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Title: Synthesis of Stable Isotope Labeled Chloroquine, Amodiaquine and Their Metabolites

Journal Article · · Journal of Labelled Compounds and Radiopharmaceuticals
DOI: https://doi.org/10.1002/jlcr.3721 · OSTI ID:1511624

Anti–malaria drugs chloroquine, amodiaquine and their metabolites were stable isotope labeled with 13C and 15N starting from uniformly 13C labeled benzene and 15N labeled potassium nitrate to give M+7 isotopomers. Here, chloroquine, and its metabolites were prepared from 7–chloro–1,2,3,4–tetrahydroquinolin–4–one through addition to the carbonyl with the corresponding amines; and the amodiaquine and its metabolites were prepared from 4,7–dichloroquinoline in a selective aryl–halogen exchange with the corresponding amines.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
89233218CNA000001
OSTI ID:
1511624
Report Number(s):
LA-UR-18-31663
Journal Information:
Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 62, Issue 5; ISSN 0362-4803
Publisher:
WileyCopyright Statement
Country of Publication:
United States
Language:
English

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  • Wu, Ruilian; ‘Pete’ Silks, L. A.; Olivault-Shiflett, Morgane
  • Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 56, Issue 11 https://doi.org/10.1002/jlcr.3066
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