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Title: LungMAP: The Molecular Atlas of Lung Development Program

Abstract

The National Heart, Lung, and Blood Institute is funding an effort to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource and public education tool. The lung is a complex organ with lengthy development time driven by interactive gene networks and dynamic cross talk among multiple cell types to control and coordinate lineage specification, cell proliferation, differentiation, migration, morphogenesis, and injury repair. A better understanding of the processes that regulate lung development, particularly alveologenesis, will have a significant impact on survival rates for premature infants born with incomplete lung development and will facilitate lung injury repair and regeneration in adults. A consortium of four research centers, a data coordinating center, and a human tissue repository provides high-quality molecular data of developing human and mouse lungs. LungMAP includes mouse and human data for cross correlation of developmental processes across species. LungMAP is generating foundational data and analysis, creating a web portal for presentation of results and public sharing of data sets, establishing a repository of young human lung tissues obtained through organ donor organizations, and developing a comprehensive lung ontology that incorporates the latest findings of the consortium. The LungMAP website (www.lungmap.net) currently contains moremore » than 6,000 high-resolution lung images and transcriptomic, proteomic, and lipidomic human and mouse data and provides scientific information to stimulate interest in research careers for young audiences. This paper presents a brief description of research conducted by the consortium, database, and portal development and upcoming features that will enhance the LungMAP experience for a community of users.« less

Authors:
 [1];  [1];  [2];  [3];  [2];  [4];  [5];  [6];  [7];  [8];  [7];  [9];  [8];  [10];  [11]
  1. RTI International, Research Triangle Park, NC (United States)
  2. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  3. Texas Advanced Computing Center, Austin, TX (United States)
  4. Univ. of Washington, Seattle, WA (United States)
  5. Univ. of California, San Diego, CA (United States)
  6. Yale Univ., New Haven, CT (United States). School of Medicine
  7. Univ. of Rochester, NY (United States). Medical Center
  8. Cincinnati Children’s Hospital Medical Center, Cincinnati, OH (United States)
  9. Children’s Hospital of Los Angeles, Los Angeles, CA (United States)
  10. Duke Univ., Durham, NC (United States). School of Medicine
  11. Univ. of Alabama, Birmingham, AL (United States)
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
Contributing Org.:
The LungMAP Consortium
OSTI Identifier:
1503219
Report Number(s):
PNNL-SA-136379
Journal ID: ISSN 1040-0605
Grant/Contract Number:  
AC05-76RL01830
Resource Type:
Accepted Manuscript
Journal Name:
American Journal of Physiology-Lung Cellular and Molecular Physiology
Additional Journal Information:
Journal Volume: 313; Journal Issue: 5; Journal ID: ISSN 1040-0605
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Ardini-Poleske, Maryanne E., Clark, Robert F., Ansong, Charles, Carson, James P., Corley, Richard A., Deutsch, Gail H., Hagood, James S., Kaminski, Naftali, Mariani, Thomas J., Potter, Steven S., Pryhuber, Gloria S., Warburton, David, Whitsett, Jeffrey A., Palmer, Scott M., and Ambalavanan, Namasivayam. LungMAP: The Molecular Atlas of Lung Development Program. United States: N. p., 2017. Web. doi:10.1152/ajplung.00139.2017.
Ardini-Poleske, Maryanne E., Clark, Robert F., Ansong, Charles, Carson, James P., Corley, Richard A., Deutsch, Gail H., Hagood, James S., Kaminski, Naftali, Mariani, Thomas J., Potter, Steven S., Pryhuber, Gloria S., Warburton, David, Whitsett, Jeffrey A., Palmer, Scott M., & Ambalavanan, Namasivayam. LungMAP: The Molecular Atlas of Lung Development Program. United States. doi:10.1152/ajplung.00139.2017.
Ardini-Poleske, Maryanne E., Clark, Robert F., Ansong, Charles, Carson, James P., Corley, Richard A., Deutsch, Gail H., Hagood, James S., Kaminski, Naftali, Mariani, Thomas J., Potter, Steven S., Pryhuber, Gloria S., Warburton, David, Whitsett, Jeffrey A., Palmer, Scott M., and Ambalavanan, Namasivayam. Wed . "LungMAP: The Molecular Atlas of Lung Development Program". United States. doi:10.1152/ajplung.00139.2017. https://www.osti.gov/servlets/purl/1503219.
@article{osti_1503219,
title = {LungMAP: The Molecular Atlas of Lung Development Program},
author = {Ardini-Poleske, Maryanne E. and Clark, Robert F. and Ansong, Charles and Carson, James P. and Corley, Richard A. and Deutsch, Gail H. and Hagood, James S. and Kaminski, Naftali and Mariani, Thomas J. and Potter, Steven S. and Pryhuber, Gloria S. and Warburton, David and Whitsett, Jeffrey A. and Palmer, Scott M. and Ambalavanan, Namasivayam},
abstractNote = {The National Heart, Lung, and Blood Institute is funding an effort to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource and public education tool. The lung is a complex organ with lengthy development time driven by interactive gene networks and dynamic cross talk among multiple cell types to control and coordinate lineage specification, cell proliferation, differentiation, migration, morphogenesis, and injury repair. A better understanding of the processes that regulate lung development, particularly alveologenesis, will have a significant impact on survival rates for premature infants born with incomplete lung development and will facilitate lung injury repair and regeneration in adults. A consortium of four research centers, a data coordinating center, and a human tissue repository provides high-quality molecular data of developing human and mouse lungs. LungMAP includes mouse and human data for cross correlation of developmental processes across species. LungMAP is generating foundational data and analysis, creating a web portal for presentation of results and public sharing of data sets, establishing a repository of young human lung tissues obtained through organ donor organizations, and developing a comprehensive lung ontology that incorporates the latest findings of the consortium. The LungMAP website (www.lungmap.net) currently contains more than 6,000 high-resolution lung images and transcriptomic, proteomic, and lipidomic human and mouse data and provides scientific information to stimulate interest in research careers for young audiences. This paper presents a brief description of research conducted by the consortium, database, and portal development and upcoming features that will enhance the LungMAP experience for a community of users.},
doi = {10.1152/ajplung.00139.2017},
journal = {American Journal of Physiology-Lung Cellular and Molecular Physiology},
number = 5,
volume = 313,
place = {United States},
year = {2017},
month = {11}
}

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Figures / Tables:

Fig. 1 Fig. 1: The LungMAP Consortium. Organizations funded by the National Heart, Lung, and Blood Institute for the Molecular Atlas of Lung Development Program. NIH, National Institutes of Health.

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    Works referencing / citing this record:

    NITPicker: selecting time points for follow-up experiments
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