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Title: Metabolic Engineering of Oleaginous Yeasts for Production of Fuels and Chemicals

Abstract

Oleaginous yeasts have been increasingly explored for production of chemicals and fuels via metabolic engineering. Particularly, there is a growing interest in using oleaginous yeasts for the synthesis of lipid-related products due to their high lipogenesis capability, robustness, and ability to utilize a variety of substrates. Most of the metabolic engineering studies in oleaginous yeasts focused on Yarrowia that already has plenty of genetic engineering tools. However, recent advances in systems biology and synthetic biology have provided new strategies and tools to engineer those oleaginous yeasts that have naturally high lipid accumulation but lack genetic tools, such as Rhodosporidium, Trichosporon, and Lipomyces. This review highlights recent accomplishments in metabolic engineering of oleaginous yeasts and recent advances in the development of genetic engineering tools in oleaginous yeasts within the last 3 years.

Authors:
 [1];  [2]
  1. Beijing Univ. of Chemical Technology (China); Science and Engineering Inst. (Singapore)
  2. Beijing Univ. of Chemical Technology (China); Science and Engineering Inst. (Singapore); Univ. of Illinois, Urbana-Champaign, IL (United States)
Publication Date:
Research Org.:
University of Illinois, Champaign, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1510464
Grant/Contract Number:  
SC0018260
Resource Type:
Accepted Manuscript
Journal Name:
Frontiers in Microbiology
Additional Journal Information:
Journal Volume: 8; Journal ID: ISSN 1664-302X
Publisher:
Frontiers Research Foundation
Country of Publication:
United States
Language:
English
Subject:
09 BIOMASS FUELS; 59 BASIC BIOLOGICAL SCIENCES; metabolic engineering; oleaginous yeasts; fuels; chemicals; fatty acids

Citation Formats

Shi, Shuobo, and Zhao, Huimin. Metabolic Engineering of Oleaginous Yeasts for Production of Fuels and Chemicals. United States: N. p., 2017. Web. doi:10.3389/fmicb.2017.02185.
Shi, Shuobo, & Zhao, Huimin. Metabolic Engineering of Oleaginous Yeasts for Production of Fuels and Chemicals. United States. doi:10.3389/fmicb.2017.02185.
Shi, Shuobo, and Zhao, Huimin. Wed . "Metabolic Engineering of Oleaginous Yeasts for Production of Fuels and Chemicals". United States. doi:10.3389/fmicb.2017.02185. https://www.osti.gov/servlets/purl/1510464.
@article{osti_1510464,
title = {Metabolic Engineering of Oleaginous Yeasts for Production of Fuels and Chemicals},
author = {Shi, Shuobo and Zhao, Huimin},
abstractNote = {Oleaginous yeasts have been increasingly explored for production of chemicals and fuels via metabolic engineering. Particularly, there is a growing interest in using oleaginous yeasts for the synthesis of lipid-related products due to their high lipogenesis capability, robustness, and ability to utilize a variety of substrates. Most of the metabolic engineering studies in oleaginous yeasts focused on Yarrowia that already has plenty of genetic engineering tools. However, recent advances in systems biology and synthetic biology have provided new strategies and tools to engineer those oleaginous yeasts that have naturally high lipid accumulation but lack genetic tools, such as Rhodosporidium, Trichosporon, and Lipomyces. This review highlights recent accomplishments in metabolic engineering of oleaginous yeasts and recent advances in the development of genetic engineering tools in oleaginous yeasts within the last 3 years.},
doi = {10.3389/fmicb.2017.02185},
journal = {Frontiers in Microbiology},
number = ,
volume = 8,
place = {United States},
year = {2017},
month = {11}
}

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Cited by: 24 works
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