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Title: Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations

Journal Article · · ChemComm
DOI: https://doi.org/10.1039/C8CC06966B · OSTI ID:1507760

A new ultrahigh resolution ion mobility platform enables the fast separation and characterization of isomeric glycoforms.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
AC05-76RL01830
OSTI ID:
1507760
Report Number(s):
PNNL-SA-137134; CHCOFS
Journal Information:
ChemComm, Vol. 54, Issue 83; ISSN 1359-7345
Publisher:
Royal Society of ChemistryCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 61 works
Citation information provided by
Web of Science

References (42)

Discrimination of Isomeric Carbohydrates as the Electron Transfer Products of Group II Cation Adducts by Ion Mobility Spectrometry and Tandem Mass Spectrometry journal May 2015
Human milk oligosaccharides: Every baby needs a sugar mama journal April 2012
Improved Sensitivity and Separations for Phosphopeptides using Online Liquid Chromotography Coupled with Structures for Lossless Ion Manipulations Ion Mobility–Mass Spectrometry journal August 2018
Rapid Ion Mobility Separations of Bile Acid Isomers Using Cyclodextrin Adducts and Structures for Lossless Ion Manipulations journal August 2018
Ultra-High Resolution Ion Mobility Separations Utilizing Traveling Waves in a 13 m Serpentine Path Length Structures for Lossless Ion Manipulations Module journal August 2016
A unified vision of the building blocks of life journal September 2008
Characterization of Isomeric Glycans by Reversed Phase Liquid Chromatography-Electronic Excitation Dissociation Tandem Mass Spectrometry journal April 2018
Anomeric memory of the glycosidic bond upon fragmentation and its consequences for carbohydrate sequencing journal October 2017
Serpentine Ultralong Path with Extended Routing (SUPER) High Resolution Traveling Wave Ion Mobility-MS using Structures for Lossless Ion Manipulations journal April 2017
Glycan Fingerprinting via Cold-Ion Infrared Spectroscopy journal June 2017
Compression Ratio Ion Mobility Programming (CRIMP) Accumulation and Compression of Billions of Ions for Ion Mobility-Mass Spectrometry Using Traveling Waves in Structures for Lossless Ion Manipulations (SLIM) journal May 2017
Human Milk Oligosaccharides Promote the Growth of Staphylococci journal May 2012
Recent Advances in the Analysis of Complex Glycoproteins journal November 2016
Symbol Nomenclature for Graphical Representations of Glycans journal November 2015
Recent advances in ion mobility–mass spectrometry for improved structural characterization of glycans and glycoconjugates journal February 2018
Cryogenic IR spectroscopy combined with ion mobility spectrometry for the analysis of human milk oligosaccharides journal January 2018
Tandem mass spectrometry and ion mobility mass spectrometry for the analysis of molecular sequence and architecture of hyperbranched glycopolymers journal January 2015
Glycan analysis by ion mobility-mass spectrometry and gas-phase spectroscopy journal February 2018
Oligosaccharide Analysis by Mass Spectrometry: A Review of Recent Developments journal December 2013
Determining the Isomeric Heterogeneity of Neutral Oligosaccharide-Alditols of Bovine Submaxillary Mucin Using Negative Ion Traveling Wave Ion Mobility Mass Spectrometry journal January 2015
Vertebrate protein glycosylation: diversity, synthesis and function journal June 2012
Cryogenic Vibrational Spectroscopy Provides Unique Fingerprints for Glycan Identification journal June 2017
Ion mobility mass spectrometry analysis of isomeric disaccharide precursor, product and cluster ions: Analysis of isomeric disaccharide precursor, product and cluster ions journal October 2013
Structural resolution of carbohydrate positional and structural isomers based on gas-phase ion mobility-mass spectrometry journal January 2011
Separation of sodiated isobaric disaccharides and trisaccharides using electrospray ionization-atmospheric pressure ion mobility-time of flight mass spectrometry journal May 2005
Glycan Analysis by Ion Mobility-Mass Spectrometry journal June 2017
Non-derivatized glycan analysis by reverse phase liquid chromatography and ion mobility-mass spectrometry journal January 2015
Energy-Resolved Ion Mobility-Mass Spectrometry—A Concept to Improve the Separation of Isomeric Carbohydrates journal January 2014
Automated Chemical Oligosaccharide Synthesis: Novel Approach to Traditional Challenges journal June 2018
Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry journal January 2016
Identification of carbohydrate anomers using ion mobility–mass spectrometry journal September 2015
Recent advances on separation and characterization of human milk oligosaccharides: General journal February 2016
Ion-neutral collisional cross sections of carbohydrate isomers as divalent cation adducts and their electron transfer products journal January 2015
Squeezing of Ion Populations and Peaks in Traveling Wave Ion Mobility Separations and Structures for Lossless Ion Manipulations Using Compression Ratio Ion Mobility Programming journal November 2016
Enhancing glycan isomer separations with metal ions and positive and negative polarity ion mobility spectrometry-mass spectrometry analyses journal September 2016
Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO 2 as drift gas : Increasing ion mobility Synapt resolution with CO2 journal December 2012
Multidimensional Analysis of 16 Glucose Isomers by Ion Mobility Spectrometry journal February 2016
Ion Mobility–Mass Spectrometry of Complex Carbohydrates: Collision Cross Sections of Sodiated N-linked Glycans journal May 2013
Ion Mobility Studies of Carbohydrates as Group I Adducts: Isomer Specific Collisional Cross Section Dependence on Metal Ion Radius journal September 2013
Breast Milk Oligosaccharides: Structure-Function Relationships in the Neonate journal July 2014
Ion Mobility Separations of Isomers based upon Long Path Length Structures for Lossless Ion Manipulations Combined with Mass Spectrometry journal July 2016
Symbol Nomenclature for Graphical Representations of Glycans text January 2015

Cited By (1)

Combining ultra-high resolution ion mobility spectrometry with cryogenic IR spectroscopy for the study of biomolecular ions journal January 2019

Figures / Tables (4)