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Title: Regioselective surface encoding of nanoparticles for programmable self-assembly

Abstract

Surface encoding of colloidal nanoparticles with DNA is fundamental for fields where recognition interaction is required, particularly controllable material self-assembly. However, regioselective surface encoding of nanoparticles is still challenging because of the difficulty associated with breaking the identical chemical environment on nanoparticle surfaces. Here we demonstrate the selective blocking of nanoparticle surfaces with a diblock copolymer (polystyrene-b-polyacrylic acid). By tuning the interfacial free energies of a ternary system involving the nanoparticles, solvent and copolymer, controllable accessibilities to the nanoparticles’ surfaces are obtained. Through the modification of the polymer-free surface region with single-stranded DNA, regioselective and programmable surface encoding is realized. The resultant interparticle binding potential is selective and directional, allowing for an increased degree of complexity of potential self-assemblies. As a result, the versatility of this regioselective surface encoding strategy is demonstrated on various nanoparticles of isotropic or anisotropic shape and a total of 24 distinct complex nanoassemblies are fabricated.

Authors:
 [1];  [2];  [2];  [2];  [2];  [3];  [3]; ORCiD logo [3]; ORCiD logo [4]; ORCiD logo [2]
  1. The Univ. of Chicago, Chicago, IL (United States); Univ. of Central Florida, Orlando, FL (United States)
  2. The Univ. of Chicago, Chicago, IL (United States)
  3. Brookhaven National Lab. (BNL), Upton, NY (United States)
  4. Brookhaven National Lab. (BNL), Upton, NY (United States); Columbia Univ., New York, NY (United States)
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1504881
Report Number(s):
BNL-211504-2019-JAAM
Journal ID: ISSN 1476-1122
Grant/Contract Number:  
SC0012704
Resource Type:
Accepted Manuscript
Journal Name:
Nature Materials
Additional Journal Information:
Journal Volume: 18; Journal Issue: 2; Journal ID: ISSN 1476-1122
Publisher:
Springer Nature - Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats

Chen, Gang, Gibson, Kyle J., Liu, Di, Rees, Huw C., Lee, Jung -Hoon, Xia, Weiwei, Lin, Ruoqian, Xin, Huolin L., Gang, Oleg, and Weizmann, Yossi. Regioselective surface encoding of nanoparticles for programmable self-assembly. United States: N. p., 2018. Web. doi:10.1038/s41563-018-0231-1.
Chen, Gang, Gibson, Kyle J., Liu, Di, Rees, Huw C., Lee, Jung -Hoon, Xia, Weiwei, Lin, Ruoqian, Xin, Huolin L., Gang, Oleg, & Weizmann, Yossi. Regioselective surface encoding of nanoparticles for programmable self-assembly. United States. doi:10.1038/s41563-018-0231-1.
Chen, Gang, Gibson, Kyle J., Liu, Di, Rees, Huw C., Lee, Jung -Hoon, Xia, Weiwei, Lin, Ruoqian, Xin, Huolin L., Gang, Oleg, and Weizmann, Yossi. Mon . "Regioselective surface encoding of nanoparticles for programmable self-assembly". United States. doi:10.1038/s41563-018-0231-1. https://www.osti.gov/servlets/purl/1504881.
@article{osti_1504881,
title = {Regioselective surface encoding of nanoparticles for programmable self-assembly},
author = {Chen, Gang and Gibson, Kyle J. and Liu, Di and Rees, Huw C. and Lee, Jung -Hoon and Xia, Weiwei and Lin, Ruoqian and Xin, Huolin L. and Gang, Oleg and Weizmann, Yossi},
abstractNote = {Surface encoding of colloidal nanoparticles with DNA is fundamental for fields where recognition interaction is required, particularly controllable material self-assembly. However, regioselective surface encoding of nanoparticles is still challenging because of the difficulty associated with breaking the identical chemical environment on nanoparticle surfaces. Here we demonstrate the selective blocking of nanoparticle surfaces with a diblock copolymer (polystyrene-b-polyacrylic acid). By tuning the interfacial free energies of a ternary system involving the nanoparticles, solvent and copolymer, controllable accessibilities to the nanoparticles’ surfaces are obtained. Through the modification of the polymer-free surface region with single-stranded DNA, regioselective and programmable surface encoding is realized. The resultant interparticle binding potential is selective and directional, allowing for an increased degree of complexity of potential self-assemblies. As a result, the versatility of this regioselective surface encoding strategy is demonstrated on various nanoparticles of isotropic or anisotropic shape and a total of 24 distinct complex nanoassemblies are fabricated.},
doi = {10.1038/s41563-018-0231-1},
journal = {Nature Materials},
number = 2,
volume = 18,
place = {United States},
year = {2018},
month = {12}
}

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Works referenced in this record:

Structural diversity in binary nanoparticle superlattices
journal, January 2006

  • Shevchenko, Elena V.; Talapin, Dmitri V.; Kotov, Nicholas A.
  • Nature, Vol. 439, Issue 7072, p. 55-59
  • DOI: 10.1038/nature04414

Colloidal Assembly: The Road from Particles to Colloidal Molecules and Crystals
journal, October 2010

  • Li, Fan; Josephson, David P.; Stein, Andreas
  • Angewandte Chemie International Edition, Vol. 50, Issue 2
  • DOI: 10.1002/anie.201001451

Janus Particles: Synthesis, Self-Assembly, Physical Properties, and Applications
journal, March 2013

  • Walther, Andreas; Müller, Axel H. E.
  • Chemical Reviews, Vol. 113, Issue 7, p. 5194-5261
  • DOI: 10.1021/cr300089t

Maximizing DNA Loading on a Range of Gold Nanoparticle Sizes
journal, December 2006

  • Hurst, Sarah J.; Lytton-Jean, Abigail K. R.; Mirkin, Chad A.
  • Analytical Chemistry, Vol. 78, Issue 24
  • DOI: 10.1021/ac0613582

Supracolloidal Reaction Kinetics of Janus Spheres
journal, January 2011


Mechanistic investigation into the spontaneous linear assembly of gold nanospheres
journal, January 2010

  • Yang, Miaoxin; Chen, Gang; Zhao, Yunfeng
  • Physical Chemistry Chemical Physics, Vol. 12, Issue 38
  • DOI: 10.1039/c0cp00127a

Self-assembly of magnetite nanocubes into helical superstructures
journal, July 2014


Stepwise Evolution of Spherical Seeds into 20-Fold Twinned Icosahedra
journal, August 2012


Morphogenic Effect of Added Ions on Crew-Cut Aggregates of Polystyrene- b -poly(acrylic acid) Block Copolymers in Solutions
journal, January 1996

  • Zhang, Lifeng; Eisenberg, Adi
  • Macromolecules, Vol. 29, Issue 27
  • DOI: 10.1021/ma961376t

DNA-guided crystallization of colloidal nanoparticles
journal, January 2008

  • Nykypanchuk, Dmytro; Maye, Mathew M.; van der Lelie, Daniel
  • Nature, Vol. 451, Issue 7178, p. 549-552
  • DOI: 10.1038/nature06560

Self-Assembled Monolayers of Thiolates on Metals as a Form of Nanotechnology
journal, April 2005

  • Love, J. Christopher; Estroff, Lara A.; Kriebel, Jennah K.
  • Chemical Reviews, Vol. 105, Issue 4
  • DOI: 10.1021/cr0300789

Organization of 'nanocrystal molecules' using DNA
journal, August 1996

  • Alivisatos, A. Paul; Johnsson, Kai P.; Peng, Xiaogang
  • Nature, Vol. 382, Issue 6592
  • DOI: 10.1038/382609a0

Size-Controlled Synthesis of Magnetite Nanoparticles
journal, July 2002

  • Sun, Shouheng; Zeng, Hao
  • Journal of the American Chemical Society, Vol. 124, Issue 28
  • DOI: 10.1021/ja026501x

Colloidosome-based Synthesis of a Multifunctional Nanostructure of Silver and Hollow Iron Oxide Nanoparticles
journal, March 2010

  • Pan, Yue; Gao, Jinhao; Zhang, Bei
  • Langmuir, Vol. 26, Issue 6
  • DOI: 10.1021/la904067q

Surface patterning of nanoparticles with polymer patches
journal, August 2016

  • Choueiri, Rachelle M.; Galati, Elizabeth; Thérien-Aubin, Héloïse
  • Nature, Vol. 538, Issue 7623
  • DOI: 10.1038/nature19089

Geometric curvature controls the chemical patchiness and self-assembly of nanoparticles
journal, August 2013

  • Walker, David A.; Leitsch, Emily K.; Nap, Rikkert J.
  • Nature Nanotechnology, Vol. 8, Issue 9, p. 676-681
  • DOI: 10.1038/nnano.2013.158

Self-Assembly at All Scales
journal, March 2002

  • Whitesides, George M.; Grzybowski, Bartosz
  • Science, Vol. 295, Issue 5564, p. 2418-2421
  • DOI: 10.1126/science.1070821

On Interaction between Two Bodies Immersed in a Solution of Macromolecules
journal, July 1954

  • Asakura, Sho; Oosawa, Fumio
  • The Journal of Chemical Physics, Vol. 22, Issue 7
  • DOI: 10.1063/1.1740347

Shape-Controlled Synthesis of Metal Nanocrystals: Simple Chemistry Meets Complex Physics?
journal, December 2008

  • Xia, Younan; Xiong, Yujie; Lim, Byungkwon
  • Angewandte Chemie International Edition, Vol. 48, Issue 1, p. 60-103
  • DOI: 10.1002/anie.200802248

Anisotropic Overgrowth of Metal Heterostructures Induced by a Site-Selective Silica Coating
journal, August 2013

  • Wang, Feng; Cheng, Si; Bao, Zhihong
  • Angewandte Chemie International Edition, Vol. 52, Issue 39
  • DOI: 10.1002/anie.201304364

Diamond family of nanoparticle superlattices
journal, February 2016


Stepwise surface encoding for high-throughput assembly of nanoclusters
journal, March 2009

  • Maye, Mathew M.; Nykypanchuk, Dmytro; Cuisinier, Marine
  • Nature Materials, Vol. 8, Issue 5
  • DOI: 10.1038/nmat2421

Site-Specific Surface Functionalization of Gold Nanorods Using DNA Origami Clamps
journal, February 2016

  • Shen, Chenqi; Lan, Xiang; Lu, Xuxing
  • Journal of the American Chemical Society, Vol. 138, Issue 6
  • DOI: 10.1021/jacs.5b11566

Asymmetric Functionalization of Gold Nanoparticles with Oligonucleotides
journal, July 2006

  • Xu, Xiaoyang; Rosi, Nathaniel L.; Wang, Yuhuang
  • Journal of the American Chemical Society, Vol. 128, Issue 29
  • DOI: 10.1021/ja061980b

Plasmon Coupling in Clusters Composed of Two-Dimensionally Ordered Gold Nanocubes
journal, September 2009


Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR
journal, May 2015


One-Dimensional Nanostructures: Synthesis, Characterization, and Applications
journal, March 2003


Transfer of molecular recognition information from DNA nanostructures to gold nanoparticles
journal, January 2016

  • Edwardson, Thomas G. W.; Lau, Kai Lin; Bousmail, Danny
  • Nature Chemistry, Vol. 8, Issue 2
  • DOI: 10.1038/nchem.2420

Self-organized architectures from assorted DNA-framed nanoparticles
journal, June 2016

  • Liu, Wenyan; Halverson, Jonathan; Tian, Ye
  • Nature Chemistry, Vol. 8, Issue 9
  • DOI: 10.1038/nchem.2540

Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method
journal, May 2003

  • Nikoobakht, Babak; El-Sayed, Mostafa A.
  • Chemistry of Materials, Vol. 15, Issue 10
  • DOI: 10.1021/cm020732l

Three-phase interactions in shear and electrical fields
journal, May 1970


Monodisperse Gold Nanotriangles: Size Control, Large-Scale Self-Assembly, and Performance in Surface-Enhanced Raman Scattering
journal, May 2014

  • Scarabelli, Leonardo; Coronado-Puchau, Marc; Giner-Casares, Juan J.
  • ACS Nano, Vol. 8, Issue 6
  • DOI: 10.1021/nn500727w

Controlling anisotropic nanoparticle growth through plasmon excitation
journal, October 2003

  • Jin, Rongchao; Charles Cao, Y.; Hao, Encai
  • Nature, Vol. 425, Issue 6957
  • DOI: 10.1038/nature02020

Hotspot-Induced Transformation of Surface-Enhanced Raman Scattering Fingerprints
journal, May 2010


Correlating the Crystal Structure of A Thiol-Protected Au25 Cluster and Optical Properties
journal, May 2008

  • Zhu, Manzhou; Aikens, Christine M.; Hollander, Frederick J.
  • Journal of the American Chemical Society, Vol. 130, Issue 18, p. 5883-5885
  • DOI: 10.1021/ja801173r

Curvature-Directed Assembly of Gold Nanocubes, Nanobranches, and Nanospheres
journal, February 2009

  • Kou, Xiaoshan; Sun, Zhenhua; Yang, Zhi
  • Langmuir, Vol. 25, Issue 3
  • DOI: 10.1021/la802883p

Step-Growth Polymerization of Inorganic Nanoparticles
journal, July 2010


Shape-Controlled Synthesis of Gold and Silver Nanoparticles
journal, December 2002


DNA-programmable nanoparticle crystallization
journal, January 2008

  • Park, Sung Yong; Lytton-Jean, Abigail K. R.; Lee, Byeongdu
  • Nature, Vol. 451, Issue 7178, p. 553-556
  • DOI: 10.1038/nature06508

Self-Assembly of Molecule-like Nanoparticle Clusters Directed by DNA Nanocages
journal, March 2015

  • Li, Yulin; Liu, Zhiyu; Yu, Guimei
  • Journal of the American Chemical Society, Vol. 137, Issue 13
  • DOI: 10.1021/jacs.5b01196

DNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response
journal, March 2012

  • Kuzyk, Anton; Schreiber, Robert; Fan, Zhiyuan
  • Nature, Vol. 483, Issue 7389
  • DOI: 10.1038/nature10889

A Hybridization Model for the Plasmon Response of Complex Nanostructures
journal, October 2003


DNA-Directed Assembly of Asymmetric Nanoclusters Using Janus Nanoparticles
journal, December 2011

  • Xing, Hang; Wang, Zidong; Xu, Zhida
  • ACS Nano, Vol. 6, Issue 1
  • DOI: 10.1021/nn2042797

Quantitation of Metal Content in the Silver-Assisted Growth of Gold Nanorods
journal, March 2006

  • Orendorff, Christopher J.; Murphy, Catherine J.
  • The Journal of Physical Chemistry B, Vol. 110, Issue 9
  • DOI: 10.1021/jp0570972

Head-group-induced structural micellar transitions in mixed cationic surfactants with identical hydrophobic tails
journal, January 2003


Semiconductor Clusters, Nanocrystals, and Quantum Dots
journal, February 1996


Properties and emerging applications of self-assembled structures made from inorganic nanoparticles
journal, December 2009

  • Nie, Zhihong; Petukhova, Alla; Kumacheva, Eugenia
  • Nature Nanotechnology, Vol. 5, Issue 1
  • DOI: 10.1038/nnano.2009.453

Depletion-Induced Shape and Size Selection of Gold Nanoparticles
journal, April 2010

  • Park, Kyoungweon; Koerner, Hilmar; Vaia, Richard A.
  • Nano Letters, Vol. 10, Issue 4
  • DOI: 10.1021/nl100345u

Controlled Assembly of Eccentrically Encapsulated Gold Nanoparticles
journal, September 2008

  • Chen, Tao; Yang, Miaoxin; Wang, Xinjiao
  • Journal of the American Chemical Society, Vol. 130, Issue 36
  • DOI: 10.1021/ja8040288

Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications
journal, July 2009

  • Huang, Xiaohua; Neretina, Svetlana; El-Sayed, Mostafa A.
  • Advanced Materials, Vol. 21, Issue 48, p. 4880-4910
  • DOI: 10.1002/adma.200802789

Solvent isotope effects on alkytrimethylammonium bromide micelles as a function of alkyl chain length
journal, August 1987


Bipyramid-templated synthesis of monodisperse anisotropic gold nanocrystals
journal, June 2015

  • Lee, Jung-Hoon; Gibson, Kyle J.; Chen, Gang
  • Nature Communications, Vol. 6, Issue 1
  • DOI: 10.1038/ncomms8571