Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations
Abstract
A new ultrahigh resolution ion mobility platform enables the fast separation and characterization of isomeric glycoforms.
- Publication Date:
- Research Org.:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1507760
- Report Number(s):
- PNNL-SA-137134
Journal ID: ISSN 1359-7345; CHCOFS
- Grant/Contract Number:
- AC05-76RL01830
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ChemComm
- Additional Journal Information:
- Journal Volume: 54; Journal Issue: 83; Journal ID: ISSN 1359-7345
- Publisher:
- Royal Society of Chemistry
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Nagy, Gavril, Attah, Isaac K., Garimella, Sandilya V. B., Tang, Keqi, Ibrahim, Yehia M., Baker, Erin M., and Smith, Richard D. Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations. United States: N. p., 2018.
Web. doi:10.1039/C8CC06966B.
Nagy, Gavril, Attah, Isaac K., Garimella, Sandilya V. B., Tang, Keqi, Ibrahim, Yehia M., Baker, Erin M., & Smith, Richard D. Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations. United States. https://doi.org/10.1039/C8CC06966B
Nagy, Gavril, Attah, Isaac K., Garimella, Sandilya V. B., Tang, Keqi, Ibrahim, Yehia M., Baker, Erin M., and Smith, Richard D. Tue .
"Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations". United States. https://doi.org/10.1039/C8CC06966B. https://www.osti.gov/servlets/purl/1507760.
@article{osti_1507760,
title = {Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations},
author = {Nagy, Gavril and Attah, Isaac K. and Garimella, Sandilya V. B. and Tang, Keqi and Ibrahim, Yehia M. and Baker, Erin M. and Smith, Richard D.},
abstractNote = {A new ultrahigh resolution ion mobility platform enables the fast separation and characterization of isomeric glycoforms.},
doi = {10.1039/C8CC06966B},
journal = {ChemComm},
number = 83,
volume = 54,
place = {United States},
year = {2018},
month = {9}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 11 works
Citation information provided by
Web of Science
Web of Science
Figures / Tables:
Figure 1: Illustration of some of the isomeric heterogeneity of glycans in various tri/tetra-saccharides (top), and a simplified schematic of the SLIM device ion path used in these experiments (bottom).
All figures and tables
(4 total)
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Discrimination of Isomeric Carbohydrates as the Electron Transfer Products of Group II Cation Adducts by Ion Mobility Spectrometry and Tandem Mass Spectrometry
journal, May 2015
- Huang, Yuting; Dodds, Eric D.
- Analytical Chemistry, Vol. 87, Issue 11
Human milk oligosaccharides: Every baby needs a sugar mama
journal, April 2012
- Bode, L.
- Glycobiology, Vol. 22, Issue 9
Improved Sensitivity and Separations for Phosphopeptides using Online Liquid Chromotography Coupled with Structures for Lossless Ion Manipulations Ion Mobility–Mass Spectrometry
journal, August 2018
- Chouinard, Christopher D.; Nagy, Gabe; Webb, Ian K.
- Analytical Chemistry, Vol. 90, Issue 18
Rapid Ion Mobility Separations of Bile Acid Isomers Using Cyclodextrin Adducts and Structures for Lossless Ion Manipulations
journal, August 2018
- Chouinard, Christopher D.; Nagy, Gabe; Webb, Ian K.
- Analytical Chemistry, Vol. 90, Issue 18
Ultra-High Resolution Ion Mobility Separations Utilizing Traveling Waves in a 13 m Serpentine Path Length Structures for Lossless Ion Manipulations Module
journal, August 2016
- Deng, Liulin; Ibrahim, Yehia M.; Hamid, Ahmed M.
- Analytical Chemistry, Vol. 88, Issue 18
A unified vision of the building blocks of life
journal, September 2008
- Marth, Jamey D.
- Nature Cell Biology, Vol. 10, Issue 9
Characterization of Isomeric Glycans by Reversed Phase Liquid Chromatography-Electronic Excitation Dissociation Tandem Mass Spectrometry
journal, April 2018
- Tang, Yang; Wei, Juan; Costello, Catherine E.
- Journal of The American Society for Mass Spectrometry, Vol. 29, Issue 6
Anomeric memory of the glycosidic bond upon fragmentation and its consequences for carbohydrate sequencing
journal, October 2017
- Schindler, Baptiste; Barnes, Loïc; Renois, Gina
- Nature Communications, Vol. 8, Issue 1
Serpentine Ultralong Path with Extended Routing (SUPER) High Resolution Traveling Wave Ion Mobility-MS using Structures for Lossless Ion Manipulations
journal, April 2017
- Deng, Liulin; Webb, Ian K.; Garimella, Sandilya V. B.
- Analytical Chemistry, Vol. 89, Issue 8
Glycan Fingerprinting via Cold-Ion Infrared Spectroscopy
journal, June 2017
- Mucha, Eike; González Flórez, Ana Isabel; Marianski, Mateusz
- Angewandte Chemie International Edition, Vol. 56, Issue 37
Compression Ratio Ion Mobility Programming (CRIMP) Accumulation and Compression of Billions of Ions for Ion Mobility-Mass Spectrometry Using Traveling Waves in Structures for Lossless Ion Manipulations (SLIM)
journal, May 2017
- Deng, Liulin; Garimella, Sandilya V. B.; Hamid, Ahmed M.
- Analytical Chemistry, Vol. 89, Issue 12
Human Milk Oligosaccharides Promote the Growth of Staphylococci
journal, May 2012
- Hunt, K. M.; Preuss, J.; Nissan, C.
- Applied and Environmental Microbiology, Vol. 78, Issue 14
Recent Advances in the Analysis of Complex Glycoproteins
journal, November 2016
- Gaunitz, Stefan; Nagy, Gabe; Pohl, Nicola L. B.
- Analytical Chemistry, Vol. 89, Issue 1
Symbol Nomenclature for Graphical Representations of Glycans
journal, November 2015
- Varki, Ajit; Cummings, Richard D.; Aebi, Markus
- Glycobiology, Vol. 25, Issue 12
Recent advances in ion mobility–mass spectrometry for improved structural characterization of glycans and glycoconjugates
journal, February 2018
- Chen, Zhengwei; Glover, Matthew S.; Li, Lingjun
- Current Opinion in Chemical Biology, Vol. 42
Cryogenic IR spectroscopy combined with ion mobility spectrometry for the analysis of human milk oligosaccharides
journal, January 2018
- Khanal, Neelam; Masellis, Chiara; Kamrath, Michael Z.
- The Analyst, Vol. 143, Issue 8
Tandem mass spectrometry and ion mobility mass spectrometry for the analysis of molecular sequence and architecture of hyperbranched glycopolymers
journal, January 2015
- Liu, Xiumin; Cool, Lydia R.; Lin, Kenneth
- The Analyst, Vol. 140, Issue 4
Glycan analysis by ion mobility-mass spectrometry and gas-phase spectroscopy
journal, February 2018
- Manz, Christian; Pagel, Kevin
- Current Opinion in Chemical Biology, Vol. 42
Oligosaccharide Analysis by Mass Spectrometry: A Review of Recent Developments
journal, December 2013
- Kailemia, Muchena J.; Ruhaak, L. Renee; Lebrilla, Carlito B.
- Analytical Chemistry, Vol. 86, Issue 1
Determining the Isomeric Heterogeneity of Neutral Oligosaccharide-Alditols of Bovine Submaxillary Mucin Using Negative Ion Traveling Wave Ion Mobility Mass Spectrometry
journal, January 2015
- Li, Hongli; Bendiak, Brad; Siems, William F.
- Analytical Chemistry, Vol. 87, Issue 4
Vertebrate protein glycosylation: diversity, synthesis and function
journal, June 2012
- Moremen, Kelley W.; Tiemeyer, Michael; Nairn, Alison V.
- Nature Reviews Molecular Cell Biology, Vol. 13, Issue 7
Cryogenic Vibrational Spectroscopy Provides Unique Fingerprints for Glycan Identification
journal, June 2017
- Masellis, Chiara; Khanal, Neelam; Kamrath, Michael Z.
- Journal of The American Society for Mass Spectrometry, Vol. 28, Issue 10
Ion mobility mass spectrometry analysis of isomeric disaccharide precursor, product and cluster ions: Analysis of isomeric disaccharide precursor, product and cluster ions
journal, October 2013
- Li, Hongli; Bendiak, Brad; Siems, William F.
- Rapid Communications in Mass Spectrometry, Vol. 27, Issue 23
Structural resolution of carbohydrate positional and structural isomers based on gas-phase ion mobility-mass spectrometry
journal, January 2011
- Fenn, Larissa S.; McLean, John A.
- Phys. Chem. Chem. Phys., Vol. 13, Issue 6
Separation of sodiated isobaric disaccharides and trisaccharides using electrospray ionization-atmospheric pressure ion mobility-time of flight mass spectrometry
journal, May 2005
- Clowers, Brian H.; Dwivedi, Prabha; Steiner, Wes E.
- Journal of the American Society for Mass Spectrometry, Vol. 16, Issue 5
Glycan Analysis by Ion Mobility-Mass Spectrometry
journal, June 2017
- Hofmann, Johanna; Pagel, Kevin
- Angewandte Chemie International Edition, Vol. 56, Issue 29
Non-derivatized glycan analysis by reverse phase liquid chromatography and ion mobility-mass spectrometry
journal, January 2015
- Lareau, Nichole M.; May, Jody C.; McLean, John A.
- The Analyst, Vol. 140, Issue 10
Energy-Resolved Ion Mobility-Mass Spectrometry—A Concept to Improve the Separation of Isomeric Carbohydrates
journal, January 2014
- Hoffmann, Waldemar; Hofmann, Johanna; Pagel, Kevin
- Journal of The American Society for Mass Spectrometry, Vol. 25, Issue 3
Automated Chemical Oligosaccharide Synthesis: Novel Approach to Traditional Challenges
journal, June 2018
- Panza, Matteo; Pistorio, Salvatore G.; Stine, Keith J.
- Chemical Reviews, Vol. 118, Issue 17
Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry
journal, January 2016
- Hinneburg, H.; Hofmann, J.; Struwe, W. B.
- Chemical Communications, Vol. 52, Issue 23
Identification of carbohydrate anomers using ion mobility–mass spectrometry
journal, September 2015
- Hofmann, J.; Hahm, H. S.; Seeberger, P. H.
- Nature, Vol. 526, Issue 7572
Recent advances on separation and characterization of human milk oligosaccharides: General
journal, February 2016
- Mantovani, Veronica; Galeotti, Fabio; Maccari, Francesca
- ELECTROPHORESIS, Vol. 37, Issue 11
Ion-neutral collisional cross sections of carbohydrate isomers as divalent cation adducts and their electron transfer products
journal, January 2015
- Huang, Yuting; Dodds, Eric D.
- The Analyst, Vol. 140, Issue 20
Squeezing of Ion Populations and Peaks in Traveling Wave Ion Mobility Separations and Structures for Lossless Ion Manipulations Using Compression Ratio Ion Mobility Programming
journal, November 2016
- Garimella, Sandilya V. B.; Hamid, Ahmed M.; Deng, Liulin
- Analytical Chemistry, Vol. 88, Issue 23
Enhancing glycan isomer separations with metal ions and positive and negative polarity ion mobility spectrometry-mass spectrometry analyses
journal, September 2016
- Zheng, Xueyun; Zhang, Xing; Schocker, Nathaniel S.
- Analytical and Bioanalytical Chemistry, Vol. 409, Issue 2
Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO 2 as drift gas : Increasing ion mobility Synapt resolution with CO2
journal, December 2012
- Fasciotti, Maíra; Sanvido, Gustavo B.; Santos, Vanessa G.
- Journal of Mass Spectrometry, Vol. 47, Issue 12
Multidimensional Analysis of 16 Glucose Isomers by Ion Mobility Spectrometry
journal, February 2016
- Gaye, M. M.; Nagy, G.; Clemmer, D. E.
- Analytical Chemistry, Vol. 88, Issue 4
Ion Mobility–Mass Spectrometry of Complex Carbohydrates: Collision Cross Sections of Sodiated N-linked Glycans
journal, May 2013
- Pagel, Kevin; Harvey, David J.
- Analytical Chemistry, Vol. 85, Issue 10
Ion Mobility Studies of Carbohydrates as Group I Adducts: Isomer Specific Collisional Cross Section Dependence on Metal Ion Radius
journal, September 2013
- Huang, Yuting; Dodds, Eric D.
- Analytical Chemistry, Vol. 85, Issue 20
Breast Milk Oligosaccharides: Structure-Function Relationships in the Neonate
journal, July 2014
- Smilowitz, Jennifer T.; Lebrilla, Carlito B.; Mills, David A.
- Annual Review of Nutrition, Vol. 34, Issue 1
Ion Mobility Separations of Isomers based upon Long Path Length Structures for Lossless Ion Manipulations Combined with Mass Spectrometry
journal, July 2016
- Deng, Liulin; Ibrahim, Yehia M.; Baker, Erin S.
- ChemistrySelect, Vol. 1, Issue 10
Symbol Nomenclature for Graphical Representations of Glycans
text, January 2015
- Varki, Ajit; Cummings, Richard D.; Aebi, Markus
- ETH Zurich
Works referencing / citing this record:
Combining ultra-high resolution ion mobility spectrometry with cryogenic IR spectroscopy for the study of biomolecular ions
journal, January 2019
- Warnke, Stephan; Ben Faleh, Ahmed; Pellegrinelli, Robert P.
- Faraday Discussions, Vol. 217
Figures / Tables found in this record:
Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.