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Title: Use of 3D imaging for providing insights into high-order structure of mitotic chromosomes

Abstract

Here, the high-order structure of metaphase chromosomes remains still under investigation, especially the 30-nm structure that is still controversial. Advanced 3D imaging has provided useful information for our understanding of this detailed structure. It is evident that new technologies together with improved sample preparations and image analyses should be adequately combined. This mini review highlights 3D imaging used for chromosome analysis so far with future imaging directions also highlighted.

Authors:
ORCiD logo [1];  [2];  [2]; ORCiD logo [3]
  1. Univ. College London, London (United Kingdom); Aga Khan Univ., Karachi (Pakistan)
  2. Osaka Univ., Osaka (Japan)
  3. Univ. College London, London (United Kingdom); Brookhaven National Lab. (BNL), Upton, NY (United States)
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1503225
Alternate Identifier(s):
OSTI ID: 1462414
Report Number(s):
BNL-211436-2019-JAAM; BNL-207897-2018-JAAM
Journal ID: ISSN 0009-5915
Grant/Contract Number:  
SC0012704
Resource Type:
Accepted Manuscript
Journal Name:
Chromosoma
Additional Journal Information:
Journal Volume: 128; Journal Issue: 1; Journal ID: ISSN 0009-5915
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; Chromosome structure; Chromatin; 3D; High-resolution imaging

Citation Formats

Yusuf, Mohammed, Kaneyoshi, Kohei, Fukui, Kiichi, and Robinson, Ian. Use of 3D imaging for providing insights into high-order structure of mitotic chromosomes. United States: N. p., 2018. Web. doi:10.1007/s00412-018-0678-5.
Yusuf, Mohammed, Kaneyoshi, Kohei, Fukui, Kiichi, & Robinson, Ian. Use of 3D imaging for providing insights into high-order structure of mitotic chromosomes. United States. doi:10.1007/s00412-018-0678-5.
Yusuf, Mohammed, Kaneyoshi, Kohei, Fukui, Kiichi, and Robinson, Ian. Mon . "Use of 3D imaging for providing insights into high-order structure of mitotic chromosomes". United States. doi:10.1007/s00412-018-0678-5. https://www.osti.gov/servlets/purl/1503225.
@article{osti_1503225,
title = {Use of 3D imaging for providing insights into high-order structure of mitotic chromosomes},
author = {Yusuf, Mohammed and Kaneyoshi, Kohei and Fukui, Kiichi and Robinson, Ian},
abstractNote = {Here, the high-order structure of metaphase chromosomes remains still under investigation, especially the 30-nm structure that is still controversial. Advanced 3D imaging has provided useful information for our understanding of this detailed structure. It is evident that new technologies together with improved sample preparations and image analyses should be adequately combined. This mini review highlights 3D imaging used for chromosome analysis so far with future imaging directions also highlighted.},
doi = {10.1007/s00412-018-0678-5},
journal = {Chromosoma},
number = 1,
volume = 128,
place = {United States},
year = {2018},
month = {9}
}

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