imaging by functionalized luminescent dendrimer lanthanide complexes
journal, December 2011


Efficient NIR Emission from Nd, Er, and Tm Complexes with Fluorinated Selenolate Ligands
journal, January 2018


Dramatic Increases in the Lifetime of the Er 3+ Ion in a Molecular Complex Using a Perfluorinated Imidodiphosphinate Sensitizing Ligand
journal, January 2005

  • Mancino, Gaetano; Ferguson, Andrew J.; Beeby, Andrew
  • Journal of the American Chemical Society, Vol. 127, Issue 2
  • DOI: 10.1021/ja0441864

Near-infrared emitting probes for biological imaging: Organic fluorophores, quantum dots, fluorescent proteins, lanthanide(III) complexes and nanomaterials
journal, September 2017


Highly luminescent, biocompatible ytterbium( iii ) complexes as near-infrared fluorophores for living cell imaging
journal, January 2018

  • Ning, Yingying; Tang, Juan; Liu, Yi-Wei
  • Chemical Science, Vol. 9, Issue 15
  • DOI: 10.1039/C8SC00259B

Near-infrared fluorophores for biomedical imaging
journal, January 2017

  • Hong, Guosong; Antaris, Alexander L.; Dai, Hongjie
  • Nature Biomedical Engineering, Vol. 1, Issue 1
  • DOI: 10.1038/s41551-016-0010

Ytterbium-Based Bioprobes for Near-Infrared Two-Photon Scanning Laser Microscopy Imaging
journal, May 2012

  • D'Aléo, Anthony; Bourdolle, Adrien; Brustlein, Sophie
  • Angewandte Chemie International Edition, Vol. 51, Issue 27
  • DOI: 10.1002/anie.201202212

Donor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance
journal, January 2018

  • Yang, Qinglai; Hu, Zhubin; Zhu, Shoujun
  • Journal of the American Chemical Society, Vol. 140, Issue 5
  • DOI: 10.1021/jacs.7b10334

A review of NIR dyes in cancer targeting and imaging
journal, October 2011


Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging
journal, January 2018

  • Ding, Feng; Zhan, Yibei; Lu, Xiaoju
  • Chemical Science, Vol. 9, Issue 19
  • DOI: 10.1039/C8SC01153B

Fluorescence lifetime imaging of upper gastrointestinal pH in vivo with a lanthanide based near-infrared τ probe
journal, January 2019

  • Ning, Yingying; Cheng, Shengming; Wang, Jing-Xiang
  • Chemical Science, Vol. 10, Issue 15
  • DOI: 10.1039/C9SC00220K