PC-12 cells adhesion and differentiation on carbon aerogel scaffolds

Journal Article · 04 November 2018 · MRS Communications

DOI: https://doi.org/10.1557/mrc.2018.206 · OSTI ID:1513110

Rodriguez Sala, Martina ^[1]; Lynch, Kyle J. ^[1]; Chandrasekaran, Swetha ^[2]; Skalli, Omar ^[3]; Worsley, Marcus ^[2]; Sabri, Firouzeh ^[1]

---

1. Univ. of Memphis, Memphis, TN (United States). Dept. of Physics and Materials Science
2. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
3. Univ. of Memphis, Memphis, TN (United States). Dept. of Biological Sciences

Electrically conducting substrates have shown much promise as neuronal scaffolds and in other biologic and biomedical applications where a smart and electrically interactive material is needed. Most materials that are inherently conducting are not suitable for biomedical applications and lack biocompatibility or biostability. On the other hand, biologically stable and compatible materials must first be manipulated, modified, and treated in order to impart the necessary electrical conductivity to the material. Here, the authors have investigated the response of PC-12 cells to two types of conducting carbon-based aerogels with different surface roughness. Results show that carbon-based aerogels support cell adhesion, proliferation, and neurite extension. The effects of surface roughness have also been investigated.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• Sponsoring Organization: USDOE National Nuclear Security Administration (NNSA)
• Grant/Contract Number: AC52-07NA27344
• OSTI ID: 1513110
• Report Number(s): LLNL-JRNL--758242; 945937
• Journal Information: MRS Communications, Journal Name: MRS Communications Journal Issue: 04 Vol. 8; ISSN 2159-6859; ISSN applab
• Publisher: Materials Research Society - Cambridge University PressCopyright Statement
• Country of Publication: United States
• Language: English