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Title: Biomimetic potassium-selective nanopores

Abstract

Reproducing the exquisite ion selectivity displayed by biological ion channels in artificial nanopore systems has proven to be one of the most challenging tasks undertaken by the nanopore community, yet a successful achievement of this goal offers immense technological potential. Here, we show a strategy to design solid-state nanopores that selectively transport potassium ions and show negligible conductance for sodium ions. The nanopores contain walls decorated with 4'-aminobenzo-18-crown-6 ether and single-stranded DNA (ssDNA) molecules located at one pore entrance. The ionic selectivity stems from facilitated transport of potassium ions in the pore region containing crown ether, while the highly charged ssDNA plays the role of a cation filter. Achieving potassium selectivity in solid-state nanopores opens new avenues toward advanced separation processes, more efficient biosensing technologies, and novel biomimetic nanopore systems.

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [3]; ORCiD logo [2]; ORCiD logo [4]
  1. Univ. of California, Irvine, CA (United States). Dept. of Physics and Astronomy; Istanbul Univ. Cerrahpasa, Avcılar-Istanbul (Turkey). Dept. of Chemistry
  2. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
  3. Univ. of California, Irvine, CA (United States). Dept. of Physics and Astronomy
  4. Univ. of California, Irvine, CA (United States). Dept. of Physics and Astronomy, Dept. of Chemistry, Dept. of Biomedical Engineering
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1513132
Report Number(s):
LLNL-JRNL-760930
Journal ID: ISSN 2375-2548; 949836
Grant/Contract Number:  
AC52-07NA27344
Resource Type:
Accepted Manuscript
Journal Name:
Science Advances
Additional Journal Information:
Journal Volume: 5; Journal Issue: 2; Journal ID: ISSN 2375-2548
Publisher:
AAAS
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Acar, Elif Turker, Buchsbaum, Steven F., Combs, Cody, Fornasiero, Francesco, and Siwy, Zuzanna S. Biomimetic potassium-selective nanopores. United States: N. p., 2019. Web. doi:10.1126/sciadv.aav2568.
Acar, Elif Turker, Buchsbaum, Steven F., Combs, Cody, Fornasiero, Francesco, & Siwy, Zuzanna S. Biomimetic potassium-selective nanopores. United States. doi:10.1126/sciadv.aav2568.
Acar, Elif Turker, Buchsbaum, Steven F., Combs, Cody, Fornasiero, Francesco, and Siwy, Zuzanna S. Fri . "Biomimetic potassium-selective nanopores". United States. doi:10.1126/sciadv.aav2568. https://www.osti.gov/servlets/purl/1513132.
@article{osti_1513132,
title = {Biomimetic potassium-selective nanopores},
author = {Acar, Elif Turker and Buchsbaum, Steven F. and Combs, Cody and Fornasiero, Francesco and Siwy, Zuzanna S.},
abstractNote = {Reproducing the exquisite ion selectivity displayed by biological ion channels in artificial nanopore systems has proven to be one of the most challenging tasks undertaken by the nanopore community, yet a successful achievement of this goal offers immense technological potential. Here, we show a strategy to design solid-state nanopores that selectively transport potassium ions and show negligible conductance for sodium ions. The nanopores contain walls decorated with 4'-aminobenzo-18-crown-6 ether and single-stranded DNA (ssDNA) molecules located at one pore entrance. The ionic selectivity stems from facilitated transport of potassium ions in the pore region containing crown ether, while the highly charged ssDNA plays the role of a cation filter. Achieving potassium selectivity in solid-state nanopores opens new avenues toward advanced separation processes, more efficient biosensing technologies, and novel biomimetic nanopore systems.},
doi = {10.1126/sciadv.aav2568},
journal = {Science Advances},
number = 2,
volume = 5,
place = {United States},
year = {2019},
month = {2}
}

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