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Title: A high-speed, high-performance, microfabricated comprehensive two-dimensional gas chromatograph

Abstract

A small, consumable-free, low-power, ultra-high-speed comprehensive GC×GC system consisting of microfabricated columns, nanoelectromechanical system (NEMS) cantilever resonators for detection, and a valve-based stop-flow modulator is demonstrated. The separation of a highly polar 29-component mixture covering a boiling point range of 46 to 253 °C on a pair of microfabricated columns using a Staiger valve manifold in less than 7 seconds, and just over 4 seconds after the ensemble holdup time is demonstrated with a downstream FID. The analysis time of the second dimension was 160 ms, and peak widths in the second dimension range from 10–60 ms. A peak capacity of just over 300 was calculated for a separation of just over 6 s. Data from a continuous operation testing over 40 days and 20 000 runs of the GC×GC columns with the NEMS resonators using a 4-component test set is presented. As a result, the GC×GC-NEMS resonator system generated second-dimension peak widths as narrow as 8 ms with no discernable peak distortion due to under-sampling from the detector.

Authors:
 [1];  [2];  [1];  [1];  [1];  [1];  [1];  [1]; ORCiD logo [1];  [1];  [1];  [1];  [1];  [1]; ORCiD logo [1];  [2];  [1]
+ Show Author Affiliations
  1. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
  2. California Inst. of Technology (CalTech), Pasadena, CA (United States)
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
DARPA Micro Gas Analyzer; USDOE
OSTI Identifier:
1507410
Alternate Identifier(s):
OSTI ID: 1503725
Report Number(s):
SAND-2019-3452J
Journal ID: ISSN 1473-0197; LCAHAM; 673864
Grant/Contract Number:  
AC04-94AL85000; 199974
Resource Type:
Accepted Manuscript
Journal Name:
Lab on a Chip
Additional Journal Information:
Journal Volume: 19; Journal Issue: 9; Journal ID: ISSN 1473-0197
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Whiting, Joshua J., Myers, Edward, Manginell, Ronald P., Moorman, Mathew W., Anderson, John, Fix, Cory S., Washburn, Cody, Staton, Al, Porter, Daniel, Graf, Darin, Wheeler, David R., Howell, Stephen, Richards, John, Monteith, Haley, Achyuthan, Komandoor E., Roukes, Michael, and Simonson, Robert J. A high-speed, high-performance, microfabricated comprehensive two-dimensional gas chromatograph. United States: N. p., 2019. Web. doi:10.1039/C9LC00027E.
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Whiting, Joshua J., Myers, Edward, Manginell, Ronald P., Moorman, Mathew W., Anderson, John, Fix, Cory S., Washburn, Cody, Staton, Al, Porter, Daniel, Graf, Darin, Wheeler, David R., Howell, Stephen, Richards, John, Monteith, Haley, Achyuthan, Komandoor E., Roukes, Michael, & Simonson, Robert J. A high-speed, high-performance, microfabricated comprehensive two-dimensional gas chromatograph. United States. https://doi.org/10.1039/C9LC00027E
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Whiting, Joshua J., Myers, Edward, Manginell, Ronald P., Moorman, Mathew W., Anderson, John, Fix, Cory S., Washburn, Cody, Staton, Al, Porter, Daniel, Graf, Darin, Wheeler, David R., Howell, Stephen, Richards, John, Monteith, Haley, Achyuthan, Komandoor E., Roukes, Michael, and Simonson, Robert J. Mon . "A high-speed, high-performance, microfabricated comprehensive two-dimensional gas chromatograph". United States. https://doi.org/10.1039/C9LC00027E. https://www.osti.gov/servlets/purl/1507410.
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@article{osti_1507410,
title = {A high-speed, high-performance, microfabricated comprehensive two-dimensional gas chromatograph},
author = {Whiting, Joshua J. and Myers, Edward and Manginell, Ronald P. and Moorman, Mathew W. and Anderson, John and Fix, Cory S. and Washburn, Cody and Staton, Al and Porter, Daniel and Graf, Darin and Wheeler, David R. and Howell, Stephen and Richards, John and Monteith, Haley and Achyuthan, Komandoor E. and Roukes, Michael and Simonson, Robert J.},
abstractNote = {A small, consumable-free, low-power, ultra-high-speed comprehensive GC×GC system consisting of microfabricated columns, nanoelectromechanical system (NEMS) cantilever resonators for detection, and a valve-based stop-flow modulator is demonstrated. The separation of a highly polar 29-component mixture covering a boiling point range of 46 to 253 °C on a pair of microfabricated columns using a Staiger valve manifold in less than 7 seconds, and just over 4 seconds after the ensemble holdup time is demonstrated with a downstream FID. The analysis time of the second dimension was 160 ms, and peak widths in the second dimension range from 10–60 ms. A peak capacity of just over 300 was calculated for a separation of just over 6 s. Data from a continuous operation testing over 40 days and 20 000 runs of the GC×GC columns with the NEMS resonators using a 4-component test set is presented. As a result, the GC×GC-NEMS resonator system generated second-dimension peak widths as narrow as 8 ms with no discernable peak distortion due to under-sampling from the detector.},
doi = {10.1039/C9LC00027E},
journal = {Lab on a Chip},
number = 9,
volume = 19,
place = {United States},
year = {Mon Mar 18 00:00:00 EDT 2019},
month = {Mon Mar 18 00:00:00 EDT 2019}
}
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https://doi.org/10.1039/C9LC00027E
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