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Title: Amphiphilic triblocks to control assembly of mixed or segregated bilayers and monolayers

Abstract

Triblock amphiphilic molecules composed of three distinct segments provide a large parameter space to obtain self-assembled structures beyond what is achievable with conventional amphiphiles. To obtain a molecular understanding of the thermodynamics of self-assembly, we develop a coarse-grained triblock polymer model and apply self-consistent field theory to investigate the packing mechanism into layer structures. Furthermore by tuning the structural and interaction asymmetry, we are able to obtain bilayers and monolayers, where the latter may additionally be mixed (symmetric) or segregated (asymmetric). Of particular interest for a variety of applications are the asymmetric monolayers, where segregation of end blocks to opposite surfaces is expected to have important implications for the development of functional nanotubes and vesicles with distinct surface chemistries.

Authors:
 [1];  [1];  [1];  [1];  [1]
  1. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1512908
Report Number(s):
SAND-2015-8294J
Journal ID: ISSN 1744-683X; SMOABF; 665192
Grant/Contract Number:  
AC04-94AL85000
Resource Type:
Accepted Manuscript
Journal Name:
Soft Matter
Additional Journal Information:
Journal Volume: 11; Journal Issue: 34; Journal ID: ISSN 1744-683X
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English

Citation Formats

Ting, Christina L., Jones, Brad Howard, Frischknecht, Amalie Lucile, Spoerke, Erik David, and Stevens, Mark J. Amphiphilic triblocks to control assembly of mixed or segregated bilayers and monolayers. United States: N. p., 2015. Web. doi:10.1039/c5sm01447f.
Ting, Christina L., Jones, Brad Howard, Frischknecht, Amalie Lucile, Spoerke, Erik David, & Stevens, Mark J. Amphiphilic triblocks to control assembly of mixed or segregated bilayers and monolayers. United States. doi:10.1039/c5sm01447f.
Ting, Christina L., Jones, Brad Howard, Frischknecht, Amalie Lucile, Spoerke, Erik David, and Stevens, Mark J. Wed . "Amphiphilic triblocks to control assembly of mixed or segregated bilayers and monolayers". United States. doi:10.1039/c5sm01447f. https://www.osti.gov/servlets/purl/1512908.
@article{osti_1512908,
title = {Amphiphilic triblocks to control assembly of mixed or segregated bilayers and monolayers},
author = {Ting, Christina L. and Jones, Brad Howard and Frischknecht, Amalie Lucile and Spoerke, Erik David and Stevens, Mark J.},
abstractNote = {Triblock amphiphilic molecules composed of three distinct segments provide a large parameter space to obtain self-assembled structures beyond what is achievable with conventional amphiphiles. To obtain a molecular understanding of the thermodynamics of self-assembly, we develop a coarse-grained triblock polymer model and apply self-consistent field theory to investigate the packing mechanism into layer structures. Furthermore by tuning the structural and interaction asymmetry, we are able to obtain bilayers and monolayers, where the latter may additionally be mixed (symmetric) or segregated (asymmetric). Of particular interest for a variety of applications are the asymmetric monolayers, where segregation of end blocks to opposite surfaces is expected to have important implications for the development of functional nanotubes and vesicles with distinct surface chemistries.},
doi = {10.1039/c5sm01447f},
journal = {Soft Matter},
number = 34,
volume = 11,
place = {United States},
year = {2015},
month = {7}
}

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Works referenced in this record:

Forming giant vesicles with controlled membrane composition, asymmetry, and contents
journal, May 2011

  • Richmond, D. L.; Schmid, E. M.; Martens, S.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 23
  • DOI: 10.1073/pnas.1016410108

Self-Assembly in Mixtures of Diblock Copolymers
journal, September 1994


NMR quantification of the partition of coronal chain segments of block copolymer vesicles
journal, October 2009


Vesicles with asymmetric membranes from amphiphilic ABC triblock copolymers
journal, November 2002

  • Stoenescu, R.; Meier, W.
  • Chemical Communications, Issue 24
  • DOI: 10.1039/b209352a

Fine Tuning of Vesicle Assembly and Properties Using Dual Hydrophilic Triblock Copolypeptides
journal, April 2012

  • Rodriguez, April R.; Choe, Uh-Joo; Kamei, Daniel T.
  • Macromolecular Bioscience, Vol. 12, Issue 6
  • DOI: 10.1002/mabi.201200002

Pluronic® block copolymers: novel functional molecules for gene therapy
journal, February 2002


Micelle formation in triblock copolymer solutions
journal, June 2000


Preparation and Properties of Asymmetric Vesicles That Mimic Cell Membranes
journal, January 2009

  • Cheng, Hui-Ting; London, Erwin
  • Journal of Biological Chemistry, Vol. 284, Issue 10
  • DOI: 10.1074/jbc.M806077200

One-Step Preparation of Block Copolymer Vesicles with Preferentially Segregated Acidic and Basic Corona Chains
journal, March 2002


Effect of Poly(acrylic acid) Block Length Distribution on Polystyrene- b -Poly(acrylic acid) Aggregates in Solution. 1. Vesicles
journal, July 2003

  • Terreau, Owen; Luo, Laibin; Eisenberg, Adi
  • Langmuir, Vol. 19, Issue 14
  • DOI: 10.1021/la0269715

Asymmetric Vesicle Constructed by AB/CB Diblock Copolymer Mixture and Its Behavior: A Monte Carlo Study
journal, July 2014

  • Cui, Jie; Han, Yuanyuan; Jiang, Wei
  • Langmuir, Vol. 30, Issue 30
  • DOI: 10.1021/la501674a

Self-Assembly Behavior of pH- and Thermosensitive Amphiphilic Triblock Copolymers in Solution: Experimental Studies and Self-Consistent Field Theory Simulations
journal, October 2008

  • Cai, Chunhua; Zhang, Liangshun; Lin, Jiaping
  • The Journal of Physical Chemistry B, Vol. 112, Issue 40
  • DOI: 10.1021/jp805072t

Theory of Unsymmetric Polymer-Polymer Interfaces in the Presence of Solvent
journal, July 1980

  • Hong, K.; Noolandi, J.; Dennis, K. S.
  • Macromolecules, Vol. 13, Issue 4
  • DOI: 10.1021/ma60076a038

Effect of Polydispersity on the Formation of Vesicles from Amphiphilic Diblock Copolymers
journal, July 2005

  • Jiang, Ying; Chen, Tao; Ye, Fangwei
  • Macromolecules, Vol. 38, Issue 15
  • DOI: 10.1021/ma050424j

Amphiphilic block copolymers for drug delivery
journal, July 2003

  • Adams, Monica L.; Lavasanifar, Afsaneh; Kwon, Glen S.
  • Journal of Pharmaceutical Sciences, Vol. 92, Issue 7
  • DOI: 10.1002/jps.10397

Vesicle Structure and Formation of AB/BC Amphiphile Mixture Based on Hydrogen Bonding in a Selective Solvent: A Monte Carlo Study
journal, July 2012

  • Han, Yuanyuan; Cui, Jie; Jiang, Wei
  • The Journal of Physical Chemistry B, Vol. 116, Issue 30
  • DOI: 10.1021/jp3009783

Tailoring Macromolecular Expression at Polymersome Surfaces
journal, September 2009

  • Blanazs, Adam; Massignani, Marzia; Battaglia, Giuseppe
  • Advanced Functional Materials, Vol. 19, Issue 18
  • DOI: 10.1002/adfm.200900201

Nanoscale double emulsions stabilized by single-component block copolypeptides
journal, September 2008

  • Hanson, Jarrod A.; Chang, Connie B.; Graves, Sara M.
  • Nature, Vol. 455, Issue 7209
  • DOI: 10.1038/nature07197

Self-Assembly of ABA Amphiphilic Triblock Copolymers into Vesicles in Dilute Solution
journal, May 2005

  • Zhu, Jintao; Jiang, Ying; Liang, Haojun
  • The Journal of Physical Chemistry B, Vol. 109, Issue 18
  • DOI: 10.1021/jp044344d

ABC Triblock Terpolymer Self-Assembled Core-Shell-Corona Nanotubes with High Aspect Ratios
journal, May 2014

  • Wang, Lulu; Huang, Haiying; He, Tianbai
  • Macromolecular Rapid Communications, Vol. 35, Issue 16
  • DOI: 10.1002/marc.201400134

The role of surfactants in dispersion of carbon nanotubes
journal, December 2006

  • Vaisman, Linda; Wagner, H. Daniel; Marom, Gad
  • Advances in Colloid and Interface Science, Vol. 128-130
  • DOI: 10.1016/j.cis.2006.11.007

Oleylamine in Nanoparticle Synthesis
journal, February 2013

  • Mourdikoudis, Stefanos; Liz-Marzán, Luis M.
  • Chemistry of Materials, Vol. 25, Issue 9
  • DOI: 10.1021/cm4000476

Structure and design of polymeric surfactant-based drug delivery systems
journal, June 2001


Structural Mimics of Viruses Through Peptide/DNA Co-Assembly
journal, November 2014

  • Ni, Rong; Chau, Ying
  • Journal of the American Chemical Society, Vol. 136, Issue 52
  • DOI: 10.1021/ja507833x

Design, Synthesis, and Properties of Inorganic and Hybrid Thin Films Having Periodically Organized Nanoporosity
journal, February 2008

  • Sanchez, Clément; Boissière, Cédric; Grosso, David
  • Chemistry of Materials, Vol. 20, Issue 3
  • DOI: 10.1021/cm702100t

Poly(ethylene oxide)poly(propylene oxide)poly(ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling
journal, March 1995

  • Alexandridis, Paschalis; Alan Hatton, T.
  • Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 96, Issue 1-2
  • DOI: 10.1016/0927-7757(94)03028-X

Aggregate Morphologies of Amphiphilic ABC Triblock Copolymer in Dilute Solution Using Self-Consistent Field Theory
journal, September 2005

  • Wang, Rong; Tang, Ping; Qiu, Feng
  • The Journal of Physical Chemistry B, Vol. 109, Issue 36
  • DOI: 10.1021/jp053248p

Rational Synthesis of Low-Polydispersity Block Copolymer Vesicles in Concentrated Solution via Polymerization-Induced Self-Assembly
journal, July 2014

  • Gonzato, Carlo; Semsarilar, Mona; Jones, Elizabeth R.
  • Journal of the American Chemical Society, Vol. 136, Issue 31
  • DOI: 10.1021/ja505406s

Ordered mesoporous non-oxide materials
journal, January 2011

  • Shi, Yifeng; Wan, Ying; Zhao, Dongyuan
  • Chemical Society Reviews, Vol. 40, Issue 7
  • DOI: 10.1039/c0cs00186d

Bolaamphiphiles
journal, June 2004

  • Fuhrhop, Jürgen-Hinrich; Wang, Tianyu
  • Chemical Reviews, Vol. 104, Issue 6
  • DOI: 10.1021/cr030602b

Bolaamphiphiles form ultrathin, porous and unsymmetric monolayer lipid membranes
journal, May 1986

  • Fuhrhop, Juergen Hinrich; Fritsch, Detlev
  • Accounts of Chemical Research, Vol. 19, Issue 5
  • DOI: 10.1021/ar00125a002

Supramolecular organic nanotubes: how to utilize the inner nanospace and the outer space
journal, January 2011

  • Kameta, Naohiro; Minamikawa, Hiroyuki; Masuda, Mitsutoshi
  • Soft Matter, Vol. 7, Issue 10
  • DOI: 10.1039/c0sm01559h

Glycopolymer vesicles with an asymmetric membrane
journal, January 2009

  • Schlaad, Helmut; You, Liangchen; Sigel, Reinhard
  • Chemical Communications, Issue 12
  • DOI: 10.1039/b820887e

Micellization of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) Triblock Copolymers in Aqueous Solutions: Thermodynamics of Copolymer Association
journal, April 1994

  • Alexandridis, Paschalis; Holzwarth, Josef F.; Hatton, T. Alan
  • Macromolecules, Vol. 27, Issue 9
  • DOI: 10.1021/ma00087a009

Micellar structures of linear triblock terpolymers: Three blocks but many possibilities
journal, April 2013


Self-Assembly Behavior of AB/AC Diblock Copolymer Mixtures in Dilute Solution
journal, February 2009

  • Zhuang, Ying; Lin, Jiaping; Wang, Liquan
  • The Journal of Physical Chemistry B, Vol. 113, Issue 7
  • DOI: 10.1021/jp809181d

Micellization of block copolymers
journal, July 2003


Interactions of a Charged Nanoparticle with a Lipid Membrane: Implications for Gene Delivery
journal, March 2011