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Title: Mussel-Inspired Hydrogel Composite with Multi-Stimuli Responsive Behavior

Abstract

A mussel-inspired adhesive hydrogel with pH, temperature, and near-infrared (NIR) light–responsive behavior is designed here. The hydrogel system is formulated by combining chitosan modified with catechol motifs, thermo-responsive poly(N-isopropylacrylamide) terminated with catechols, and light-absorbing polypyrrole nanoparticles (PpyNPs). The effects of catechol concentration, molar ratio of Fe 3+ to catechol units, pH, and the incorporation of the PpyNPs on the mechanical property of the formed hydrogel are investigated. The responsive behaviors of the resulting hydrogel composite to pH, temperature, and NIR light are also demonstrated. The obtained hydrogel also shows promising adhesive property to glass and steel substrates. It is anticipated that the fabricated adhesive hydrogel with multi-responsive behavior, especially NIR light response, can potentially be useful in a wide range of biomedical applications, such as remotely controlled release systems and removable sealant materials.

Authors:
 [1];  [1];  [1];  [2];  [3]; ORCiD logo [1]
+ Show Author Affiliations
  1. Case Western Reserve Univ., Cleveland, OH (United States). Dept. of Macromolecular Science and Engineering
  2. Univ. of California, Berkeley, CA (United States). Dept. of Bioengineering
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Chemical Sciences Division
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Case Western Reserve Univ., Cleveland, OH (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); National Science Foundation (NSF)
OSTI Identifier:
1511921
Grant/Contract Number:  
AC05-00OR22725; CHE 1608457; CMMI NM 1333651; STC-0423914
Resource Type:
Accepted Manuscript
Journal Name:
Macromolecular Materials and Engineering
Additional Journal Information:
Journal Name: Macromolecular Materials and Engineering; Journal ID: ISSN 1438-7492
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
adhesive properties; catechol-rich polymers; Fe3+–catechol complexation; multi-stimuli responsiveness; near-infrared light responsiveness

Citation Formats

Yan, Yun‐Hui, Rong, Li‐Han, Ge, Jin, Tiu, Brylee David B., Cao, Peng‐Fei, and Advincula, Rigoberto C. Mussel-Inspired Hydrogel Composite with Multi-Stimuli Responsive Behavior. United States: N. p., 2019. Web. doi:10.1002/mame.201800720.
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Yan, Yun‐Hui, Rong, Li‐Han, Ge, Jin, Tiu, Brylee David B., Cao, Peng‐Fei, & Advincula, Rigoberto C. Mussel-Inspired Hydrogel Composite with Multi-Stimuli Responsive Behavior. United States. doi:10.1002/mame.201800720.
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Yan, Yun‐Hui, Rong, Li‐Han, Ge, Jin, Tiu, Brylee David B., Cao, Peng‐Fei, and Advincula, Rigoberto C. Tue . "Mussel-Inspired Hydrogel Composite with Multi-Stimuli Responsive Behavior". United States. doi:10.1002/mame.201800720.
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@article{osti_1511921,
title = {Mussel-Inspired Hydrogel Composite with Multi-Stimuli Responsive Behavior},
author = {Yan, Yun‐Hui and Rong, Li‐Han and Ge, Jin and Tiu, Brylee David B. and Cao, Peng‐Fei and Advincula, Rigoberto C.},
abstractNote = {A mussel-inspired adhesive hydrogel with pH, temperature, and near-infrared (NIR) light–responsive behavior is designed here. The hydrogel system is formulated by combining chitosan modified with catechol motifs, thermo-responsive poly(N-isopropylacrylamide) terminated with catechols, and light-absorbing polypyrrole nanoparticles (PpyNPs). The effects of catechol concentration, molar ratio of Fe3+ to catechol units, pH, and the incorporation of the PpyNPs on the mechanical property of the formed hydrogel are investigated. The responsive behaviors of the resulting hydrogel composite to pH, temperature, and NIR light are also demonstrated. The obtained hydrogel also shows promising adhesive property to glass and steel substrates. It is anticipated that the fabricated adhesive hydrogel with multi-responsive behavior, especially NIR light response, can potentially be useful in a wide range of biomedical applications, such as remotely controlled release systems and removable sealant materials.},
doi = {10.1002/mame.201800720},
journal = {Macromolecular Materials and Engineering},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {4}
}
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Journal Article:
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This content will become publicly available on April 16, 2020
Publisher's Version of Record
DOI:  10.1002/mame.201800720
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Works referenced in this record:

pH-induced metal-ligand cross-links inspired by mussel yield self-healing polymer networks with near-covalent elastic moduli
journal, January 2011

  • Holten-Andersen, N.; Harrington, M. J.; Birkedal, H.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 7, p. 2651-2655
  • DOI: 10.1073/pnas.1015862108
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