Tuning crystallization pathways through sequence engineering of biomimetic polymers

Ma, Xiang; Zhang, Shuai; Jiao, Fang; Newcomb, Christina J.; Zhang, Yuliang; Prakash, Arushi; Liao, Zhihao; Baer, Marcel D.; Mundy, Christopher J.; Pfaendtner, James; Noy, Aleksandr; Chen, Chun-Long; De Yoreo, James J.

doi:10.1038/NMAT4891

Title: Tuning crystallization pathways through sequence engineering of biomimetic polymers

Journal Article · 17 April 2017 · Nature Materials

DOI: https://doi.org/10.1038/NMAT4891 · OSTI ID:1513103

Ma, Xiang ^[1];

^[1]; Jiao, Fang ^[2]; Newcomb, Christina J. ^[1]; Zhang, Yuliang ^[3]; Prakash, Arushi ^[4]; Liao, Zhihao ^[5]; Baer, Marcel D. ^[1]; Mundy, Christopher J. ^[4]; Pfaendtner, James ^[4];

^[3]; Chen, Chun-Long ^[1]; De Yoreo, James J. ^[6]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Physical Sciences Division
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Physical Sciences Division; East China Normal Univ. (ECNU), Shanghai (China). School of Chemistry and Molecular Engineering
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Physical and Life Sciences Directorate
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Physical Sciences Division; Univ. of Washington, Seattle, WA (United States). Dept. of Chemical Engineering
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Physical Sciences Division; Zhejiang University, Hangzhou, Zhejiang (China). Center for Biomaterials and Biopathways, Dept. of Chemistry
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Physical Sciences Division; Univ. of Washington, Seattle, WA (United States). Dept. of Materials Science and Engineering

Two-step nucleation pathways in which disordered, amorphous, or dense liquid states precede the appearance of crystalline phases have been reported for a wide range of materials, but the dynamics of such pathways are poorly understood. Moreover, whether these pathways are general features of crystallizing systems or a consequence of system-specific structural details that select for direct versus two-step processes is unknown. Using atomic force microscopy to directly observe crystallization of sequence-defined polymers, we show that crystallization pathways are indeed sequence dependent. When a short hydrophobic region is added to a sequence that directly forms crystalline particles, crystallization instead follows a two-step pathway that begins with the creation of disordered clusters of 10–20 molecules and is characterized by highly non-linear crystallization kinetics in which clusters transform into ordered structures that then enter the growth phase. The results shed new light on non-classical crystallization mechanisms and have implications for the design of self-assembling polymer systems.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC52-07NA27344; AC05-76RL01830

OSTI ID:: 1513103

Report Number(s):: LLNL-JRNL-772920; 961673

Journal Information:: Nature Materials, Vol. 16, Issue 7; ISSN 1476-1122

Publisher:: Springer Nature - Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 85 works

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