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Title: Photonic crystal nanobeam biosensors based on porous silicon

Abstract

Photonic crystal (PhC) nanobeams (NB) patterned on porous silicon (PSi) waveguide substrates are demonstrated for the specific, label-free detection of oligonucleotides. These photonic structures combine the large active sensing area intrinsic to PSi sensors with the high-quality (Q) factor and low-mode volume characteristic of compact resonant silicon-on-insulator (SOI) PhC NB devices. The PSi PhC NB can achieve a Q-factor near 9,000 and has an approximately 40-fold increased active sensing area for molecular attachment, compared to traditional SOI PhC NB sensors. The PSi PhC NB exhibits a resonance shift that is more than one order of magnitude larger than that of a similarly designed SOI PhC NB for the detection of small chemical molecules and 16-base peptide nucleic acids. Furthermore the design and fabrication of PSi PhC NB sensors are compatible with CMOS processing, sensor arrays, and integration with lab-on-chip systems.

Authors:
 [1];  [1];  [2];  [3]; ORCiD logo [1];  [1]; ORCiD logo [1]; ORCiD logo [4]; ORCiD logo [4]; ORCiD logo [1]
  1. Vanderbilt Univ., Nashville, TN (United States)
  2. Vanderbilt Univ., Nashville, TN (United States); Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
  3. Vanderbilt Univ., Nashville, TN (United States); Daffodil International Univ., Dhaka (Bangladesh)
  4. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1504022
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Optics Express
Additional Journal Information:
Journal Volume: 27; Journal Issue: 7; Journal ID: ISSN 1094-4087
Publisher:
Optical Society of America (OSA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 47 OTHER INSTRUMENTATION

Citation Formats

Rodriguez, Gilberto A., Markov, Petr, Cartwright, Alyssa P., Choudhury, Moinul H., Afzal, Francis O., Cao, Tengfei, Halimi, Sami I., Retterer, Scott T., Kravchenko, Ivan I., and Weiss, Sharon M. Photonic crystal nanobeam biosensors based on porous silicon. United States: N. p., 2019. Web. doi:10.1364/OE.27.009536.
Rodriguez, Gilberto A., Markov, Petr, Cartwright, Alyssa P., Choudhury, Moinul H., Afzal, Francis O., Cao, Tengfei, Halimi, Sami I., Retterer, Scott T., Kravchenko, Ivan I., & Weiss, Sharon M. Photonic crystal nanobeam biosensors based on porous silicon. United States. doi:10.1364/OE.27.009536.
Rodriguez, Gilberto A., Markov, Petr, Cartwright, Alyssa P., Choudhury, Moinul H., Afzal, Francis O., Cao, Tengfei, Halimi, Sami I., Retterer, Scott T., Kravchenko, Ivan I., and Weiss, Sharon M. Tue . "Photonic crystal nanobeam biosensors based on porous silicon". United States. doi:10.1364/OE.27.009536. https://www.osti.gov/servlets/purl/1504022.
@article{osti_1504022,
title = {Photonic crystal nanobeam biosensors based on porous silicon},
author = {Rodriguez, Gilberto A. and Markov, Petr and Cartwright, Alyssa P. and Choudhury, Moinul H. and Afzal, Francis O. and Cao, Tengfei and Halimi, Sami I. and Retterer, Scott T. and Kravchenko, Ivan I. and Weiss, Sharon M.},
abstractNote = {Photonic crystal (PhC) nanobeams (NB) patterned on porous silicon (PSi) waveguide substrates are demonstrated for the specific, label-free detection of oligonucleotides. These photonic structures combine the large active sensing area intrinsic to PSi sensors with the high-quality (Q) factor and low-mode volume characteristic of compact resonant silicon-on-insulator (SOI) PhC NB devices. The PSi PhC NB can achieve a Q-factor near 9,000 and has an approximately 40-fold increased active sensing area for molecular attachment, compared to traditional SOI PhC NB sensors. The PSi PhC NB exhibits a resonance shift that is more than one order of magnitude larger than that of a similarly designed SOI PhC NB for the detection of small chemical molecules and 16-base peptide nucleic acids. Furthermore the design and fabrication of PSi PhC NB sensors are compatible with CMOS processing, sensor arrays, and integration with lab-on-chip systems.},
doi = {10.1364/OE.27.009536},
journal = {Optics Express},
number = 7,
volume = 27,
place = {United States},
year = {2019},
month = {3}
}

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