Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations

Nagy, Gavril; Attah, Isaac K.; Garimella, Sandilya V. B.; Tang, Keqi; Ibrahim, Yehia M.; Baker, Erin M.; Smith, Richard D.

doi:10.1039/C8CC06966B

Title: Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations

Abstract

A new ultrahigh resolution ion mobility platform enables the fast separation and characterization of isomeric glycoforms.

Authors:

Nagy, Gavril ^[1]; Attah, Isaac K. ^[1];

^[1]; Tang, Keqi ^[1];

^[1];

^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Publication Date:: Tue Sep 25 00:00:00 EDT 2018

Research Org.:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1507760

Report Number(s):: PNNL-SA-137134
Journal ID: ISSN 1359-7345; CHCOFS

Grant/Contract Number:: AC05-76RL01830

Resource Type:: Accepted Manuscript

Journal Name:: ChemComm

Additional Journal Information:: Journal Volume: 54; Journal Issue: 83; Journal ID: ISSN 1359-7345

Publisher:: Royal Society of Chemistry

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Nagy, Gavril, Attah, Isaac K., Garimella, Sandilya V. B., Tang, Keqi, Ibrahim, Yehia M., Baker, Erin M., and Smith, Richard D. Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations.  United States: N. p., 2018. 
Web.  doi:10.1039/C8CC06966B.

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                    Nagy, Gavril, Attah, Isaac K., Garimella, Sandilya V. B., Tang, Keqi, Ibrahim, Yehia M., Baker, Erin M., & Smith, Richard D. Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations.  United States.  https://doi.org/10.1039/C8CC06966B

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                    Nagy, Gavril, Attah, Isaac K., Garimella, Sandilya V. B., Tang, Keqi, Ibrahim, Yehia M., Baker, Erin M., and Smith, Richard D. Tue .  
"Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations".  United States.  https://doi.org/10.1039/C8CC06966B.  https://www.osti.gov/servlets/purl/1507760.

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@article{osti_1507760,

  title        = {Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations},

  author       = {Nagy, Gavril and Attah, Isaac K. and Garimella, Sandilya V. B. and Tang, Keqi and Ibrahim, Yehia M. and Baker, Erin M. and Smith, Richard D.},

  abstractNote = {A new ultrahigh resolution ion mobility platform enables the fast separation and characterization of isomeric glycoforms.},

  doi          = {10.1039/C8CC06966B},

  journal      = {ChemComm},

  number       = 83,

  volume       = 54,

  place        = {United States},

  year         = {Tue Sep 25 00:00:00 EDT 2018},

  month        = {Tue Sep 25 00:00:00 EDT 2018}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (DOE)

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https://doi.org/10.1039/C8CC06966B

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Citation Metrics:

Cited by: 51 works

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Figures / Tables:

Figure 1: Illustration of some of the isomeric heterogeneity of glycans in various tri/tetra-saccharides (top), and a simplified schematic of the SLIM device ion path used in these experiments (bottom).

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Works referenced in this record:

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Title: Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations

Abstract

Citation Formats

Figures / Tables:

Discrimination of Isomeric Carbohydrates as the Electron Transfer Products of Group II Cation Adducts by Ion Mobility Spectrometry and Tandem Mass Spectrometry journal, May 2015

Human milk oligosaccharides: Every baby needs a sugar mama journal, April 2012

Improved Sensitivity and Separations for Phosphopeptides using Online Liquid Chromotography Coupled with Structures for Lossless Ion Manipulations Ion Mobility–Mass Spectrometry journal, August 2018

Rapid Ion Mobility Separations of Bile Acid Isomers Using Cyclodextrin Adducts and Structures for Lossless Ion Manipulations journal, August 2018

Ultra-High Resolution Ion Mobility Separations Utilizing Traveling Waves in a 13 m Serpentine Path Length Structures for Lossless Ion Manipulations Module journal, August 2016

A unified vision of the building blocks of life journal, September 2008

Characterization of Isomeric Glycans by Reversed Phase Liquid Chromatography-Electronic Excitation Dissociation Tandem Mass Spectrometry journal, April 2018

Anomeric memory of the glycosidic bond upon fragmentation and its consequences for carbohydrate sequencing journal, October 2017

Serpentine Ultralong Path with Extended Routing (SUPER) High Resolution Traveling Wave Ion Mobility-MS using Structures for Lossless Ion Manipulations journal, April 2017

Glycan Fingerprinting via Cold-Ion Infrared Spectroscopy journal, June 2017

Compression Ratio Ion Mobility Programming (CRIMP) Accumulation and Compression of Billions of Ions for Ion Mobility-Mass Spectrometry Using Traveling Waves in Structures for Lossless Ion Manipulations (SLIM) journal, May 2017

Human Milk Oligosaccharides Promote the Growth of Staphylococci journal, May 2012

Recent Advances in the Analysis of Complex Glycoproteins journal, November 2016

Symbol Nomenclature for Graphical Representations of Glycans journal, November 2015

Recent advances in ion mobility–mass spectrometry for improved structural characterization of glycans and glycoconjugates journal, February 2018

Cryogenic IR spectroscopy combined with ion mobility spectrometry for the analysis of human milk oligosaccharides journal, January 2018

Tandem mass spectrometry and ion mobility mass spectrometry for the analysis of molecular sequence and architecture of hyperbranched glycopolymers journal, January 2015

Glycan analysis by ion mobility-mass spectrometry and gas-phase spectroscopy journal, February 2018

Oligosaccharide Analysis by Mass Spectrometry: A Review of Recent Developments journal, December 2013

Determining the Isomeric Heterogeneity of Neutral Oligosaccharide-Alditols of Bovine Submaxillary Mucin Using Negative Ion Traveling Wave Ion Mobility Mass Spectrometry journal, January 2015

Vertebrate protein glycosylation: diversity, synthesis and function journal, June 2012

Cryogenic Vibrational Spectroscopy Provides Unique Fingerprints for Glycan Identification journal, June 2017

Ion mobility mass spectrometry analysis of isomeric disaccharide precursor, product and cluster ions: Analysis of isomeric disaccharide precursor, product and cluster ions journal, October 2013

Structural resolution of carbohydrate positional and structural isomers based on gas-phase ion mobility-mass spectrometry journal, January 2011

Separation of sodiated isobaric disaccharides and trisaccharides using electrospray ionization-atmospheric pressure ion mobility-time of flight mass spectrometry journal, May 2005

Glycan Analysis by Ion Mobility-Mass Spectrometry journal, June 2017

Non-derivatized glycan analysis by reverse phase liquid chromatography and ion mobility-mass spectrometry journal, January 2015

Energy-Resolved Ion Mobility-Mass Spectrometry—A Concept to Improve the Separation of Isomeric Carbohydrates journal, January 2014

Automated Chemical Oligosaccharide Synthesis: Novel Approach to Traditional Challenges journal, June 2018

Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry journal, January 2016

Identification of carbohydrate anomers using ion mobility–mass spectrometry journal, September 2015

Recent advances on separation and characterization of human milk oligosaccharides: General journal, February 2016

Ion-neutral collisional cross sections of carbohydrate isomers as divalent cation adducts and their electron transfer products journal, January 2015

Squeezing of Ion Populations and Peaks in Traveling Wave Ion Mobility Separations and Structures for Lossless Ion Manipulations Using Compression Ratio Ion Mobility Programming journal, November 2016

Enhancing glycan isomer separations with metal ions and positive and negative polarity ion mobility spectrometry-mass spectrometry analyses journal, September 2016

Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO 2 as drift gas : Increasing ion mobility Synapt resolution with CO2 journal, December 2012

Multidimensional Analysis of 16 Glucose Isomers by Ion Mobility Spectrometry journal, February 2016

Ion Mobility–Mass Spectrometry of Complex Carbohydrates: Collision Cross Sections of Sodiated N-linked Glycans journal, May 2013

Ion Mobility Studies of Carbohydrates as Group I Adducts: Isomer Specific Collisional Cross Section Dependence on Metal Ion Radius journal, September 2013

Breast Milk Oligosaccharides: Structure-Function Relationships in the Neonate journal, July 2014

Ion Mobility Separations of Isomers based upon Long Path Length Structures for Lossless Ion Manipulations Combined with Mass Spectrometry journal, July 2016

Symbol Nomenclature for Graphical Representations of Glycans text, January 2015

Discrimination of Isomeric Carbohydrates as the Electron Transfer Products of Group II Cation Adducts by Ion Mobility Spectrometry and Tandem Mass Spectrometry
journal, May 2015

Human milk oligosaccharides: Every baby needs a sugar mama
journal, April 2012

Improved Sensitivity and Separations for Phosphopeptides using Online Liquid Chromotography Coupled with Structures for Lossless Ion Manipulations Ion Mobility–Mass Spectrometry
journal, August 2018

Rapid Ion Mobility Separations of Bile Acid Isomers Using Cyclodextrin Adducts and Structures for Lossless Ion Manipulations
journal, August 2018

Ultra-High Resolution Ion Mobility Separations Utilizing Traveling Waves in a 13 m Serpentine Path Length Structures for Lossless Ion Manipulations Module
journal, August 2016

A unified vision of the building blocks of life
journal, September 2008

Characterization of Isomeric Glycans by Reversed Phase Liquid Chromatography-Electronic Excitation Dissociation Tandem Mass Spectrometry
journal, April 2018

Anomeric memory of the glycosidic bond upon fragmentation and its consequences for carbohydrate sequencing
journal, October 2017

Serpentine Ultralong Path with Extended Routing (SUPER) High Resolution Traveling Wave Ion Mobility-MS using Structures for Lossless Ion Manipulations
journal, April 2017

Glycan Fingerprinting via Cold-Ion Infrared Spectroscopy
journal, June 2017

Compression Ratio Ion Mobility Programming (CRIMP) Accumulation and Compression of Billions of Ions for Ion Mobility-Mass Spectrometry Using Traveling Waves in Structures for Lossless Ion Manipulations (SLIM)
journal, May 2017

Human Milk Oligosaccharides Promote the Growth of Staphylococci
journal, May 2012

Recent Advances in the Analysis of Complex Glycoproteins
journal, November 2016

Symbol Nomenclature for Graphical Representations of Glycans
journal, November 2015

Recent advances in ion mobility–mass spectrometry for improved structural characterization of glycans and glycoconjugates
journal, February 2018

Cryogenic IR spectroscopy combined with ion mobility spectrometry for the analysis of human milk oligosaccharides
journal, January 2018

Tandem mass spectrometry and ion mobility mass spectrometry for the analysis of molecular sequence and architecture of hyperbranched glycopolymers
journal, January 2015

Glycan analysis by ion mobility-mass spectrometry and gas-phase spectroscopy
journal, February 2018

Oligosaccharide Analysis by Mass Spectrometry: A Review of Recent Developments
journal, December 2013

Determining the Isomeric Heterogeneity of Neutral Oligosaccharide-Alditols of Bovine Submaxillary Mucin Using Negative Ion Traveling Wave Ion Mobility Mass Spectrometry
journal, January 2015

Vertebrate protein glycosylation: diversity, synthesis and function
journal, June 2012

Cryogenic Vibrational Spectroscopy Provides Unique Fingerprints for Glycan Identification
journal, June 2017

Ion mobility mass spectrometry analysis of isomeric disaccharide precursor, product and cluster ions: Analysis of isomeric disaccharide precursor, product and cluster ions
journal, October 2013

Structural resolution of carbohydrate positional and structural isomers based on gas-phase ion mobility-mass spectrometry
journal, January 2011

Separation of sodiated isobaric disaccharides and trisaccharides using electrospray ionization-atmospheric pressure ion mobility-time of flight mass spectrometry
journal, May 2005

Glycan Analysis by Ion Mobility-Mass Spectrometry
journal, June 2017

Non-derivatized glycan analysis by reverse phase liquid chromatography and ion mobility-mass spectrometry
journal, January 2015

Energy-Resolved Ion Mobility-Mass Spectrometry—A Concept to Improve the Separation of Isomeric Carbohydrates
journal, January 2014

Automated Chemical Oligosaccharide Synthesis: Novel Approach to Traditional Challenges
journal, June 2018

Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry
journal, January 2016

Identification of carbohydrate anomers using ion mobility–mass spectrometry
journal, September 2015

Recent advances on separation and characterization of human milk oligosaccharides: General
journal, February 2016

Ion-neutral collisional cross sections of carbohydrate isomers as divalent cation adducts and their electron transfer products
journal, January 2015

Squeezing of Ion Populations and Peaks in Traveling Wave Ion Mobility Separations and Structures for Lossless Ion Manipulations Using Compression Ratio Ion Mobility Programming
journal, November 2016

Enhancing glycan isomer separations with metal ions and positive and negative polarity ion mobility spectrometry-mass spectrometry analyses
journal, September 2016

Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO ₂ as drift gas : Increasing ion mobility Synapt resolution with CO2
journal, December 2012

Multidimensional Analysis of 16 Glucose Isomers by Ion Mobility Spectrometry
journal, February 2016

Ion Mobility–Mass Spectrometry of Complex Carbohydrates: Collision Cross Sections of Sodiated N-linked Glycans
journal, May 2013

Ion Mobility Studies of Carbohydrates as Group I Adducts: Isomer Specific Collisional Cross Section Dependence on Metal Ion Radius
journal, September 2013

Breast Milk Oligosaccharides: Structure-Function Relationships in the Neonate
journal, July 2014

Ion Mobility Separations of Isomers based upon Long Path Length Structures for Lossless Ion Manipulations Combined with Mass Spectrometry
journal, July 2016

Symbol Nomenclature for Graphical Representations of Glycans
text, January 2015